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Felix Hoffmann, a German chemist, was searching for something to relieve his father's arthritis. In doing so, he "rediscovered" acetylsalicylic acid and in 1900, patented a stable process for developing it. Hence, we have aspirin.
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| Number | Title | Issue Date |
| 7041641 | Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects Disclosed herein are improved osteogenic devices and methods of use thereof for repair of bone and cartilage defects. The devices and methods promote accelerated formation of repair tissue with enhanced stability using less osteogenic protein than devices in the art... | 05/09/2006 |
| 7037527 | Bifunctionalized polyester material for surface treatment and biomodification The invention features a method of treating polyester material to generate functional carboxylic acid and amine groups. These functional groups can be used as sites for covalent bond formation to attach chemical or biological moieties. This bifunctionalized polyeste... | 05/02/2006 |
| 7033608 | “Burst-free” sustained release poly-(lactide/glycolide) microspheres Novel burst-free, sustained release biocompatible and biodegrable microcapsules which can be programmed to release their active core for variable durations ranging from 1–100 days in an aqueous physiological environment. The microcapsules are comprised of a core o... | 04/25/2006 |
| 7034037 | Compositions and medical devices utilizing bioabsorbable polymeric waxes and rapamycin The present invention is directed to medical devices and pharmaceutical or agricultural compositions, and seeds, each containing a synthetic, bioabsorbable, biocompatible polymeric wax that is the reaction product of a polybasic acid or derivative thereof, a polyol ... | 04/25/2006 |
| 7033602 | Polycationic peptide coatings and methods of coating implantable medical devices Coatings for medical devices which include polycationic peptides such as L-arginine and methods for fabricating the coatings are disclosed. ... | 04/25/2006 |
| 7033606 | Pharmaceutical composition intended in particular for the prevention and the treatment of radiomucositis and chemomucositis The invention concerns a pharmaceutical composition designed to adhere to a mucous membrane for preventing or treating radiotherapy-related and chemotherapy-related mucositis, induced by radiotherapy or combined radiochemotherapy, comprising an effective amount of a... | 04/25/2006 |
| 7030155 | Emulsion vehicle for poorly soluble drugs A method of making an emulsion of tocopherol incorporating a co-solvent and, stabilized by biocompatible surfactants, as a vehicle or carrier for therapeutic drugs, which is substantially ethanol free and which can be administered to animals or humans by various rou... | 04/18/2006 |
| 7030218 | Pseudo native chemical ligation The present invention concerns methods and compositions for extending the technique of native chemical ligation of a wider range of peptides, polypeptides, other polymers and other molecules via an amide bond (see FIG. 1). The invention further provides metho... | 04/18/2006 |
| 7030097 | Controlled nucleic acid delivery systems One aspect of the present invention relates to a nucleic acid delivery system including a polymeric structure formed of a biocompatible polymer and a mixture comprising one or more nucleic acid molecules and a first co-dispersant, the mixture being contained within ... | 04/18/2006 |
| 7029609 | Composition which can be foamed from a pressurized container for producing insulating foams The invention relates to a composition which can be foamed from pressurized containers. Said composition is based on an aqueous plastic dispersion containing an aqueous dispersion of at least one film-forming plastic material consisting of 30% to 80% by weight of a ... | 04/18/2006 |
| 7025869 | Nitric oxide delivery system Inhalation of low levels of nitric oxide can rapidly and safely decrease pulmonary hypertension in mammals. Precise delivery of nitric oxide at therapeutic levels of 20 to 100 ppm and inhibition of reaction of nitric oxide with oxygen to form toxic impurities such a... | 04/11/2006 |
| 7025990 | Methods for forming regional tissue adherent barriers and drug delivery systems Methods are provided for forming hydrogel barriers in situ that adhere to tissue and prevent the formation of post-surgical adhesions or deliver drugs or other therapeutic agents to a body cavity. The hydrogels are crosslinked, resorb or degrade over a period of tim... | 04/11/2006 |
| 7026418 | Emulsion polymerization process utilizing ethylenically unsaturated amine salts of sulfonic, phosphoric and carboxylic acids Disclosed is an improved method of making polymers. The method utilizes at least one ethylenically unsaturated monomer and at least one polymerizable surface active agent. The polymerizable surface active agent is capable of co-polymerization with traditional monome... | 04/11/2006 |
| 7024955 | Methods and systems for dissolution testing Methods and systems for determining a dissolution profile of a sample material, and for solubilization screening of a library defined by an array comprising multiple sample materials are disclosed. The methods and systems are particularly advantageous for sampling a... | 04/11/2006 |
| 7022663 | Oral, nasal and pulmonary dosage formulations of copolymer 1 Pharmaceutical compositions useful for treating autoimmune diseases in a mammal comprising as an active ingredient a therapeutically effective amount of Copolymer 1, and microcrystalline cellulose are disclosed. Processes for the manufacture of such compositions are... | 04/04/2006 |
| 7022737 | Manipulating nitrosative stress to kill pathologic microbes, pathologic helminths and pathologically proliferating cells or to upregulate nitrosative stress defenses Mammals are treated for infections or for conditions associated with pathologically proliferating mammalian cell growth by administration of a manipulator of nitrosative stress to selectively kill or reduce the growth of the microbes or helminths causing the infecti... | 04/04/2006 |
| 7022344 | Process for producing solid dosage forms A process for producing solid dosage forms by mixing at least one polymer binder, at least one active ingredient and, where appropriate, conventional additives to form a plastic mixture, and shaping, wherein a physiologically tolerated, water-swellable graft copolym... | 04/04/2006 |
| 7022335 | Suppository of retaining in lower region of rectum A suppository of retaining in a lower region of rectum, which contains a suppository base containing: (A) a fatty acid triglyceride, (B) one or more C14-18 fatty acid glycerides, and (C) a base ingredient for retaini... | 04/04/2006 |
| 7022345 | Oral solid pharmaceutical formulations with pH-dependent multiphasic release Oral solid pharmaceutical compositions with pH-dependent multiphasic release, containing, as active ingredient, a molecule useful in the inflammatory bowel disease therapy, are described, being such compositions suitable to the release of the active ingredient in th... | 04/04/2006 |
| 7018654 | Pharmaceutical composition containing an active agent in an amino acid copolymer structure A method of protecting a chemical compound from degradation comprising combining the chemical compound with an amino acid polymer. Disclosed are methods of combining chemical compounds with synthetic amino acid polymers for protection from degradation of the chemica... | 03/28/2006 |
| 7018645 | Mixtures of various triblock polyester polyethylene glycol copolymers having improved gel properties A water soluble, biodegradable reverse thermal gelation system comprising a mixture of at least two types of tri-block copolymer components is disclosed. The tri-block copolymer components are made of a hydrophobic biodegradable polyester A-polymer block and a hydro... | 03/28/2006 |
| 7018655 | Amphiphilic diblock, triblock and star-block copolymers and their pharmaceutical compositions This invention relates to novel amphiphilic diblock, triblock copolymers and star-shaped block copolymers comprising a biodegradable polymer covalently attached at the polymer ends, to a hydrophilic vinyl polymer, via divalent sulfur atom; to a process for producing... | 03/28/2006 |
| 7019182 | Method of hydrocarbon preservation and environmental protection Gas phase hydrocarbons resulting from the operation of offshore petroleum wells are converted into corresponding liquid products which are mixed with liquid phased hydrocarbons resulting from operation of the offshore petroleum well for delivery therewith. ... | 03/28/2006 |
| 7011842 | Polycationic peptide coatings and methods of making the same Polycationic peptide coatings for implantable medical devices and methods of making the same are described. The methods include applying an emulsion on the device, the emulsion including a polymer and a polycationic peptide. Other methods include incorporation of th... | 03/14/2006 |
| 7009034 | Biocompatible crosslinked polymers Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having electrophilic and nucleophilic functional groups capable of reacting and cros... | 03/07/2006 |
| 7008643 | Delivery system for biological material The present invention relates to a composition and method for delivery of biological material, especially nucleic acids into target cells and into the nucleus. ... | 03/07/2006 |
| 7008634 | Cell growth substrates with tethered cell growth effector molecules Described are compositions with tethered growth effector molecules, and methods of using these compositions for growing cells and tissues. Growth effector molecules, including growth factors and extracellular matrix molecules, are flexibly tethered to a solid substr... | 03/07/2006 |
| 7005137 | Coating for implantable medical devices A coating for an implantable medical device, such as a stent, is disclosed. The coating comprising a block copolymer obtained by a polymerization reaction of at least two reagents. A method for forming the coating is also disclosed. ... | 02/28/2006 |
| 7005142 | Veterinary delivery systems and methods of delivering effective agents to animals A veterinary delivery system in the form of a pliable film comprising at least one binder, at least one lubricant, at least one solvent for the binder and lubricant, and an effective amount of at least one effective agent. According to one embodiment, a flavorant is... | 02/28/2006 |
| 7005454 | Polymeric drug formulations Polymeric drug formulations containing a non-releasing single-phase dispersion of a water-soluble drug in a water-insoluble tissue-compatible polymer matrix. Polymeric drug formulations are also disclosed containing a single-phase dispersion of a water-soluble drug ... | 02/28/2006 |
| 7001613 | Skin friendly active substance patch for transdermal administration of hyperemic active substances An active substance matrix patch for controlled delivery of at least one hyperemic active substance to the skin, comprising a flexible cover layer and a water insoluble, pressure sensitive adhesive active substance matrix, wherein said adhesive matrix is free from m... | 02/21/2006 |
| 7001894 | Blood flow improvers and thrombosis preventives or remedies Glucosamine salts and derivatives are effective for the improvement of blood flow, and hence, for the prevention and/or treatment of diseases caused by blood flow disturbances, such as thrombosis. Use of glucosamine salts or glucosamine derivatives as active ingredi... | 02/21/2006 |
| 7001615 | Sustained release ophthalmic, otic and nasal suspension Sustained release suspension formulations for ophthalmic, otic and nasal administration are disclosed. The formulations comprise a basic active, a cation exchange resin, and a combination of a polymeric suspending agents to provide superior resuspendability. ... | 02/21/2006 |
| 6998426 | Nanoemulsion containing nonionic polymers, and its uses These objects and others may be accomplished with the present invention, the first embodiment of which provides an oil-in-water nanoemulsion, which includes: an oily phase dispersed in an aqueous phase; (i) at leas... | 02/14/2006 |
| 6998155 | Woven materials with incorporated solids and processes for the production thereof The invention relates woven and knit materials with an incorporated particulate solid and to a process for producing woven materials incorporated with a particulate solid. The process comprises: entraining a particulate solid in a gaseous carrier; disposing one face... | 02/14/2006 |
| 6998134 | Biologically active implants This invention relates to an implant for treating pathological changes in the spinal column and/or locomotor system. According to one embodiment of the invention, the implant may be provided with an enamel-like or varnish-like coating up to 100 μm thick and made of... | 02/14/2006 |
| 6998137 | Proteins deposited onto sparingly soluble biocompatible particles for controlled protein release into a biological environment from a polymer matrix The present invention relates to compositions and methods for the modulated release of one or more proteins or peptides. The composition is comprised of a biocompatible polymeric matrix, a protein and/or peptide, and a sparingly water-soluble or essentially insolubl... | 02/14/2006 |
| 6998394 | Process for isolating physalins from plants and pharmaceutical compositions containing physalins The present invention relates to a process for obtaining Physalis angulata extracts, particularly to isolate ergostane-type steroidal derivatives, such as physalins, which are useful in the treatment of infections caused by protozoans. The physalins of the in... | 02/14/2006 |
| 6994867 | Biocompatible carrier containing L-arginine L-arginine conjugated to a polymeric matrix is disclosed. The matrix can be used as, for example, a coating for an implantable medical device such as a stent. ... | 02/07/2006 |
| 6995150 | Pharmaceutical compositions and uses for androst-5-ene-3β, 17β-diol Androst-5-ene-3β,17β diol is used to treat or reduce the likelihood of acquiring osteoporosis or menopausal symptoms, or other diseases affected by estrogen receptor activity, and for conditions which respond well to DHEA treatment, but where a higher ratio of est... | 02/07/2006 |
