Quotables
"The abolishment of pain in surgery is a chimera. It is absurd to go on seeking it...knife and pain are two words in surgery that must forever be associated in the consciousness of the patient."
Dr. Alfred Velpeau, French surgeon ; 1839
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| Number | Title | Issue Date |
| 8137689 | Transplant/implant device and method for its production A transplant/implant device for delivering at least one predetermined biologically active compound to a human or animal host system or for another biological function in the host system is produced by genetically engineering vital chondrocytes or mixing chondrocytes... | 03/20/2012 |
| 8133501 | Implantable or insertable medical devices for controlled drug delivery Implantable or insertable medical devices are provided, which comprises: (a) a biocompatible polymer; and (b) at least one therapeutic agent selected from an anti-inflammatory agent, an analgesic agent, an anesthetic agent, and an antispasmodic agent. The medical de... | 03/13/2012 |
| 8097269 | Bioactive material delivery systems comprising sol-gel compositions Implantable medical devices employing a sol-gel composition coatings that functions as a bioactive material reservoir, and the use of sol-gel composition coatings for improved adhesion of organic and inorganic substrates are disclosed. ... | 01/17/2012 |
| 8092824 | Antibiotic coating of implants An antibiotic coating of implants is described, which is characterized in that the coating comprises at least one saturated, organic, hydrophobic, low molecular matrix former whose melting point is in the temperature range of 45° C. to 100° C., in which a low mole... | 01/10/2012 |
| 8067027 | Tissue augmentation material and method A material and method for augmenting soft tissue. The tissue augmentation material consists essentially of water and a polysaccharide gel former selected from the group consisting of a cellulose polysaccharide, starch, chitin, chitosan, hyaluronic acid, hydrophobe m... | 11/29/2011 |
| 8067026 | Drug release regions for medical devices, which include polycyclic-structure-containing polymers According to an aspect of the present invention, implantable or insertable medical devices are provided, which contain polymeric release regions that control the release of one or more therapeutic agents. The polymeric release regions, in turn, contain one or more p... | 11/29/2011 |
| 7972617 | Anti-thrombogenic device and method of manufacturing the same One embodiment of an anti-thrombogenic device includes a substrate, an attachment compound including a first end directly, mechanically secured to the substrate a second end positioned opposite the substrate, and an anti-thrombogenic species bonded to the second end... | 07/05/2011 |
| 7964209 | Orienting polymer domains for controlled drug delivery The present invention provides a method for the formation of a medical device that comprises a therapeutic agent and a release region, which regulates the rate at which the therapeutic agent is released from the medical device. The method comprises providing a precu... | 06/21/2011 |
| 7951392 | Microarray drug delivery coatings The present invention relates to microarray polymeric barriers designed to control the release rate of therapeutic agents. By varying the thickness of the coating or affecting, physically and/or chemically, the constituents of the barrier composition, the release pr... | 05/31/2011 |
| 7951393 | Keloid therapy Therapeutic compositions, devices and protocols for the treatment of keloids and other abnormal scars with improved appearance and a much lower recurrence rate. A therapeutic drug delivery device comprises an injectable mixture of a fibroblast inhibitor such as cort... | 05/31/2011 |
| 7939093 | Method and apparatus for representing myocardial tissues in different states of damage The invention relates to a method for differentially representing myocardial tissue in different states of damage, comprising the following steps: administering a myocardium-suitable contrast agent to a patient under examination; entering at least one patient-specif... | 05/10/2011 |
| 7919110 | Medical device drug release regions containing non-covalently bound polymers According to one aspect, implantable or insertable medical devices are provided, which contain polymeric release regions that release one or more therapeutic agents. The polymeric release regions, in turn, contain the following: (i) a first bonding polymer having a ... | 04/05/2011 |
| 7919111 | Biodegradable hydrophobic polysaccharide-based drug delivery implants Medical implants formed of hydrophobic derivatives of natural biodegradable polysaccharides and that include bioactive agent are described. The implants demonstrate desirable bioactive agent release profiles and can be prepared to have high drug loading. The implant... | 04/05/2011 |
| 7914810 | Methods for the in situ treatment of bone cancer The present invention relates to methods for in situ treatment of malignant cells from a cancer associated with bone. In one method, the treatment is for a primary cancer and entails positioning an implant containing and/or coated with at least one active agent for ... | 03/29/2011 |
| 7875285 | Medicated coatings for implantable medical devices having controlled rate of release A coating for a medical device, particularly for a drug eluting stent, is described. The coating can include a polymer having in a dry state a glass transition temperature within a range of between about 20° C. and about 55° C. ... | 01/25/2011 |
| 7695731 | Local vascular delivery of etoposide in combination with rapamycin to prevent restenosis following vascular injury Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of bioc... | 04/13/2010 |
| 7618647 | Using bucky paper as a therapeutic aid in medical applications Methods, systems, and uses of bucky paper are provided in the present invention. These embodiments include covering medical implants with single or multiple layers of bucky paper, treating bucky paper with various therapeutics to be released through the bucky paper ... | 11/17/2009 |
| 7588776 | Pharmaceutical use of water-soluble fraction of A pharmaceutical composition containing a water-soluble fraction of Graptopetalum and its use in treating a liver disease or condition, such as inflammation, steatosis, and fibrosis. ... | 09/15/2009 |
| 7572462 | Peri-operative and peri-procedure nutritional supplementation The invention provides a nutritional supplement system and program for patients undergoing or who have undergone a surgical or other invasive or stressful procedure, or who have suffered an injury. This nutritional supplement for the peri-operative period is designe... | 08/11/2009 |
| 7537781 | Polymer-filler composites for controlled delivery of therapeutic agents from medical articles A medical article comprising: (a) a therapeutic agent; and (b) a release region comprising (i) a polymer and (ii) a filler comprising inorganic platelet particles. Upon placement of such a medical article at a position on or within a patient, the release region regu... | 05/26/2009 |
| 7364859 | Methods of using bioelastomers Bioelastomers are disclosed for use in methods of binding compounds including immunoassay methods, in biosensors and methods or regenerating biosensors, and in methods for targeting the delivery of a compound to a particular location within an animal subjects. In ge... | 04/29/2008 |
| 7358232 | Method for the antibiotic coating of bodies with interconnecting microcavities as well as coated bodies and their usage The invention relates to a method for the antibiotic coating of bodies with interconnecting microcavities as well as bodies coated this way and their usage. The invented method is characterized in that in the microcavities of non-metallic bodies an aqueous solution ... | 04/15/2008 |
| 7342047 | Crosslinkable hydrophilic materials from reactive oligomers having pendent unsaturated groups The present invention provides cross linkable compositions useful in the preparation of hydrophilic gels, and are prepared from obligers having pendent hydrophilic ploy(alkenylene oxide) groups, and pendent pulverizable functional groups, and cross linked by polyfun... | 03/11/2008 |
| 7338706 | Resin composition for capstock A resin composition for capstock, comprising 100 to 30 parts by weight of an impact resistance modifier having a multilayer structure, and 0 to 70 parts by weight of a methyl methacrylate (co)polymer containing 50 to 100% by weight of methyl methacrylate and 50 to 0... | 03/04/2008 |
| 7335185 | Protective coatings for medical devices A dilatation balloon formed of a first material and further including at least one first plasma polymerized layer which forms the top most surface of the balloon, and a method of making the same. ... | 02/26/2008 |
| 7335391 | Method for coating implantable devices A method of forming a coating for an implantable medical device, such as a stent, is provided which includes applying a composition to the device in an environment having a selected pressure. ... | 02/26/2008 |
| 7329789 | Method for extraction and concentration of carotenoids using supercritical fluids Carotenoids are extracted and/or enriched from a mixture containing such compounds. The extraction/enrichment process involves the use of liquefied or supercritical solvents to extract lipids and carotenoids from carotenoid-containing substrates. The extraction proc... | 02/12/2008 |
| 7323425 | Crosslinking of hyaluronan solutions and nanofiberous membranes made therefrom A method for producing a non-chemically crosslinked hyaluronan is provided which involves contacting a sample of hyaluronan with an acidic solvent/water mixture for a period of time and at a temperature sufficient to effect crosslinking, wherein the acidic solvent/w... | 01/29/2008 |
| 7323190 | Cell delivery system comprising a fibrous matrix and cells Cell storage and delivery systems and methods for storing and delivering viable cells to a mammal are disclosed. The cell storage and delivery systems include a biodegradable and/or bioabsorbable fibrous matrix physically associated with viable cells to contain and ... | 01/29/2008 |
| 7318932 | Coatings for drug delivery devices comprising hydrolitically stable adducts of poly(ethylene-co-vinyl alcohol) and methods for fabricating the same A polymer coating for medical devices based on a derivatized poly(ethylene-co-vinyl alcohol) is disclosed. A variety of polymers are described to make coatings for medical devices, particularly, for drug delivery stents. The polymers include poly(ethylene-co-vinyl a... | 01/15/2008 |
| 7318944 | Extrusion process for coating stents The present invention provides a method of coating a stent. A stent framework is provided. A polymeric mixture is injected through at least one inlet port in an extrusion die, and the polymeric mixture is extruded through a shaped orifice onto at least a portion of ... | 01/15/2008 |
| 7314636 | Biodegradable injectable implants containing glycolic acid This invention is directed to the field of medical implants, and more specifically to biodegradable injectable implants and their methods of manufacture and use. The injectable implants disclosed herein comprise glycolic acid and bio-compatible/bio-absorbable polyme... | 01/01/2008 |
| 7311970 | Medical device having surface modification with superoxide dismutase mimic A medical device comprising a substrate having a plasma polymerized functionality bonded to at least a portion of the substrate. A superoxide dismutase mimic agent having a complimentary functional group to the plasma polymerized functionality is bonded to the porti... | 12/25/2007 |
| 7294345 | Otorhinological delivery device The invention relates to an otorhinological delivery device comprising at least one pharmaceutically active agent. According to the invention the device comprises a core comprising said at least one pharmaceutically active agent wherein said core is made of an elast... | 11/13/2007 |
| 7294409 | Medical devices having porous layers and methods for making same Methods for fabricating a medical device having at least one porous layer include providing a medical device having at least one alloy and removing at least one component of the alloy to form the porous layer. Although methods may be used to make stent devices with ... | 11/13/2007 |
| 7291616 | Aryl triazines as LPAAT-β inhibitors and uses thereof The invention relates to aryl triazines and uses thereof, including to inhibit lysophosphatidic acid acyltransferase β (LPAAT-β) activity and/or proliferation of cells such as tumor cells. ... | 11/06/2007 |
| 7288609 | Coatings for drug delivery devices based on poly (orthoesters) A polymer coating for implantable medical devices based on polyorthoesters and methods for fabricating the coating are disclosed. The implantable medical devices made of polyorthoesters and methods for fabricating thereof are also disclosed. ... | 10/30/2007 |
| 7282213 | Method for applying a drug coating to a medical device A method for coating a medical device with a drug is provided. Energy, preferably thermal energy, is applied to a crystalline deposit of a drug on the surface of a medical device to increase the molecular mobility and form a conformable drug coating with a low densi... | 10/16/2007 |
| 7268109 | Method for reducing pain The present invention is direct to a method of producing analgesia in a mammalian subject. The method includes administering to the subject an omega conopeptide, preferably ziconotide, in combination with an analgesic selected from the group consisting of morphine, ... | 09/11/2007 |
| 7265257 | Absorbent articles comprising a bodily exudate modifying agent and a film-forming skin care formulation Absorbent articles having enhanced absorption of bodily exudates are disclosed. The absorbent articles comprise a bodily exudate modifying agent and a skin care formulation. The bodily exudate modifying agent is capable of reducing the viscosity of bodily exudates s... | 09/04/2007 |
