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| Number | Title | Issue Date |
| 7229642 | Amino acid modulated extended release dosage form Disclosed herein is a oral extended release dosage form comprising a plurality of granules of an effective amount of a pharmaceutically active compound, at least one amino acid, and an intragranular polymer in which the granule is dispersed within a hydrophilic extr... | 06/12/2007 |
| 7138139 | Tablet coating The present invention relates to water soluble tablet coatings prepared from water soluble, partially and completely neutralized acrylic polymers and at least one film modifying agent. ... | 11/21/2006 |
| 7012129 | Antiviral composition comprising glycine amide Embodiments relate to the discovery that certain tripeptide amides and glycine amide can be used to inhibit viral infection, including human immunodeficiency virus (HIV) infection. More specifically, medicaments comprising said tripeptide amides and/or glycine amide... | 03/14/2006 |
| 6994873 | Multiparticulate formulations of lithium salts for oral administration suitable for once-a-day administration This invention refers to: multiparticulate formulations of Lithium salts for oral administration constituted by either modified release granules or mixtures of modified and conventional release granules, suitable for once-a-day adm... | 02/07/2006 |
| 6946145 | Block copolymers based on poly(ortho esters) containing amine groups Block copolymers based on poly(ortho esters) containing amine groups. These block copolymers have both hydrophilic and hydrophobic blocks. They form micelles in aqueous solution, making them suitable for encapsulation or solubilization of hydrophobic or water-insolu... | 09/20/2005 |
| 6946146 | Coating for a sustained release pharmaceutical composition The present invention is directed to a coating composition for coating a solid dosage form of a medicament, where the coating composition controls the release of the medicament, said coating composition comprising (a) at least 50% (w/w) by dry weight of a water inso... | 09/20/2005 |
| 6867181 | Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides A method of spherifying a sustained release ionic conjugate which contains a free carboxyl group-containing polymer and a free amino group-containing drug which are ionically bonded to each other. ... | 03/15/2005 |
| 6783771 | Physiologically active substance EEM-S originating in mushrooms, process for producing the same and drugs EEM-S obtained by extracting with hot water or a lower alcohol at least one mushroom selected from among Lentinus edodes, Flammulina velutipes, Hypsizygus marmoreus, Pleurotus ostreatus, Pholiota nameko, Grifola fondosa, Volvariella speciosa ver. speciosa,... | 08/31/2004 |
| 6706284 | Bitterness-reduced oral pharmaceutical composition The invention relates to an oral pharmaceutical composition which has excellent drug release-controlling ability in the mouth even 5 to 10 minutes after its administration and also has excellent drug releasing ability in the digestive tract without using capsules. I... | 03/16/2004 |
| 6616944 | Self-assembling colloidal carriers for protein delivery The invention is directed to self-assembling, polymer-based delivery systems for proteins. The delivery systems comprises an active agent and a polyol ester of the invention, having a linear polyol containing six or more hydroxyl groups as a central backb... | 09/09/2003 |
| 6610329 | Compositions for the delivery of antigens The present invention relates to compositions and methods for orally delivering antigens. The antigen and an adjuvant are combined with an acylated amino acid or polyamino acid and, a sulfonated amino acids or polyamino acid, or a salt of the foregoing.... | 08/26/2003 |
| 6531152 | Immediate release gastrointestinal drug delivery system A gastrointestinal delivery system is provided. The system comprises a drug in combination with a swellable core material, the core being surrounded by a water-insoluble or relatively water-insoluble coating material in which particulate water-insoluble m... | 03/11/2003 |
| 6429193 | CELL CHEMOTACTIC FACTOR (CCTF) ORIGINATING IN MAMMALIAN TOOTH PRICEMENT OR CEMENT, METHOD FOR PURIFYING THE SAME, AND NOVEL CONNECTIVE TISSUE ADHESION PROMOTERS CONTAINING THE SAME AS THE ACTIVE INGREDIENT A precementum- and/or cementum-derived chemotactic factor (CCTF) of a tooth of a Mammalian is characterized by a molecular weight measured by SDS-PAGE of 67000&#b1;1000. A process for purifying a precementum- and/or cementum-derived gingival fibroblast ch... | 08/06/2002 |
| 6387404 | Immediate release tablet cores of insoluble drugs having sustained-release coating A controlled release tablet for oral administration is disclosed which has a tablet core including an insoluble therapeutically active agent having an aqueous solubility of less than or equal to about 5 mg/ml in a sufficient amount to render a therapeutic... | 05/14/2002 |
| 6372254 | Press coated, pulsatile drug delivery system suitable for oral administration A press coated, pulsatile drug delivery system suitable for oral administration having an immediate-release compartment, which contains a compressed blend of an active agent and one or more polymers, substantially enveloped by an extended-release compartm... | 04/16/2002 |
| 6335027 | Controlled delivery compositions and processes for treating organisms in a column of water or land Controlled release compositions of matter are disclosed comprising complexes for treating a population of one or more aquatic organisms in a column of water. The complexes comprise at least one system wherein the system comprises at least one bioactive ag... | 01/01/2002 |
| 6319683 | Method and composition for controlling formaldehyde fixation by delayed quenching A method and composition for quenching formaldehyde fixation of cell and tissue specimens. The composition includes a formaldehyde-reactive agent. The formaldehyde-reactive agent reacts with the formaldehyde to quench the fixation of the cell or tissue sp... | 11/20/2001 |
| 6210714 | Immediate release tablet cores of acetaminophen having sustained-release coating A controlled release tablet for oral administration is disclosed which has a tablet core including an insoluble therapeutically active agent having an aqueous solubility of less than or equal to about 5 mg/ml in a sufficient amount to render a therapeutic... | 04/03/2001 |
| 6086918 | Oral peptide pharmaceutical products Bioavailability of peptide active agents to be administered orally is enhanced by a pharmaceutical composition providing targeted release of the peptide to the intestine by virtue of an acid-resistant protective vehicle which transports components of the ... | 07/11/2000 |
| 6077540 | Gelatin spray coating This invention provides a coating composition in which the principal film former is gelatin for use in coating tablets. The gelatin coating may be used with tablets, with or without any subcoating, and may be applied using conventional equipment. For a su... | 06/20/2000 |
| 6056974 | Rapid-release S1452 tablets The present invention provides a rapid-release tablet of S1452 at least containing the following components: a. a principal agent comprising (+)-(Z)-calcium 7-[(1R,2S,3S,4S)-3-benzenesulfonaidobicyclo[2.2.1]hept-2-yl]-5-heptenoate dihydrate (S1452), and b... | 05/02/2000 |
| 6030640 | Oligoglycine compound, fibrous microtube of oligoglycine compound and process of producing fibrous microtube A lipid represented by the following formula: MO--(CO--CH2 --NH)p --CO--(CH2)n --CO--(NH--CH2 --CO)q --OM wherein M represents a hydrogen atom or an alkali metal, n is an integer of 6-18 and p a... | 02/29/2000 |
| 5958457 | Compositions for the delivery of antigens The present invention relates to compositions and methods for orally delivering antigens. The antigen and an adjuvant are combined with an acylated amino acid or polyamino acid and, a sulfonated amino acids or polyamino acid, or a salt of the foregoing.... | 09/28/1999 |
| 5912014 | Oral salmon calcitonin pharmaceutical products Bioavailability of salmon calcitonin to be administered orally is enhanced by a pharmaceutical composition providing targeted release of the peptide to the intestine, together with an absorption enhancer and a sufficient amount of a pH-lowering agent to l... | 06/15/1999 |
| 5882715 | Method of preparing an oral preparation provided on the outer side with an enteric coating, as well as an oral preparation obtained by the method A method of preparing an oral preparation, especially in the form of hard gelatin capsules, tablets or pellets, for use by the administration of drugs or supplementary nutrients for human beings or animals, said preparation on its outer side being provide... | 03/16/1999 |
| 5876748 | Fibrous microtube of oligoglycine compound A lipid represented by the following formula: MO--(CO--CH2 --NH)p --CO--(CH2)n --CO--(NH--CH2 --CO)q --OM wherein M represents a hydrogen atom or an alkali metal, n is an integer of 6-18 and p a... | 03/02/1999 |
| 5753265 | Multiple unit pharmaceutical preparation A new pharmaceutical multiple unit tableted dosage form containing as active ingredient an acid labile H+ K+ -ATPase inhibitor or an alkaline salt thereof or one of its single enantiomers or an alkaline salt thereof, a method for the... | 05/19/1998 |
| 5750145 | Stable gelatin coated aspirin tablets Gelatin coated pharmaceutical dosage units containing, for example, analgesic compounds, such as aspirin, stabilized with a proteolytic enzyme, such as pepsin, are described.... | 05/12/1998 |
| 5573934 | Gels for encapsulation of biological materials Water soluble macromers are modified by addition of free radical polymerizable groups, such as those containing a carbon-carbon double or triple bond, which can be polymerized under mild conditions to encapsulate tissues, cells, or biologically active mat... | 11/12/1996 |
| 5455286 | Bioactive composition An improved bioactive agent delivery composition and method of application are described. The composition comprises a bioactive agent, a hydrophilic polymer in an incompletely hydrated state and a substantially water-miscible solvent system. The agent and... | 10/03/1995 |
| 5451410 | Modified amino acids for encapsulating active agents Modified amino acids and methods for their preparation and use as oral delivery systems for pharmaceutical agents are described. The modified amino acids are preparable by reacting single amino acids or mixtures of two or more kinds of amino acids with an... | 09/19/1995 |
| 5393333 | Film-forming product for coating solid forms, process for its manufacture and products coated with this film-forming product The present invention relates to a film-forming product for coating solid forms, to a process for the manufacture of this film-forming product and to products coated with this film-forming product. According to the invention, this film-forming product tak... | 02/28/1995 |
| 5350741 | Enteric formulations of physiologically active peptides and proteins An enteric formulation for a proteinous drug which protects it from enzymatic degradation and promotes its uptake by the intestinal tract when administered orally, comprises either a solid mass of an intimate mixture of the drug, a nontoxic nonionic surfa... | 09/27/1994 |
| 5328697 | Compositions and processes for the sustained release of drugs The present invention relates to compositions for the sustained release of drugs and to methods for the production of such compositions. In one embodiment, somatotropin is layered onto non-pareil seeds, which, in turn are sprayed with a glycine solution. ... | 07/12/1994 |
| 5240712 | Therapeutic agents A high content of 2-(4-isobutylphenyl)propionic acid is achieved in a pharmaceutical composition by solidifying molten 2-(4-isobutylphenyl)propionic acid to provide a unit dose composition. The composition may be prepared by heating the 2-(4-isobutylpheny... | 08/31/1993 |
| 5189148 | Stabilized FGF composition and production thereof Disclosed are (1) a stabilized FGF protein composition which comprises an FGF protein and water-insoluble hydroxypropyl cellulose; (2) a method for preparing a stabilized FGF protein composition, which comprises admixing an FGF protein with a water-insolu... | 02/23/1993 |
| 5185159 | Pharmaceutical composition based on valproic acid and a process for preparing it New pharmaceutical composition based on valproic acid and one of the pharmaceutically acceptable salts thereof, obtained by a new galenic preparation process which makes it possible to improve and simplify the galenic production, this composition also con... | 02/09/1993 |
| 5182130 | Method for producing an edible prolamine coating from an aqueous latex A continuous edible coating or barrier is formed on a substrate by applying to the substrate a water-based prolamine latex which is substantially free of organic solvent. Additives to the latex may be used to modify the properties of the coating or barrie... | 01/26/1993 |
| 5077053 | Zein as a moisture barrier for sugarless edible compositions and method for preparing same The present invention pertains to an edible coated composition which comprises (a) a core material comprising sorbitol, (b) a primary coating layer comprising zein over the core material, and (c) a sugarless secondary coasting layer over the primary coati... | 12/31/1991 |
| 5025004 | Water-dispersible polymeric compositions Disclosed is a process for preparing polymeric compositions which are suitable for coating medicaments or for use in cosmetic formulations and the novel compositions prepared therefrom. The process makes stable, colloidal, latex-like dispersions of coatin... | 06/18/1991 |
