Did You Know...
...that the Slinky toy was the result of a failed attempt by engineer Richard James to produce an antivibration device for ship instruments? His goal was to develop a spring that would instantaneously counterbalance the wave motion that rocks a ship at sea. Instead, he developed the Slinky.
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| Number | Title | Issue Date |
| 5880150 | Antimicrobial agent containing allyl isothiocyanate and method for controlling release speed of allyl isothiocyanate An antimicrobial agent comprising allyl isothiocyanate (AIT) packaged in a packaging material having a structure wherein part of the pores of a porous packaging substrate is filled with, or said pores are partially or entirely narrowed by a resin impervio... | 03/09/1999 |
| 5876759 | Rapidly disintegrating pharmaceutical dosage form and process for preparation thereof The present invention relates to a compressed pharmaceutical dosage form containing pharmaceutical particles coated with a taste-masking composition, a water-disintegratable, compressible carbohydrate and a binder. These components are dry blended and com... | 03/02/1999 |
| 5876760 | Granules containing pranlukast, process for producing the granules, and method of improving adhesiveness of pranlukast Spray-dried granules comprising pranlukast (A) and one or more saccharide(s) (B) as essential ingredients and further comprising one or more water-soluble polymer(s) (C) and/or one or more surfactant(s) (D); a process for producing the same; and a method ... | 03/02/1999 |
| 5869102 | Solid pharmaceutical compositions containing (S)-2-(4-isobutylphenyl) propionic acid active ingredient and microcrystalline cellulose and colloidal silica as excipients The present invention relates to a solid pharmaceutical composition containing (S)-2-(4-isobutylphenyl) propionic acid as active ingredient and it relates to a solid pharmaceutical composition suitable for the preparation of pharmaceutical forms in tablet... | 02/09/1999 |
| 5869101 | Process for the preparation of S(+)-ibuprofen-particles A process for the production of S(+)-ibuprofen-particles having improved flow properties comprises the steps that coarse-crystalline S(+)-ibuprofen is molten and then in a molten condition is finely distributed in a non-solving medium, preferably in cold ... | 02/09/1999 |
| 5866166 | Pharmaceutical excipient having improved compressibility A composition, comprising (a) microcrystalline cellulose; and (b) a compressibility augmenting agent which (i) physically restricts the proximity of the interface between adjacent cellulose surfaces; or (ii) inhibits interactions between adjacent cellulos... | 02/02/1999 |
| 5858409 | Hydrolyzed cellulose granulations for pharmaceuticals The present invention provides a method for preparing a spray-dried compressible granular formulation for preparing pharmaceutical tablets in which hydrolyzed cellulose is used as a granulation aid, the resulting granulations, and pharmaceutical tablets c... | 01/12/1999 |
| 5858410 | Pharmaceutical nanosuspensions for medicament administration as systems with increased saturation solubility and rate of solution Provided is a drug carrier comprising particles of at least one pure active compound which is insoluble, only sparingly soluble or moderately soluble in water, aqueous media and/or organic solvents, wherein said active ingredient is solid at room temperat... | 01/12/1999 |
| 5858412 | Sustained release formulations utilizing pharmaceutical excipient having improved compressibility with modified microcrystalline Sustained release formulations include an augmented microcrystalline cellulose, an active agent, and a sustained release carrier and methods for making same are disclosed.... | 01/12/1999 |
| 5855914 | Granules having core and their production Granules having a core are produced by spraying core granules with a dispersion of a low substituted hydroxypropylcellulose (L-HPC), and, if necessary, simultaneously applying a dusting powder. The granules having a core thus obtained exhibit increased gr... | 01/05/1999 |
| 5851579 | Aqueous enteric coating compositions The present invention sets forth an enteric coating composition comprising a blend of a) an alkali-soluble acrylic latex polymer and b) an aqueous solution of ammonium or alkaline salts of cellulose polymers. The invention also sets forth a method for preparing an ... | 12/22/1998 |
| 5843743 | Gels for encapsulation of biological materials Water soluble macromers are modified by addition of free radical polymerizable groups, such as those containing a carbon-carbon double or triple bond, which can be polymerized under mild conditions to encapsulate tissues, cells, or biologically active mat... | 12/01/1998 |
| 5840329 | Pulsatile drug delivery system A pulsatile drug delivery system comprising of a plurality of particles is able to deliver drug in any desired patterns. A plurality of particles with multi-layer core capable of short-pulse release interlaced with long-duration release is designed for de... | 11/24/1998 |
| 5840332 | Gastrointestinal drug delivery system A gastrointestinal delivery system is provided. The system comprises a drug in combination with a core material, the core being surrounded by a water-insoluble or relatively water-insoluble coating material in which particulate water-insoluble material is... | 11/24/1998 |
| 5837292 | Granulate for the preparation of fast-disintegrating and fast-dissolving compositions containing a high amount of drug A granulate, containing a drug having a solubility in water of 1:>10 and ࣘ15 weight percent of a water dispersible hydrocolloid incorporated into a fast-disintegrating and fast-dissolving composition.... | 11/17/1998 |
| 5837379 | Once daily pharmaceutical tablet having a unitary core A controlled release nifedipine tablet which comprises: (a) a homogeneous compressed core which comprises: (i) a medicament; (ii) a water soluble osmotic compound (iii) one or more osmotic polymers; and (b) a membrane coating which completely covers said core tablet whi... | 11/17/1998 |
| 5837291 | Enteric preparation coated with a non-solvent enteric coating agent using a liquid plasticizer An enteric preparation prepared by coating a solid dosage form with a fine powder enteric coating agent while spraying a liquid plasticizer.... | 11/17/1998 |
| 5834024 | Controlled absorption diltiazem pharmaceutical formulation A controlled absorption diltiazem pellet formulation for oral administration comprises a core having diltiazem or a pharmaceutically acceptable salt thereof as the active ingredient. The core is surrounded by a coating which has only a single layer which ... | 11/10/1998 |
| 5834021 | Prednisolone metasulphobenzoate preparation for the treatment of inflammatory bowel disease The dissolution at pH 6.5 of prednisolone metasulphobenzoate or a pharmacologically acceptable salt thereof from a non-disintegratable solid enteric composition comprising the prednisolone metasulphobenzoate in an excipient matrix is increased by the pres... | 11/10/1998 |
| 5827541 | Process for preparing solid pharmaceutical dosage forms of hydrophobic substances Process for preparing an oral rapidly disintegrating dosage form of a hydrophobic pharmaceutically active substance comprising forming a suspension of the hydrophobic pharmaceutically active substance in a solvent containing a pharmaceutically acceptable ... | 10/27/1998 |
| 5817340 | Pharmaceutical compositions containing famotidine and aluminum hydroxide or magnesium hydroxide A solid oral dosage form for the treatment of gastrointestinal disorders comprising a therapeutically effective amount of a therapeutically effective amount of guanidinothiazole compound; and a therapeutically effective amount of an antacid wherein the ph... | 10/06/1998 |
| 5814336 | Pharmaceutical dosage form for colonic delivery The present invention relates to a pharmaceutical composition in a unit dosage form for peroral administration in a human or lower animal, having a gastrointestinal tract comprising a small intestine and a colon with a lumen therethrough having an inlet t... | 09/29/1998 |
| 5800834 | Liquisolid systems and methods of preparing same Liquisolid systems are acceptably flowing and compressible powdered forms of liquid medications. According to the concept of liquisolid systems, liquid lipophilic drugs, or water-insoluble solid drugs dissolved in suitable non-volatile solvents, may be co... | 09/01/1998 |
| 5800836 | Pelletized pharmaceutical composition A pelletized sustained release pharmaceutical composition including a core element including approximately 0.1 to 95% by weight, based on the total weight of the core element, of an active ingredient of low aqueous solubility; approximately 0.1 to 55% by ... | 09/01/1998 |
| 5792471 | Dispensing devices powered by hydrogel This invention relates to devices useful for the controlled delivery of one or more beneficial agents to an environment of use. More specifically, this invention concerns such devices which are powered by hydrogel. This invention also relates to the contr... | 08/11/1998 |
| 5783215 | Pharmaceutical preparation Controlled release beads containing a core around which is a drug-containing layer e.g. a layer containing furosemid and a process for their preparation and their use in a pharmaceutical preparation. The controlled release beads have excellent mechanical ... | 07/21/1998 |
| 5776501 | Coating base for solid enteric pharmaceutical preparations The present invention provides a base for coating a solid enteric pharmaceutical preparation whose dissolution pH ranges from 3 to 4. The coating base is a cellulose acetate maleate which is prepared by substituting a water-soluble cellulose derivative wi... | 07/07/1998 |
| 5776489 | Controlled release carbonic anhydrase inhibitor containing pharmaceutical compositions from spherical granules in capsule oral dosage unit form A controlled release pharmaceutical composition in oral dosage unit form comprising a hard or a soft shell capsule containing a filling comprising a therapeutically effective number of active spherical granules comprising an effective amount of at least o... | 07/07/1998 |
| 5759580 | Compositions containing micronized nebivolol The present invention relates to pharmaceutical compositions containing as active ingredient micronized nebivolol of formula (I) and ways of preparing said compositions. ##STR1##... | 06/02/1998 |
| 5760093 | Halohydrocarbon-free delayed release lacquer solution for pharmaceutical preparation The invention relates to a delayed-release lacquer solution for pharmaceutical preparations which is characterised in that it is free from halogenated hydrocarbons.... | 06/02/1998 |
| 5756123 | Capsule shell A capsule shell comprising 79.6-98.7% by weight of a hydroxypropylmethyl cellulose, 0.03-0.5% by weight of carrageenan, and 0.14-3.19% by weight of a potassium ion and/or a calcium is prepared by drying an solution comprising 18-28% by weight of hydroxypr... | 05/26/1998 |
| 5753253 | Composition and method for inducing satiety A composition and method for the control of appetite having food grade nutrients as the active ingredients, and a pharmaceutically acceptable delivery agent, formulated so that the active ingredient is released predominantly in the ileum. The active ingre... | 05/19/1998 |
| 5750148 | Method for preparing solid enteric pharmaceutical preparation A cellulosic enteric base is dissolved in an organic solvent capable of being admixed with water in any rate or a mixed solvent of the organic solvent and water to give a polymer solution, followed by mixing the polymer solution with water, then removing ... | 05/12/1998 |
| 5750128 | Pesticide composition A solid pesticide composition is taught which includes a solid carrier, a pesticide and an amount of flour and/or starch to promote the dispersion of the pesticide into the wax. The solid carrier includes paraffin oil, paraffin wax and microcrystalline wa... | 05/12/1998 |
| 5741524 | Sustained-release formulations utilizing pharmaceutical excipient having improved compressibility Sustained release formulations include an augmented microcrystalline cellulose, an active agent, and a sustained release carrier and methods for making same are disclosed.... | 04/21/1998 |
| 5733551 | Process for preparing spheroids of plant origin Compositions of natural, especially plant, constituents in the form of spheroids in particular of the medicinal type and formulations necessary to their preparation by a technical extrusion and spheronization system. Compositions characterized by the dire... | 03/31/1998 |
| 5725883 | Pharmaceutical excipient having improved compressibility A microcrystalline cellulose-based excipient having improved compressibility, whether utilized in direct compression, dry granulation or wet granulation formulations, is disclosed. The excipient is an agglomerate of microcrystalline cellulose particles an... | 03/10/1998 |
| 5725880 | Pharmaceutical preparation controlled to release medicinal active ingredient at targeted site in intestinal tract A pharmaceutical preparation for oral administration which is controlled to release a medicinal active ingredient at a targeted site in the intestinal tract comprising (a) a core containing a medicinal active ingredient and (b) a press-coated layer compri... | 03/10/1998 |
| 5723151 | Cellulose acetate phthalate enteric coating compositions Provided are enteric coating compositions which utilize a low viscosity cellulose acetate phthalate polymer as a film former. The cellulose acetate phthalates have an inherent viscosity of about 0.2 to 0.6 dL/g and phthalyl values of from 30 to 40% and ca... | 03/03/1998 |
| 5721221 | Lowering blood cholesterol levels using water soluble cellulose ethers A method for reducing the cholesterol level in mammalian blood by administering a water soluble cellulose ether thereto. The cellulose ethers have a viscosity, measured as a 2% aqueous solution at 20° C., of at least about 35 cps. Oral administration is ... | 02/24/1998 |
