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| Number | Title | Issue Date |
| 8349353 | Controlled release cytotoxic agent compositions and methods for the treatment of otic disorders Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with cytotoxic agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these c... | 01/08/2013 |
| 7959943 | Solvating system and sealant for medical use in the middle or inner ear Chronic Otitis Media with Effusion (COME), Recurrent Acute Otitis Media (RAOM), cholesteatoma, and other bacterial ear conditions may be treated by applying a solvating system containing greater than 0.2 wt. % surfactant to a bacterial biofilm in the middle or inner... | 06/14/2011 |
| 7524512 | Composition and method for the prevention and relief of the symptoms of an incompetent or patulous Eustachian tube A composition and methods for the treatment of symptoms due to disorders, disease or trauma that impairs normal function of die Eustachian tube and alters vital structures or tissues of the middle ear. This includes diseases and disorders of the Eustachian tube alte... | 04/28/2009 |
| 7294345 | Otorhinological delivery device The invention relates to an otorhinological delivery device comprising at least one pharmaceutically active agent. According to the invention the device comprises a core comprising said at least one pharmaceutically active agent wherein said core is made of an elast... | 11/13/2007 |
| 6960346 | Vehicles for delivery of biologically active substances A formulation containing one or more biologically active substances dissolved, dispersed, emulsified, or suspended within a vehicle of one or more citric acid esters and/or citric acid ethers. Methods for making and using are disclosed, as are kits for administratio... | 11/01/2005 |
| 6793932 | Preparation for veterinary use A veterinary composition comprising at least one keratolytic and cerumenilytic cleaning agent, a at least one bactericide agent, at least one yeast control agent and at least one anti-irritant and anti-pruriginous agent, which is useful for preventing otitis in dogs... | 09/21/2004 |
| 6743439 | Ophthalmic compositions containing copolymers of sulfonated styrene and maleic anhydride Aqueous pharmaceutical solution compositions preserved with a cationic preservative and comprising a cationic drug and a sulfonated styrene/maleic anhydride copolymer are disclosed. The compositions are particularly well suited for topical ophthalmic use, but may al... | 06/01/2004 |
| 6726904 | Method for transmitting acoustic waves The invention relates to the use of a gel mass based on reaction products of polyols and polyisocyanates, wherein the polyol component consists of one or more polyols with hydroxyl numbers below 112 and where appropriate other polyols and additives known from polyol... | 04/27/2004 |
| 6548554 | Ionic aqueous composition containing levomenthol A composition for relieving a sensation of respiratory discomfort and/or for promoting natural regeneration of mucous membranes of the nasal cavity. The composition contains levomenthol at a concentration between 10 and 250 mg/l, dissolved in an aqueous i... | 04/15/2003 |
| 6541039 | Nanoscale particles having an iron oxide-containing core enveloped by at least two shells The invention relates to nanoscale particles suited especially for use in tumor therapy by hyperthermia. Said particles comprise a (preferably superparamagnetic) iron oxide-containing core and at least two shells surrounding said core. The (innermost) she... | 04/01/2003 |
| 6521259 | Formulations and methods for providing prolonged local anesthesia A formulation and methods for inducing sustained regional local anesthesia in a patient comprising a substrate comprising a local anesthetic and an effective amount of a biocompatible, biodegradable, controlled release material prolonging the release of t... | 02/18/2003 |
| 6432440 | Pectin compositions and methods of use for improved delivery of drugs to mucosal surfaces Liquid pharmaceutical compositions for administration to a mucosal surface, comprising a therapeutic agent and a pectin with a low degree of esterification are described. Such compositions gel, or can be adapted to gel, at the site of application in the a... | 08/13/2002 |
| 6423694 | Method of treating otitis media with uridine triphosphates and related compounds A method of promoting drainage of congested middle ear fluid in a subject in need of such treatment is disclosed. The method comprises administering to the middle ear of the subject a uridine triphosphate such as uridine 5'-triphosphate (UTP), an analog o... | 07/23/2002 |
| 6395295 | Use of surface active agent for the manufacture of a medicament for treatment of disorders of the middle ear The invention relates to the treatment of serous otitis media (glue ear). A medicament is disclosed which comprises a surface active phospholipid (SAPL) which is instilled as a powder into the middle ear. The SAPL has an affinity for the surface of the Eu... | 05/28/2002 |
| 6361526 | Antimicrobial tympanostomy tube An antimicrobial tympanostomy tube used to alleviate bacteriostatic infections following myringotomy which is compatible with otologic tissue associated with the middle ear. The tube is formed from a microporous thermoplastic or thermoset resin having inc... | 03/26/2002 |
| 6352721 | Combined diffusion/osmotic pumping drug delivery system Delivery devices capable of delivering one or more active substances by diffusion through plural micropores in the membrane or by osmotic pumping through one or more preformed passageways in the membrane are provided. The device has an about centrally loc... | 03/05/2002 |
| 6333045 | Aqueous liquid pharmaceutical composition comprised of gatifloxacin There is provided an aqueous liquid pharmaceutical composition which comprises Gatifloxacin (chemical nomenclature: (&#b1;)-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piperazi nyl)-4-oxo-3-quinoline carboxylic acid) or its salt and disodium... | 12/25/2001 |
| 6322804 | Implantable biocompatible immunoisolatory vehicle for the delivery of selected therapeutic products An immunoisolatory vehicle for the implantation into an individual of cells which produce a needed product or provide a needed metabolic function. The vehicle is comprised of a core region containing isolated cells and materials sufficient to maintain the... | 11/27/2001 |
| 6306845 | Method for treating demyelinating disease The present invention provides a method for treating a demyelinating disease in a subject which includes administering to the subject a therapeutically effective amount of a high affinity neuromodulatory Na,K-ATPase so as to treat the demyelinating diseas... | 10/23/2001 |
| 6261594 | Chitosan-based nitric oxide donor compositions A chitosan-based polymeric nitric oxide donor composition comprising a modified chitosan polymer and a nitric oxide [N2O2] dimer, wherein the nitric oxide [N2O2] dimer is bonded directly to the backbone of the modified chitosan polymer without further bin... | 07/17/2001 |
| 6235315 | Stable, pulverulent lycopene formulations, comprising lycopene having a degree of crystallinity of greater than 20% The invention relates to stable, pulverulent lycopene formulations, comprising lycopene having a degree of crystallinity of greater than 20%, processes for their preparation and their use as an additive to foodstuffs, cosmetics, pharmaceuticals and animal... | 05/22/2001 |
| 6156293 | Moistening preparation The present invention relates to preparations alleviating the symptoms caused by drying of the mucous membranes of the body. The preparations contain trimethylglycine as an active agent. The invention also relates to the use of trimethylglycine as an agen... | 12/05/2000 |
| 6093417 | Composition to treat ear disorders A topical ear composition that uses penetration enhancers to diffuse the therapeutic agents through the tympanic membrane into the middle and inner ear for the purpose of reducing the inflammation of ear tissues, providing pain relief, and introducing age... | 07/25/2000 |
| 6017554 | Composition for treating abnormal conditions of the epithelium of bodily orifices A stable solution cream, salve, or spray composition containing activated stabilized chlorine dioxide and phosphates, such as disodium hydrogen phosphate, sodium dihydrogen phosphate, trisodium phosphate, and sodium monofluorophosphate, is disclosed for t... | 01/25/2000 |
| 6004573 | Biodegradable low molecular weight triblock poly(lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties A water soluble biodegradable ABA-type block copolymer made up of a major amount of hydrophobic poly(lactide-co-glycolide) copolymer A-blocks and a minor amount of a hydrophilic polyethylene glycol polymer B-block, having an overall average molecular weig... | 12/21/1999 |
| 6004575 | Use of (meth) acrylic acid/maleic acid copolymers for improving mucosal permeability (Meth)acrylic acid/maleic acid copolymers for improving mucosal permeability and pharmaceutical compositions containing them are described.... | 12/21/1999 |
| 5945115 | Polymeric compositions useful as controlled release implants The invention is directed to an improved system for controlled release of biologically active materials and to a liquid composition for its formation. The liquid composition is composed of a thermoplastic polymer, rate modifying agent, bioactive material ... | 08/31/1999 |
| 5942241 | Formulations and methods for providing prolonged local anesthesia A formulation and methods for inducing sustained regional local anesthesia in a patient comprising a substrate comprising a local anesthetic and an effective amount of a biocompatible, biodegradable, controlled release material prolonging the release of t... | 08/24/1999 |
| 5935592 | Method for treating vaginitis and endometriosis A stable solution, cream, salve, or spray composition containing activated chlorine dioxide and phosphates, such as disodium hydrogen phosphate, sodium dihydrogen phosphate, trisodium phosphate, and sodium monofluorophosphate, is disclosed for the treatme... | 08/10/1999 |
| 5935594 | Process and device for treating and healing a tissue deficiency An improved method or process and device for treating and healing a bone void is disclosed, and in particular a method employing a surfactant for efficiently incorporating a biologically active agent into the interstices (voids or pares) of a porous hydro... | 08/10/1999 |
| 5902575 | Method for treating the epithelium of bodily orifices with chlorine dioxide and a phosphate compound A stable solution, cream, salve, or spray composition containing chlorine dioxide and a phosphate, such as disodium hydrogen phosphate, sodium dihydrogen phosphate, trisodium phosphate, and sodium monofluorophosphate, is disclosed for the prevention and t... | 05/11/1999 |
| 5874099 | Methods for making immunoisolatary implantable vehicles with a biocompatible jacket and a biocompatible matrix core A method of forming an implantable and retrievable immunoisolatory vehicles is disclosed, the method comprising the steps of first forming a core comprising a volume of at least 1 μl and at least 104 cells capable of providing a biologically a... | 02/23/1999 |
| 5871767 | Methods for treatment or prevention of neurodegenerative conditions using immunoisolatory implantable vehicles with a biocompatible jacket and a biocompatible matrix core A method for treatment of a neurodegenerative condition in a patient comprising implanting in the patient at least one immunoisolatory vehicle comprising a corc comprising a volume of at least 1 μl and at least 104 living cells which secrete a... | 02/16/1999 |
| 5843930 | Method of treating otitis with ciprofloxacin-hydrocortisone suspension The invention is directed to a method of treating otitis which comprises introducing an antibacterially-effective amount of a composition comprising a non-ototoxic, topical, otic pharmaceutic composition comprising (a) ciprofloxacin in aqueous solution in... | 12/01/1998 |
| 5834003 | Method for oxidatively consuming volatile sulfur compounds at bodily orifices A method for oxidatively consuming volatile sulfur compounds selected from the group consisting of dimethylsulfide, hydrogen sulfide, and methylmercaptan at the epithelial barrier of the rectal, vaginal, urethral, oral, nasal, ocular, and auditory canal o... | 11/10/1998 |
| 5834001 | Methods for making immunoisolatory implantable vehicles with a biocompatiable jacket and a biocompatible matrix core A method of forming an implantable and retrievable immunoisolatory vehicle is disclosed, the method comprising the steps of first forming a jacket of biocompatible thermoplastic or hydrogel, and then loading the jacket with a core comprising a volume of a... | 11/10/1998 |
| 5811115 | Composition for treating abnormal conditions of the epithelium of bodily orifices A stable solution, cream, salve, or spray composition containing chlorine dioxide and phosphates, such as disodium hydrogen phosphate, sodium dihydrogen phosphate, trisodium phosphate, and sodium monofluorophosphate, is disclosed for the prevention and tr... | 09/22/1998 |
| 5800828 | Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products Immunoisolatory vehicles having a core and a surrounding jacket are disclosed, the core having a volume in excess of 1 μl and at least about 104 living cells capable of secreting a biologically active product or of providing a biological funct... | 09/01/1998 |
| 5800829 | Methods for coextruding immunoisolatory implantable vehicles with a biocompatible jacket and a biocompatible matrix core A method of making an immunoisolatory vehicle comprised of a core comprising living cells dispersed in a biocompatible matrix is disclosed, the cells being capable of secreting a biologically active product or of providing a metabolic or immunologic funct... | 09/01/1998 |
| 5798113 | Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products A method of providing a biologically active molecule or metabolic or immunologic function to a patient, comprising implanting into the body of the patient at least one immunoisolatory vehicle comprising a core comprising a volume in excess of 1 μl and at... | 08/25/1998 |
