...that while attempting to develop a super strong glue, 3M employee Spencer Silver accidentally developed a glue that was so weak it would barely hold two pieces of paper together? However, his colleague Art Fry needed the glue. Fry sang with his church choir and marked the pages of his hymnal with small scraps of paper that often fell out. He used Silver's glue to hold the papers in place. Today we call this invention Post-it Notes.
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| Number | Title | Issue Date |
| 8187628 | Dermal composition for controlling drug flux comprising two acrylic adhesive polymers having different functionalities and different solubility parameters A dermal composition for administration of an amphetamine drug comprising a blend of two or more acrylic-based polymers having differing functionalities so as to modulate the drug solubility in the polymer matrix and the delivery rate of the drug, and methods theref... | 05/29/2012 |
| 8158145 | Percutaneous absorption type plaster A transdermal patch comprising a backing 2 and an adhesive layer 3 laminated on the backing 2, wherein the adhesive layer 3 comprises a rosin-based resin and petroleum resin as a tackifier, the total compounding amount of the rosin-based ... | 04/17/2012 |
| 8153151 | Composition and method for controlling drug delivery from silicone adhesive blends Compositions and methods for controlling transdermal drug delivery, particularly of amine-functional and basic drugs, comprising a blend of a first silicone-based polymer having a reduced silanol concentration and a second silicone-based polymer have a substantial o... | 04/10/2012 |
| 8124122 | Female hormone-containing patch Provided herein is a female hormone-containing patch wherein an active ingredient is highly soluble in a pressure-sensitive adhesive layer and the active ingredient is not adsorbed to a backing, and the patch per se can follow the irregularities on the skin surface ... | 02/28/2012 |
| 8114434 | Diclofenac sodium patches for topical treatment of pain The invention provides an analgesic anti-inflammatory patch of a hydrophobic type for topical application containing, in a Pressure Sensitive Adhesive(PSA), diclofenac sodium, pyrrolidone or a derivative thereof, a polyhydric alcohol fatty acid ester, and an organic... | 02/14/2012 |
| 8105624 | Topical patch for pain relief using cooling agent Topical patch preparations that contain an odorless physiological cooling agent, and methods for using the same are provided. The subject topical patch preparations are made up of an adhesive gel composition that is present on a support, where the adhesive gel compo... | 01/31/2012 |
| 8080261 | 1-chloro-2,4-dinitrobenzene non-aqueous gel compositions and methods for using the same Gel compositions that contain 1-dichloro-2,4-dinitrobenzene (DNCB) are provided. Embodiments of the subject gel compositions include DNCB, an organic solvent and a viscosity agent, wherein the organic solvent and viscosity agent are inert with respect to the DNCB. A... | 12/20/2011 |
| 8075912 | Autodestructive transdermal therapeutic system The invention relates to a transdermal therapeutic system (TTS), preferably in the form of a transdermal plaster, that contains an active substance and an agent which can destroy the active substance. The TTS further includes a means of bringing the active substance... | 12/13/2011 |
| 8075911 | Transparent transdermal nicotine delivery devices A transparent transdermal delivery device for delivering nicotine which has an Opacity Index of less than 48.6%. ... | 12/13/2011 |
| 8071126 | Percutaneous absorption type patch A percutaneous absorption type patch adapted to be applied to a skin surface of a patient. The percutaneous absorption type patch comprises: a stratum-corneum release member constituted from a sheet-like first supporting substrate and a pressure-sensitive adhesive l... | 12/06/2011 |
| 8071125 | Transdermal patch containing isosorbide dinitrate and bisoprolol This invention relates to a transdermal patch in the form of a layer complex, comprising a backing layer, a drug-reservoir layer comprising pharmacologically active ingredients and pharmaceutically acceptable adjuvants, and a release liner covering the drug-reservoi... | 12/06/2011 |
| 8034374 | Patch containing nonsteroidal anti-inflammatory and analgesic agent An adhesive patch containing a non-steroidal anti-inflammatory agent, comprising a support and an adhesive layer laminated on this support, wherein the adhesive layer contains a non-steroidal anti-inflammatory agent having a carboxyl group or its salt, and polyethyl... | 10/11/2011 |
| 8017146 | Transdermal delivery system with two superimposed adhesive layers having different affinities to the active substance comprised A device for the transdermal delivery of a pharmacologically active substance has first and second superimposed mutually contacting adhesive layers (2, 3). The first layer (3) is in use brought into contact with the skin. The active substance is dissol... | 09/13/2011 |
| 7993671 | Transdermal compositions containing low molecular weight drugs which are liquid at room temperatures A transdermal composition is disclosed which contains a blend of one or more polymers, one or more drugs, at least one of which has a low molecular weight and is liquid at or about room temperatures. The composition is substantially free of water and liquids which h... | 08/09/2011 |
| 7976867 | Dermal, transdermal, mucosal or transmucosal ingredient delivery devices A dermal, transdermal, mucosal or transmucosal delivery device is provided. The device includes a backing layer, defining an ingredient containing reservoir, a cover for the reservoir having at least one opening therethrough, an adhesive layer and a liner layer. Upo... | 07/12/2011 |
| 7964213 | Patch and production method thereof The present invention relates to a patch containing a substrate, a non-crosslinked adhesive layer (A) containing a drug laminated on one surface of the substrate and a crosslinked adhesive layer (B) laminated on the adhesive layer (A). According to the present inven... | 06/21/2011 |
| 7951395 | Dermal application system for aminolaevulinic acid The invention relates to a dermal for aminolaevulinic acid, wherein a self-adhesive matrix system is used containing crystalline aminolaevulinic acids. ... | 05/31/2011 |
| 7947304 | Human growth hormone patch formulations The invention encompasses a transdermal patch formulation comprising hGH, at least one sugar, one amino acid or polyol, and a buffer, wherein the buffer maintains the pH of the formulation in the range of about 5 to about 9 and the formulation does not contain both ... | 05/24/2011 |
| 7914813 | Interface for transdermal drug administration device It is intended to provide an interface for a transdermal drug administration device that can supply a drug almost evenly and favorably from a plurality of projections through skin. This interface for a transdermal drug administration device has a flat plate 8... | 03/29/2011 |
| 7892574 | Topical administration of oxazolidinones for transdermal delivery Disclosed is a method of treating a non-topical infection selected from the group consisting of ear infections, skin and soft tissue infections, acne, infected wounds, bacteremia, in a useful warm blooded mammal who is in need of such treatment which comprises topic... | 02/22/2011 |
| 7867511 | Abuse potential reduction in abusable substance dosage form The potential for substance abuse involving residual amounts of abusable substances remaining in used skin-worn patches is reduced by the provision of a system and method for combining the abusable substance with a separate anti-abuse substance agent as part of a re... | 01/11/2011 |
| 7858112 | Percutaneous absorption system and percutaneous absorption method The present invention provides a percutaneous absorption system and a percutaneous absorption method, which have a simple constitution and can realize the easy and continuous percutaneous absorption of medicine even when the medicine is formed of a water-soluble oli... | 12/28/2010 |
| 7858114 | Percutaneous absorption preparations of antidementia drugs Disclosed is a percutaneous absorption preparation which enables the stable administration of an antidementia drug over a long period of time. More particularly, the percutaneous absorption preparation of the antidementia drug which is used as a plaster on skin comp... | 12/28/2010 |
| 7858113 | Method and device for improving the permeability of the human skin The invention relates to a method for improving the permeability of the human skin in order to transdermally supply active substances, permeability being improved by means of a plaster that is transparent in at least some areas, contains active substance, and is fle... | 12/28/2010 |
| 7824707 | Transdermal therapeutic system provided with improved long-term carrying comfort The invention relates to transdermal therapeutic systems (TTS) comprising a backing, a reservoir layer containing at least one pharmaceutical active ingredient, and an adhesive. Said transdermal therapeutic systems are characterised in that they are able to continuo... | 11/02/2010 |
| 7820197 | Percutaneous preparations A bisphosphonic acid derivative-containing percutaneous preparation of an excellent percutaneous permeability, comprising a bisphosphonic acid derivative such as incadronic acid, minodronic acid, etc., or pharmaceutically acceptable salts thereof, a solubilizing age... | 10/26/2010 |
| 7785622 | Adhesive patch for fentanyl administration An adhesive patch for percutaneous fentanyl administration which is easily produced, has long-term continuity, and is excellent in adhesion and conformability to the skin. The adhesive patch comprises a backing layer and a pressure-sensitive adhesive layer formed on... | 08/31/2010 |
| RE41571 | Method of providing sustained analgesia with buprenorphine A method of effectively treating pain in humans is achieved by administering buprenorphine in accordance with first order kinetics over an initial three-day dosing interval, such that a maximum plasma concentration from about 20 pg/ml to about 1052 pg/ml is attained... | 08/24/2010 |
| 7780981 | Biosynchronous transdermal drug delivery Systems and methods for treating diseases, addictions and disorders in humans and animals involving synchronizing and tailoring the administration of drug compounds with the body's natural circadian rhythms, in order to counteract symptoms when they are likely to be... | 08/24/2010 |
| RE41489 | Method of providing sustained analgesia with buprenorphine A method of effectively treating pain in humans is achieved by administering buprenorphinein accordance with first order kinetics over an initial three-day dosing interval, such that a maximum plasma concentration from about 20 pg/ml to about 1052 pg/ml is attained,... | 08/10/2010 |
| 7767224 | Method for the continuous production and coating of self-adhesive compounds on the basis of SBC that includes at least one pharmaceutically active substance A process for the solvent-free and mastication-free production of a self-adhesive composition which is based on SBC and comprises a pharmaceutically active substance, in a continuously operating apparatus which comprises a feeding section and a compounding section. ... | 08/03/2010 |
| 7763274 | Administration form with active substance-containing particles, for application on the skin or mucosa Administration forms for application to the skin or mucosa, comprising a carrier matrix and at least one active substance, are characterized in that the carrier matrix has a plurality of particles having open pores or containing capillary spaces, said particles serv... | 07/27/2010 |
| 7754236 | Patch with improved anchoring properties between a substrate and an adhesive The present invention relates to a patch which is free from any migration of a drug into a substrate and has favorable anchoring properties between the substrate and adhesive layer, in which the drug containing adhesive layer firmly adheres onto the substrate and wh... | 07/13/2010 |
| 7754237 | Transdermal thiamine insect repellant A method for repelling insects from the skin of a subject by applying thiamine to the skin in a transdermal patch in an effective amount for systemic absorption through the skin. The area of transdermal patch which contacts the skin is about 35 cm2, and t... | 07/13/2010 |
| RE41408 | Method of providing sustained analgesia with buprenorpine A method of effectively treating pain in humans is achieved by administering buprenorphine in accordance with first order kinetics over an initial three-day dosing interval, such that a maximum plasma concentration from about 20 pg/ml to about 1052 pg/ml is attained... | 06/29/2010 |
| 7740879 | Abuse resistant transdermal drug delivery patch A transdermal drug delivery patch has an excipient matrix containing an agonist for administration across the skin of a user, with the matrix further containing a plurality of spaced apart hollow cilia filled with an antagonist, whereby if an abuser attempts to phys... | 06/22/2010 |
| 7718188 | Transdermal patch for external use comprising fentanyl A transdermal patch for external use having a backing layer and a pressure-sensitive adhesive layer formed on one surface of the backing layer, which contains polyisobutylene, a mineral oil and fentanyl employed as the active ingredient in the pressure-sensitive adh... | 05/18/2010 |
| 7704524 | Transdermal botulinum toxin administration for the treatment of spastic muscle pain Pharmaceutical compositions for transdermal administration of neurotoxins to a patient include a neurotoxin, such as a botulinum toxin, and an enhancing agent that facilitates absorption of the neurotoxin through the skin of the patient and does not eliminate the bi... | 04/27/2010 |
| 7695733 | Application of topical anesthetics for modulation of neurogenic tremor A method of ameliorating neurogenic tremor in mammals, which comprises topically administering to a mammal, which has been diagnosed with a neurogenic tremor, an effective amount of a topical anesthetic. ... | 04/13/2010 |
| 7658942 | Cosmetic devices The present invention relates to pre-formed devices for delivering benefit agents to the skin, hair or nails. The devices are patches or masks for cosmetic or therapeutic use and comprise a unilamellar, solid gel sheet having at least one surface at least partially ... | 02/09/2010 |