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| Number | Title | Issue Date |
| 8124119 | Coatings for drug delivery devices A polymer coating for medical devices based on a polyolefin derivative. A variety of polymers are described to make coatings for medical devices, particularly, for drug delivery stents. The polymers include homo-, co-, and terpolymers having at least one olefin-deri... | 02/28/2012 |
| 8119152 | Implant material and process for producing the same The present invention provides an implant material comprising an organic-inorganic complex porous article and a production method thereof. The organic-inorganic complex porous article is a biodegradable and bioabsorbable bioactive porous article in which a bioactive... | 02/21/2012 |
| 8105621 | Nonwoven tissue scaffold A biocompatible meniscal repair device is disclosed. The tissue repair device includes a scaffold adapted to be placed in contact with a defect in a meniscus, the scaffold comprising a high-density, dry laid nonwoven polymeric material and a biocompatible foam. The ... | 01/31/2012 |
| 8048851 | Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response This invention provides novel active agents (e.g. peptides, small organic molecules, amino acid pairs, etc.) peptides that ameliorate one or more symptoms of atherosclerosis and/or other pathologies characterized by an inflammatory response. In certain embodiment, t... | 11/01/2011 |
| 7993666 | Methods and compositions for treating pain comprising a statin Methods and compositions are provided for reducing, treating or preventing pain and/or inflammation in a patient in need of such treatment, the methods and compositions comprising administering a therapeutically effective amount of a statin or pharmaceutically accep... | 08/09/2011 |
| 7955615 | Polycationic peptide coatings and methods of coating implantable medical devices Coatings for medical devices which include polycationic peptides such as L-arginine and methods for fabricating the coatings are disclosed. ... | 06/07/2011 |
| 7910124 | Load bearing biocompatible device Implantable biomaterials, particularly hydrogel substrates with porous surfaces, and methods for enhancing the compatibility of biomaterials with living tissue, and for causing physical attachment between biomaterials and living tissues are provided. Also provided a... | 03/22/2011 |
| 7763271 | Polymeric micelle-based local delivery methods and devices Methods using PEG-PE micelles for the local delivery of substantially water insoluble drugs and bioactive agents are disclosed. ... | 07/27/2010 |
| 7618646 | Matrix, cell implant and method for their production and use The invention relates to porous matrices based on a biologically compatible polymer or polymer mixture, to a cell implantation that is established on said matrices and to additional cell implantation based on cell mixtures of hepatocytes and islets of Langerhans. Th... | 11/17/2009 |
| 7585516 | Coatings for drug delivery devices A polymer coating for medical devices based on a polyolefin derivative. A variety of polymers are described to make coatings for medical devices, particularly, for drug delivery stents. The polymers include homo-, co-, and terpolymers having at least one olefin-deri... | 09/08/2009 |
| 7541048 | Coating compositions for bioactive agents A coating composition and related method for use in applying a bioactive agent to a surface in a manner that will permit the bioactive agent to be released from the coating in vivo. The composition is particularly well suited for coating the surface of implantable m... | 06/02/2009 |
| 7510725 | Process for producing a dura substitute The invention relates to dura substitutes to be used as prostheses for dural defects in the field of neurosurgery and processes for producing the same. The present invention provides artificial dura mater materials comprising sheets of microbial-derived polysacchari... | 03/31/2009 |
| 7442384 | Bioresorbable hydrogel compositions for implantable prostheses Crosslinked compositions formed from water-insoluble copolymers are disclosed. These compositions are copolymers having a bioresorbable region, a hydrophilic region and at least two cross-linkable functional groups per polymer chain. Crosslinking of these polymers c... | 10/28/2008 |
| 7422849 | Method for determining expression of a PI3 kinase gene This invention relates to new polypeptides which exhibit kinase activity or, more specifically, which show phosphoinositide (PI) 3-kinase activity. Such polypeptides are involved in pathways responsible for cellular growth and differentiation. An isolated polypeptid... | 09/09/2008 |
| 7374775 | Dura substitute and a process for producing the same The invention relates to dura substitutes to be used as prostheses for dural defects in the field of neurosurgery and processes for producing the same. The present invention provides artificial dura mater materials comprising sheets of microbial-derived polysacchari... | 05/20/2008 |
| 7364592 | Biointerface membrane with macro-and micro-architecture Disclosed herein are biointerface membranes including a macro-architecture and a micro-architecture co-continuous with and bonded to and/or located within at least a portion of the macro-architecture. The macro- and micro-architectures work together to manage and ma... | 04/29/2008 |
| 7364748 | Controlled morphologies in polymer drug for release of drugs from polymer films The present invention includes a drug release system. The drug release system comprises a bulk polymer phase and a polymeric drug-enriched phase within the bulk polymer phase. At least one drug is incorporated into the drug-enriched phase. ... | 04/29/2008 |
| 7356368 | Light-activated anti-infective coatings and devices made thereof An implantable medical device is provided including a vascular access device and a coating on at least one of an inner surface and an outer surface of the vascular access device. The coating includes: (a) a polymeric component including at least one of a light react... | 04/08/2008 |
| 7354702 | Processing tissue to produce a biopolymer scaffold for tissue engineering A method of forming and preserving a bioremodelable, biopolymer scaffold material by subjecting animal tissue, particularly fetal or neo-natal tissue, to chemical and mechanical processing. The process includes, but is not limited to, harvesting the tissue, optional... | 04/08/2008 |
| 7323425 | Crosslinking of hyaluronan solutions and nanofiberous membranes made therefrom A method for producing a non-chemically crosslinked hyaluronan is provided which involves contacting a sample of hyaluronan with an acidic solvent/water mixture for a period of time and at a temperature sufficient to effect crosslinking, wherein the acidic solvent/w... | 01/29/2008 |
| 7320799 | Coatings, coated articles and methods of manufacture thereof A multi-layer coating is particularly useful for the coating of implants such as orthopedic and dental implants, particularly metallic implants. The multi-layer coating has both high bond strength to implants and excellent bioactivity with the surrounding body tissu... | 01/22/2008 |
| 7320798 | Coatings, coated articles and methods of manufacture thereof A multi-layer coating is particularly useful for the coating of implants such as orthopedic and dental implants, particularly metallic implants. The first layer comprises a dense material insoluble and inert in body fluids. The second layer comprises apatite and a b... | 01/22/2008 |
| 7311980 | Polyactive/polylactic acid coatings for an implantable device A polymeric coating for a medical device that comprises poly(lactic acid) and a block copolymer including blocks of poly(ethylene glycol) and poly(butylene terephthalate) is provided. ... | 12/25/2007 |
| 7311970 | Medical device having surface modification with superoxide dismutase mimic A medical device comprising a substrate having a plasma polymerized functionality bonded to at least a portion of the substrate. A superoxide dismutase mimic agent having a complimentary functional group to the plasma polymerized functionality is bonded to the porti... | 12/25/2007 |
| 7303758 | Local vascular delivery of mycophenolic acid in combination with rapamycin to prevent restenosis following vascular injury Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of bioc... | 12/04/2007 |
| 7300662 | Drug/drug delivery systems for the prevention and treatment of vascular disease A drug and drug delivery system may be utilized in the treatment of vascular disease. A local delivery system is coated with rapamycin or other suitable drug, agent or compound and delivered intraluminally for the treatment and prevention of neointimal hyperplasia f... | 11/27/2007 |
| 7294145 | Stent with differently coated inside and outside surfaces A medical device, e.g., a stent, is provided with different coatings on different surfaces, or with a coating on only one of the inside or outside surface. In accordance with certain embodiments, two different stent members are provided, one to fit inside of the oth... | 11/13/2007 |
| 7294345 | Otorhinological delivery device The invention relates to an otorhinological delivery device comprising at least one pharmaceutically active agent. According to the invention the device comprises a core comprising said at least one pharmaceutically active agent wherein said core is made of an elast... | 11/13/2007 |
| 7288084 | Drug-loaded medical device A medical device is designed to be placed in a patient's body and release one or more therapeutic agents therefrom. The medical device includes an elongated member defining a passage for passing bodily fluids therethrough and at least one enclosed internal space for... | 10/30/2007 |
| 7255879 | Post-partum mammalian placenta, its use and placental stem cells therefrom The present invention provides a method of extracting and recovering embryonic-like stem cells, including, but not limited to pluripotent or multipotent stem cells, from an exsanguinated human placenta. A placenta is treated to remove residual umbilical cord blood b... | 08/14/2007 |
| 7252838 | Drug releasing elastic band and method A ligating band according to the present invention comprises an elastomeric layer and an inner drug releasing layer. The inner drug releasing layer includes a therapeutic agent, for example a chemotherapeutic agent for treating a mucosa, polyp or other growth. A lig... | 08/07/2007 |
| 7247364 | Coating for implantable medical devices An implantable medical device, such as a stent, is disclosed having a coating. The coating includes a poly(butylene terephthalate-co-ethylene glycol)polymer. The coating can also include a drug. ... | 07/24/2007 |
| 7241457 | Osmotically driven active agent delivery device providing an ascending release profile In one aspect, the present invention is directed to an osmotic pump that automatically provides an ascending release rate of active agent as the osmotic pump functions in an environment of operation and may be designed for implantation within a desired animal or hum... | 07/10/2007 |
| 7238478 | Compositions and methods for protein isolation The invention provides for polynucleotides and vectors comprising at least two tag sequences. The invention also provides for polynucleotides and vectors comprising a streptavidin binding peptide sequence and a calmodulin binding peptide sequence. The invention also... | 07/03/2007 |
| 7235362 | Compositions and methods for protein isolation The invention provides for polynucleotides and vectors comprising at least two tag sequences. In particular, preferred vectors are viral vectors. The invention also provides for polynucleotides and vectors comprising a streptavidin binding peptide sequence and a cal... | 06/26/2007 |
| 7235257 | Drugs for relieving hemicrania comprising 1-menthol and essential oils This invention relates to external drugs for dermal application which have a migraine-alleviating effect, in more detail ointments and patches comprising in mixing l-menthol and an essential oil into a base containing a hydrophilic high-molecular weight compound, a ... | 06/26/2007 |
| 7229473 | Local delivery of rapamycin for treatment of proliferative sequelae associated with PTCA procedures, including delivery using a modified stent Methods of preparing intravascular stents with a polymeric coating containing macrocyclic lactone (such as rapamycin or its analogs), stents and stent graphs with such coatings, and methods of treating a coronary artery with such devices. The macrocyclic lactone-bas... | 06/12/2007 |
| 7226978 | Techniques to improve polyurethane membranes for implantable glucose sensors The invention provides an implantable membrane for regulating the transport of analytes therethrough that includes a matrix including a first polymer; and a second polymer dispersed throughout the matrix, wherein the second polymer forms a network of microdomains wh... | 06/05/2007 |
| 7226589 | Treatment of diseases by site specific instillation of cells or site specific transformation of cells and kits therefor A method for the direct treatment towards the specific sites of a disease is disclosed. This method is based on the delivery of proteins by catheterization to discrete blood vessel segments using genetically modified or normal cells or other vector systems. Endothel... | 06/05/2007 |
| 7223286 | Local delivery of rapamycin for treatment of proliferative sequelae associated with PTCA procedures, including delivery using a modified stent Methods of preparing intravascular stents with a polymeric coating containing macrocyclic lactone (such as rapamycin or its analogs), stents and stent graphs with such coatings, and methods of treating a coronary artery with such devices. The macrocyclic lactone-bas... | 05/29/2007 |
