Did You Know...
...that the inventor of the electric motor was a blacksmith named Thomas Davenport? Described as "a brilliantly unsuccessful inventor", Davenport invented the first rotary electric motor. In 1836 he headed out -- on foot -- from his Vermont home to file a patent application at the Patent Office in Washington, D.C. By the time he got there, he had squandered away his money and couldn't afford the $30 filing fee so he turned around and went home. When he later mailed in his application with money he'd raised, the Patent office was destroyed in a fire. He did finally get credit for his invention on Feb. 5, 1837.
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| Number | Title | Issue Date |
| 8097270 | Use of nanoparticles as carriers for biocides in ophthalmic compositions The use of nanoparticles of inorganic materials (e.g., synthetic smectite clays) in ophthalmic compositions is described. The nanoparticles are utilized as biologically inert carriers or depots for biocides. The nanoparticles are particularly useful in preventing or... | 01/17/2012 |
| 8075909 | Contact lens based bioactive agent delivery system A bioactive agent delivery system comprising an optically transparent contact lens having dispersed therein (1) an ophthalmically bioactive agent capable of diffusion through the contact lens and into the post-lens tear film when placed on the eye and (2) associated... | 12/13/2011 |
| 8071121 | Dispersions of microemulsions in hydrogels for drug delivery An ophthalmically bioactive agent delivery system comprising a contact lens having dispersed therein as an oil-in-water microemulsion, an ophthalmically bioactive agent encapsulated in the oil phase, the oil phase comprising a material from which the agent VAN diffu... | 12/06/2011 |
| 7976863 | Biomedical devices with antimicrobial coatings Biomedical devices with antimicrobial coatings are provided. One or more surfaces of the device are coated with a cationic peptide, cationic proteins, or mixtures thereof to impart antimicrobial properties to the surface. ... | 07/12/2011 |
| 7901706 | Materials containing multiple layers of vesicles The present invention provides a composite material, preferably an ophthalmic device, more preferably a contact lens, which comprises a vesicle-containing coating including at least one layer of a vesicle and one layer of a polyionic material having charges opposite... | 03/08/2011 |
| 7811601 | Ophthalmic lenses capable of sustained drug release and preservative solutions therefor An object of the present invention is to provide a practical ophthalmic lens which has an effect of effectively retaining and sustainedly releasing a drug and has form stability before and after release of the drug, wherein the ionic polymer gel having sustained dru... | 10/12/2010 |
| 7771743 | Infection resistant polymers, their preparation and uses A family of infection resistant and biocidal polymeric materials incorporates an infection resistant biguanide such as chlorhexidine or polyhexanide pendant to the polymer chain, chemically linked to the polymer through the biguanide group secondary nitrogen atoms. ... | 08/10/2010 |
| 7674478 | Polymer micelle as monolayer or layer-laminated surface The present invention is directed to a coated biomedical device said micelle having a hydrophilic outer shell and a hydrophobic inner core, or a hydrophobic outer shell and a hydrophilic inner core said micelle comprised of a block copolymer having a HLB value rangi... | 03/09/2010 |
| 7638137 | Ophthalmic drug delivery system A drug delivery system comprising a contact lens having dispersed therein as nanoparticles having a particle size less than about 50 nm, an ophthalmic drug nanoencapsulated in a material from which said ophthalmic drug is capable of diffusion into and migration thro... | 12/29/2009 |
| 7416737 | Antimicrobial lenses, processes to prepare them and methods of their use This invention relates to solutions for packaging ophthalmic devices comprising at least one antimicrobial metal salt which prevent the loss of said antimicrobial metal salt during autoclaving and storage. ... | 08/26/2008 |
| 7402562 | Composition for stabilizing corneal tissue during or after orthokeratology lens wear An orthokeratological procedure is provided that prevents or retards relaxation of corneal tissue back to the original anterior curvature of the cornea. The procedure comprises applying a stabilizing agent that comprises fibril associated collagens with interrupted ... | 07/22/2008 |
| 7368127 | Biomedical devices with peptide containing coatings Biomedical devices with stable peptide coatings are provided. The coatings are formed by incorporating at least one latent reactive component into the reactive mixture, forming a medical device from said reactive mixture and reacting said medical device with a coati... | 05/06/2008 |
| 7351430 | Shape-retentive hydrogel particle aggregates and their uses The present invention is related to hydrogel particles and aggregates formed therefrom having characteristics including, without limitation, shape-retentiveness, elasticity, controllable pore sizes and controllable degradation rates that render them useful for a wid... | 04/01/2008 |
| 7348022 | Biomedical composition A method of preparing intraocular lenses in situ is disclosed. The method involves the injection of an unsaturated macromonomer of the formula The macromonomer is then polymerized to give a polymer having an E modulus in th... | 03/25/2008 |
| 7329415 | Materials containing multiple layers of vesicles The present invention provides a composite material, preferably an ophthalmic device, more preferably a contact lens, which comprises a vesicle-containing coating including at least one layer of a vesicle and one layer of a polyionic material having charges opposite... | 02/12/2008 |
| 7326423 | Copolymerizable azo compounds and articles containing them Polymerizable light absorbing azo dyes are disclosed useful as monomers in the formation of devices such as, but not limited to ocular lenses. Specifically, intraocular lenses (IOL) are disclosed wherein one or more of the light absorbing dye is covalently bonded to... | 02/05/2008 |
| 7323189 | Liquid and low melting coatings for stents A method for forming liquid coatings for medical devices such as stents and angioplasty balloons is provided. The liquid coatings can be made from biodegradable materials in liquid, low melting solid, or wax forms, which preferably degrade in the body without produc... | 01/29/2008 |
| 7303278 | Multifocal contact lens A contact lens formed from a transparent material having front and rear surfaces, wherein the rear surface has a base curve which is adapted to fit an eye of a wearer of the lens. The front surface has a central zone which has two different cylindrical curvatures wh... | 12/04/2007 |
| 7282214 | Biomedical devices with antimicrobial coatings Biomedical devices with antimicrobial coatings are provided. One or more surfaces of the device are coated with a cationic peptide, cationic proteins, or mixtures thereof to impart antimicrobial properties to the surface. ... | 10/16/2007 |
| 7270678 | Surface modification of functional group-containing medical devices with catalyst-containing reactive polymer system Surface modified medical devices such as intraocular lens implants formed from one or more functional group-containing materials using reactive, hydrophilic polymers with catalyst functionality for the purpose of reducing or eliminating lens epithelial cell growth t... | 09/18/2007 |
| 7249848 | Wettable hydrogels comprising reactive, hydrophilic, polymeric internal wetting agents The present invention relates to wettable silicone hydrogels comprising the reaction product of at least one siloxane containing component and at least one reactive, hydrophilic polymeric internal wetting agent. The present invention further relates to silicone hydr... | 07/31/2007 |
| 7229473 | Local delivery of rapamycin for treatment of proliferative sequelae associated with PTCA procedures, including delivery using a modified stent Methods of preparing intravascular stents with a polymeric coating containing macrocyclic lactone (such as rapamycin or its analogs), stents and stent graphs with such coatings, and methods of treating a coronary artery with such devices. The macrocyclic lactone-bas... | 06/12/2007 |
| 7223286 | Local delivery of rapamycin for treatment of proliferative sequelae associated with PTCA procedures, including delivery using a modified stent Methods of preparing intravascular stents with a polymeric coating containing macrocyclic lactone (such as rapamycin or its analogs), stents and stent graphs with such coatings, and methods of treating a coronary artery with such devices. The macrocyclic lactone-bas... | 05/29/2007 |
| 7217286 | Local delivery of rapamycin for treatment of proliferative sequelae associated with PTCA procedures, including delivery using a modified stent Methods of preparing intravascular stents with a polymeric coating containing macrocyclic lactone (such as rapamycin or its analogs), stents and stent graphs with such coatings, and methods of treating a coronary artery with such devices. The macrocyclic lactone-bas... | 05/15/2007 |
| 7179286 | Stent with stepped connectors A stent comprises a plurality of serpentine circumferential bands and a plurality of connector columns. Each connector column is located between two adjacent serpentine circumferential bands and comprises a plurality connector struts. Each connector strut is connect... | 02/20/2007 |
| 7169406 | Growth factor delivery systems for the healing of wounds and the prevention of inflammation and disease The present invention features hydrogel drug delivery systems and methods of producing and using such systems for the treatment of wounds. The systems are based on a hydrogel into which a low concentration of growth factor, e.g., epidermal growth factor, is passivel... | 01/30/2007 |
| 7147644 | Apparatus for delivery of ocular implants An apparatus and methods for delivering ocular implants or microimplants. The apparatus is ergonomically designed for ease of use, and a simple manual depression of an actuator produces proportional movement of a linkage causing the implant or microimplant to be eje... | 12/12/2006 |
| 7141248 | Methods of producing intraocular lenses Methods of producing an intraocular lens include introducing a solution into a lens forming enclosure, wherein the solution comprises discrete crosslinkable units of a size small enough to provide an optically clear solution while contributing to a high refractive i... | 11/28/2006 |
| 7105352 | Intelligent polymerized crystalline colloidal array carbohydrate sensors The present invention is related to glucose sensors that are capable of detecting the concentration or level of glucose in a solution or fluid having either low or high ionic strength. The glucose sensors of the present invention comprise a polymerized crystalline c... | 09/12/2006 |
| 7083646 | Surface modification of functional group-containing intraocular lenses Surface modified medical devices such as intraocular lens implants formed from one or more functional group-containing materials using reactive, hydrophilic polymers for the purpose of reducing or eliminating lens epithelial cell growth thereon, reducing or eliminat... | 08/01/2006 |
| 7060288 | Biomedical devices The present invention is concerned with biomedical device comprising (a) a biocompatible organic or inorganic bulk material and (b) a coating comprising polymerizable carbon-carbon double bonds covalently attached ... | 06/13/2006 |
| 7052490 | Corneal surgery apparatus and correction data determining methods A corneal surgery apparatus for correcting a refractive error by ablating corneal tissue with a laser beam, being capable of finding a correction pattern optimum for a patient to ensure precise correction, and a method of determining correction data. The apparatus i... | 05/30/2006 |
| 7037337 | Implant for altering the iris color and method of locating and fixing an implant for altering the iris color The present invention discloses an implant for altering the iris color, consisting of a completely or partially transparent, semi-transparent or non-transparent, colored, biocompatible and flexible material, wherein the implant is formed annularly, and forms an annu... | 05/02/2006 |
| 7030149 | Combination of brimonidine timolol for topical ophthalmic use Disclosed are pharmaceutical compositions comprising brimondine and timolol for topical ophthalmic delivery and a method of treatment comprising administering said composition when indicated for glaucoma and associated conditions such as elevated intraocular pressur... | 04/18/2006 |
| 6982090 | More easily visualized punctum plug configurations An improved punctum plug is more easily visualized when positioned within a punctual canal of a recipient. The body of the plug features an outwardly exposed surface when properly positioned, and a substance causing at least the outwardly exposed surface to contrast... | 01/03/2006 |
| 6921541 | Formulations and methods for providing prolonged local anesthesia A formulation and methods for inducing sustained regional local anesthesia in a patient comprising a substrate comprising a local anesthetic and an effective amount of a biocompatible, biodegradable, controlled release material prolonging the release of the local an... | 07/26/2005 |
| 6902548 | Use of enzyme in ophthalmic treatments A highly specific and easily purified form of hyaluronidase is described for use in ophthalmic treatments. The enzyme, from Streptomyces hyalurolyticus is specific for hyaluronidase and carries out an elimination reaction that results in the production of dou... | 06/07/2005 |
| 6900188 | System for treating wounds and method for producing this system The wound-treatment system is natural and is adapted to change state in a reversible manner by passing from the gel state to the solution state and vice-versa, and has polysaccharide macromolecules (10, 20, 30) and aliphatic chains (11-15, 21-24, 31-33... | 05/31/2005 |
| 6787131 | Method for enhancing integrity of epithelium using retinoic acid A method for improving the integrity of the corneal epithelium by introducing into the eye an effective amount of a ophthalmically compatible retinoid sufficient to enhance the integrity of the corneal epithelium. ... | 09/07/2004 |
| 6767934 | Macromolecular compounds Macromolecular photocrosslinkers have polymeric backbones of substituted siloxane groups carrying photoactive groups. When exposed to light of wavelength above 305 nm, the photocrosslinkers are adapted to generate radicals which are retained on the macromolecular ph... | 07/27/2004 |
