Did You Know...
...that in the early 1940s GE engineer James Wright was charged with a task of utmost importance to the war effort: develop a cheap substitute for rubber that could be used to produce tires, gas masks and a whole host of military gear. Wright tackled the task diligently -- and wound up inventing Silly Putty.
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| Number | Title | Issue Date |
| 8119154 | Sustained release intraocular implants and related methods Biocompatible intraocular implants include a steroid and a polymer associated with each other to facilitate release of the steroid into an eye for a period of time greater than about two months. The steroid may be associated with a biodegradable polymer matrix, such... | 02/21/2012 |
| 8105623 | Fluorinated poly(ether)s end-capped with polymerizable cationic hydrophilic groups The present invention relates to polymeric compositions useful in the manufacture of biocompatible medical devices. More particularly, the present invention relates to certain cationic monomers capable of polymerization to form polymeric compositions having desirabl... | 01/31/2012 |
| 8092825 | Glycan binding proteins as therapeutic targets for retinal disorders and treatment methods based thereon Disclosed are novel methods of treatment for retinal diseases and conditions including age-related macular degeneration, genetic-based retinal degenerations and retinal detachment. A novel glycan binding protein thought to be a cell surface receptor has been discove... | 01/10/2012 |
| 8088407 | Method for reducing or preventing transplant rejection in the eye and intraocular implants for use therefor Methods for reducing or preventing transplant rejection in the eye of an individual are described, comprising: a) performing an ocular transplant procedure; and b) implanting in the eye a bioerodible drug delivery system comprising an immunosuppressive agent and a b... | 01/03/2012 |
| 8071120 | Methods for treating neovascularization and intravitreal implants Methods for reducing or preventing transplant rejection in the eye of an individual are described, comprising: a) performing an ocular transplant procedure; and b) implanting in the eye a bioerodible drug delivery system comprising an immunosuppressive agent and a b... | 12/06/2011 |
| 8062657 | Ocular therapy using glucocorticoid derivatives selectively penetrating posterior segment tissues Ophthalmically therapeutic materials, such as liquid-containing compositions and polymeric drug delivery systems, include a therapeutic component that includes an Glucocorticoid Derivative which, upon delivery to the posterior segment of a mammalian eye, does not si... | 11/22/2011 |
| 8043628 | Methods for reducing edema Methods for reducing or preventing neovascularization or edema in the eye by implanting in the eye a bioerodible drug delivery system comprising an immunosuppressive agent and a bioerodible polymer. ... | 10/25/2011 |
| 8034369 | Controlled release bioactive agent delivery device The invention provides a controlled release bioactive agent delivery device for treatment of an eye that includes a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at lea... | 10/11/2011 |
| 8034370 | Ocular implant made by a double extrusion process The invention provides biodegradable implants sized for implantation in an ocular region and methods for treating medical conditions of the eye. The implants are formed from a mixture of hydrophilic end and hydrophobic end PLGA, and deliver active agents into an ocu... | 10/11/2011 |
| 8021680 | Controlled release bioactive agent delivery device The invention provides a controlled release bioactive agent delivery device that includes a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body... | 09/20/2011 |
| 7976862 | Controlled release bioactive agent delivery device The invention provides implantable sustained release bioactive agent delivery devices that include a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of... | 07/12/2011 |
| 7959942 | Bioabsorbable medical device with coating A biodegradable, bioabsorbable medical device with a coating for capturing progenitor endothelial cells in vivo and delivering a therapeutic agent at the site of implantation. The coating on the medical device is provided with a biabsorbable polymer composition such... | 06/14/2011 |
| 7906136 | Conveniently implantable sustained release drug compositions This invention provides for biocompatible and biodegradable syringeable liquid, implantable solid, and injectable gel pharmaceutical formulations useful for the treatment of systemic and local disease states. ... | 03/15/2011 |
| 7846468 | Methods for reducing or preventing transplant rejection in the eye and intraocular implants for use therefor Methods for reducing or preventing transplant rejection in the eye of an individual are described, comprising: a) performing an ocular transplant procedure; and b) implanting in the eye a bioerodible drug delivery system comprising an immunosuppressive agent and a b... | 12/07/2010 |
| 7824704 | Controlled release bioactive agent delivery device The invention provides retrievable devices for sustained delivery of bioactive agent to a site within a patient, the devices including a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a dista... | 11/02/2010 |
| 7799336 | Hypotensive lipid-containing biodegradable intraocular implants and related methods Biocompatible intraocular implants include a prostamide component and a biodegradable polymer that is effective in facilitating release of the prostamide component into an eye for an extended period of time. The prostamide component may be associated with a biodegra... | 09/21/2010 |
| 7771742 | Sustained release intraocular implants containing tyrosine kinase inhibitors and related methods Biocompatible intraocular implants include a tyrosine kinase inhibitor and a biodegradable polymer that is effective to facilitate release of the tyrosine kinase inhibitor into an eye for an extended period of time. The therapeutic agents of the implants may be asso... | 08/10/2010 |
| 7767223 | Methods for reducing or preventing transplant rejection in the eye and intraocular implants for use Methods for reducing or preventing transplant rejection in the eye of an individual are described, comprising: a) performing an ocular transplant procedure; and b) implanting in the eye a bioerodible drug delivery system comprising an immunosuppressive agent and a b... | 08/03/2010 |
| 7727545 | Polymeric fluorinated dioxole and medical devices comprising same A polymeric material having improved gas permeability comprises units of fluorinated dioxole. The polymeric material may further comprise units of a hydrophobic monomer, a hydrophilic monomer, or combinations thereof. Such a polymeric material is desirably used to p... | 06/01/2010 |
| 7585517 | Transscleral delivery Diseases associated with the tissues in the posterior segment of the eye can be effectively treated by administering therapeutic agents transsclerally to those tissues. Compositions, devices, and methods for delivering therapeutic agents so that they cross the scler... | 09/08/2009 |
| 7563455 | Highly-mineralized osteogenic sponge compositions, and uses thereof Osteogenic sponge compositions having enhanced osteoinductive properties for use in bone repair are described. The compositions include a quickly resorbable porous carrier, a more slowly resorbed mineral scaffold and an osteogenic factor, preferably a bone morphogen... | 07/21/2009 |
| 7422642 | Method for preparing chemical adsorption film and solution for preparing chemical adsorption film used in the method To provide a method which allows the combination of rapid formation of a chemical adsorption film with the preparation of the film which is reduced in the content of impurities and having a dense structure. A method for preparing a chemical adsorption film on the su... | 09/09/2008 |
| RE40493 | Porous paclitaxel matrices and methods of manufacture thereof Paclitaxel is provided in a porous matrix form, which allows the drug to be formulated without Cremophor and administered as a bolus. The paclitaxel matrices preferably are made using a process that includes (i) dissolving paclitaxel in a volatile solvent to form a ... | 09/09/2008 |
| 7384649 | Particulate compositions for pulmonary delivery This invention concerns an improved particulate composition for delivering a drug to the pulmonary system. Applicants disclose a method of identifying an optimal form of aerodynamically light particles which are highly dispersible. The particles of the instant inven... | 06/10/2008 |
| 7374775 | Dura substitute and a process for producing the same The invention relates to dura substitutes to be used as prostheses for dural defects in the field of neurosurgery and processes for producing the same. The present invention provides artificial dura mater materials comprising sheets of microbial-derived polysacchari... | 05/20/2008 |
| 7364859 | Methods of using bioelastomers Bioelastomers are disclosed for use in methods of binding compounds including immunoassay methods, in biosensors and methods or regenerating biosensors, and in methods for targeting the delivery of a compound to a particular location within an animal subjects. In ge... | 04/29/2008 |
| 7335508 | Porous plasma protein matrices and methods for preparation thereof The present invention relates to porous freeze-dried plasma protein matrices having an open channel structure and a concentration gradient of plasma proteins crosslinked by the action of thrombin, and methods of producing said matrices. The compositions of the prese... | 02/26/2008 |
| 7332566 | Biocompatible crosslinked polymers with visualization agents Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having electrophilic and nucleophilic functional groups capable of reacting and cros... | 02/19/2008 |
| 7329411 | Ophthalmic compositions containing a synergistic combination of three polymers Ophthalmic compositions suitable for use as artificial tears or as vehicles for ophthalmic drugs are disclosed. The compositions contain a combination of three polymers that have a synergistic effect on viscosity. ... | 02/12/2008 |
| 7326423 | Copolymerizable azo compounds and articles containing them Polymerizable light absorbing azo dyes are disclosed useful as monomers in the formation of devices such as, but not limited to ocular lenses. Specifically, intraocular lenses (IOL) are disclosed wherein one or more of the light absorbing dye is covalently bonded to... | 02/05/2008 |
| 7285287 | Carbon dioxide-assisted methods of providing biocompatible intraluminal prostheses Methods of producing biocompatible intraluminal prostheses are provided and include immersing polymeric material of an intraluminal prosthesis in a densified carbon dioxide composition under controlled conditions such that toxic materials are absorbed by the densifi... | 10/23/2007 |
| 7276050 | Trans-scleral drug delivery method and apparatus A method of treating ocular disorders involving angiogenesis includes the steps of providing a trans-scleral drug delivery device comprising an insert stabilizer for attachment to a scleral surface and having an interlock opening and a replaceable implant having a r... | 10/02/2007 |
| 7244440 | Ophthalmic compositions containing a synergistic combination of three polymers Ophthalmic compositions suitable for use as artificial tears or as vehicles for ophthalmic drugs are disclosed. The compositions contain a combination of three polymers that have a synergistic effect on viscosity. ... | 07/17/2007 |
| 7238678 | Adhesive N,O-carboxymethylchitosan coatings which inhibit attachment of substrate-dependent cells and proteins The present invention relates to a method of inhibiting cellular and protein attachment to substrates by applying a composition containing an effective amount of adherent N,O-carboxymethylchitosan to a substrate with such that cellular and protein attachment are pre... | 07/03/2007 |
| 7235255 | Biological bioadhesive compositions and methods of preparation and use The present invention relates generally to the preparation and use of biological tissue adhesives which rely on combining fibrinogen and thrombin. More particularly, the present invention relates to a method of preparing a fibrin sealant whereby said sealant is form... | 06/26/2007 |
| 7230153 | Multilayer conductive appliance having wound healing and analgesic properties A dressing for promoting healing and pain relief of the body of a living organism having a pathologic condition has at least one layer of conductive material having a resistance no greater than 1000 Ω/cm2. When placed proximate a portion of the body of t... | 06/12/2007 |
| 7229959 | Supplemented fibrin matrix delivery systems This invention provides supplemented and unsupplemented tissue sealants as well as methods for their production and use thereof. Disclosed are tissue sealants supplemented with at least one antibody. The composition may be further supplemented with, for example, one... | 06/12/2007 |
| 7229633 | Biological bioadhesive compositions and methods of preparation and use The present invention relates generally to the preparation and use of biological tissue adhesives which rely on combining fibrinogen and thrombin. More particularly, the present invention relates to a method of preparing a fibrin sealant whereby said sealant is form... | 06/12/2007 |
| 7208179 | Methods for treating disease and forming a supplemented fibrin matrix This invention provides supplemented and unsupplemented tissue sealants as well as methods for their production and use thereof. Disclosed are tissue sealants supplemented with at least one oligonucleotide. The composition may be further supplemented with, for examp... | 04/24/2007 |
| 7208177 | Resorbable extracellular matrix for reconstruction of cartilage A resorbable extracellular matrix for reconstruction of cartilage tissue includes a purified collagen II derived from natural cartilage tissue from which non-collagen proteins have been removed. The matrix can be utilized as a scaffold implant for meniscal or verteb... | 04/24/2007 |
