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| Number | Title | Issue Date |
| 8182832 | Bone replacement material comprising crystalline phases The present invention relates to an X-ray amorphous-crystalline material with high solubility which can be used as a bioactive bone replacement material and as a substrate material in biotechnology. The new material comprising crystalline and X-ray amorphous phases ... | 05/22/2012 |
| 8182831 | Stable and taste masked pharmaceutical dosage form using porous apatite grains A stable and taste masked pharmaceutical dosage form includes porous apatite grains and a drug entrapped in pores of said grains, wherein said grains have a size of 0.1-1000 μm and said pores of said grains have an opening of 0.5-300 nm. A process for preparing the... | 05/22/2012 |
| 8158143 | Systems for releasing active ingredients, based on biodegradable or biocompatible polymers with a shape memory effect A drug release system is disclosed comprising a laminate structure comprising at least one layer comprising a matrix made from a shape memory material and at least one drug dispersed in the matrix, and layers from a shape memory material not containing a drug and sa... | 04/17/2012 |
| 8153149 | Controlled delivery system The present invention relates to novel anesthetic compositions containing a non-polymeric carrier material and an anesthetic, where the compositions are suitable for providing a sustained local anesthesia without an initial burst and having a duration for about 24 h... | 04/10/2012 |
| 8153150 | Methods of administering tetrazole-containing rapamycin analogs with other therapeutic substances for treatment of vascular disorder A medical device comprising a supporting structure capable of containing or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient may contain one or more therapeutic agents or substances, with the carrier preferably including a co... | 04/10/2012 |
| 8153148 | Porous biocompatible implant material and method for its fabrication A biocompatible and biodegradable implant for a cavity in a bone of a living organism is made of biocompatible and biodegradable granules. The biocompatible and biodegradable granules are provided with a coating, which includes at least one layer of a biocompatible ... | 04/10/2012 |
| 8147864 | Implants for administering substances and methods of producing implants A porous silicon implant impregnated with a beneficial substance, such as a micromineral required for healthy physiology, is implanted subcutaneously and is entirely corroded away over the following months/year to release the micromineral in a controlled manner. In ... | 04/03/2012 |
| 8128954 | Biodegradable drug-polymer delivery system A sustained-release biodegradable polymeric drug-eluting fiber is disclosed. In some embodiments, the therapeutic drug is complexed with cyclodextrin. In certain embodiments, the polymeric component of the fiber comprises cyclodextrin. The fiber may be fabricated to... | 03/06/2012 |
| 8124120 | Crosslinked hyaluronic acid compositions for tissue augmentation Disclosed are hyaluronic acid (HA) compositions including crosslinked, water-insoluble, hydrated HA gel particles. Also disclosed are methods of making the HA compositions, and methods of using the HA composition to augment tissue in a subject. ... | 02/28/2012 |
| 8119153 | Stents with drug eluting coatings The present invention relates generally to medical devices, preferably a stent, having a drug eluting surface coated or covered with a coating of particles comprising at least an outer layer, an inner layer, and a core comprising a therapeutic agent. Specifically, t... | 02/21/2012 |
| 8110213 | Method of forming a tissue structure by introducing cells into an implanted matrix Polymeric materials are used to make a pliable, non-toxic, injectable porous template for vascular ingrowth. The pore size, usually between approximately 100 and 300 microns, allows vascular and connective tissue ingrowth throughout approximately 10 to 90% of the ma... | 02/07/2012 |
| 8105622 | Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels Pharmaceutically acceptable hydrogel polymers of natural, recombinant or synthetic origin, or hybrids thereof, are introduced in a dry, less hydrated, or substantially deswollen state and rehydrate in a physiological environment to undergo a volumetric expansion and... | 01/31/2012 |
| 8101200 | Targeted therapeutic agent release devices and methods of making and using the same Generally, the present invention provides devices and methods for delivering high, efficacious concentrations of therapeutic agents, i.e., medicaments such as drugs, antibiotics, etc., to specific sites in a patient's body, such as tumors and infected lesions. In on... | 01/24/2012 |
| 8088406 | Pioneer projectile drug delivery technology The invention relates to a novel drug delivery technology. More particularly the invention relates to a method of delivering at least one therapeutic compound or a formulation comprising the at least one therapeutic compound to a patient; to a throwaway or reusable ... | 01/03/2012 |
| 8088404 | Biocompatible controlled release coatings for medical devices and related methods Biocompatible coatings for medical devices are disclosed. Specifically, polymer coatings designed to control the release of bioactive agents from medical devices in vivo are disclosed wherein the solubility parameters of polymers and drugs are closely matched to con... | 01/03/2012 |
| 8088405 | Therapeutic compositions and methods Methods of promoting healing through enhanced regeneration of tissue (e.g. hard tissue or soft tissue) by contacting the tissue or the surrounding tissue with an anti-inflammatory agent. These methods are useful in a variety of dental and orthopedic applications. | 01/03/2012 |
| 8084054 | Bioerodible film for ophthalmic drug delivery Drug delivery film compositions containing a combination of a water-soluble, film-forming polymers and a fatty acid glyceride or ester are suitable for delivering ophthalmic drugs. ... | 12/27/2011 |
| 8067028 | Drug delivery device Drug delivery devices are provided herein including crosslinked polymeric compositions. The devices may, in embodiments, possess at least two drug release profiles, in embodiments at least three drug release profiles. ... | 11/29/2011 |
| 8062655 | Composite scaffold structure A composite resilient scaffold may be used to grow, repair, and/or regenerate tissue such as articular cartilage. The composite scaffold is porous and at least substantially bioremovable. The composite scaffold includes a support structure coated with a discontinuou... | 11/22/2011 |
| 8062654 | Drug releasing biodegradable fiber for delivery of therapeutics The present invention relates to fiber compositions comprising gels or hydrogels. The invention further relates to the composition of a gel or hydrogel loaded biodegradable fiber and methods of fabricating such fibers. The present invention further provides tissue e... | 11/22/2011 |
| 8062656 | Methods of treating disease with nitric oxide (NO)-releasing polymers and soluble no-releasing nitrosamines The invention provides NO-releasing polymers and low molecular weight NO-releasing compounds which may be used to for the treatment of medical conditions associated with NO-deficiency. The NO-releasing polymers or the low molecular weight NO-releasing compounds may ... | 11/22/2011 |
| 8052990 | Biocompatible crosslinked gel The invention relates to a method for producing a biocompatible crosslinked gel consisting in crosslinking a determined quantity of at least one type of liquid biocompatible polymer by adding a quantity of crosslinking agent, in carrying out a crosslinking reaction,... | 11/08/2011 |
| 8048444 | Apparatus and method for preventing adhesions between an implant and surrounding tissues An anti-adhesion membrane is placed onto an implant introduced into a surgical site of a patient to prevent post-surgical adhesions between the implant and surrounding tissue. The implant may comprise either biological material, such as a transplanted organ, or non-... | 11/01/2011 |
| 8048443 | Pliable medical device and method of use A firm but pliable medical device for use as a bone graft substitute or bone graft extender retains its shape without the requirement of a containment device, such as a syringe. Because the device is solid, it is easy to locate or position in-vivo and, in the moist ... | 11/01/2011 |
| 8048445 | Ocular implant made by a double extrusion process The invention provides biodegradable implants sized for implantation in an ocular region and methods for treating medical conditions of the eye. The implants are formed from a mixture of hydrophilic end and hydrophobic end PLGA, and deliver active agents into an ocu... | 11/01/2011 |
| 8034367 | Tissue adhering compositions A method mixes a first component, a second component, and a buffer material. The first component includes an electrophilic polymer material comprising poly(ethylene glycol) having a functionality of at least three. The second component includes a nucleophilic materi... | 10/11/2011 |
| 8034366 | Ocular implant made by a double extrusion process The invention provides biodegradable implants sized for implantation in an ocular region and methods for treating medical conditions of the eye. The implants are formed from a mixture of hydrophilic end and hydrophobic end PLGA, and deliver active agents into an ocu... | 10/11/2011 |
| 8034368 | Drug delivery device for providing local analgesia, local anesthesia or nerve blockage The invention relates to a drug delivery device for providing local analgesia, local anesthesia or nerve blockade at a site in a human or animal in need thereof, the device comprising a fibrillar collagen matrix; and at least one drug substance selected from the gro... | 10/11/2011 |
| 8034365 | N-substituted monomers and polymers Described herein are N-substituted monomers and polymers, methods of making such monomers and polymers, and methods of using them in various applications, such as medical devices. In preferred embodiments, the medical device is a stent. ... | 10/11/2011 |
| 8029817 | Silicon substituted oxyapatite The invention is a silicon substituted oxyapatite compound (Si-OAp) for use as a synthetic bone biomaterial either used alone or in biomaterial compositions. The silicon substituted oxyapatite compound has the formula Ca5(PO4)3-x(SiO... | 10/04/2011 |
| 8021678 | Implantable medical device with polymer coating in a surface area to volume ratio providing surface erosion characteristics The present invention relates to an implantable medical device comprising therapeutic agents coated on the device using polyesters for the drug reservoir layer that exhibit surface-eroding characteristics. ... | 09/20/2011 |
| 8021679 | Nitric oxide-releasing biodegradable polymers useful as medical devices and coatings therefore Nitric Oxide (NO)-releasing polymers useful as implantable medical devices and coatings therefore are provided. Specifically the implantable medical devices and/or coatings comprise NO-releasing biodegradable polymers derived from [1,4] oxazepan-7-one and its deriva... | 09/20/2011 |
| 8017144 | Controlled release polymeric compositions of bone growth promoting compounds The present invention is directed to an improved system for controlled release of a bone growth promoting compound and to a flowable composition for its formation. The flowable composition is composed of a bone growth promoting compound, a thermoplastic polymer and ... | 09/13/2011 |
| 8017143 | Coating agent for drug releasing stent, preparation method thereof and drug releasing stent coated therewith Disclosed are a coating agent for drug releasing stents, a method for preparing the same and a drug releasing stent coated therewith. The coating agent comprises a biologically active material and a coating material selected from among pullulan acetate, represented ... | 09/13/2011 |
| 8012501 | Flexible bone composite The present invention relates in general to implantable flexible bone composites, and method for preparing the same. The flexible bone composite includes at least one polymeric layer and at least one calcium-containing layer. The polymeric layer can be a polymeric l... | 09/06/2011 |
| 8007823 | Microporous articles comprising biodegradable medical polymers, method of preparation thereof and method of use thereof The present invention relates to a highly controlled method of preparation of a microporous biodegradable polymeric article. Firstly, at least one biodegradable polymer A, one polymer B, biodegradable or not, partially or totally immiscible with A, and a compatibili... | 08/30/2011 |
| 8007822 | Bioabsorbable composition and coatings including same Bioabsorbable compositions of A) blends of bioabsorbable homopolymers and/or copolymers containing glycolide and lactide and B) salts of fatty acids and/or fatty acid esters are described. Processes for making the compositions and surgical articles made totally or i... | 08/30/2011 |
| 7998499 | Calcium-containing bone implants This invention relates to a method for preparing a porous bone implant containing a calcium-based mineral. The method includes immersing a porous matrix in an acidic solution containing a calcium-based mineral; removing the matrix from the solution; and exposing the... | 08/16/2011 |
| 7988987 | Medical devices containing crazed polymeric release regions for drug delivery A medical device that contains (a) at least one polymeric release region that either contains crazing or which is adapted to undergo crazing as a result of stresses (e.g., mechanical, chemical or thermal) that are applied during the implantation or insertion of the ... | 08/02/2011 |
| 7985415 | Medical devices employing novel polymers Medical devices with at least one surface comprising a polymer or polymers on the surface are provided. The polymer or polymers are capable of breaking down (e.g., including, but not limited to, hydrolyzing) in the physiologic milieu to form an active agent or agent... | 07/26/2011 |
