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| Number | Title | Issue Date |
| 6682759 | Manufacture of oral dosage forms delivering both immediate-release and sustained-release drugs A method is disclosed for manufacturing a pharmaceutical tablet for oral administration, the tablet combining both immediate-release and prolonged-release modes of drug delivery and using an immediate-release drug that is either insoluble in water or only... | 01/27/2004 |
| 6680071 | Opioid agonist in a fast dispersing dosage form This invention relates to a pharmaceutical composition for oral administration comprising a carrier and, as active ingredient, an opioid (μreceptor) agonist, such as fentanyl, or a salt thereof, characterized in that the composition is in the form of a f... | 01/20/2004 |
| 6676970 | Subcutaneous osteoporosis compositions The invention is concerned with a pharmaceutical preparation for subcutaneous, parenteral administration, which contains bisphosphonic acids or their salts as the active substance, as well as the production of this preparation. By means of the preparation... | 01/13/2004 |
| 6673767 | Gel composition and methods Methods and compositions for systemically or locally administering by implantation a beneficial agent to a subject are described, and include, for example, compositions having burst indices of 8 or less for systemic applications and systems releasing 10% ... | 01/06/2004 |
| 6673835 | Method and composition for delivering zinc to the nasal membrane A viscous gel for delivering minor effective amounts of active substances through the nasal membrane into the body.... | 01/06/2004 |
| 6673369 | Controlled release formulation The present invention relates to a controlled release pharmaceutical composition comprising amounts ranging from about 0.1 to about 4.5% w/w, of one or more of rate controlling cellulosic ether polymers.... | 01/06/2004 |
| 6670454 | Method for crosslinking porous biodegradable polymers The present invention relates to crosslinking of porous materials made of biodegradable polymers. The method comprises: (a) placing a porous biodegradable polymer in a chamber; (b) introducing a supercritical fluid containing a crosslinking agent into the... | 12/30/2003 |
| 6667060 | Pregelatinized starch in a controlled release formulation The present invention concerns the use of pregelatinized starch to prevent dose-dumping from a hydrophilic controlled release formulation. It also concerns a hydrophilic controlled release formulation, more in particular a hydrophilic controlled release m... | 12/23/2003 |
| 6664099 | Method for the preservation of viruses and mycoplasma A biologically-active material comprising a live virus or mycoplasma is preserved by a method of desiccation, without lyophilisation, in a matrix of glassy trehalose having a residual moisture content of not greater than 2%. The method comprises two vacuu... | 12/16/2003 |
| 6660302 | Dry-powder film coating composition and method of preparation An edible dry-powder formulation of a film coating for pharmaceuticals and confectionaries using gum acacia as a low-cost film former is provided. A cellulosic polymer such as hydroxypropyl methylcellulose is used in addition to the gum acacia. A plastici... | 12/09/2003 |
| 6660300 | Method of use of a biphasic controlled release delivery system for high solubility pharmaceuticals and method A biphasic controlled release delivery system for pharmaceuticals which have high water solubility, such as the antidiabetic metformin HCl salt, is provided which provides a dosage form that has prolonged gastric residence so that a dosing regimen of at l... | 12/09/2003 |
| 6660290 | Mycopesticides The present invention utilizes the non-sporulating mycelial stage of insect-specific parasitic fungi. The fungus can be present on grain, attracting the pest, and also infecting it through digestion. More than one fungus can be used in combination. The ma... | 12/09/2003 |
| 6656508 | Sustained-release alginate gels The present invention relates to sustained-release formulations using alginate gel beads and methods thereof.... | 12/02/2003 |
| 6656502 | Sustained-release prostaglandin I derivative preparation A sustained release preparation of prostaglandin I derivatives, which is highly safe and has stable drug-releasing and absorption properties, is disclosed. In the orally administrable preparation, the active component is a prostaglandin I derivative and t... | 12/02/2003 |
| 6656487 | Composition containing fibers and a dispersing copolymer The invention relates to a composition containing fibers and a copolymer comprising carboxylate groups and polydimethylsiloxane groups. The composition according to the invention may especially constitute a care or make-up composition for keratin material... | 12/02/2003 |
| 6652840 | Bleeding control and healing aid compositions and methods of use A composition is disclosed which has been shown to stop or control bleeding and seal open small blood vessels while accelerating the healing process of abraded oral "gum" and other "skin" (epithelial) tissues. The composition is preferably in the form of ... | 11/25/2003 |
| 6652886 | Biodegradable cationic copolymers of poly (alkylenimine) and poly (ethylene glycol) for the delivery of bioactive agents A biodegradable, novel cationic coopolymer comprising a a poly(alkylenimine)(PAI), a hydrophilic polymer, and a biodegradable linker, wherein the biodegradable linker covalently links the PAI and the hydrophilic polymer. The biodegradable cationic copolym... | 11/25/2003 |
| 6649162 | Hemostatic sponge based on collagen The invention relates to a hemostatic sponge based on collagen and an activator or proactivator of blood coagulation homogeneously distributed therein, which is dried and contains a water content of at least 2%, preferably in the range of 2 to 25%, more p... | 11/18/2003 |
| 6649191 | Orally administrable compositions comprising cation cross-linked polysaccharide and a polymer digestible in the lower gastrointestinal tract Orally administrable compositions comprising cation cross-linked polysaccharides are provided. The compositions have the ability to mask the taste and delay the release of an active material included therein. A novel method for the preparation of the comp... | 11/18/2003 |
| 6641831 | Medical products with sustained pharmacological activity and process for producing them A non-degradable medical product comprising at least two substances or groups of substances, of which a first substance is referred to as substance A and a second is referred to as substance B, substance A being more lipophilic than substance B, wherein s... | 11/04/2003 |
| 6641843 | Pharmaceutical compositions The present invention relates to pharmaceutical compostions of (1S,4R)-cis-4-[2-amino-6-cyclopropylamino}-9H-purin-9-yl]-2-cyclopentene-1 -methanol (1592U89).... | 11/04/2003 |
| 6641822 | Composition containing humidity regulators for preparing tissue products A composition is provided containing moisture regulators for tissue products. The composition contains 1% to 15% by weight, preferably 2% to 20% by weight, relative to the total composition, of at least one special non-ionic surfactant selected from among... | 11/04/2003 |
| 6635280 | Extending the duration of drug release within the stomach during the fed mode Drugs are formulated as unit oral dosage forms by incorporating them into polymeric matrices comprised of hydrophilic polymers that swell upon imbibition of water to a size that is large enough to promote retention of the dosage form in the stomach during... | 10/21/2003 |
| 6632446 | Coating substrates by polymerizing macromers having free radical-polymerizable substituents Water soluble macromers are modified by addition of free radical polymerizable groups, such as those containing a carbon-carbon double or triple bond, which can be polymerized under mild conditions to encapsulate tissues, cells, or biologically active mat... | 10/14/2003 |
| 6630154 | Polymer formulations containing perfluorinated compounds for the engineering of cells and tissues for transplantation that improves cell metabolism and survival, and methods for making same Disclosed and claimed are: a composition including at least one glycosaminoglycan, e.g., CIS, at least one perfluorinated substance and at least one alginate, e.g., sodium alginate, wherein: the at least one glycosaminoglycan and/or the perfluorinated subs... | 10/07/2003 |
| 6630486 | Inorganic-polymer complexes for the controlled release of compounds including medicinals This invention relates generally to the production and use of inorganic-polymer complexes for the controlled release of compounds including medicinals. Advantageously, the inorganic used is calcium sulfate.... | 10/07/2003 |
| 6630168 | Gel delivery vehicles for anticellular proliferative agents Methods and compositions are provided for the treatment of a host suffering from a cellular proliferative disease. In the subject methods, antiproliferative agents are administered in a substantially non-aqueous gel delivery vehicle comprising at least on... | 10/07/2003 |
| 6627226 | Dry solid medium for storage and analysis of genetic material The present invention provides for device for obtaining and storing genetic material. The device has a support and a head portion. The head portion is composed of a solid matrix for sorbing genetic material and a preserving mechanism for the protection of... | 09/30/2003 |
| 6624300 | Method for concentrating beta-glucan film An entirely aqueous method for concentrating beta-glucan from a beta-glucan source, such as milled cereal bran, grain or distiller's dried grain. The method comprises providing an alkaline aqueous extract of a beta-glucan source; acidifying or neutralizin... | 09/23/2003 |
| 6620432 | Phenytoin sodium pharmaceutical compositions A pharmaceutical composition is provided containing an admixture of phenytoin sodium and an erodible matrix which extends the release of the phenytoin sodium over about a two hour period. The erodible matrix comprises binder(s) and diluent(s) which contro... | 09/16/2003 |
| 6620435 | Compositions for topical application of therapeutic agents The present invention generally relates to pharmaceutical compositions that enable control of drug, delivery properties and the development of optimal drug delivery strategies customized for particular drugs and particular diseases. The composition includ... | 09/16/2003 |
| 6616937 | Cosmetic composition containing a distillate of a green plant juice and a process for preparing the same An improved cosmetic composition comprises at least one cosmetically effective ingredient and water, where at least a potion of the water has been replaced by a distillate of a green plant juice. The distillate is obtained from a green plant juice, produc... | 09/09/2003 |
| 6607748 | Cross-linked high amylose starch for use in controlled-release pharmaceutical formulations and processes for its manufacture The present invention relates to a novel form of cross-linked high amylose starch and processes for its manufacture. Such cross-linked high amylose starch is useful as an excipient in a controlled-release pharmaceutical formulation when compressed with ph... | 08/19/2003 |
| 6607751 | Controlled release delivery device for pharmaceutical agents incorporating microbial polysaccharide gum The present invention provides a controlled release device for sustained or pulsatile delivery of pharmaceutically active substances for a predetermined period of time. This invention further provides such device in which sustained or pulsatile delivery i... | 08/19/2003 |
| 6599530 | Oral compacted composition comprising catechol derivatives The present invention relates to an oral compacted composition comprising entacapone, nitecapone, or a pharmaceutically acceptable salt thereof and croscarmellose sodium. The composition is premised on the discovery that croscarmellose sodium increases th... | 07/29/2003 |
| 6596308 | Controlled release pharmaceutical composition A sustained/prolonged release pharmaceutical dosage form is disclosed. The form comprises a hard shell capsule and a formulation comprising (a) a water insoluble medicant, (b) a high melting fatty ester, (c) a low viscosity oil, (d) a cellulosic polymer, ... | 07/22/2003 |
| 6596293 | Polyurethane-biopolymer composite A method is provided for preparing a drug delivery material and device comprising cross-linking a biological polymer with a cross-linking agent and loading the cross-linked biopolymer with a bioactive agent. Preferred embodiments are disclosed wherein the... | 07/22/2003 |
| 6592898 | Bioadhesive compositions comprising hydrophobic polymers Bioadhesive compositions which comprise a hydrophobic polymer wherein the concentration of the polymer at the surface of the adhesive is greater than its concentration in the bulk of the adhesive are described; and biomedical electrodes, fixation products... | 07/15/2003 |
| 6589546 | Polymeric coatings for controlled delivery of active agents Implantable medical device having a structure adapted for introduction into a patient wherein the structure is composed of a base material positioned over the structure. The implantable medical device further includes at least one composite layer of a bio... | 07/08/2003 |
| 6589556 | Rapid-melt semi-solid compositions, methods of making same and methods of using same A novel rapid-melt, semi-solid molded composition, including methods of making the same, and methods of using the same for the delivery of prophylactic and therapeutic active materials to a mammal wherein the prophylactic or therapeutic active is a psycho... | 07/08/2003 |
