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| Number | Title | Issue Date |
| 8187637 | Formulations decreasing particle exhalation Formulations have been developed for pulmonary delivery to treat or reduce the infectivity of diseases such as viral infections, especially tuberculosis, SARS, influenza and respiratory synticial virus in humans and hoof and mouth disease in animals, or to reduce th... | 05/29/2012 |
| 8187638 | Preferential killing of cancer cells and activated human T cells using ZnO nanoparticles Here we disclose the response of normal human cells to ZnO nanoparticles under different signaling environments and compare it to the response of cancerous cells. ZnO nanoparticles exhibit a strong preferential ability to kill cancerous T cells (˜28-35X) compared t... | 05/29/2012 |
| 8182838 | Dry powder composition comprising co-jet milled particles for pulmonary inhalation The present invention relates to particles and to methods of making particles. In particular, the invention relates to methods of making composite active particles comprising a pharmaceutically active material for pulmonary inhalation, the method comprising a jet mi... | 05/22/2012 |
| 8173164 | Oral administration forms for administering a fixed tramadol and diclofenac combination An oral administration unit containing the active substances Tramadol and Diclofenac and/or physiologically acceptable salts thereof, in which both active substances are contained in the same administration unit as two separately formulated subunits. ... | 05/08/2012 |
| 8173169 | Formulation and process for the preparation of modafinil The present invention provides pharmaceutical tablets comprising modafinil particles, processes for preparing such pharmaceutical tablets, and methods of treating a disease or disorder using the pharmaceutical tablet of the invention. In particular, the pharmaceutic... | 05/08/2012 |
| 8173165 | Water-dispersible pellets A water-dispersible particle for delivery of nitrogen to a plant is disclosed. The water-dispersible particle also delivers an active ingredient such as a plant hormone to a desirable plant or a pesticide or herbicide to an undesirable organism. Methods for making a... | 05/08/2012 |
| 8173167 | Micelle composition of polymer and passenger drug Hydrophobic drugs become more practical for treatments by being encapsulated in micelle compositions for increasing solubility. Micelle compositions may include an excipient tocopherol and/or prodrug formulations of the drug. Micelles extend the time period the drug... | 05/08/2012 |
| 8173170 | Drug carrier and drug carrier kit for inhibiting fibrosis An astrocyte-specific drug carrier containing a retinoid derivative and/or a vitamin A analog as a constituent; a drug delivery method with the use of the same; a drug containing the same; and a therapeutic method with the use of the drug. By binding a drug carrier ... | 05/08/2012 |
| 8173166 | Methods of producing tungsten nanoparticles The present teachings are directed methods of producing tungsten-containing nanoparticles, specifically tungsten nanoparticles and tungsten oxide nanoparticles with an average particle size of less than about five nanometers. ... | 05/08/2012 |
| 8173168 | Dispersible macromolecule compositions and methods for their preparation and use A process for preparing ultrafine powders of biological macromolecules comprises atomizing liquid solutions of the macromolecules, drying the droplets formed in the atomization step, and collecting the particles which result from drying. By properly controlling each... | 05/08/2012 |
| 8173171 | Hydrogel microparticle composition, application thereof and method for preparing the same Disclosed herein is a method for preparing a hydrogel microparticle composition. A dispersion including 1 part by weight of N-isopropyl acrylamide, about 0.1-0.5 part by weight of chitosan, about 0-0.05 part by weight of N,N′-methylene bisacrylamide, about 0.1-0.5... | 05/08/2012 |
| 8168224 | Sodium alginate microsphere vascular embolus containing water-soluble drug and preparation and application thereof The present disclosure relates to a kind of sodium alginate microsphere vascular embolus that contains water-soluble drug and preparation and application thereof. The embolus preparation falls into dry microsphere type and wet one that are made of degradable materia... | 05/01/2012 |
| 8168223 | Engineered particles and methods of use Engineered particles are provided may be used for the delivery of a bioactive agent to the respiratory tract of a patient. The particles may be used in the form of dry powders or in the form of stabilized dispersions comprising a nonaqueous continuous phase. In part... | 05/01/2012 |
| 8163307 | Controlled release compositions for interferon based PEGT/PBT block copolymers and method for preparation thereof The invention discloses a pharmaceutical composition for the controlled release of relatively toxic active compounds, in particular for bioactive proteins from the class of interferons. The composition comprises a biodegradable block copolymer constructed from poly(... | 04/24/2012 |
| 8158155 | Odor control cellulose-based granules A cellulose-based granule that functions as a carrier vehicle for an odor control agent is described. The granule has a relatively porous substrate body having a high-surface area of at least about 200 m2/gram, and metal-modified silica particles either a... | 04/17/2012 |
| 8158153 | Nanoparticulate bisphosphonate compositions Nanoparticulate bisphosphonate compositions, having an effective average particle size of less than 2000 nm, are described. The compositions are useful in treating bone resorption in a mammal. ... | 04/17/2012 |
| 8158154 | Nasal pharmaceutical formulations and methods of using the same Nasal pharmaceutical formulations comprising a drug substance having a specific particle size distribution profile are disclosed herein. Such profile provides increased bioavailability, increased efficacy or prolonged therapeutic effect of the drug substance when ad... | 04/17/2012 |
| 8158152 | Lyophilization process and products obtained thereby A lyophilization process which comprises dissolving a material in one or more solvents for said material to form a solution; forcing said material at least partially out of solution by combining the solution and a non-solvent for the material, which non-solvent is m... | 04/17/2012 |
| 8153157 | Porous cellulose aggregate and molding composition thereof A porous cellulose aggregate characterized by having a secondary aggregate structure resulting from aggregation of primary cellulose particles, having a pore volume within a particle of 0.265 to 2.625 cm3/g, containing I-type crystals and having an averag... | 04/10/2012 |
| 8153156 | Hydrogel nanocompsites for ophthalmic applications The present invention relates to reversible hydrogel systems. Particularly, the hydrogel of the present invention is made up of copolymers that can be a hydrogel when in an oxidize state and can be a solution when in a reduced state. A solution of the copolymer can ... | 04/10/2012 |
| 8153158 | Tissue substitutes comprising stem cells and reduced ceria A biocompatible composite includes a solid biocompatible material and a plurality of living human progenitor or living stem cells attached thereto. The composition resulting in accelerated repair to damaged bones and tissues. ... | 04/10/2012 |
| 8147872 | Pharmaceutical compositions of drugs and neutralized acidic polymers Pharmaceutical compositions comprised of low-solubility and/or acid-sensitive drugs and neutralized acidic polymers are disclosed. ... | 04/03/2012 |
| 8147874 | Coated pellets Coated pellets which comprise an active pharmaceutical ingredient that is poorly soluble in water, release at least 80% of the active ingredient under in vitro conditions in phosphate buffer at pH 5.0 after 30 minutes and are bioeq... | 04/03/2012 |
| 8147873 | Methods and compositions for treatment of ion imbalances The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising sodium-binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceut... | 04/03/2012 |
| 8142815 | Injectable and swellable microspheres for dermal augmentation The present invention relates to injectable compositions comprising biocompatible, swellable, hydrophilic, non-toxic and substantially spherical microspheres microspheres and a biocompatible carrier for use in dermal augmentation. The present invention further relat... | 03/27/2012 |
| 8142814 | Method and apparatus for supercritical fluid assisted particle production The present invention provides an apparatus and methods of producing particles that include a polymer, a wax and/or lipid and, optionally, a biologically active substance. In accordance with the methods of the invention, a load stock including a polymer, a wax and/o... | 03/27/2012 |
| 8137697 | Nanoparticles for protein/peptide delivery and delivery means thereof The invention discloses the biodegradable nanoparticle for use in nanoparticle projectile bombardment as a carrier for administering nucleic acid, DNA, RNA or siRNAs transdermally to an animal subject. The nanoparticles are composed of positively charged chitosan su... | 03/20/2012 |
| 8137698 | Method and composition for hyperthermally treating cells A method and composition for hyperthermally diagnosing and monitoring treatment of cells in an animal with photoacoustic sound and nanoparticles. The heat (temperature) and photoacoustic sound wave production inside the target tissue is measured. The desired tempera... | 03/20/2012 |
| 8133514 | Carbon-substituted diketopiperazine delivery systems Compositions useful in the delivery of active agents are provided. These delivery compositions include (a) an active agent; and (b) a carrier of at least one mono-C-substituted or di-C-substituted diketopiperazine. Methods for preparing these compositions and admini... | 03/13/2012 |
| 8128960 | Low viscosity, highly flocculated triamcinolone acetonide suspensions for intravitreal injection Triamcinolone acetonide suspension compositions are disclosed. The suspension compositions have a relatively low viscosity and are easy to extrude through a 27- or 30-gauge needle but are highly flocculated and easily redispersed. The compositions are particularly s... | 03/06/2012 |
| 8124129 | Crystalline form of the compound A-348441 There is provided a hemihydrate of (3β,5β,7α,12α)-7,12-dihydroxy-3-{2-[{4-[17β-hydroxy-3-oxo-17α-prop-1-ynylestra-4,9-dien-11β-yl]phenyl}(methyl)amino]ethoxy}cholan-24-oic acid in a crystalline form which is characterised by an X-ray diffraction pattern havin... | 02/28/2012 |
| 8124128 | Amphiphilic block copolymers and nano particles comprising the same An amphiphilic block copolymer. The amphiphilic block copolymer includes one or more hydrophilic polymers, one or more hydrophobic polymer, and one or more zwitterions. The invention also provides a nano particle and carrier comprising the amhpiphilic block copolyme... | 02/28/2012 |
| 8119161 | Blister pack and solid dosage form therefor The present invention relates to a blister pack for pharmaceutical use comprising blisters containing a solid dosage form of desmopressin, or a pharmaceutically acceptable salt thereof, and to said solid dosage form. In one embodiment it specifically relates to a bl... | 02/21/2012 |
| 8119165 | Method and composition for hyperthermally treating cells A method and composition for hyperthermally diagnosing and monitoring treatment of cells in an animal with photoacoustic sound and nanoparticles. The heat (temperature) and photoacoustic sound wave production inside the target tissue is measured. The desired tempera... | 02/21/2012 |
| 8119163 | Nanoparticulate and controlled release compositions comprising cefditoren The present invention provides a composition comprising a cefditoren, or a salt, derivative, prodrug, or other form thereof, for example, cefditoren pivoxil, useful in the treatment and prevention of infections and related conditions. The invention provides a compos... | 02/21/2012 |
| 8119164 | Perfuming or flavouring microcapsules comprising an explosion suppressant A method for preparing a powder that includes perfuming or flavoring microcapsules of a perfuming or flavoring ingredient, a carrier material, and an explosion suppressant. The powder, when suspended in hot air during its preparation, has a reduced tendency for expl... | 02/21/2012 |
| 8119162 | Particles that disrupt or impede bacterial adhesion, related compositions and methods Oral care and other compositions comprising particles having cores attached to bioadhesive polymers for inhibition of pellicle formation, plaque formation, biofilm formation, biofouling, and microbial adhesion or attachment are described. Methods using said composit... | 02/21/2012 |
| 8114438 | DPI formulation containing sulfoalkyl ether cyclodextrin An inhalable dry powder formulation containing SAE-CD and an active agent is provided. The formulation is adapted for administration by DPI. The SAE-CD serves as a carrier rather than as an absorption enhancer. The average particle size of the SAE-CD is large enough... | 02/14/2012 |
| 8114841 | Maxillofacial bone augmentation using rhPDGF-BB and a biocompatible matrix The present invention provides effective new methods and materials for maxillofacial bone augmentation, particularly alveolar ridge augmentation, that are free of problems associated with prior art methods. In one embodiment, these materials include human recombinan... | 02/14/2012 |
| 8110225 | Treatment using dantrolene Provided are low-volume, safe for injection formulations of dantrolene yielding significant advantages over the currently approved and marketed dantrolene for malignant hyperthermia (MH) threatening anesthetic crisis. Once dantrolene can be made immediately availabl... | 02/07/2012 |
