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...that the first rickshaw was invented in 1869 by an American Baptist minister, the Rev. E. Jonathan Scobie, to transport his invalid wife around the streets of Yokohama?
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| Number | Title | Issue Date |
| 8173158 | Methods of treating gastrointestinal disorders independent of the intake of food The present invention relates to a method of treating a gastrointestinal disorder by administering to a patient in need of treatment thereof a pharmaceutical composition, wherein said pharmaceutical composition can be administered to the patient independent of the i... | 05/08/2012 |
| 8119157 | Pharmaceutical compositions for lipophilic drugs Stable solutions of lipophilic drugs, such as cyclosporin, forming a polar lipid self-emulsifying drug delivery system. The solutions can include lipophilic drugs, such as cyclosporin, dissolved in a polar lipid, such as having a C6-C12 fatty a... | 02/21/2012 |
| 8114435 | Oral pharmaceutical dosage forms comprising a proton pump inhibitor and a NSAID An oral pharmaceutical dosage form comprising an acid susceptible proton pump inhibitor and one or more NSAIDs in a fixed formulation, wherein the proton pump inhibitor is protected by an enteric coating layer. The fixed formulation is in the form of an enteric coat... | 02/14/2012 |
| 8101204 | Hard capsule composition and method of use A method for making clear hard vegetarian gelatin free two piece capsules by creating the first phase of the biphasic system using seaweed extract, gellan gum, metallic element, maltol extract, seaweed extract and water. A filler is created for the first phase of th... | 01/24/2012 |
| 8101203 | Hard capsule composition and method of use A method for making a clear hard vegetarian gelatin free two piece capsule by creating a first phase network system using a seaweed extract, a galactomannan extract and a rheology modifier. A filler is created for the first phase network by blending a water, a cryst... | 01/24/2012 |
| 8097278 | Compartmentalized dosage form The present invention provides a dosage form that prevents misuse of the medicament contained within. The dosage form contains an inactivating substance in combination with the medicament, wherein the two substances are separated by a permeable or semi-permeable par... | 01/17/2012 |
| 8039018 | Solid dosage form of wetted heparin The present invention relates to a solid pharmaceutical composition (such as a solid dosage form) comprising a delivery agent and wetted heparin. The inclusion of wetted heparin rather than un-wetted heparin in the solid pharmaceutical composition results in increas... | 10/18/2011 |
| 8029821 | Capsule comprising low-substituted cellulose ether and method for preparing the same A capsule with good disintegration properties that can quickly display its content's efficacy as well as a method for preparing the same are provided. More specifically, provided is a capsule comprising a shell comprising low-substituted cellulose ether. Also, provi... | 10/04/2011 |
| 7988992 | Superporous hydrogels for heavy-duty applications The present invention features modified superporous hydrogels (SPHs) and methods for their formation. The SPHs of the present invention are prepared by careful selection of the hydrophobic/hydrophilic reactive ingredients and by harmonizing the foaming and polymeriz... | 08/02/2011 |
| 7972620 | Polysaccharide capsules and methods of preparation The present invention is directed to seamless capsules and methods for making seamless capsules having a high oil content. More specifically, the present invention is directed to seamless capsules, and methods for making seamless capsules, made from a process involv... | 07/05/2011 |
| 7968118 | Anti-acid pharmaceutical composition in powder form and process for making it An anti-acid pharmaceutical composition for the rapid and prolonged neutralization of gastric acidity with mucosa-protecting activity in powder form to prepare, by dispersion in water, a pharmaceutical solution or suspension for oral use characterized in that the co... | 06/28/2011 |
| 7943167 | Compositions with hydrophilic drugs in a hydrophobic medium In various embodiments of the present invention, a capsule is provided including a hydrophobic inner layer and at least one hydrophilic outer layer. The hydrophobic layer may include a hydrophilic component such as an active pharmaceutical ingredient (API) which may... | 05/17/2011 |
| 7923025 | Pharmaceutical composition for oral use with improved absorption The present invention relates to an agent for inhibiting decomposition of a biologically active peptide by a digestive enzyme, which is aminoalkyl methacrylate copolymer E as an effective ingredient, and an agent for reducing viscosity of the gastrointestinal mucosa... | 04/12/2011 |
| 7914816 | Endoparasiticidal agents for voluntary oral ingestion by animals The present invention relates to pharmaceutical presentations for animals which are administered orally and which are accepted readily by the animals (for example dogs, cats and horses), to processes for their preparation and to their use, in particular as endoparas... | 03/29/2011 |
| 7883721 | Pharmaceutical formulation The present invention is directed to pharmaceutically acceptable polymeric compositions suitable for injection molding of single or multi-component pharmaceutical dosage forms comprising a plurality of drug substance containing sub-units, being capsule compartments ... | 02/08/2011 |
| 7875291 | Composition for managing diabetes, obesity, and hyperlipidemia and associated methods A nutritional supplement includes a first formulation including minerals: chromium polynicotinate, magnesium glycinate, manganese sulfate, selenium, vanadyl sulfate, zinc gluconate, copper gluconate, iodine, and boron; and vitamins: vitamins C, B1, B2, B3, B6, B12, ... | 01/25/2011 |
| 7875290 | Method and form of a drug delivery device, such as encapsulating a toxic core within a non-toxic region in an oral dosage form A drug delivery device such as an oral dosage form (ODF) with a toxic or potent core encapsulated by a non-toxic region. The non-toxic region may be a region including multiple layers, coatings, shells, and combinations thereof, which provides protection to and isol... | 01/25/2011 |
| 7867513 | Soft capsule It is an object of the present invention to provide a capsule anti-sticking agent which can provide excellent anti-sticking effect on a soft capsule without impairing various properties such as water activity, disintegration property and safety, a coated soft capsul... | 01/11/2011 |
| 7846474 | Use of bisphosphonates for the treatment of osteogenesis imperfecta This procedure consists in the first stage, of the administration of enough quantity of bisphosphonate preparation during the necessary period of time to acquire a degree of volumetric mineral density of the cortical tissue of application, within the normal range (a... | 12/07/2010 |
| 7842308 | Pharmaceutical formulation The present invention is directed to pharmaceutically acceptable polymeric compositions suitable for injection molding of single or multi-component pharmaceutical dosage forms comprising a plurality of drug substance containing sub-units, being capsule compartments ... | 11/30/2010 |
| 7838026 | Burst-release polymer composition and dosage forms comprising the same A composition comprising a high molecular weight, water soluble polymer having a cloud point from about 20 to about 90° C. and at least one carrageenan is provided. The composition may be used as a component of a pharmaceutical dosage form, such as the shell of a d... | 11/23/2010 |
| 7829114 | Capsules containing aqueous fill compositions stabilized with derivatized cyclodextrin A capsule containing an aqueous fill composition that comprises water, a derivatized cyclodextrin, such as sulfoalkyl ether cyclodextrin (SAE-CD) or hydroxypropyl cyclodextrin (HPCD), optionally one or more active agents and optionally one or more excipients is stab... | 11/09/2010 |
| 7815935 | Orally distintegrating formulation and process for preparing the same An orally disintegrating formulation and its preparation are provided. The orally disintegrating formulation comprises an effective amount of a pharmaceutically active ingredient and a matrix, wherein the matrix contains an amino acid and pullulan. The orally disint... | 10/19/2010 |
| 7815934 | Sequestering subunit and related compositions and methods A sequestering subunit comprising an aversive agent and a blocking agent, wherein the blocking agent substantially prevents release of the aversive agent from the sequestering subunit in the gastrointestinal tract for a time period that is greater than 24 hours; a c... | 10/19/2010 |
| 7807194 | Homogeneous, thermoreversible gel film containing kappa-2 carrageenan and soft capsules made therefrom The present invention is directed to a homogeneous, thermoreversible gel film comprising a film forming amount of kappa-2 carrageenan, and optionally at least one of a plasticizer, a second film former, a bulking agent, and a pH controlling agent; and processes for ... | 10/05/2010 |
| 7803401 | Dosage form comprising liquid formulation A sustained release dosage form includes a capsule made of a thermoplastic polymer having a softening point below 200° C. and an orifice formed or formable within the capsule, an emulsion formulation contained within the capsule, and an expandable composition withi... | 09/28/2010 |
| 7754239 | Capsule for rapid solubilization and release of the content The present invention relates to a capsule comprising a core and at least one envelope comprising at least one film-forming polymer, characterized in that it exhibits a total solubilization time for its envelope of less than or equal to 85 s, according to a test A, ... | 07/13/2010 |
| 7744922 | Capsule with fast content solubilization and release The present invention relates to a capsule comprising a core and at least one envelope comprising at least one film-forming polymer, characterized in that it exhibits a total solubilization time for its envelope of less than or equal to 85 s, according to a test A, ... | 06/29/2010 |
| 7691406 | Zeaxanthin formulations for human ingestion A composition of matter comprising a capsule or tablet, sized and designed for oral ingestion by a human, containing the 3R-3′R stercoisorner of zeaxanthin. The 3R-3′R stereoisomer of zeaxanthin constitutes at least about 90 percent o... | 04/06/2010 |
| 7670618 | Pharmaceutical compositions Discloses is a pharmaceutical composition suitable for oral administration in the form of a homogeneous solution which on exposure to water or gastrointestinal fluids forms an emulsion having a particle size of less than 5 microns, the solution containing: ... | 03/02/2010 |
| 7662406 | Chewable softgel capsules A chewable softgel capsule configured for encasing orally ingestible articles. The chewable soft capsule is provided with an outer shell composition which comprises at least one gelatin in a range of 20% to 60% of the total weight of the shell composition, at least ... | 02/16/2010 |
| 7641916 | Digestible and volume adjustable multi medication delivery device A volume-adjustable device for the delivery of multiple medications to a subject, the device comprising multiple medication elements; an outer containment means having at least one open end into which the medication elements are removeably inserted; and a closure me... | 01/05/2010 |
| 7632519 | TRPV1 agonist compounds, formulations, prodrugs, methods for using the same Described here are TRPV1 agonist compounds and their methods of synthesis and use. In addition to specifically identified compounds, capsaicin prodrugs, gemini dimers, and mutual prodrugs are also described. Formulations of the TRPV1 agonist compounds may be in the ... | 12/15/2009 |
| 7553497 | Gelatin hard capsule enhancing the film strength A process for preparing gelatin hard capsule having enhanced film strength by the steps including i) adding 1˜10 wt part of PEG mixture of PEG 600 and PEG 1500 in weight ratio 40˜60:60˜40 to the solution having 100 wt part of gelatin; ii) adding 0.1˜1.2 wt part ... | 06/30/2009 |
| 7494667 | Blends of different acyl gellan gums and starch The present invention relates to a method of producing a film forming blend of different acyl gellan gums with starch having similar textural and functional properties compared to gelatin. Films prepared using such blends have a high modulus and excellent strength a... | 02/24/2009 |
| 7470434 | Methods and compositions for blocking microbial adherence to eukaryotic cells A method of blocking microbial adherence to a eukaryotic cell surface in a mammal by applying a pharmacologically acceptable composition containing at least one compound selected from the group consisting of isoleucine, an active isomer thereof, and an active analog... | 12/30/2008 |
| 7445795 | Delivery device, method of using and method of manufacturing An active principle delivery device (1) comprising an inner capsule (4) within an outer capsule (2), the inner and outer capsules (4,2) containing the same active principle (5,3), with at least the outer capsule (2) being a ... | 11/04/2008 |
| 7438930 | Controlled release formulations having rapid onset and rapid decline of effective plasma drug concentrations The invention is directed to oral modified/controlled release drug formulations which provide a rapid initial onset of effect and a prolonged duration of effect. Preferably, the peak concentration is lower than that provided by the reference standard for immediate r... | 10/21/2008 |
| 7435715 | Microcapsules Microcapsules for use in liquid detergents having a core and a polyelectrolyte complex shell in the form of a semipermeable membrane capable of withstanding a force before bursting of from about 20 mN to about 20,00 N and having a density of from about 900 Kg/m... | 10/14/2008 |
| 7431944 | Delivery of multiple doses of medications Dosage forms for oral administration of a methylphenidate drug are provided. The dosage forms provide a substantially immediate dose of methylphenidate upon ingestion, followed by one or more additional doses at predetermined times. By providing such a drug release ... | 10/07/2008 |
