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| Number | Title | Issue Date |
| 4728512 | Formulations providing three distinct releases A therapeutic preparation consisting of three groups of spheroids containing an active medicinal substance. The first group of spheroids is uncoated and rapidly disintegrates upon ingestion to release an initial dose of medicinal substance a second group ... | 03/01/1988 |
| 4726966 | Preparation of coated granular ibuprofen microsphere This invention provides a simple method for preparing granular ibuprofen microsphere whose surface is coated with acrylic acid resin. By this method granulation of ibuprofen and coating of its surface can be simultaneously accomplished. Namely, the method... | 02/23/1988 |
| 4722838 | Self-microencapsulating controlled release pesticide compositions This invention relates to a self-microencapsulating pesticidal composition consisting essentially of a solution of a polymeric barrier material in an organic solvent system, a dissolved or dispersed pesticidal agent and a surfactant.... | 02/02/1988 |
| 4721619 | Controlled absorption diltiazen pharmaceutical formulation A controlled absorption diltiazem formulation for oral administration comprises a pellet having a core of diltiazem or a pharmaceutically acceptable salt thereof in association with an organic acid and a lubricant, and an outer membrane which permits rele... | 01/26/1988 |
| 4717567 | Rumen-stable pellets Disclosed are coatings for protecting pellet cores from environmental conditions of predetermined pH conditions. The coatings have a pH sensitive portion and a pH insensitive portion. The pH sensitive portion allows the cores to be protected by the coatin... | 01/05/1988 |
| 4716040 | Controlled absorption methyldopa pharmaceutical formulation A controlled absorption methyldopa formulation for oral administration comprises a pellet having a core of methyldopa or a pharmaceutically acceptable salt thereof in association with an organic acid, and an outer membrane which permits release of methyld... | 12/29/1987 |
| 4713247 | Long-acting formulation of cefaclor Highly potent long-acting formulation of cefaclor for treating bacterial infections in human or animals, comprising a rapid-release and a slow-release component at a ratio of about 3:7 to about 5:5 by potency of cefaclor, convenient for administration or ... | 12/15/1987 |
| 4711749 | Process for producing microcapsules A stable emulsion of microcapsules is obtained by polymerizing at least one water-soluble vinyl monomer in an aqueous solution of an oil-soluble vinyl monomer-maleic anhydride-maleic ester multipolymer to prepare a water-soluble resin, dispersing or emuls... | 12/08/1987 |
| 4708867 | Minipellets A minipellet dosage form of prednisone or prednisolone, resistant to attack by saliva but readily dissolvable in gastric juice, which comprises a mixture of prednisone or prednisolone and polyvinylpyrrolidone coated onto a nonpareil seed, and further coat... | 11/24/1987 |
| 4708861 | Liposome-gel compositions Compositions and methods for maintaining reservoirs of bioactive agents by sequestering the reservoir in a gel matrix are described. In particular, liposomes containing an entrapped bioactive agent are sequestered in a gel matrix. The resulting liposome-g... | 11/24/1987 |
| 4690786 | Process for producing a microcapsule containing a liquid active material A process for producing a microcapsule containing a liquid active material is described, comprising the steps of: (1) dissolving in an organic solvent a polymer, esp. a polysulfone and an active material which has a limited solubility of about 0.01 to about 2 ... | 09/01/1987 |
| 4675189 | Microencapsulation of water soluble active polypeptides This invention concerns novel sustained release microcapsule compositions comprising water-soluble, hormonally active polypeptides and, optionally, a polymer hydrolysis modifying agent encapsulated in a biocompatible, biodegradable polymer.... | 06/23/1987 |
| 4600577 | Pharmaceutical preparations of pinacidal New pharmaceutical preparation containing pinacidil (N"-cyano-N-4-pyridyl-N'-1,2,2-trimethylpropylguanidine) in slow-release form, providing more uniform absorption rates and resulting blood levels when administered to the individual patients.... | 07/15/1986 |
| 4587118 | Dry sustained release theophylline oral formulation A dry sustained release oral dosage formulation of theophylline and a method of orally administering theophylline is disclosed. The oral formulation is comprised of a capsule which includes upper and lower parts which are connectible and easily separable ... | 05/06/1986 |
| 4578264 | Retard form of pharmaceuticals with insoluble porous diffusion coatings This invention relates to a pharmaceutical dosage unit composition consisting essentially of a gelatin capsule containing (1) a disintegrating core comprising clonidine, said disintegrating core having a readily water-soluble coating, and (2) a plurality ... | 03/25/1986 |
| 4562069 | Two-phase formulation In the treatment of cardiovascular and coronary disorders by administering to a patent suffering therefrom a solid preparation comprising nifedipine, the improvement which comprises administering such nifedipine in the form of a solid two-phase medicament... | 12/31/1985 |
| 4542015 | Dialysis apparatus and process for controlling the phosphate level of blood An apparatus for purifying blood has a blood compartment and a clearance compartment separated by a semi-permeable membrane. The apparatus includes a device containing a cation exchange resin charged with metal ions whose phosphates are insoluble in water... | 09/17/1985 |
| 4539199 | Sustained release pharmaceutical compositions Pharmaceutical compositions for sustained release of pharmaceutical compounds comprising a reaction product of a water soluble salt of a pharmaceutically active compound containing a primary, secondary or tertiary amino group, and an alkali or ammonium sa... | 09/03/1985 |
| 4525339 | Enteric coated oral dosage form There is presented a method, in the form of a dosage formulation, for transforming substantially orally inactive ଲ-lactam antibiotics or their pharmaceutically acceptable salts or the esters, ethers, or hydrates of said antibiotics or their salts in... | 06/25/1985 |
| 4421736 | Sustained release diethylpropion compositions Sustained release formulations for the anorectic agent, diethylpropion hydrochloride, are disclosed which are suitable for use in capsules.... | 12/20/1983 |
| 4411882 | Galenical compositions The invention provides solid enteric-coated compositions in unit dose form for oral application, the core of the composition containing an ergot alkaloid and a polyalkoxyalkylene sterol ether. The compositions are characterized by a prolonged effect and a... | 10/25/1983 |
| 4404183 | Sustained release pharmaceutical composition of solid medical material Sustained release pharmaceutical compositions of a solid medical material which contains an amorphous solid medical material, polyethylene oxide, and at least one basic substance selected from the group consisting of hydroxypropylmethyl cellulose, hydroxy... | 09/13/1983 |
| 4376112 | Encapsulated efficacious zinc phosphide rodenticide A rodenticide composed of particulate zinc phosphide which has been encapsulated with a layer or coating of a thermoplastic polymer. This polymer coating will inhibit reaction, in the rodent's mouth so that the zinc phosphide will be consumed without the ... | 03/08/1983 |
| 4367217 | Dipyricamole sustained release forms comprising lacquer-coated particles and the preparation thereof This invention relates to a composition for the sustained release of dipyridamole which comprises (i) spheroid particles comprised of dipyridamole or crystallized salts thereof and pharmacologically acceptable acid or acid substance, and (ii) a coating su... | 01/04/1983 |
| 4361546 | Retard form of pharmaceuticals with insoluble porous diffusion coatings A pharmaceutical dosage unit retard form having a constant, pH-independent release rate of active ingredient, consisting of a core comprising an active ingredient, and a semi-permeable diffusion coating over the core, were the coating consists of a water-... | 11/30/1982 |
| 4193985 | Multiple-units drug dose A controlled release multiple-units drug dose is described, which comprises a tablet or a capsule enclosing a plurality of subunits, each containing a therapeutically active agent and being enclosed in an insoluble membrane allowing for diffusion of the j... | 03/18/1980 |
| 4173626 | Sustained release indomethacin A sustained release indomethacin pharmaceutical product is provided that utilizes a pellet formulation encapsulated in a hard gelatin capsule. A portion of the pellets is uncoated for immediate and rapid release of indomethacin for elevating the plasma le... | 11/06/1979 |
| 4154636 | Method of film-coating medicines A method of film-coating medicines which comprises either putting a prescribed dose of a medicine between two sheets capable of releasing the medicine wrapped therein within the digestive organs or putting a prescribed dose of a medicine in a tablet-shape... | 05/15/1979 |
| 4064230 | Polyenic macrolide compositions A method of increasing the overall effectiveness, including stability and gastrointestinal tolerability, of a polyenic macrolide selected from the class consisting of candicidin, fungimycin, hamycin and mediocidin is described which comprises orally admin... | 12/20/1977 |
| 4000254 | Fungimycin compositions A method of increasing the overall effectiveness, including stability and gastrointestinal tolerability, of a polyenic macrolide selected from the class consisting of candicidin, fungimycin, hamycin and mediocidin is described which comprises orally admin... | 12/28/1976 |
| 3977992 | Controlled release capsules The disclosed substantially spherical capsules are particularly adapted for containing a liquid and have permeable or semi-permeable capsule walls. The capsule walls can comprise a first crystalline phase, an amorphous phase which ordinarily is intimately... | 08/31/1976 |
| 3944064 | Self-monitored device for releasing agent at functional rate A delivery device for the controlled and continuous release of a useful agent at a functional rate is comprised of an erodible capsule housing a self monitored delivery device attached to a collapsed support. The device is comprised of a hollow container ... | 03/16/1976 |
