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| Number | Title | Issue Date |
| 8333995 | Protein microspheres having injectable properties at high concentrations The present invention relates to compositions of methods of making and compositions small compositions of particles of an active agent. In accordance with the method of production, the active agent is dissolved in an aqueous or aqueous-miscible solvent containing a ... | 12/18/2012 |
| 8178128 | Nanoparticles containing polymeric nucleic acid homologs A nanoparticle capable of delivery of an encapsulated molecule into a living cell. The nanoparticle includes an encapsulation media and an isolated nucleic acid homolog sequence. The encapsulation media is primarily polymeric. The nanoparticles release the encapsula... | 05/15/2012 |
| 8173172 | Preparation of powder agglomerates The invention relates to a method of producing an agglomerate of drug and solid binder. The process involves producing individual agglomerate particles and then converting the convertible amorphous content of same, following agglomeration, by the application of, for... | 05/08/2012 |
| 7981446 | Pharmaceutical compositions and methods for delivering nucleic acids into cells The present invention relates to methods of delivering nucleic acids into cells using a nucleic acid binding molecule containing a multimeric or spacer-incorporated protein transduction domain (PTD). The invention also relates to novel compositions that contain a nu... | 07/19/2011 |
| 7947309 | Use of hyaluronic acid polymers for mucosal delivery of vaccine antigens and adjuvants Compositions are provided which include hyaluronic acid derivatives in combination with vaccine antigens, and optionally adjuvants, for mucosal delivery. Also provided are methods of making the compositions, as well as methods of immunization using the same. ... | 05/24/2011 |
| 7879361 | Nanoparticles for drug delivery The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one bioactive agent of HMG-CoA reductase inhibitors or erythropoietin. The nanoparticles are characterized with a positive surface charge and their enhanced permeability... | 02/01/2011 |
| 7854945 | Functionalized nanotubes Graphitic nanotubes, which includes tubular fullerenes (commonly called “buckytubes”) and fibrils, which are functionalized by chemical substitution or by adsorption of functional moieties. More specifically the invention relates to graphitic nanotubes which are... | 12/21/2010 |
| RE41157 | Microparticle carriers of maximal uptake capacity by both M cells and non-M cells In a solvent extraction process for preparing microspheres of a biodegradable polymer, the improvement comprising: preparing a homogenized antigen-sucrose matrix and adding a solvent to the sucrose-antigen matrix to form a solution; preparing a solution of a biodegr... | 03/02/2010 |
| 7597908 | Use of microparticles with adsorbed antigen to stimulate immune responses The use of poly(lactide) or poly(lactide-co-glycolide) microparticles with adsorbed antigen is disclosed. The microparticles are useful for enhancing CTL responses to a selected antigen. ... | 10/06/2009 |
| 7563457 | Nanoparticle assembled hollow spheres A design strategy for constructing hierarchically structured materials using nanoparticles and synthetic biopolymers has been developed. Block copolypeptides or homopolymer polyelectrolytes are used as structure-directing agents to arrange nanoparticles (composed of... | 07/21/2009 |
| 7425543 | Microencapsulated materials and method of making same A method of forming microspheres of a bioactive material, such as a protein polymer or drug by nebulizing a solubilized form of a material to be encapsulated and an encapsulating material, such as albumin, in a stirred chilled solvent system comprising a vegetable o... | 09/16/2008 |
| 7413781 | Gels for encapsulation of biological materials This invention provides novel methods for the formation of biocompatible membranes around biological materials using photopolymerization of water soluble molecules. The membranes can be used as a covering to encapsulate biological materials or biomedical devices, as... | 08/19/2008 |
| 7378110 | High pressure spray-dry of bioactive materials This invention provides compositions and methods providing, e.g., stable powder particles containing bioactive materials. The methods include, e.g., high pressure spraying of the bioactive materials in solution or suspension, with viscosity enhancing agents and/or s... | 05/27/2008 |
| 7375077 | In vivo synthesis of connective tissues The in vivo synthesis of connective tissue by fibroblast or fibroblast precursor cells ensconced within a biocompatible scaffold is disclosed. The cells are preferably present in a biocompatible scaffold such as gelatin and placed between two other biocompatible sca... | 05/20/2008 |
| 7351741 | Compounds and compositions for delivering active agents Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provide as well. ... | 04/01/2008 |
| 7348026 | Nanoparticles for targeting hepatoma cells The invention discloses the nanoparticles composed of γ-PGA-PLA block copolymers conjugated with galactosamine as a potential drug delivery system for treating liver cancers. ... | 03/25/2008 |
| 7348030 | Nanoparticles for targeting hepatoma cells The nanoparticles composed of γ-PGA-PLA block copolymers that are conjugated with galactosamine as a potential drug delivery system and loaded with anticancer drugs for treating liver cancers. ... | 03/25/2008 |
| 7332586 | Nanoparticle delivery vehicle A nanoparticle delivery vehicle, comprising a nanoparticle, an active agent and a nuclear localization signal and methods of modulating gene expression and protein expression employing the nanoparticle delivery vehicle. A representative method includes providing a n... | 02/19/2008 |
| RE40059 | Sensitive substance encapsulation A process for stabilizing a sensitive substance; (a) plating a sensitive substance onto a solid carrier under a controlled atmosphere to reduce loss of the sensitive substance; (b) encapsulating the plated material under controlled atmosphere and airflow to reduce v... | 02/12/2008 |
| 7316819 | Oral peptide pharmaceutical dosage form and method of production A pharmaceutical composition for oral delivery of a peptide is in the form of a lamination having at least two layers. The first layer of the lamination includes at least one pharmaceutically acceptable pH-lowering agent. The second layer includes a therapeutically ... | 01/08/2008 |
| 7314640 | Formulation and process for drug loaded cores The present invention relates to a controlled release pellet of metoprolol and its pharmaceutically acceptable salts that uses a water soluble or a water swellable inert starting seed or core. ... | 01/01/2008 |
| 7311926 | Biocomposite materials and methods for making the same A particle (and a composition that includes a plurality of the particles) that includes at least one polypeptide molecule and at least one polymer covalently bound to the polypeptide molecule so as to form a polymer shell substantially encompassing the polypeptide m... | 12/25/2007 |
| 7309500 | Microparticles A method of forming particles, comprises accelerating a first stream comprising a first liquid, applying a charging voltage of at most 1.5 kV to the first stream, and vibrating the first stream, to form particles. ... | 12/18/2007 |
| 7304035 | Stimulation of bone growth with thrombin peptide derivatives Disclosed is a method of stimulating bone growth at a site in a subject in need of osteoinduction. The method comprises the step of administering a therapeutically effective amount of an agonist of the non-proteolytically activated thrombin receptor to the site.... | 12/04/2007 |
| 7303756 | Multiphase system The invention relates to a preparation comprising a carrier phase and at least one further phase which cannot be mixed with the carrier phase or only partially mixed therewith, wherein the change in ambient conditions alters the viscosity of the carrier phase. The i... | 12/04/2007 |
| 7288267 | Bioadhesive nanoparticulate compositions having cationic surface stabilizers Bioadhesive nanoparticulate compositions, comprising active agent particles and one or more cationic surface stabilizers, are described. The cationic surface stabilizers prevent aggregation of the nanoparticles and increase bioadhesion of the nanoparticles to biolog... | 10/30/2007 |
| 7279597 | Phenyl amine carboxylic acid compounds and compositions for delivering active agents Phenyl amine carboxylic acid compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well. ... | 10/09/2007 |
| 7258873 | Preservation of bioactive materials by spray drying This invention provides methods and compositions to preserve bioactive materials in a matrix of powder particles. Methods provide high-pressure gas spraying and/or near supercritical spraying of formulations followed by drying in a stream of conditioned gas to form ... | 08/21/2007 |
| 7247318 | Controlled release formulations having rapid onset and rapid decline of effective plasma drug concentrations The invention is directed to oral modified/controlled release drug formulations which provide a rapid initial onset of effect and a prolonged duration of effect. Preferably, the peak concentration is lower than that provided by the reference standard for immediate r... | 07/24/2007 |
| 7238371 | Triggered release from proteinoid microspheres The invention provides proteinoid microsphere made up of a mixture of thermally condensed amino acids that are crosslinked with a bis dithiol crosslinker reagent. The proteinoid microspheres of the invention may be used to encapsulate a material or a compound and to... | 07/03/2007 |
| 7226618 | Colloidal suspension of submicronic particles as vectors for active principles and method for preparing same A suspension of vector particles (PV) based on polyamino acids and have a mean hydrodynamic diameter between 30 and 120 nm, and an insulin load factor of from 5 to 25% of associated insulin volume relative to the polyamino acid volume forming the vector particles. T... | 06/05/2007 |
| 7220414 | Degradable polyacetal polymers Degradable polyacetal polymers and functionalized degradable polyacetal polymers have properties favorable for use in pharmaceutical and biomedical applications. The degradable polyacetal polymers are relatively stable at physiological pH with favorable biodistribut... | 05/22/2007 |
| 7208483 | Polymeric delivery agents and delivery agent compounds Polymeric delivery agents, delivery agent compounds and compositions comprising them which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well. ... | 04/24/2007 |
| 7189395 | Complexes of immunoglobulins and polysaccharides for oral and transmucosal absorption The present invention relates to complexes consisting of immunoglobulins and polysaccharides for oral and transmucosal use. The polysaccharides comprised in the complexes according to the invention form an envelope which protects and carries immunoglobulins a... | 03/13/2007 |
| 7186796 | Method for drying water-borne materials Provided is a method of isolating a bio-molecule from a water-borne mixture, the method comprising: contacting the water-borne mixture with dimethyl ether to form solid particles of the bio-molecule. ... | 03/06/2007 |
| 7168605 | Microtubes for therapeutic delivery A medical implant that delivers therapeutic via microtubes and a method of making the same is provided. In one embodiment a biologically implantable structure adapted to fit within the body of a patient is provided. This structure may have a plurality of individual ... | 01/30/2007 |
| 7166295 | Methods of treatment and diagnostic visualization, particularly in cancer Methods and reagents for improved treatment and diagnostic imaging, particularly of cancer. The methods and reagents utilize specific targeting of treatment and imaging ligands to the targeted tumor, or specific organ or tissue, in association with extracorporeal af... | 01/23/2007 |
| 7166296 | Pharmaceutical formulations and ligands for use therein; mimetics for UEA-1 UEA-1 Mimetics, pharmaceutical formulations comprising them, and their uses as targeting agents for therapeutic and diagnostic purposes. ... | 01/23/2007 |
| 7163700 | Amorphous drug beads The present inventive subject matter relates to amorphous drug beads comprising an amorphous active drug and an organic surfactant having improved solubility, absorption and wettability characteristics. The present inventive subject matter further relates to methods... | 01/16/2007 |
| 7163701 | Controlled release microencapsulated NGF formulation NGF microencapsulation compositions having controlled release characteristics, preferably with increased stability, for the NGF component, particularly human recombinant NGF (“rhNGF”) are provided that yield enhanced stability of NGF for use in promoting nerve c... | 01/16/2007 |
