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| Number | Title | Issue Date |
| 8178127 | Stable laquinimod preparations The subject invention provides a pharmaceutical composition comprising N-ethyl-N-phenyl-1,2,-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide or the salt thereof; a pharmaceutically acceptable carrier; and not more than 0.5% w/w relative to N-ethyl-N... | 05/15/2012 |
| 8119159 | Solid oral dosage form containing an enhancer The invention relates to a pharmaceutical composition and oral dosage forms comprising a bisphosphonate in combination with an enhancer to promote absorption of the bisphosphonate at the GIT cell lining. The enhancer is a medium chain fatty acid or a medium chain fa... | 02/21/2012 |
| 8093207 | Fast-acting oral peptide pharmaceutical products A finished pharmaceutical product adapted for oral delivery of a physiologically active peptide agent, wherein the product comprises a therapeutically effective amount of the active peptide agent; at least one pharmaceutically acceptable pH-lowering agent; and at le... | 01/10/2012 |
| 8088411 | Direct compressible trehalose solids The present invention relates to direct compressible crystalline or semi-crystalline trehalose solids having a crystal form selected from the group consisting of trehalose dihydrate and mixtures of trehalose dihydrate and anhydrous trehalose, and having a specific s... | 01/03/2012 |
| 8071129 | 3′-[(2Z)-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2′-hydroxy-[1,1′-biphenyl]-3-carboxylic acid bis-(monoethanolamine) Disclosed are novel pharmaceutical compositions containing 3′-[(2Z)-[1-(3,4-dimethylphenyl) -1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2′-hydroxy-[1,1′-biphenyl]-3-carboxylic acid bis-(monoethanolamine) (eltrombopag olamine) and processes for ... | 12/06/2011 |
| 8062665 | 3′-[(2Z)-[1-(3,4-dimethylphenyl)-1 ,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2′-hydroxy-[1,1′-biphenyl]-3-carboxylic acid bis-(monoethanolamine) Disclosed are novel pharmaceutical compositions containing 3′-[(2Z)-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2′-hydroxy-[1,1′-biphenyl]-3-carboxylic acid bis-(monoethanolamine) (eltrombopag olamine) and processes for p... | 11/22/2011 |
| 8052993 | 3′-[(2Z)-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2′-hydroxy[1,1′-biphenyl]-3-carboxylic acid bis-(monoethanolamine) Disclosed are novel pharmaceutical compositions containing 3′-[(2Z)-[1-(3,4-dimethylphenyl) -1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2′-hydroxy-[1,1′-biphenyl]-3-carboxylic acid bis-(monoethanolamine) (eltrombopag olamine) and processes for ... | 11/08/2011 |
| 8052994 | 3′-[(2Z)-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene] hydrazino]-2′-hydroxy-[1,1′-biphenyl]-3-carboxylic acid bis-(monoethanolamine) Disclosed are novel pharmaceutical compositions containing 3′-[(2Z)-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2′-hydroxy-[1,1′-biphenyl]-3-carboxylic acid bis-(monoethanolamine) (eltrombopag olamine) and processes for p... | 11/08/2011 |
| 8052995 | 3'-[(2Z)-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene] hydrazino]-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid bis-(monoethanolamine) Disclosed are novel pharmaceutical compositions containing 3′-[(2Z)-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2′-hydroxy-[1,1′-biphenyl]-3-carboxylic acid bis-(monoethanolamine) (eltrombopag olamine) and processes for p... | 11/08/2011 |
| 8048449 | Mouth dissolving pharmaceutical composition and process for preparing the same Disclosed herein is a orally disintegrating and/or dissolving oral pharmaceutical composition, comprising one or more active pharmaceutical ingredients, one or more fillers having particle size of 100 microns or above, a high and desirable amount of silicon dioxide,... | 11/01/2011 |
| 8021687 | Modified release compositions of milnacipran A milnacipran formulation that provides delayed and extended release of milnacipran has been developed. The formulation comprises milnacipran or a salt thereof; an extended release excipient, and a delayed release excipient. The formulation provides, upon administra... | 09/20/2011 |
| 8012503 | Method of enhancing absorptions of transmucosal administration formulations A method for enhancing absorption of a compound in a medicament that is suitable for administering transmucosally to a subject is conducted in an environment having a suitable pH. The suitable pH is determined based on the ionization constant (dissociation constant)... | 09/06/2011 |
| 7998505 | Dry granulation binders, products, and use thereof A method for the preparation of microcrystalline cellulose containing tablets by roller compaction followed by tabletting is disclosed. A tablet formulation is converted to a dry granulate by roller compaction, and the dry granulate is lubricated and compacted to a ... | 08/16/2011 |
| 7993674 | Drug dose-form and method of manufacture Disclosed is a novel solid dosage unit, preferably in the form of a film or thin troche, containing at least one pharmaceutical agent, and its method of manufacture, which involves introduction of a fluid containing at least one non-volatile material, such as a poly... | 08/09/2011 |
| 7976869 | Fenofibrate tablets The present invention relates to a novel galenic formulation of fenofibrate for oral administration and to the process for its preparation. According to the invention, the formulation is a tablet obtained by compressing a mixture comprising: ... | 07/12/2011 |
| 7972622 | Method and apparatus for manufacturing dissolvable tablets Consumable or dissolvable tablets are manufactured by supplying a liquid containing a biodissolvable carrier to an outlet; establishing an electric field between the outlet and a support surface to cause liquid issuing from the outlet to form at least one fiber or f... | 07/05/2011 |
| 7959945 | Dispersible bosentan tablet The invention relates to dispersible tablets comprising the compound 4-tert-butyl-N-[6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-2-(pyrimidin-2-yl)-pyrimidin-4-yl]-benzenesulfonamide. ... | 06/14/2011 |
| 7955621 | Pharmaceutical formulation comprising levothyroxine sodium There is provided a stable pharmaceutical formulation comprising (a) an effective amount of levothyroxine sodium, (b) microcrystalline cellulose which has a mean particle size of less than 125 μm and is present in an amount of 60 to 85% w/w based upon the total wei... | 06/07/2011 |
| 7951399 | Process for activation of drugs in a vibrational mill A process is described for the activation (increase in solubility and bioavailability) of drugs. The process, carried out in a vibrational mill, is characterised by the use of given proportions between the physical mixture made up of drug and pharmaceutical carrier ... | 05/31/2011 |
| 7939101 | Cellulose powder Cellulose powder having an especially excellent balance among moldability, fluidity and disintegrating property is provided. Cellulose powder having an average polymerization degree of 150-450, an average L/D (the ratio of the major axis to the minor axis) value of ... | 05/10/2011 |
| 7919114 | Compositions and methods using Dietary supplements include a complementary blend of fruits including at least noni and Luo Han Guo. Other fruits having a high ORAC value, such as blueberries and raspberries, are also preferably incorporated. The combination of the Luo Han Guo and noni masks the n... | 04/05/2011 |
| 7892575 | Orodispersible pharmaceutical composition for oromucosal or sublingual administration of agomelatine The invention relates to a coated solid orodispersible pharmaceutical composition for the administration of agomelatine by the oral, oromucosal or sublingual route. ... | 02/22/2011 |
| 7892576 | Tablets comprising a biologically active substance and an excipient containing calcium carbonate Tablet comprising at least one biologically active substance and an excipient, in which the excipient contains calcium carbonate and at least one additive selected from fatty acids, their salts, their esters, lipid materials, polysaccharides, polyvinylpyrrolidone an... | 02/22/2011 |
| 7887840 | Pharmaceutical compositions comprising drug and concentration-enhancing polymers A solubility-improved drug form is combined with a concentration-enhancing polymer in a sufficient amount so that the combination provides substantially enhanced drug concentration in a use environment relative to a control comprising the same amount of the same dru... | 02/15/2011 |
| 7867515 | Orally disintegrating solid dosage forms comprising progestin and methods of making and use thereof The present invention is directed to non-effervescent, orally disintegrating solid pharmaceutical dosage forms comprising progestin and methods of making and using the dosage forms to treat conditions in females in need thereof. ... | 01/11/2011 |
| 7815937 | Quick dissolve compositions and tablets based thereon The invention provides a composition useful for making oral dosage forms capable of dissolving in the mouth in less than 40 seconds without the need for a conventional super disintegrant and having a friability of less than 1%; wherein the composition includes liqui... | 10/19/2010 |
| 7811604 | Non-effervescent, orally disintegrating solid pharmaceutical dosage forms comprising clozapine and methods of making and using the same The present invention is directed to non-effervescent, orally disintegrating dosage forms comprising free base clozapine that are substantially free of acids, water-soluble polymers, taste-masking polymers, and coatings, and methods of making and using the same.... | 10/12/2010 |
| 7807196 | Process for drying amoxicillin Process for drying amoxicillin (compositions), characterised in that a gas, which is inert towards amoxicillin (compositions) and having a relative humidity content which is greater than zero is used for drying. ... | 10/05/2010 |
| 7749535 | Compositions and methods using Dietary supplements include a complementary blend of fruits including at least noni and Luo Han Guo. Other fruits having a high ORAC value, such as blueberries and raspberries, are also preferably incorporated. The combination of the Luo Han Guo and noni masks the n... | 07/06/2010 |
| 7749536 | Pharmaceutical formulations of aliphatic amine polymers and methods for their manufacture The present invention provides pharmaceutical compositions comprising aliphatic amine polymers such as for example Sevelamer HCl as the active pharmaceutical ingredient, wherein the aliphatica amine polymers are spray granulated. The present invention further provid... | 07/06/2010 |
| 7749534 | Pharmaceutical composition comprising oxoplatin, the salts and derivatives thereof The invention relates to a pharmaceutical agent, particularly a chemotherapeutical agent, comprising cis-diammoniumdichloro-trans-dihydroxoplatinum(IV) or salts and/or derivatives thereof in the form of capsules, tablets, creams, ointments and infusion solutions, an... | 07/06/2010 |
| 7740882 | Enhanced oral and transcompartmental delivery of therapeutic or diagnostic agents The invention is directed to pharmaceutical compositions and methods for delivery of a therapeutic or diagnostic agent from one bodily compartment to one or more other bodily compartment by administering one of the following conjugates: a polymer having multiple fun... | 06/22/2010 |
| 7727548 | Rapidly disintegrable tablet containing polyvinyl alcohol The present invention provides a quickly disintegrating tablet which has quick disintegrability and solubility in an oral cavity, and does not have uncomfortable tastes such as bitterness, has a small variation of a tablet physical property even in storage under a h... | 06/01/2010 |
| 7727549 | Pharmaceutical compositions for otic use Otic compositions are disclosed. The compositions contain an otic drug and a carrier comprising a low molecular weight compound. The compositions do not drain out of the ear after administration. ... | 06/01/2010 |
| 7709023 | Quick dissolve compositions and tablets based thereon The invention provides a composition useful for making oral dosage forms capable of dissolving in the mouth in less than 40 seconds without the need for a conventional super disintegrant and having a friability of less than 1%; wherein the composition includes liqui... | 05/04/2010 |
| 7700128 | Solid preparation comprising an insulin sensitizer, an insulin secretagogue and a polyoxyethylene sorbitan fatty acid ester A solid preparation useful as a diabetes-treating agent or the like and excellent in the dissolution properties of an insulin sensitizer and an insulin secretagogue, which comprises an insulin sensitizer, an insulin secretagogue and a polyoxyethylene sorbitan fatty ... | 04/20/2010 |
| 7691410 | Use of dicalcium phosphate anhydride powder The invention relates to dicalcium phosphate anhydride powder, at least 50 wt. % thereof having a particle size of between 45 and 150 μm, a maximum of 50 wt. % having a particle size of 150 μm. Said powd... | 04/06/2010 |
| 7611728 | Osmotic delivery of therapeutic compounds by solubility enhancement The present invention is directed to the oral osmotic delivery of therapeutic compounds that have limited solubility in an aqueous environment due to inherent hydrophobicity or to saturation limitations in the core of the osmotic system. The present invention is sui... | 11/03/2009 |
| 7431942 | Orally disintegrable tablets An orally disintegrable tablet of the present invention, which comprises (i) fine granules having an average particle diameter of 400 μm or less, which fine granules comprise a composition coated by an enteric coating layer, said composition having 10 weight % or m... | 10/07/2008 |
| 7431943 | Controlled release and taste masking oral pharmaceutical compositions Controlled release and taste masking compositions containing one or more active principles inglobated in a three-component matrix structure, i.e. a structure formed by successive amphiphilic, lipophilic or inert matrices and finally inglobated or dispersed in hydrop... | 10/07/2008 |
