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| Number | Title | Issue Date |
| 6930098 | Use of polysulphated cyclodextrins for treating osteoarthritis The present invention relates to the method of using polysulphated cyclodextrins or addition salts thereof for use in the treatment of arthrosis, and pharmaceutical compositions thereof. ... | 08/16/2005 |
| 6926919 | Method for fabricating a coating for a medical device Methods for fabricating coatings for implantable medical devices are disclosed. The coatings include blends of hydrophilic and hydrophobic polymers. The methods provide for treatment of the coatings to cause enrichment a region close to the outer surface of the coat... | 08/09/2005 |
| 6924273 | Chondroprotective/restorative compositions and methods of use thereof The instant invention provides a method of treating or preventing osteoarthritis, joint effusion, joint inflammation and pain, synovitis, lameness, post operative arthroscopic surgery, deterioration of proper joint function including joint mobility, the reduction or... | 08/02/2005 |
| 6923985 | Bioerodable polymeric adhesives for tissue repair Improved matrices and adhesives for tissue repair comprising a biocompatible, bioerodable polymer, said polymer comprising a thermoplastic lactide-containing terpolymer of monomer units derived from lactic acid, glycolic acid, and either caprolactone or valerolacton... | 08/02/2005 |
| 6923986 | Multiblock biodegradable hydrogels for drug delivery and tissue treatment Gel-forming macromers including at least four polymeric blocks, at least two of which are hydrophobic and at least one of which is hydrophilic, and including a crosslinkable group are provided. The macromers can be covalently crosslinked to form a gel on a tissue su... | 08/02/2005 |
| 6921541 | Formulations and methods for providing prolonged local anesthesia A formulation and methods for inducing sustained regional local anesthesia in a patient comprising a substrate comprising a local anesthetic and an effective amount of a biocompatible, biodegradable, controlled release material prolonging the release of the local an... | 07/26/2005 |
| 6919076 | Conjugates of agents and transglutaminase substrate linking molecules Methods, products, compositions and kits are provided for attaching agents to tissue with a linking molecule in the presence of transglutaminase. The linking molecule and/or agent is a substrate of transglutaminase. The agent can be a nonprotein or an enzyme such as... | 07/19/2005 |
| 6919473 | Photostabilizers, UV absorbers, and methods of photostabilizing a sunscreen composition Derivatives of fluorene, including ester derivatives of cyano(9H-fluoren-9-ylidene) acetic acid, and sunscreen compositions including a mixture of a photoactive compound and an ester derivative of cyano(9H-fluoren-9-ylidene) acetic acid are disclosed herein. Also di... | 07/19/2005 |
| 6916480 | Wiper containing a controlled-release anti-microbial agent A wiper having a controlled release anti-microbial agent therein for providing anti-microbial cleansing of surfaces is provided. The wiper is formed from an absorbent base web to which an anti-microbial formulation is adhered. The formulation includes an anti-microb... | 07/12/2005 |
| 6916788 | Liquid composition of biodegradable block copolymer for drug delivery system and process for the preparation thereof The present invention relates to a liquid polymeric composition capable of forming a physiologically active substance-containing implant when it is injected into a living body and a method of preparation thereof. The composition comprises a water-soluble biocompatib... | 07/12/2005 |
| 6913759 | Gel composition and method for treatment of vaginal infections A pharmaceutical composition having a gel consistency at room temperature and suitable for the treatment of a vaginal infection comprises, on a total composition weight basis, about 0.1 to about 3 weight percent of benzydamine hydrochloride, about 16 to about 35 wei... | 07/05/2005 |
| 6913760 | Drug delivery composition The invention provides a drug delivery compositions and methods for treating pain. A drug delivery composition contains a polymer and at least two drugs sucha as an analgesic agent and an anesthetic agent. ... | 07/05/2005 |
| 6914051 | Penetrating antibiotic gel for soft tissue diseases A penetrating antibiotic gel for treating pain, inflammation and other pathological conditions affecting musculoskeletal tissues and other soft tissues of the body. The composition includes an antibiotic compound and a mobilizing agent in an amount sufficient to ena... | 07/05/2005 |
| 6913767 | Compositions for microencapsulation of antigens for use as vaccines Methods and compositions are provided for the encapsulation of antigens in PLGA microspheres for use as vaccines. Such microspheres can also contain adjuvants. Mixtures of microspheres are provided which release antigen at desired intervals to provide boosts with an... | 07/05/2005 |
| 6914050 | Stimulation of bone growth with thrombin peptide derivatives Disclosed is a method of stimulating bone growth at a site in a subject in need of osteoinduction. The method comprises the step of administering a therapeutically effective amount of an agonist of the non-proteolytically activated thrombin receptor to the site.... | 07/05/2005 |
| 6913768 | Sustained release delivery of amphetamine salts A pharmaceutical composition comprises a once-a-day sustained release formulation of at least one amphetamine salt which provides mean plasma concentration profile aspects in human ADHD patients which are substantially the same as that provided by ADDERALL XR® type... | 07/05/2005 |
| 6911572 | Water-absorbing polymers having supramolecular hollow molecules, method for producing them and use of the same The invention relates to absorbent polymers based on optionally partially neutralised, monoethylenically unsaturated, acid group-carrying monomers. The surfaces of said polymers are re-cross-linked. The inventive polymers also have cyclodextrines and/or cyclodextrin... | 06/28/2005 |
| 6908624 | Coating for implantable devices and a method of forming the same Coatings for implantable devices or endoluminal prosthesis, such as stents, are provided, including a method of forming the coatings. The coatings can be used for the delivery of an active ingredient or a combination of active ingredients. ... | 06/21/2005 |
| 6905700 | Hydrogel entrapping therapeutic agent and stent with coating comprising this A hydrogel forming system which comprises a hydrophobic macromer with unsaturated group terminated ends and a hydrophilic polymer which is a polysaccharide containing hydroxy groups which are reacted with unsaturated group introducing compound, is convertible by fre... | 06/14/2005 |
| 6905709 | Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer A stabilized solid controlled release dosage form having a coating derived from an aqueous dispersion of ethylcellulose is obtained by overcoating a substrate including a therapeutically active with an aqueous dispersion of ethylcellulose and then curing the coated ... | 06/14/2005 |
| 6902741 | Laminates containing an active substance transdermal system The transdermal system includes a sex hormone-containing adhesive matrix, which contains inclusions of a sex hormone in a hydrophilic non-crosslinked polymer in dissolved or dispersed form. The inclusions have a concentration of 20 to 90 percent by weight of the sex... | 06/07/2005 |
| 6902743 | Therapeutic treatment and prevention of infections with a bioactive material(s) encapuslated within a biodegradable-bio-compatable polymeric matrix Novel burst-free, sustained release biocompatible and biodegrable microcapsules which can be programmed to release their active core for variable durations ranging from 1-100 days in an aqueous physiological environment. The microcapsules are comprised of a core of ... | 06/07/2005 |
| 6902905 | Glucose measuring assembly with a hydrogel This invention relates to methods for reducing the presence of a compound in an ionically conductive material, e.g., for use in iontophoretic devices, wherein the presence of the compound interferes with detecting a selected analyte. Removal of the compound can typi... | 06/07/2005 |
| 6899889 | Biocompatible material composition adaptable to diverse therapeutic indications A biocompatible material genus serves as the foundation for multiple material composition species, each adapted to a specific therapeutic indication. ... | 05/31/2005 |
| 6896903 | Bioadhesive compositions A bioadhesive composition formed by polymerizing a homogeneous aqueous reaction mixture comprising from about 5% to about 50%, by weight of the reaction mixture, of at least one ionic water soluble monomer, from about 10% to about 50%, by weight of the reaction mixt... | 05/24/2005 |
| 6896904 | Collagen/polysaccharide bilayer matrix Disclosed are bilayer matrices of a polysaccharide such as collagen (COL) and another polysaccharide such as hyaluronic acid (HA) with various COL/HA ratios. Each layer has a porous structure. These materials are useful for tissue regeneration, particularly when use... | 05/24/2005 |
| 6894027 | Stimulation of bone growth with thrombin peptide derivatives Disclosed is a method of stimulating bone growth at a site in a subject in need of osteoinduction. The method comprises the step of administering a therapeutically effective amount of an agonist of the non-proteolytically activated thrombin receptor to the site.... | 05/17/2005 |
| 6893662 | Pharmaceutical dosage form with multiple coatings for reduced impact of coating fractures The present invention relates to a pharmaceutical composition in a solid unit dosage form for oral administration in a human or lower animal comprising: a. a safe and effective amount of a therapeutically active agent; b. an inner coating layer selected from the gro... | 05/17/2005 |
| 6890560 | Negatively charged amphiphilic block copolymer as drug carrier The present invention provides an anionic group-containing amphiphilic block copolymer that is biocompatible and biodegradable and, when used as a drug carrier for a cationic drug, provides several advantages such as increased blood concentration and improved stabil... | 05/10/2005 |
| 6890522 | Cosmetic and personal care compositions Cosmetic or personal care compositions, such as for styling hair, comprise a thermoplastic elastomer which is a block copolymer comprising a core polymer having a backbone comprising at least a proportion of C—C bonds and two or more flanking polymers. Each flanki... | 05/10/2005 |
| 6887857 | Microparticle protection of therapeutic agents The present invention is directed to the use of microparticles to protect the pharmaceutical effectiveness of a pharmaceutically active agent. According to one embodiment, a pharmaceutically acceptable suspension is provided that comprises microparticles and a pharm... | 05/03/2005 |
| 6884434 | Transdermal therapeutic system which contains a d2 agonist and which is provided for treating parkinsonism, and a method for the production thereof A transdermal therapeutic system, comprising a backing layer inert to the components of the matrix, a self-adhesive matrix layer containing (−)-5,6,7,8-tetrahydro-6-[propyl-[2-(2-thienyl)ethyl]amino]-1-naphthalenol in an effective amount and a protective foil or s... | 04/26/2005 |
| 6884427 | Filamentary means for introducing agents into tissue of a living host The present invention provides a filamentary structure for the introduction of agents into a living host, comprising a filament comprising a solid core and a porous sheath which coats at least a portion of the solid core. When the filamentary structure is to be perm... | 04/26/2005 |
| 6884778 | Biocompatible macromers A new oligomer based on alternating fumaric acid and poly(ethylene glycol) (PEG) units is provided. The oligo(PEG fumarate) (OPF) may be functionalized by modification with a biocompatible organic group. Further, the OPF may be cross-linked using radical polymerizat... | 04/26/2005 |
| 6878384 | Hydrogels that undergo volumetric expansion in response to changes in their environment and their methods of manufacture and use Hydrogels that expand volumetrically in response to a change in their environment (e.g., a change in pH or temperature) and their methods of manufacture and use. Generally, the hydrogels are prepared by forming a liquid reaction mixture that contains a) monomer(s) a... | 04/12/2005 |
| 6875441 | Composition for delivery of hematopoietic growth factor A hematopoietic growth factor delivery composition includes a hematopoietic growth factor, a liquid vehicle, a first biocompatible polymer and a second biocompatible polymer. The composition exhibits reverse-thermal viscosity behavior, due to interaction between the... | 04/05/2005 |
| 6872403 | Polymethylmethacrylate augmented with carbon nanotubes An augmented synthetic resin is provided. That resin includes carbon nanotubes dispersed in a polymethylmethacrylate matrix. The method of preparing this synthetic resin includes the mixing and disaggregating of the carbon nanotubes. ... | 03/29/2005 |
| 6872576 | Antigens embedded in thermoplastic The invention relates to an immunoassays, binding assays, solid phase substrates (12) and other devices with an antigen or antibody or ligand or receptor (11) embedded into a solid phase substrate (12). The antigen or antibody is mixed with a mo... | 03/29/2005 |
| 6869976 | Inorganic-polymer complexes for the controlled release of compounds including medicinals This invention relates generally to the production and use of inorganic-polymer complexes for the controlled release of compounds including medicinals. Advantageously, the inorganic used is calcium sulfate. ... | 03/22/2005 |
| 6861068 | Pharmaceutical compositions using semi-solid delivery vehicle A semi-solid delivery vehicle contains a polyorthoester and an excipient, and a semi-solid pharmaceutical composition contains an active agent and the delivery vehicle. The pharmaceutical composition may be a topical, syringable, or injectable formulation; and is su... | 03/01/2005 |
