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| Number | Title | Issue Date |
| 7897159 | Parapoxviruses in combination with classical cytotoxic chemotherapeutic agents as biochemotherapy for the treatment of cancer The invention relates to a method for the production of a pharmaceutical composition for treating cancer by combining Parapoxvirus ovis with at least one anticancer agent. The invention furthermore relates to a method for treating a patient afflicted with can... | 03/01/2011 |
| 7862829 | Viral adjuvants The present invention provides viral adjuvants for enhancing an immune response to an immunogen. In particular embodiments, the viral adjuvant is an alphavirus adjuvant or a Venezuelan Equine Encephalitis viral adjuvant. Also provided are compositions comprising the... | 01/04/2011 |
| 7335364 | Modified Vaccinia Ankara virus variant The present invention provides an attenuated virus, which is derived from Modified Vaccinia Ankara virus and characterized by the loss of its capability to reproductively replicate in human cell lines. It further describes recombinant viruses derived from this virus... | 02/26/2008 |
| 7320793 | Molecular antigen array The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array. The invention also provides a process for produc... | 01/22/2008 |
| 7264810 | Molecular antigen array The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array. The invention also provides a process for produc... | 09/04/2007 |
| 7157089 | Immune responses using compositions containing stress proteins The present invention relates to a vaccine for inducing an immune response to an antigen in a vertebrate (e.g., mammal) comprising an antigen and all or a portion of a stress protein or all or a portion of a protein having an amino acid sequence sufficiently homolog... | 01/02/2007 |
| 7122192 | Porcine circoviruses, vaccines and diagnostic reagents The invention relates to new porcine circovirus strains isolated from pulmonary or ganglionic samples obtained from farms affected by the post-weaning multisystemic wasting syndrome (PMWS). It relates to purified preparations of these strains, conventional attenuate... | 10/17/2006 |
| 7118755 | Herpes viruses for immune modulation An attenuated herpes virus which lacks a functional vhs gene or a functional equivalent thereof, but which has a functional UL43 gene or functional equivalent thereof, stimulates an immune response when dendritic cells are infected with the virus. ... | 10/10/2006 |
| 7090853 | Noscapine derivatives as adjuvant compositions and methods of use thereof An adjuvant composition comprising noscapine and its derivatives, for use in the treatment of tumors, cancer, as an adjuvant for vaccines. ... | 08/15/2006 |
| 7056689 | Methods of treating and detecting cancer using viruses The invention provides a method of treating cancer in a mammal comprising administering to the mammal an effective amount of virus, particularly Newcastle Disease Virus or other Paramyxovirus. The invention also provides a method of treating cancer in a mammal compr... | 06/06/2006 |
| 7030094 | Immunostimulant compositions comprising an aminoalkyl glucosaminide phosphate and QS-21 The invention provides pharmaceutical compositions, particularly vaccine compositions, employing an adjuvant system comprising RC-529 (an aminoalkyl glucosaminide phosphate compound) and QS-21 (a saponin). Such compositions synergistically enhance the immune respons... | 04/18/2006 |
| 6964769 | Molecular antigen array The invention provides compositions and processes for the production of ordered and repetitive antigen or antigenic determinant arrays. The compositions of the invention are useful for the production of vaccines for the prevention of infectious diseases, the treatme... | 11/15/2005 |
| 6913752 | Modified Vaccinia Ankara virus variant The present invention provides an attenuated virus, which is derived from Modified Vaccinia Ankara virus and characterized by the loss of its capability to reproductively replicate in human cell lines. It further describes recombinant viruses derived from this virus... | 07/05/2005 |
| 6844000 | Use of Parapox B2L protein to treat cancer and modify immune responses A purified Parapoxvirus ovis envelope protein termed “B2L” can be used as a monotherapeutic agent. B2L protein also can be used in screening methods to identify potential therapeutic agents for modulating a subject's immune response to the B2L protein. | 01/18/2005 |
| 6805870 | Paramunity inducer based on combinations of poxvirus components, process to prepare it and its use as medicament Multipotent paramunity inducers are described which are based on combinations of poxvirus components derived from various poxviruses with paramunizing properties and which have been improved in terms of their potency and their paramunization-related activities as co... | 10/19/2004 |
| 6756044 | Antigenic complexes and methods The present invention provides a complex that includes a virion having a ligand that recognizes an epitope present on an immune effector cell surface and at least a first nucleic acid encoding a first non-native antigen. The invention also provides a library includi... | 06/29/2004 |
| 6685950 | Methods of treating viral infections The present invention relates to the use of strains of Parapoxvirus ovis as immunotherapeutic agents for immunodeficiencies of an infectious or non-infectious nature, and to the use of strains of Parapoxvirus ovis for treating tumor diseases and viral inf... | 02/03/2004 |
| 6682743 | Altered strain of the modified vaccinia virus ankara (MVA) The invention provides new strains of the Modified Vaccinia Virus Ankara (MVA) that have a strongly reduced virulence for most mammals, especially humans, but nevertheless grows in cells of a continuous cell line approved for the production of a therapeut... | 01/27/2004 |
| 6667295 | DNA vaccine against feline immunodeficiency virus The present invention is directed to vaccine compositions that can be used to protect cats against feline immunodeficiency virus. More particularly, the present invention relates to polynucleotide molecules that can be used as vaccine components against f... | 12/23/2003 |
| 6660272 | Porcine circoviruses, vaccines and diagnostic reagents The invention relates to new porcine circovirus strains isolated from pulmonary or ganglionic samples obtained from farms affected by the post-weaning multisystemic wasting syndrome (PMWS). It relates to purified preparations of these strains, conventiona... | 12/09/2003 |
| 6632647 | Use of strains of parapoxvirus ovis against organ fibrosis The present invention relates to the use, in humans, of inactivated parapoxviruses for the prophylaxis and treatment of diseases which are accompanied by an increased deposition of collagen, with it being possible for both internal organs, such as the liv... | 10/14/2003 |
| 6534067 | Rotavirus enterotoxin adjuvant This invention relates to a method of potentiating an immune response by administering a viral enterotoxin or derivative as an adjuvant. More particularly it relates to administering a viral enterotoxin or derivative as an adjuvant and an antigen to a muc... | 03/18/2003 |
| 6506385 | Live vaccines and methods of treatment therewith Disclosed herein are methods and pharmaceutical formulations for administering vaccines to birds. In preferred embodiments, the invention provides methods of administering live pathogenic virus vaccines to birds in ovo, more preferably, during the last qu... | 01/14/2003 |
| 6379679 | Multiple branch peptide construction Multiple branch peptide constructions formed from peptides derived from the envelope transmembrane glycoprotein gp41 of HIV, and including the consensus sequence RQGY preceded by 0 to 4 amino acid residues and succeeded by 2 to 4 amino acid residues, most... | 04/30/2002 |
| 6372221 | Immunogenic constructs comprising flaviviruses or flavivirus derivatives The invention concerns an immunogenic construct comprising as components (i) an inactive flavivirus or a derivative thereof, and (ii) at least one immunogenic component which is bonded to the flavivirus or adsorbed therewith. The invention further concern... | 04/16/2002 |
| 6190666 | DNA expression systems based on alphaviruses The disclosure describes recombinant alphavirus RNA molecules and expression of heterologous proteins therefrom in animal cells. Recombinant alphaviruses of the present invention, when made to express an antigenic protein, can be administered as vaccines.... | 02/20/2001 |
| 6162600 | Indications for the use as medicaments of multipotent parapox immunity inducers from attenuated, non-immunogenic pox viruses or parapox viruses The use is disclosed of multipotent parapox immunity inducers from attenuated, non-immunogenic pox or parapox viruses (pox inducers) to produce medicaments with new indication ranges in human medicine.... | 12/19/2000 |
| 6048530 | Stress protein-peptide complexes as prophylactic and therapeutic vaccines against intracellular pathogens Disclosed is a family of vaccines that contain stress protein-peptide complexes which when administered to a mammal are operative to initiate in the mammal a cytotoxic T cell response against cells infected with a preselected intracellular pathogen. Also ... | 04/11/2000 |
| 6045802 | Enhanced immune response to an antigen by a composition of a recombinant virus expressing the antigen with a recombinant virus expressing an immunostimulatory molecule The present invention is a composition of recombinant virus which has incorporated into its genome or portion thereof a gene encoding an antigen to a disease causing agent and a recombinant virus which has incorporated into its genome or portion thereof a... | 04/04/2000 |
| 5879685 | Immunostimulating and immunopotentiating reconstituted influenza virosomes and vaccines containing them Immunostimulating reconstituted influenza virosomes (IRIVs) are provided wherein an antigen or a combination of antigens are incorporated into a virosome further containing a mixture of phospholipids, an essentially reconstituted functional virus envelope... | 03/09/1999 |
| 5718904 | Adjuvants for viral vaccines The present invention discloses mammalian vaccine compositions having an effective amount of an adjuvant, the adjuvant comprising squalene or squlane, glycerol and a surfactant. These compositions also optionally contain an aluminum salt and one or more p... | 02/17/1998 |
| 5674495 | Alginate-based vaccine compositions A vaccine composition including an antigen dispersed in an alginate gel is described. The alginate gel is preferably in the form of discrete particles coated with a polymer. Vaccination of vertebrate species can be accomplished by administering the algina... | 10/07/1997 |
| 5565203 | Hepatitis A virus in a reconstituted influenza virosome and use as a vaccine Disclosed are immunostimulating reconstituted influenza virosomes (IRIVs) comprising reconstituted functional virus envelopes containing an inactivated hepatitis A virus and an influenza hemagglutinin protein (HA) or a peptide with the amino terminal 21 a... | 10/15/1996 |
| 5503833 | VP6 encapsulated drug delivery Compositions and methods for preparing and delivering encapsulated biologically active agents to specific cell types are disclosed. Substances can be encapsulated in the VP6 inner capsid protein of rotavirus and delivered to selected cells, tissues and or... | 04/02/1996 |
| 5273745 | Virus-modified tumor vaccines for immunotherapy of tumor metastases The invention discloses a virus-modified tumour-specific vaccine consisting of corresponding separated tumour cells inactivated by irradiation and incubated with NDV (Newcastle Disease Virus) under sterile conditions in serum-free medium. The vaccine may ... | 12/28/1993 |
| 5215745 | Method for treating viral diseases with attenuated virus A method for treating human disease of viral etiology which employs the administration of a pharmaceutically effective amount of a live attenuated virus. Avian paramyxovirus is the virus preferred for use in live attenuated vaccine form, although other vi... | 06/01/1993 |
| 5124148 | Method for treating viral diseases with attenuated virus A method for treating human disease of viral etiology which employs the administration of a pharmaceutically effective amount of a live attenuated virus. Avian paramyxovirus is the virus preferred for use in live attenuated vaccine form, although other vi... | 06/23/1992 |
| 4883662 | Method of increasing natural killer cell population of cancer patients An in vivo method is described for increasing the population of Natural Killer (NK) cells in the blood of patients suffering from cancer, such NK cells having known activity against tumor cells. The method broadly involves injecting a specially prepared b... | 11/28/1989 |
| 4315914 | Pharmaceutical compositions useful as cellular immunopotentiator and antitumor agent and process for production thereof Compositions comprising an attenuated strain of vaccinia virus as active ingredient are found to be useful as cellular immunopotentiator and antitumor agent. The attenuated strain of vaccinia virus is obtained by serial passages of vaccinia virus in cell ... | 02/16/1982 |
| 4053582 | Attenuated fowl pox virus preparation for the treatment of infectious diseases, method for the manufacture thereof, and its use Preparation for the treatment of interferon-sensitive infectious diseases for use in human and veterinary medicine, characterized by the fact that it contains as active principle a fowl pox virus which has been attenuated by 420 to 800 cell culture passag... | 10/11/1977 |
