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| Number | Title | Issue Date |
| 8084045 | Pharmaceutical formulations for the prolonged release of active principle(s) and their applications The present invention relates to novel pharmaceutical formulations based on stable, fluid aqueous colloidal suspensions for the prolonged release of active principle(s), particularly protein active principle(s), and to the applications, especially therapeutic applic... | 12/27/2011 |
| 8003115 | Chimeric immunomodulatory compounds and methods of using the same The invention provides immunomodulatory compounds and methods for immunomodulation of individuals using the immunomodulatory compounds. ... | 08/23/2011 |
| 7785612 | Polyamino acid for use as adjuvant Use of a polyamino acid as an adjuvant; an application of a polyamino acid as an adjuvant in the production of a vaccine; a vaccine comprising a polyamino acid as an adjuvant; a biodegradable nanoparticle having a virus antigen immobilized thereon; and a vaccine com... | 08/31/2010 |
| 7588774 | Molecules enhancing dermal delivery of influenza vaccines The present invention relates to dermal vaccine formulations, designed for targeted delivery of an immunogenic composition to a dermal compartment of skin including the intradermal and epidermal compartments. The dermal vaccine formulations of the invention comprise... | 09/15/2009 |
| 7425332 | Treatment of autoimmune conditions with Copolymer 1 and related Copolymers The present invention is directed to polypeptides containing at least three amino acids randomly joined in a linear array; wherein at least one of the three amino acids is an aromatic amino acid, at least one of the three amino acids is a charged amino acid and at l... | 09/16/2008 |
| 7393541 | Mycobacterial vaccine Compositions and methods for enhancing the immunity of a subject or vaccinating a subject against mycobacterial infections are disclosed. The invention provides compositions comprising formalin inactivated cultures of a mycobacterium, such as M. bovis, and a ... | 07/01/2008 |
| 7367948 | Acoustic monitoring method and system in laser-induced optical breakdown (LIOB) An acoustic monitoring method and system in laser-induced optical breakdown (LIOB) provides information which characterize material which is broken down, microbubbles in the material, and/or the microenvironment of the microbubbles. In one embodiment of the inventio... | 05/06/2008 |
| 7368119 | Compositions and methods for WT1 specific immunotherapy Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an antigen-presenting cell presenting a WT1 polypeptide, an antibody that sp... | 05/06/2008 |
| 7323167 | Method of treatment with modified arginine deiminase The present invention is directed to arginine deiminase modified with polyethylene glycol, to methods of treating cancer, and to methods of treating and/or inhibiting metastasis. ... | 01/29/2008 |
| 7285282 | Mucin peptide with immunoenhancing properties An isolated peptide or polypeptide containing the sequence VSIGLSFPMLP (SEQ ID NO:1), found in the secreted form of human MUC1, that enhances an immune response when administered to a mammal, compositions containing the peptide, host cells producing the peptide and ... | 10/23/2007 |
| 7279172 | Treatment of autoimmune conditions with copolymer 1 and related copolymers The present invention provides heteropolymer compositions and peptide compositions, and methods of making and using therapeutic compositions comprising amino acid heteropolymers for treatment of a subject for an autoimmune or an inflammatory disease, the heteropolym... | 10/09/2007 |
| 7270808 | Cyclodextrin-based polymers for therapeutics delivery The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug... | 09/18/2007 |
| 7267963 | Modified plant viruses and methods of use thereof The present invention relates to modulating the nature and/or level of an immune response to a molecule. In particular, the invention relates to effecting an increase in the TH1 immune response to molecules such as, but not limited to, antigens or immunogens. The in... | 09/11/2007 |
| 7255868 | Chimeric immunomodulatory compounds and methods of using the same—I The invention provides immunomodulatory compounds and methods for immunomodulation of individuals using the immunomodulatory compounds. ... | 08/14/2007 |
| 7244438 | Uses for polycationic compounds The invention relates to the use of a polycationic compound for the preparation of a medicament with retarded in vivo release. ... | 07/17/2007 |
| 7220717 | Interleukin-18 binding proteins, their preparation and use Interleukin-18 binding proteins which are capable of binding IL-18 and of modulating and/or blocking IL-18 activity are provided. Methods for the isolation and recombinant production, DNAs encoding them. DNA vectors expressing them, vectors useful for their expressi... | 05/22/2007 |
| 7217781 | Polyphosphazenes including ionic or ionizable moieties and fluorine-containing moieties A polyphosphate polymer which includes both (i) ionic or ionizable moieties; and (ii) fluorine-containing moieties. Such polymers may be used as matrices for pharmaceuticals, as multilayer coatings for fuel cell membranes, as dopant for electrically conductive polym... | 05/15/2007 |
| 7176296 | Modulation of oligonucleotide CpG-mediated immune stimulation by positional modification of nucleosides The invention provides compounds having increased or reduced immunostimulatory effect, said compounds comprising a CpG dinucleotide and an immunomodulatory moiety wherein the increased or reduced immunomodulatory effect is relative to a similar compound lacking the ... | 02/13/2007 |
| 7166302 | Complexing agents for compositions containing inclusion complexes The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the complexing agent in a host-guest or a guest-host interaction to form an inclu... | 01/23/2007 |
| 7144580 | outer membrane protein P1pE as a vaccine or vaccine component against shipping fever Vaccines and methods against M. haemolytica infections in cattle. The vaccine compositions include a recombinant outer membrane protein of M. haemolytica designated PlpE and/or subunits thereof, alone or in combination with other antigenic components, ... | 12/05/2006 |
| 7141246 | Lubricious coating A lubricant coating vehicle for medical devices used to reduce the coefficient of friction of such devices upon exposure thereof to moisture. The lubricant coating vehicle allows the introduction of a pharmacological additive having a release rate that is within acc... | 11/28/2006 |
| 7115579 | Modulation of oligonucleotide CpG-mediated immune stimulation by positional modification of nucleosides The invention provides methods for modulating the immune response caused by CpG dinucleotide-containing compounds. The methods according to the invention enables both decreasing the immunostimulatory effect for antisense applications, as well as increasing the immun... | 10/03/2006 |
| 7105495 | Modulation of oligonucleotide CpG-mediated immune stimulation by positional modification of nucleosides The invention provides methods for modulating the immune response caused by CpG dinucleotide-containing compounds. The methods according to the invention enables both decreasing the immunostimulatory effect for antisense applications, as well as increasing the immun... | 09/12/2006 |
| 7105162 | Pharmaceutical composition for immunomodulation based on peptides and adjuvants Pharmaceutical composition containing at least one peptide or protein (fragment) with an immunomodulatory activity together with an adjuvant. The peptide is derived from a pathogenic agent or a tumour antigen. The adjuvant is capable of increasing the binding of the... | 09/12/2006 |
| 7087236 | Method for inducing a cell-mediated immune response and improved parenteral vaccine formulations thereof A method of inducing either a TH1 polarized immune response, a TH2 polarized immune response or a combined TH1 and TH2 response to an antigen and associated vaccine formulations are disclosed. A method is provided for indu... | 08/08/2006 |
| 7081495 | Cationic compounds and their use as macro molecular carriers Dendrimers comprising a dentritic polypeptide with one dendron having terminal cationic groups and a lipidic anchor, preferably comprising C6-24-alkyl group containing α-amino acyl groups, preferably joined to the focal group, are used to assist transfec... | 07/25/2006 |
| 7074256 | Phosphazene membranes for gas separations A polyphosphazene having a glass transition temperature (“Tg”) of approximately −20° C. or less. The polyphosphazene has at least one pendant group attached to a backbone of the polyphosphazene, wherein the pendant group has no halogen atoms. In ad... | 07/11/2006 |
| 7045576 | Adjuvants and copolymer compositions The present invention comprises novel polyoxyethylene/polyoxypropylene block copolymers compositions and compounds. The compositions comprise block copolymers that are useful in gene therapy methods. ... | 05/16/2006 |
| 7029755 | Silane copolymer compositions containing active agents The invention is drawn to silane copolymers prepared from the reaction of one or more polyisocyanates with one or more lubricious polymers having at least two functional groups, which may be the same or different, that are reactive with an isocyanate functional grou... | 04/18/2006 |
| 7014856 | Ganglioside-KLH conjugate vaccines plus OS-21 This invention provides a vaccine for stimulating or enhancing in a subject to which the vaccine is administered, production of an antibody which recognizes a ganglioside, comprising an amount of ganglioside or oligosaccharide portion thereof conjugated to an immuno... | 03/21/2006 |
| 7001601 | Ganglioside-KLH conjugate vaccine plus QS-21 This invention provides a vaccine for stimulating or enhancing in a subject to which the vaccine is administered, production of an antibody which recognizes a ganglioside, comprising an amount of ganglioside or oligosaccharide portion thereof conjugated to an immuno... | 02/21/2006 |
| 6933286 | Therapeutic delivery compositions and methods of use thereof The present invention relates to compositions and methods for treating infectious diseases and genetic disorders through gene therapy and intracellular delivery of antisense oligonucleotides or other nucleic acid sequences. In particular, compositions and methods us... | 08/23/2005 |
| 6921531 | Administering bifunctional molecules containing a drug moiety and presenter protein ligand for therapy Bifunctional molecules and methods for their use in the production of binary or tripartite complexes in a host are provided. The bifunctional molecule is a conjugate of a drug moiety and a presenter protein ligand. The molecular weight of the bifunctional molecule i... | 07/26/2005 |
| 6870012 | Chain-extended peo/ppo/peo block copolymer, optionally with polyester blocks, combined with cellular or bioactive material A composition exhibiting reverse thermal gellation properties comprises a block polymer having the structure: {[An(BCB)An]}m wherein A is a polyester unit, B is a poly(ethylene oxide) unit, C is a poly(propylene o... | 03/22/2005 |
| 6844001 | Adjuvants and copolymer compositions The present invention comprises novel polyoxyethylene/polyoxypropylene block copolymer compositions and compounds. The compositions comprise block copolymers that are high molecular weight molecules, and are useful in gene therapy methods. ... | 01/18/2005 |
| 6803041 | Equine herpesvirus vaccine A vaccine for protecting a horse against diseases associated with EHV-1 and/or EHV-4 is provided. The vaccine commonly includes inactivated EHV-1 (e.g., chemically inactivated EHV-1 KyA virus) and an adjuvant. The adjuvant can include a cross-linked olefinically uns... | 10/12/2004 |
| 6656459 | Compositions of non-ionic block copolymers to treat autoimmune and inflammatory diseases, and to reduce graft/implantation, and methods of use thereof Compositions comprising non-ionic block copolymers are useful for the treatment of autoimmune, inflammatory and proliferative diseases and for reducing graft/implantation rejection. The present invention also relates to methods of treating animals having ... | 12/02/2003 |
| 6649170 | Adjuvant combinations for immunization composition and vaccines A kit useful for immunization is described. The kit contains an antigenic substance from a Mycobacterium and an adjuvant combination of dimethyl dioctadecyl ammonium bromide and monophosphoryl lipid A.... | 11/18/2003 |
| 6610310 | Polyanionic polymers as adjuvants for mucosal immunization Mucosal adjuvants for vaccines contain water-soluble polyanionic polymers which have anionic constitutional units obtained from acids such as acrylic acid, methacrylic acid, maleic acid, fumaric acid, ethylsulphonic acid, vinylsulphuric acid, vinylsulphon... | 08/26/2003 |
| 6596401 | Silane copolymer compositions containing active agents The invention is drawn to silane copolymers prepared from the reaction of one or more polyisocyanates with one or more lubricious polymers having at least two functional groups, which may be the same or different, that are reactive with an isocyanate func... | 07/22/2003 |
