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Class 424/470 - Where particles are granulated


Subclass of Class 424 - Drug, bio-affecting and body treating compositions
Definition: Subject matter in which the particles entrapped in the matrix
No. of patents: 516
Last issue date: 05/10/2011


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NumberTitleIssue Date
7939102Controlled release formulation of lamotrigine
Rapidly disintegrating multiparticulate controlled release formulations of lamotrigine having an improved pharmacokinetic profile and improved patient compliance, and process of preparing the formulations. It provides better control of blood plasma levels than conve...
05/10/2011
7790197Pharmaceutical compositions of atorvastatin
A wet granulated pharmaceutical composition comprising atorvastatin or a pharmaceutically acceptable salt thereof with less than about 5 weight % of an alkaline earth metal salt additive with a disintegrant which provides the atorvastatin with not more than about 3%...
09/07/2010
7553499Sustained release tablet containing indapamide
The present invention relates to a sustained release tablet containing indapamide and the process of manufacturing sustained release tablet containing indapamide. The tablet contains indapamide in the amount of 1.5 to 2.5% of the total mass of the tablet, lactose mo...
06/30/2009
7431943Controlled release and taste masking oral pharmaceutical compositions
Controlled release and taste masking compositions containing one or more active principles inglobated in a three-component matrix structure, i.e. a structure formed by successive amphiphilic, lipophilic or inert matrices and finally inglobated or dispersed in hydrop...
10/07/2008
7425341Rapidly disintegrable tablets
The invention provides a rapidly disintegrating tablet comprising an active ingredient, a water soluble, directly compressible carbohydrate, and a water soluble, directly compressible filler. Also provided is a method of producing a rapidly disintegrating tablet, wh...
09/16/2008
7425342Odourless garlic supplement comprising an enteric coating and a deodorising layer
A garlic supplement comprising: (a) one or more cores comprising garlic; (b) an enteric coating encasing the core(s) which is insoluble at pH less than about 5 but soluble at a pH greater than about 5; and (c) a deodorizer applied external of the core. ...
09/16/2008
7413750Process for producing solid oral dosage forms with sustained release of active ingredient
The present invention relates to a process for producing solid oral dosage forms with sustained release of active ingredient, comprising at least one active ingredient, a preformulated mixture of polyvinyl acetate and polyvinylpyrrolidone, where appropriate, water-s...
08/19/2008
7410651Controlled release and taste masking oral pharmaceutical composition
Controlled release and taste masking compositions containing one or more active principles inglobated in a three-component matrix structure, i.e. a structure formed by successive amphiphilic, lipophilic or inert matrices and finally inglobated or dispersed in hydrop...
08/12/2008
7410652Controlled release and taste masking oral pharmaceutical composition
Controlled release and taste masking compositions containing one or more active principles inglobated in a three-component matrix structure, i.e. a structure formed by successive amphiphilic, lipophilic or inert matrices and finally inglobated or dispersed in hydrop...
08/12/2008
7351853Method of manufacturing a granular mineral composition
A method for forming mineral granules can be accomplished with a granulation reaction of edible acids and mineral bases to form mineral salts. The reaction is carried out in a manner that produces granules without requiring a binder or requiring the use of extrusion...
04/01/2008
7348027Taste masked veterinary formulation
A method of producing a self-take anthelmintic that includes active components that are undesirable to at least one sense of a target animal. The active ingredients including praziquantel are mixed with artificial beef and yeast components and subjected to a first c...
03/25/2008
7335380Amlodipine free base
Amlodipine free base can be formulated into a convenient oral dosage form, especially a tablet, without excessive stickiness or tablet punch residue. The amlodipine free base can be crystalline Form I or a novel Form II. Methods of making and using the amlodipine fr...
02/26/2008
7323192Immediate release tablet
An immediate release tablet is provided. The tablet comprises at least 60 weight % of an active ingredient and powdered wax having a melting point greater than about 90° C. The tablet may advantageously be produced by direct compression. Although the wax is hydroph...
01/29/2008
7320802Methods of treatment using nanoparticulate fenofibrate compositions
The present invention is directed to fibrate compositions having improved pharmacokinetic profiles and reduced fed/fasted variability. The fibrate particles of the composition have an effective average particle size of less than about 2000 nm. ...
01/22/2008
7316821Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer
A stabilized solid controlled release dosage form having a coating derived from an aqueous dispersion of ethylcellulose is obtained by overcoating a substrate including a therapeutically active with an aqueous dispersion of ethylcellulose and then curing the coated ...
01/08/2008
7316818Liposome drug delivery of polycyclic, aromatic, antioxidant or anti-inflammatory compounds
This invention comprises pharmaceutical compositions for administering a polycyclic, aromatic, antioxidant or anti-inflammatory compound to an animal. Particularly provided are proliposomal compositions that are advantageously used to deliver polycyclic, aromatic, a...
01/08/2008
7282221Antiviral product, use and formulation thereof
An antiviral product is comprised of at least three dosages forms, each of which has a different release profile, with the Cmax for the antiviral product being reached in less than about twelve hours. In one embodiment, there is an immediate release dosag...
10/16/2007
7282217Rapidly disintegrable tablets
The invention provides a rapidly disintegrating tablet comprising an active ingredient, a water soluble, directly compressible carbohydrate, and a water soluble, directly compressible filler. Also provided is a method of producing a rapidly disintegrating tablet, wh...
10/16/2007
7276249Nanoparticulate fibrate formulations
The present invention is directed to fibrate compositions having improved pharmacokinetic profiles and reduced fed/fasted variability. The fibrate particles of the composition have an effective average particle size of less than about 2000 nm. ...
10/02/2007
7276250Sustained release formulations of oxymorphone
Sustained release formulations of oxymorphone or pharmaceutically acceptable salts thereof; methods for making the sustained release formulations of oxymorphone or pharmaceutically acceptable salts thereof; and methods for using the sustained release formulations of...
10/02/2007
7273624Stable dosage forms containing ubiquinones
The invention relates to stable solid dosage forms for peroral administration containing, in addition to an ubiquinone, at least one thermoplastically processible matrix-forming auxiliary agent. ...
09/25/2007
7270831Orally administrable opioid formulations having extended duration of effect
Sustained release oral solid dosage forms of opioid analgesics are provided as multiparticulate systems which are bioavailable and which provide effective blood levels of the opioid analgesic for at least about 24 hours. A unit dose of the opioid analgesic contains ...
09/18/2007
7258872Chromone enteric release formulation
Orally administered chromones have been found to be effective in the treatment of allergic conditions such as asthma, general food allergies, ulcerative colitis, atopic eczema, chronic urticaria, and irritable bowel syndrome if it is presented such that the respecti...
08/21/2007
7255876Composition comprises sustained-release fine particles and manufacturing method thereof
The present invention relates to a composition comprising sustained-release fine particles, characterized in that it contains sustained-release fine particles that can be used in quick-disintegrating tablets in the buccal cavity, one or more fillers selected from th...
08/14/2007
7235258Sustained-release formulations for treating CNS-mediated disorders
Sustained-release compositions for delivering therapeutic concentrations of isovaleramide, isovaleric acid, and certain structurally related compounds are provided for the treatment for a variety of pathological conditions, including epilepsy and spasticity, which a...
06/26/2007
7229644Pharmaceutical formulations of modafinil
The present invention is related to compositions of modafinil, including compositions of modafinil and one or more diluents, disintegrants, binders and lubricants, and the processes for their preparation thereof. ...
06/12/2007
7229642Amino acid modulated extended release dosage form
Disclosed herein is a oral extended release dosage form comprising a plurality of granules of an effective amount of a pharmaceutically active compound, at least one amino acid, and an intragranular polymer in which the granule is dispersed within a hydrophilic extr...
06/12/2007
7217430Compositions and methods of treatment comprising amoxicillin and potassium clavulanate with xanthan
Bacterial infections may be treated using a high dosage regimen of amoxicillin and potassium clavulanate. Preferably, the dosage is provided by a bilayer tablet. ...
05/15/2007
7217429Tableted oral pharmaceutical dosage form, with enteric coating, containing a compound of benzimidazole labile in an acid medium
The pharmaceutical dosage form consists of a plurality of units containing a benzimidazole compound labile in an acid medium as the active principle, each unit being comprised of an inert core, a layer containing the active principle and an intermediate layer. These...
05/15/2007
7217431Controlled agglomeration
A process for the preparation of a particulate material by a controlled agglomeration method, i.e. a method that enables a controlled growth in particle size. The method is especially suitable for use in the preparation of pharmaceutical compositions containing a th...
05/15/2007
7211275Composite materials for controlled release of water soluble products
Composite materials comprising a water-soluble compound adsorbed onto a basic inorganic material and a bio-degradable polymer which yields acidic degradation products, methods of producing same, and methods of use thereof are described, wherein the composite materia...
05/01/2007
7192608Method of manufacturing drug granules, the drug granules and pharmaceutical preparation containing the drug granules
The present invention provides coated granules using drug granules containing a water soluble drug as an active ingredient at a high density, which is superior in uniform content and stability, and which is capable of providing a pharmaceutical preparation superior ...
03/20/2007
7189416Method for stable and controlled delivery of (-)-hydroxycitric acid
A method for making the potassium, sodium and other hygroscopic salts of (−)-hydroxycitric acid and mixtures thereof workable by initial treatment with a desiccating agent, such as fumed silicon dioxide. These may be further rendered non-hygroscopic and non-reacti...
03/13/2007
7189415Rapidly disintegrable pharmaceutical composition
The present invention relates to a pharmaceutical composition useful for rapid disintegration, which comprises a sparingly soluble medicament held on a gel-forming water-soluble polymer as a solid dispersion, wherein it contains a salt substance that comprises an al...
03/13/2007
7179486Process for preparing sustained release tablets
The present invention is directed to the process of preparing a sustained release niacin tablet and the product prepared therefrom. ...
02/20/2007
7176221Low dose pharmaceutical composition having uniform drug distribution and potency
A method for manufacturing a pharmaceutical composition having uniform drug distribution and potency is described which utilizes silicon dioxide to reduce the loss of active ingredient during the manufacturing process. The method is particularly useful for the manuf...
02/13/2007
7172767Opioid agonist / antagonist combinations
The invention is directed in part to oral dosage forms comprising a combination of an orally analgesically effective amount of an opioid agonist and an orally active opioid antagonist, the opioid antagonist being included in a ratio to the opioid agonist to provide ...
02/06/2007
7153840Aqueous fludarabine phosphate composition
This invention is directed towards a ready-to-use aqueous composition of fludarabine phosphate. In one embodiment, the invention is directed to an aqueous fludarabine phosphate composition which comprises fludarabine phosphate, a base, and water. The concentration o...
12/26/2006
7148207Oral fludara of high-purity formulation with quick release of active ingredient
This invention relates to a quick-release tablet formulation with >99.19% pure fludara (high-purity fludara) as an active ingredient in a defined composition of residual contaminants. ...
12/12/2006
7132114Rapidly disintegrating methylcellulose tablets
The present invention relates to a novel pharmaceutical composition and process for preparing swallowable methylcellulose tablets that disintegrate rapidly and meet USP disintegration standards in 0.1N hydrochloric acid as well as water. ...
11/07/2006
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