William F. Semple, a dentist, was awarded the first US Patent on chewing gum in 1869. His recipe contained powdered chalk.
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| Number | Title | Issue Date |
| 8110221 | Encapsulation of oxygen sensitive agents with soy protein or casein and a modified starch The present invention relates to the use of a mixture of modified starch and protein for encapsulating oxygen sensitive agents, wherein the modified starch is a starch derivative containing a hydrophobic group or both a hydrophobic and a hydrophilic group which has ... | 02/07/2012 |
| 8062668 | Stimuli-responsive systems for controlled drug delivery A method of delivering a therapeutic agent by providing a cross-linked polymer encapsulating the therapeutic agent to a site in a patient. The degradation rate of the cross-linked polymer is correlated with a local concentration of an indicator, and the therapeutic ... | 11/22/2011 |
| 8043632 | Process for making antimicrobial articles by reacting chitosan with amino-reactive polymer surfaces Polymer articles are rendered antimicrobial by a process that includes contacting a chitosan solution with a polymer surface that inherently contains amino-reactive functional groups as polymerized. The process requires no pretreatment with agents such as oxidizing ... | 10/25/2011 |
| 7985425 | Non-pharmacological method for treating depression, skin disorders and improving overall health and wellness The present invention is a method for manufacture and treatment of depression and health disorders using a non-pharmacologic stable negative ion solution. ... | 07/26/2011 |
| 7914819 | Polysaccharide-based biomaterials Disclosed are a series of kneadable, pliable polymers for use in forming compositions that can be used as bone wax or as a cellular scaffold. Polymers can include a polysaccharide backbone and can be biocompatible and thrombogenic. In addition, the compositions can ... | 03/29/2011 |
| 7906143 | Controlled release pharmaceutical delivery device and process for preparation thereof The present invention relates to a controlled release pharmaceutical delivery device which provides sustained or pulsatile delivery of a selected pharmaceutically active substance for a predetermined period of time. The device comprises about 1 to 80% by weight cova... | 03/15/2011 |
| 7829118 | Modified hyaluronic acid polymer compositions and related methods The present application provides compositions comprising hyaluronic acid having low levels of functional group modification, mixtures formed by controlled reaction of such lightly modified hyaluronic acid with suitable difunctional or multi-functional crosslinkers, ... | 11/09/2010 |
| 7758887 | Warming and nonirritating lubricant compositions and method of comparing irritation This invention relates to substantially anhydrous warming, non-toxic and nonirritating lubricating compositions containing polyhydric alcohols and an insulating agent as well as gel and jelly compositions related thereto. The invention also relates to methods of usi... | 07/20/2010 |
| 7749540 | Compositions comprising modafinil compounds Particle-forming compositions of modafinil compounds, and aqueous compositions of particles, wherein the particles comprise a modafinil compound, are disclosed, along with methods of their preparation, and their use in the treatment of diseases. ... | 07/06/2010 |
| 7736669 | Porous structures, and methods of use The present invention provides porous structures that each comprise chitosan, alginate and divalent metal cations, wherein: (a) the chitosan is ionically linked to the alginate; and (b) the structure is porous and has a compressive yield strength of at least 0.35 MP... | 06/15/2010 |
| 7691411 | Pharmaceutical formulae for thyroid hormones and procedures for obtaining them The present invention provides pharmaceutical formulation for thyroid hormones which allow safe and stable administration by mouth within the ambit of the narrow therapeutic index prescribed in the case of thyroid dysfunctions, as well as procedures for obtaining th... | 04/06/2010 |
| 7674480 | Rapidly expanding composition for gastric retention and controlled release of therapeutic agents, and dosage forms including the composition The present invention provides a pharmaceutical composition for use in a dosage form for oral administration to a patient. The composition expands upon contact with gastric fluid and promotes retention of the dosage form in the patient's stomach for a prolonged peri... | 03/09/2010 |
| 7658947 | Thermo-gelling composition There is provided a new thermo-gelling composition made with methylcellulose and citric acid. This composition may also have an effective amount of a treating agent, which may be a medicinal agent, cosmetic agent, moisturizer, adjuvant, nutritional agent, other ingr... | 02/09/2010 |
| 7651702 | Crosslinking hyaluronan and chitosanic polymers Materials and methods related to crosslinking hyaluronan and chitosan are described herein. Also described are products of the described methods. ... | 01/26/2010 |
| 7622138 | Pharmaceutical compositions for drug delivery and methods of treating or preventing conditions using same The present invention relates to pharmaceutical compositions in the form of a gel for controlled- or sustained-release of a pharmaceutically active agent and to methods for treating or preventing or preventing a condition in an animal by administering to an animal i... | 11/24/2009 |
| 7618651 | Pharmaceutical compositions for drug delivery and methods of treating or preventing conditions using same The present invention relates to pharmaceutical compositions in the form of a gel for controlled- or sustained-release of a pharmaceutically active agent and to methods for treating or preventing or preventing a condition in an animal by administering to an animal i... | 11/17/2009 |
| 7531191 | Stimuli-responsive systems for controlled drug delivery A method of delivering a therapeutic agent by providing a cross-linked polymer encapsulating the therapeutic agent to a site in a patient. The degradation rate of the cross-linked polymer is correlated with a local concentration of an indicator, and the therapeutic ... | 05/12/2009 |
| 7531192 | Delivery systems for functional ingredients The present invention provides oral delivery systems for functional ingredients, such as drugs, nutritional supplements, botanicals, and vitamins. The delivery systems comprise an ingestible matrix within which the functional ingredient(s) are substantially uniforml... | 05/12/2009 |
| 7527807 | Compositions and methods for increasing the oral absorption of antimicrobials The present invention provides compositions and methods for increasing absorption of antibacterial agents, particularly third generation cephalosporin antibacterial agents, in oral dosage solid and/or suspension forms. Specifically, the composition is comprised of a... | 05/05/2009 |
| 7524514 | Biomimetic composition reinforced by a polyelectrolytic complex of hyaluronic acid and chitosan The present invention relates to a three dimensional, malleable cell culture composition and method of forming the same comprising hyaluronic acid, chitosan and a polyelectrolytic complex of hyaluronic acid and chitosan. These three components in combination constit... | 04/28/2009 |
| 7494669 | Delivery of physiological agents with in-situ gels comprising anionic polysaccharides In-situ gelation of a pectic substance. Composition, method of preparation, and method of use of a pectin in-situ gelling formulation for the delivery and sustained release of a physiologically active agent to the body of an animal. The pectin can be isolated from | 02/24/2009 |
| 7439044 | High viscosity xanthan polymer preparations Increasing the molecular length of xanthan polymer makes a higher viscosity xanthan composition. Xanthan with higher specific viscosity characteristics provides more viscosity at equivalent concentration in food, industrial and oilfield applications. Methods for inc... | 10/21/2008 |
| 7439214 | Cationic derivatives and applications therefor This invention relates to cationically derivatized polycalactomannans obtained from cassia tora and cassia obtusifolia and to their use in personal care, household care, and institutional care compositions. ... | 10/21/2008 |
| 7431943 | Controlled release and taste masking oral pharmaceutical compositions Controlled release and taste masking compositions containing one or more active principles inglobated in a three-component matrix structure, i.e. a structure formed by successive amphiphilic, lipophilic or inert matrices and finally inglobated or dispersed in hydrop... | 10/07/2008 |
| 7417021 | Biologically active conjugate of a biopolymer and therapeutic agent A biologically active conjugate is disclosed comprising a biopolymer and a therapeutic agent joined by a disulfide bond. The conjugate, when formulated in a pharmaceutical composition with a suitable carrier, has improved in vivo stability and activity, and can be t... | 08/26/2008 |
| 7417020 | Compositions comprising low-DP polymerized surfactants and methods of use thereof Provided are low-irritation personal care compositions comprising a low-DP polymerized surfactants. Also provided are methods of making and using such compositions. ... | 08/26/2008 |
| 7410947 | Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects Disclosed herein are improved osteogenic devices and methods of use thereof for repair of bone and cartilage defects. The devices and methods promote accelerated formation of repair tissue with enhanced stability using less osteogenic protein than devices in the art... | 08/12/2008 |
| 7407671 | Temperature controlled solute delivery system A system for delivering solute to a target location within a mammalian body, the system including a medical device, a thermosensitive cellulose gel structure over the medical device, and a biologically active solute within said gel structure. The gel structure deswe... | 08/05/2008 |
| 7399739 | Vertebral augmentation composition and method A flowable vertebral augmentation composition for the treatment and repair of a vertebral body defect, e.g., an osteoporotic condition, contains biocompatible, optionally osteoconductive, support elements that are resistant to deformation or fracture under the norma... | 07/15/2008 |
| 7399483 | Carrier with solid fibrinogen and solid thrombin The present invention relates to a solid composition useful for tissue gluing, tissue sealing and haemostasis consisting essentially of a) a carrier which has at least one of the following physical properties: elasticity module in the range of 5-100 N/cm, density of... | 07/15/2008 |
| 7381227 | Fabric laundering Relatively low levels of polysaccharides in combination with small, deformable, water-insoluble particles of a size in the range 0.05-5 microns are capable of giving benefits in a wash liquor in terms of reduced fabric abrasion. ... | 06/03/2008 |
| 7374775 | Dura substitute and a process for producing the same The invention relates to dura substitutes to be used as prostheses for dural defects in the field of neurosurgery and processes for producing the same. The present invention provides artificial dura mater materials comprising sheets of microbial-derived polysacchari... | 05/20/2008 |
| 7375096 | Method of preparing a supramolecular complex containing a therapeutic agent and a multi-dimensional polymer network A method of preparing a supramolecular complex containing at least one therapeutic agent and a multi-dimensional polymer network is described. A supramolecular complex prepared by a method of the invention is described. A method of treatment by administering a thera... | 05/20/2008 |
| 7364753 | Magnesium-containing compositions and methods for enhancing dehydroepiandrosterone levels Compositions and methods for using the same to restore dehydroepiandrosterone (DHEA) levels in humans are described. The compositions comprise magnesium chloride, a suitable solvent, a gelling agent and a glycerin. The compositions are administered to the skin of hu... | 04/29/2008 |
| 7365172 | Loop peptide and TGFα for stimulating stem cell proliferation and migration There is disclosed a novel genus of small peptides, much smaller than human TGFα, was discovered as having TGFα biological activity and therefore are useful as pharmacologic agents for the same indications as full length TGFα polypeptide. There is further disclos... | 04/29/2008 |
| 7361634 | Pain-sensitive therapeutic wound dressings The invention provides a wound dressing comprising a therapeutic agent and a matrix comprising polymers joined by cross-linkages which cross-linkages comprise oligopeptidic sequences which are cleavable by a kallikrein associated with wound fluid such that the rate ... | 04/22/2008 |
| 7357946 | Uses for cellulose-containing aggregates Aggregates of cellulose-containing particles, such as particles of waste paper and optional other vegetation or waste particles are used as a carrier for additives such as insecticides, herbicides, fertilizers and nutrients. The particles can be also used as a carri... | 04/15/2008 |
| 7354606 | Nutritional supplement containing alpha-glucosidase and alpha-amylase inhibitors A nutritional supplement composition contains inhibitors of alpha-glucosidase and alpha-amylase substantially in the absence of lipase inhibitors. The composition can include touchi extract and phaseolamin as the alpha-glucosidase and alpha-amylase inhibitor, respec... | 04/08/2008 |
| 7354607 | Drink containing ultrafine powder of ginseng and the method thereof The present invention relates to a method of preparation of a drink composition containing powder of ginseng or red ginseng, and more particularly, it relates to a health drink containing powder of ginseng or red ginseng ultrafinely pulverized by a suitable pulveriz... | 04/08/2008 |
| 7351430 | Shape-retentive hydrogel particle aggregates and their uses The present invention is related to hydrogel particles and aggregates formed therefrom having characteristics including, without limitation, shape-retentiveness, elasticity, controllable pore sizes and controllable degradation rates that render them useful for a wid... | 04/01/2008 |