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| Number | Title | Issue Date |
| 6569406 | Inhaleable spray dried 4-helix bundle protein powders having minimized aggregation The present invention provides highly dispersible spray-dried powder compositions, and in particular, inhaleable dry powder compositions for aerosolized delivery to the lungs. The powders of the invention are produced by spray drying a 4 -helix bun... | 05/27/2003 |
| 6565871 | Solid dose delivery vehicle and methods of making same The present invention encompasses a solid dose delivery vehicle for ballistic administration of a bioactive material to subcutaneous and intradermal tissue, the delivery vehicle being sized and shaped for penetrating the epidermis. The delivery vehicle fu... | 05/20/2003 |
| 6558651 | Aerosols containing annealed particulate salbutamol and tetrafluoroethane This invention relates to aerosol formulations of use for the administration of medicaments by inhalation. More particularly, the invention relates to a pharmaceutical aerosol formulation which comprises particulate salbutamol sulphate having a crystallin... | 05/06/2003 |
| 6555675 | Dinucleoside polyphosphate compositions and their therapuetic use as purinergic receptor agonists The present invention relates to certain novel dinucleotide polyphosphates of general Formulae I, II and III, and formulations thereof which are selective agonists of the P2Y purinergic receptors. They are useful in the prevention, management or treatment... | 04/29/2003 |
| 6544497 | Modulated release particles for aerosol delivery A modulated release aerosol formulation is disclosed. The formulation comprises a polymer, e.g. silica gel, fumed silica gel, having a selected medicament associated therewith, a fluid carrier for carrying and delivering the construct and a stabilizer.... | 04/08/2003 |
| 6544542 | Fat emulsions for inhalational administration The object of the present invention is to provide a pharmaceutical composition optimized for the administration of a drug, particularly a drug which is only sparingly soluble in water, by way of inhalation. The present invention is a fat emulsion for inhalatio... | 04/08/2003 |
| 6537524 | Combinations of formoterol and a tiotropium salt A medicament containing, separately or together, (A) formoterol or a pharmaceutically acceptable salt thereof or a solvate of formoterol or said salt and (B) a tiotropium salt of a pharmaceutically acceptable acid, for simultaneous, sequential or separate... | 03/25/2003 |
| 6534078 | Micro-encapsulated pepper-mustard composition and methods of using the same A micro-encapsulated pepper-mustard composition which comprises positioning pepper and mustard mixtures within a cluster of surfactant molecules, i.e. micelles, dispersed in water. This micro-encapsulation process involves first forming the micelles in wa... | 03/18/2003 |
| 6531112 | Formulations for administering calcitonin and processes for preparing the same The present invention provides a non-invasive method for administering polypeptides across epithelial membranes. The formulations in the present invention comprise solid polypeptide particles mixed with a permeation enhancer and excipients which are dispe... | 03/11/2003 |
| 6528096 | Carrier mixed with additives having lubricant properties for preparing powdery pharmaceutical compositions for inhalation Powdery pharmaceutical compositions including an active ingredient and carrier particles containing only a small amount of lubricant, 0.1-0.5% by weight, are used to prepare dry powder inhalers in order to increase the fine particle dose. A process for co... | 03/04/2003 |
| 6524555 | Metered dose inhaler for salmeterol A metered dose inhaler having part or all of its internal metallic surfaces coated with one or more fluorocarbon polymers, optionally in combination with one or more non-fluorocarbon polymers, for dispensing an inhalation drug formulation comprising salme... | 02/25/2003 |
| 6524557 | Aerosol formulations of peptides and proteins A pharmaceutical aerosol formulation comprising (a) a HFA propellant; (b) a pharmaceutically active polypeptide dispersible in the propellant; and (c) a surfactant which is a C8 -C16 fatty acid or salt thereof, a bile salt, a phospho... | 02/25/2003 |
| 6521212 | Method for treating peripheral vascular disease by administering benzindene prostaglandins by inhalation A method of delivering benzindene prostaglandins to a patient by inhalation is discussed. A benzindene prostaglandin known as UT-15 has unexpectedly superior results when administered by inhalation compared to parenterally administered UT-15 in sheep with... | 02/18/2003 |
| 6511652 | Metered dose inhaler for beclomethasone dipropionate A metered dose inhaler having part or all of its internal surfaces coated with one or more fluorocarbon polymers, optionally in combination with one or more non-fluorocarbon polymers, for dispensing an inhalation drug formulation comprising beclomethasone... | 01/28/2003 |
| 6511653 | Metered dose inhaler for beclomethasone dipropionate A metered dose inhaler having part or all of its internal surfaces coated with one or more fluorocarbon polymers, optionally in combination with one or more non-fluorocarbon polymers, for dispensing an inhalation drug formulation comprising beclomethasone... | 01/28/2003 |
| 6509006 | Devices compositions and methods for the pulmonary delivery of aerosolized medicaments According to the subject invention, dispersible dry powder pharmaceutical-based compositions are provided, including methods for their manufacture and dry powder dispersion devices. A dispersible dry powder pharmaceutical-based composition is one having a... | 01/21/2003 |
| 6503482 | Non-chlorofluorocarbon aerosol formulations Aerosol formulations substantially free of chlorofluorocarbons, for oral and/or nasal administration, are described. The formulations comprise 1,1,1,2-tetrafluoroethane, a medicament, optionally an excipient and optionally a surfactant. Methods of treatme... | 01/07/2003 |
| 6503480 | Aerodynamically light particles for pulmonary drug delivery Improved aerodynamically light particles for delivery to the pulmonary system, and methods for their preparation and administration are provided. In a preferred embodiment, the aerodynamically light particles are made of a biodegradable material and have ... | 01/07/2003 |
| 6495154 | On demand administration of clomipramine and salts thereof to treat premature ejaculation A method is provided for delaying the onset of ejaculation in an individual. The method involves systemic and on demand administration to an individual of a pharmaceutical formulation containing an amount of an active agent selected from the group consist... | 12/17/2002 |
| 6491897 | Stable pharmaceutical budesonide preparation for producing propellant-free aerosols A stable ethanolic solution of budesonide is disclosed, which solution is suitable for use in nebulizers, together with a process for making such stable solution.... | 12/10/2002 |
| 6485706 | Formulations comprising dehydrated particles of pharma-ceutical agents and process for preparing the same A formulation for non-invasive delivery of pharmaceutical agents, particularly proteins and peptides, by absorption through a membrane at a targeted site is provided, along with a process of making the formulation. The formulation comprises a suspension o... | 11/26/2002 |
| 6482390 | Aerosol formulations and method A hand held apparatus and method for creating an aerosolized mist of particles is described. The apparatus comprises a high pressure vessel containing a solution or suspension of the substance to be aerosolized in a high pressure liquefied gas, a manually... | 11/19/2002 |
| 6479049 | Methods and compositions for the dry powder formulation of interferons According to the present invention, methods and compositions are provided for spray-dried, interferon-based dry powder compositions, particularly interferon-beta. The compositions are useful for treating conditions in humans that are responsive to treatme... | 11/12/2002 |
| 6475523 | Powders comprising anti-adherant materials for use in dry powder inhalers A powder for use in a dry powder inhaler comprises active material and additive material. The additive material comprises an anti-adherent material and the powder includes at least 60% by weight of active material. The inclusion of the additive material i... | 11/05/2002 |
| 6475468 | Modulated release particles for aerosol delivery A modulated release aerosol formulation is disclosed. The formulation comprises a polymer, e.g. Silica gel, fumed silica gel, having a selected medicament associated therewith, and a fluid carrier for carrying and delivering the construct.... | 11/05/2002 |
| 6475467 | Medicinal aerosol formulations The use of solid, pharmaceutically acceptable salts of cromoglycic acid and/or nedocromil as carriers in a therapeutically and prophylactically inefficacious amount in suspension aerosol formulations of pharmaceutical active compounds improves the dispers... | 11/05/2002 |
| 6475524 | Composition of matter The invention provides a process for crystallization of amorphous and/or meta-stable crystalline regions of preformed particles by treating the particles with a supercritical or subcritical fluid containing an anti-solvent and a solvent. The invention fur... | 11/05/2002 |
| 6471944 | Aerosol powder with improved skin adhesion Powdery aerosol preparations, which are characterized in that 50 to 90% by weight of a propellant having a vapor pressure at 20° C. of 4.5 kg/cm2 or less, 5 to 30% by weight of an aliphatic hydrocarbon having a boiling point of 5 to 40° C., 0... | 10/29/2002 |
| 6464886 | Device and method for creating spherical particles of uniform size Spherical particles having a size on the order of 0.1 to 100 microns in size are created by systems and devices of several types. The device includes a source of a stream of gas which is forced through a liquid held under pressure in a pressure chamber wi... | 10/15/2002 |
| 6461592 | Method for transferring one or more active ingredients between different phase carriers The present invention relates to a method for transferring one or more active ingredients between different phase carriers, which includes: (a) providing a solid, semi-solid, or nonaqueous liquid drug which contains at least one active ingredient; (b) adm... | 10/08/2002 |
| 6458338 | Amino acid stabilized medicinal aerosol formulations This invention relates to a medicinal aerosol formulation and more particularly, to a medicinal aerosol formulation containing a particulate drug, a propellant and a stabilizing agent selected from an amino acid, an amino acid derivative and a mixture of ... | 10/01/2002 |
| 6455028 | Ipratropium formulation for pulmonary inhalation Pharmaceutical aerosol formulations are provided comprising substantially nonacicular particles of a bronchodilator selected from the group consisting of ipratropium and pharmacologically acceptable salts, solvates, hydrates, esters and isomers thereof. T... | 09/24/2002 |
| 6451285 | Suspension aerosol formulations containing formoterol fumarate and a fluoroalkane propellant Provided are pressurized metered dose inhalers containing stable formulations of a ଲ-agonist drug in suspension or solution. Also provided are aerosol formulations suitable for inhalation therapy containing a ଲ-agonist drug in suspension or so... | 09/17/2002 |
| 6451286 | Pharmaceutical compositions for buccal and pulmonary administration comprising an alkali metal alkyl sulfate and at least three micelle-forming compounds Pharmaceutical compositions comprising a macromolecular pharmaceutical agent in mixed micellar form are disclosed. The mixed micelles are formed from an alkali metal alkyl sulfate, and at least three different micelle-forming compounds as described in the... | 09/17/2002 |
| 6451288 | Method of treating lung diseases with uridine 5'-diphosphate and analogs thereof Compounds of Formula I: ##STR1## wherein: X1, and X2 are each independently either O- or S- ; X3 and X4 are each independently either --H or --OH, with the proviso that X3 and X4... | 09/17/2002 |
| 6447752 | Amorphous porous particles for deep lung delivery Improved porous particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the porous particles are made of a biodegradable material and have a mass density less than 0.... | 09/10/2002 |
| 6447751 | Method and device for facilitating combined aerosol and oral treatments for diabetes mellitus A dispensing container which incorporates an aerosolizable topical insulin preparation, at least one oral hypoglycemic agent, and indicia and instructions for their coordinated use as a single therapeutic regimen for the treatment of diabetes mellitus in ... | 09/10/2002 |
| 6447753 | Porous particles for deep lung delivery Improved porous particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the porous particles are made of a biodegradable material and have a mass density less than 0.... | 09/10/2002 |
| 6447750 | Medicinal aerosol formulation This invention relates to a medical aerosol formulation and more particularly, to a medicinal aerosol formulation containing a rosiglitazone maleate and a fluid carrier.... | 09/10/2002 |
| 6440415 | Odor eliminating items and methods of use for hunting A regimen for hunting includes using a number of activated carbon-containing personal items in connection with a hunter's apparel and body to reduce the hunter's scent for improved hunting. The personal items include mouthwash, deodorant/antiperspirant, b... | 08/27/2002 |
