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| Number | Title | Issue Date |
| 8173152 | Stabilized compositions containing alkaline labile drugs A stabilized bioadhesive composition containing an alkaline labile drug and a method for its preparation are provided. In one aspect, the composition is a hot-melt extruded (HME) composition comprising a preformed excipient mixture comprising an acidic component and... | 05/08/2012 |
| 8133502 | System for delivering a composition to the nasal membrane and method of using same A quick and easy system and method for delivering a composition to a nasal membrane is presented. The applicator assembly includes a sleeve member which encases a swab having a portion that contacts a gelled composition. The sleeve member is manually severed to expo... | 03/13/2012 |
| 8088408 | Method and composition for delivery of medicants to animals According to the present invention, a vaccine or pharmaceutical-containing composition is applied to the muzzle area of the animal, which will then naturally use its tongue to clean itself. This behavior will cause the animal to deposit applied composition to the mu... | 01/03/2012 |
| 8034371 | Intranasal compositions The present invention provides compositions for the intranasal administration of zolpidem or a pharmaceutically acceptable salt thereof. Preferred compositions of the invention are in the form of aqueous solutions. Optionally the compositions of the invention compri... | 10/11/2011 |
| 7939098 | Compositions and method for transmucosal drug delivery and cryoprotection Compositions and methods for vaginal, buccal or nasal transmucosal delivery of drugs and for cryoprotecting of cells and embryos. For cryoprotection, the composition consisting essentially consist of a non-ionizable glycol derivative. For transmucosal delivery, the ... | 05/10/2011 |
| 7923023 | Method and composition for delivery of medicants to animals According to the present invention, a vaccine or pharmaceutical-containing composition is applied to the muzzle area of the animal, which will then naturally use its tongue to clean itself. This behavior will cause the animal to deposit applied composition to the mu... | 04/12/2011 |
| 7906137 | Delivery agents for enhancing mucosal absorption of therapeutic agents A delivery agent for delivering a biologically active agent to a warm-blooded animal includes a hydrophobic moiety covalently bonded to a hydrophilic moiety. The hydrophobic moiety can include bile acids, sterols, or hydrophobic small molecules. The hydrophilic moie... | 03/15/2011 |
| 7879349 | Cyanocobalamin low viscosity aqueous formulations for intranasal delivery A stable pharmaceutical mercury-free aqueous solution of cyanocobalamin comprised of cyanocobalamin and water wherein said solution of cyanocobalamin is suitable for intranasal administration, has a viscosity less than about 1000 cPs, and wherein said solution of cy... | 02/01/2011 |
| 7867508 | Treatment of upper respiratory conditions Provided are compositions and methods useful for the non-addictive treatment and prevention of upper respiratory conditions in man and animals, e.g., allergic, non-allergic and mixed rhinitis in man or pharyngitis and IAD in horses. Compositions of the invention com... | 01/11/2011 |
| 7799337 | Method for directed intranasal administration of a composition Methods, kits, apparatus, and compositions for inhibiting a cerebral neurovascular disorder, a muscular headache, or cerebral inflammation in a human patient are provided. The methods comprise intranasally administering to the patient a pharmaceutical composition co... | 09/21/2010 |
| 7662403 | Pharmaceutical formulations for intranasal administration of protein comprising a chitosan or a derivative thereof There is provided a powder formulation for nasal delivery including a protein having a molecular weight of 10 kDa or greater and chitosan or a derivative thereof or a salt of chitosan or a salt of a derivative of chitosan. Preferably the protein is human growth horm... | 02/16/2010 |
| 7638138 | Compositions for nasal administration of pharmaceuticals Compositions for nasal administration, which comprise a pharmaceutical, a physiologically active peptide, or a peptide-related compound, and as the carrier thereof, crystalline cellulose with a specific particle diameter and/or partially pregelatinized starch are pr... | 12/29/2009 |
| RE40812 | Nasal calcitonin formulation A liquid pharmaceutical composition is disclosed comprising calcitonin or an acid addition salt thereof and citric acid or salt thereof in a concentration from about to about 50 mM, said composition being in a form table for nasal administration. A liquid pharmaceut... | 06/30/2009 |
| 7442368 | Delivery of stimulants through an inhalation route The present invention relates to the delivery of stimulants through an inhalation route. Specifically, it relates to aerosols containing stimulants that are used in inhalation therapy. In a method aspect of the present invention, a stimulant is delivered to a patien... | 10/28/2008 |
| 7439269 | Composition and method for moisturizing nasal tissue An improved composition and method for moisturizing a nasal membrane are disclosed. The composition includes a viscous carrier and one or more moisturizing agents disposed with the carrier. The composition is applied to a portion of a nasal membrane using a spray, a... | 10/21/2008 |
| 7435407 | Inhibition of olfactory neurosensory function to treat eating disorders and obesity The use of calcium channel blockers administered intra-nasally to inhibit olfactory sensory perception to treat eating disorders, including obesity, is described. Also described is a method of reducing food intake in a subject by administering a pharmaceutical compo... | 10/14/2008 |
| 7404489 | Cyanocobalamin low viscosity aqueous formulations for intranasal delivery A stable pharmaceutical mercury-free aqueous solution of cyanocobalamin comprised of cyanocobalamin and water wherein said solution of cyanocobalamin is suitable for intranasal administration, has a viscosity less than about 1000 cPs, and wherein said solution of cy... | 07/29/2008 |
| 7399528 | Powder particles with smooth surface for use in inhalation therapy Carrier particles, for use in the preparation of powdery mixtures for administration by inhalation, and having a median diameter of greater than 90 microns and a surface rugosity expressed as the fractal dimension of less than or equal to 1.1, may be prepared by sub... | 07/15/2008 |
| 7393543 | Vaginally administratable progesterone-containing tablets and method for preparing same The present invention provides a method for preparing a tablet for the vaginal administration of progesterone for systemic use. The method comprises first mixing water with micronized progesterone, the total amount of water mixed with said micronized progesterone no... | 07/01/2008 |
| 7393544 | Dispersion for pulmonary delivery of a bioactive agent Stabilized dispersions are provided for the delivery of a bioactive agent. The dispersions preferably comprise a plurality of perforated microstructures dispersed in a suspension medium that typically comprises a liquid fluorochemical. As density variations between ... | 07/01/2008 |
| 7384914 | Night-time oral insulin therapy A method for protection of a mammal that has impaired glucose tolerance or early stage diabetes mellitus from developing overt or insulin dependent diabetes comprises administering an orally effective dose of a pharmaceutical formulation comprising insulin at nightt... | 06/10/2008 |
| 7381402 | Stable pharmaceutical solution formulations for pressurized metered dose inhalers Aerosol solution formulations for use in an aerosol inhaler which comprise 8-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]-ethyl]-2(1H)-quinolinone or a salt thereof, in particular the hydrochloride salt (TA 2005), as an active ingredie... | 06/03/2008 |
| 7381419 | Medical composition kit for treating lesioned abnormal tissue Optimum compounding composition of a local injection preparation for treating rectal submucous lesioned abnormal tissue with local anesthetic is decided to provide a medical composition kit. In a composition kit for the treatment where respective containers are unse... | 06/03/2008 |
| 7378082 | Method for treating allergic rhinitis without adverse effects The present invention is directed to a method for treating allergic rhinitis without causing an adverse effect of bitter taste. The method comprises administering to a patient an aqueous pharmaceutical formulation comprising 0.1-0.15% (w/v) of epinastine or an acid ... | 05/27/2008 |
| 7368104 | Treatment of respiratory diseases A pharmaceutical composition for pulmonary delivery comprises glycopyrrolate in a controlled release formulation, wherein, on administration, the glycopyrrolate exerts its pharmacological effect over a period greater than 12 hours. ... | 05/06/2008 |
| 7368450 | Sodium channel blockers The present invention relates to compounds represented by formula (I): in which at least one of R3 and R4 is a group represented by formula (A): where the st... | 05/06/2008 |
| 7361168 | Implantable device and methods for delivering drugs and other substances to treat sinusitis and other disorders Implantable devices and methods for delivering drugs and other substances to locations within the body of a human or animal subject to treat or diagnose sinusitis and a variety of other disorders. The invention includes implantable substance delivery devices that co... | 04/22/2008 |
| 7348362 | Bronchodilating β-agonist compositions and methods Bronchodilating compositions and methods are provided. The compositions are intended for administration as a nebulized aerosol. In certain embodiments, the compositions contain formoterol, or a derivative thereof. Methods for treatment, prevention, or amelioration o... | 03/25/2008 |
| 7348360 | Method and composition for delivering zinc to the nasal membrane A viscous gel for delivering minor effective amounts of active substances through the nasal membrane into the body. ... | 03/25/2008 |
| 7341737 | Medicated tampon A tampon adapted to deliver a therapeutic agent, the tampon including a tampon body having a distal end; and a dosage form affixed to the distal end of the tampon body, wherein the dosage form includes a formulation including a therapeutic agent, and wherein the dos... | 03/11/2008 |
| 7337776 | Methods for easing pain and anxiety from atrial or ventricular defibrillation Methods for easing a patient's pain and anxiety from atrial or ventricular defibrillation are disclosed. The methods include causing the patient to inhale a medical gas prior to activation of a atrial defibrillation device or subsequent to activation of a ventricula... | 03/04/2008 |
| 7338665 | Methods compositions and devices utilizing stinging cells/capsules for delivering a therapeutic or a cosmetic agent into a tissue A delivery device including at least one stinging capsule and methods of use are described. ... | 03/04/2008 |
| 7335181 | Nitric oxide decontamination of the upper respiratory tract A method of topically treating the respiratory tract of a mammal with nitric oxide exposure includes the steps of providing a source of nitric oxide containing gas and delivering the nitric oxide containing gas nasally to the upper respiratory tract of the mammal. A... | 02/26/2008 |
| 7332230 | Multilayer preparation in film form, consisting of hydrophilic polymers, for the rapid release of active ingredients A multilayer preparation in the form of films of hydrophilic polymers for rapid release of substances present in the film layers into liquid surroundings is characterized in that adjacent layers differ from one another in that in each case one layer is soluble in a ... | 02/19/2008 |
| RE40045 | Medicaments Pharmaceutical compositions comprising effective amounts of salmeterol (and a physiologically acceptable salt thereof) and fluctuations propionate as a combined preparation for simultaneous, sequential or separate administration by inhalation in the treatment of res... | 02/05/2008 |
| 7323161 | Patch for tooth whitening The patch for tooth whitening of the present invention includes a tooth-adhering layer (1) containing erodible polymer complexes formed by hydrogen bonding of a polymer with a carboxyl group (—COOH) and a polymer with a carbonyl group (—C═O) or ether gr... | 01/29/2008 |
| 7320800 | Vaginally administrable progesterone-containing tablets and method for preparing same The present invention provides a method for preparing a tablet for the vaginal administration of progesterone for systemic use. The method comprises first mixing water with micronized progesterone, the total amount of water mixed with said micronized progesterone no... | 01/22/2008 |
| 7306787 | Engineered particles and methods of use Engineered particles are provided may be used for the delivery of a bioactive agent to the respiratory tract of a patient. The particles may be used in the form of dry powders or in the form of stabilized dispersions comprising a nonaqueous continuous phase. In part... | 12/11/2007 |
| 7306812 | Dissolvable backing layer for use with a transmucosal delivery device A dissolvable backing layer for use with transmucosal drug delivery devices includes a dissolvable hydrophilic region and a non-hydrophilic region that inhibits or slows migration of water, drugs, other active agents, or other molecules through the backing layer. Th... | 12/11/2007 |
| 7303756 | Multiphase system The invention relates to a preparation comprising a carrier phase and at least one further phase which cannot be mixed with the carrier phase or only partially mixed therewith, wherein the change in ambient conditions alters the viscosity of the carrier phase. The i... | 12/04/2007 |
