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| Number | Title | Issue Date |
| 7867503 | Chimeric recombinant antigens of A method for treatment or prevention of Toxoplasma gondii infections pharmaceutical composition comprising an antigen fragments of Toxoplasma gondii in the form of a chimeric fusion product or a nucleotide sequence coding for the chimeric fusion produc... | 01/11/2011 |
| 7803389 | mutant with enhanced homologous recombination and uses thereof The present invention relates to a mutant Toxoplasma gondii which exhibits enhanced homologous recombination. The mutant of the present invention is a knockout in the KU80-dependent nonhomologous end-joining pathway which finds application in generating T.... | 09/28/2010 |
| 7790187 | Chimeric recombinant antigens of The invention described herein relates to a method for combining antigen fragments of Toxoplasma gondii proteins, in the form of chimeric fusion products, and their use as diagnostic and immunogenic agents. ... | 09/07/2010 |
| 7279162 | Isolated broadly reactive opsonic immunoglobulin for treating a pathogenic coagulase-negative staphylococcus infection The invention describes the identification, making, and isolation of immunoglobulin and antigen useful for preventing, diagnosing, and treating staphylococcal infections. The invention further describes an in vivo animal model useful for testing the efficacy of phar... | 10/09/2007 |
| 7276232 | Formulation of microorganisms for use in bait gels for rodent control The present invention relates to compositions containing different stages of pathogenic protozoans in a gel and to their use for controlling rodents. ... | 10/02/2007 |
| 7176286 | Antigen fragments for the diagnosis of The invention described herein relates to a method for identifying antigen fragments of Toxoplasma gondii proteins, and their use as diagnostic and immunogenic agents. Said method is implemented by means of selection of DNA fragments libraries of the parasite... | 02/13/2007 |
| 7067315 | Identification of anti-protozoal agents The present invention provides novel assay systems and methods for monitoring cell invasion by protozoal parasites. The present invention further provides methods of using these assays systems to identify compounds that treat or prevent protozoal infection. The pres... | 06/27/2006 |
| 7029678 | Vaccines The present invention provides vaccine compositions comprising an oil-in-water emulsion optionally with 3 De-O-acylated monophosphoryl lipid A and QS21. The vaccine compositions are potent induces of a range of immune responses. ... | 04/18/2006 |
| 6998126 | Selection of poultry strains through extra-intestinal sporozoites A method for obtaining an immunogenic strain useful for producing a vaccine against Coccidiosis comprises the cycle of infecting at least one first group of specific pathogen-free donor birds with oocysts from an Eimeria species. Blood is then collected from ... | 02/14/2006 |
| 6902926 | Toxoplasma gondii apical membrane antigen-1 The invention provides polypeptide fragments derived from TgAMA-1, nucleic acids that encode the polypeptide fragments, and TgAMA-binding polypeptides such as antibodies. Methods for using the polypeptide and nucleic acid molecules to produce vaccines are also provi... | 06/07/2005 |
| 6780415 | Animal model for infection by an apicomplexan parasite An animal model for CNS infection by Apicomplexan parasites was produced by inoculating a homologous cell or other type of cell with the merozoite stage of the Apicomplexan parasite and inoculating the infected homologous cell or a cell line prepared therefrom back ... | 08/24/2004 |
| 6656479 | Attenuated live neospora vaccine The present invention provides attenuated live cultures of the pathogenic protozoan parasite, Neospora, and live vaccines against neosporosis prepared therefrom which are useful in the prevention of clinical disease and abortion in mammals.... | 12/02/2003 |
| 6623739 | Vaccines The present invention provides vaccine compositions comprising an oil-in-water emulsion optionally with 3 De-O-acylated monophosphoryl lipid A and QS21. The vaccine compositions are potent inducers of a range of immune responses.... | 09/23/2003 |
| 6436410 | DNA encoding neospora dihydrofolate reductase-thymidylate synthase The present invention provides isolated polynucleotide molecules comprising a nucleotide sequence encoding the DHFR-TS protein of Neospora which polynucleotide molecules are useful in preparing modified live vaccines against neosporosis, and as diagnostic... | 08/20/2002 |
| 6420540 | Toxoplasma gondii antigens The present invention relates to peptides immunoreactive with antibodies to Toxoplasma gondii, nucleic acid sequences encoding these peptides, recombinant vector molecules, comprising these nucleic acid sequences, host cells transformed with the recombina... | 07/16/2002 |
| 6399077 | Method of augmenting T cell-mediated immunity against Toxoplasma gondii A method of augmenting T cell-mediated immunity against Toxoplasma gondii is provided. Immunization with Toxoplasma gondii soluble parasite antigen and exogenous rIL-15 was found to protect against Toxoplasma gondii infection.... | 06/04/2002 |
| 6392014 | Cloning of gene encoding the GP28.5 protein of Toxoplasma gondii; peptide fragments of said protein and their applications The invention relates to cloning of the gene for the toxoplasma GP28.5 antigen. It also encompasses purified GP28.5 antigen preparations and antigenic polypeptides derived from said antigen, and their applications.... | 05/21/2002 |
| 6387378 | Device for storage and mucosal delivery of biological or pharmaceutical materials to animals Disclosed herein is a device for storing and/or delivering an effective amount of biological or pharmaceutical material to an animal comprising a tube disposed to contain said biological or pharmaceutical material and sealed at its ends and adapted to pro... | 05/14/2002 |
| 6372897 | Mimotopic polypeptides of toxoplasma gondii and applications The invention relates to a polypeptide capable of reacting specifically with an anti-Toxoplasma gondii P30 protein antibody, and comprising a peptide sequence, in which any succession of 6 contiguous amino acids exhibits at most 67 % homology with the pep... | 04/16/2002 |
| 6326008 | Toxoplasma gondii antigens, the preparation thereof and the use thereof The present invention relates to the identification of toxoplasma gondii antigens and the preparation thereof by genetic engineering. A cDNA expression gene bank of this parasite was prepared. Recombinant clones which are of diagnostic interest were ident... | 12/04/2001 |
| 6146632 | Vaccines The present invention provides vaccine compositions comprising an oil-in-water emulsion optionally with 3 De-O-acylated monophosphoryl lipid A and QS21. The vaccines compositions are potent inducers of a range of immune responses.... | 11/14/2000 |
| 6022546 | Toxoplasma gondii antigens, the preparation thereof and the use thereof The present invention relates to the identification of Toxoplasma gondii antigens and the preparation thereof by genetic engineering. A cDNA expression gene bank of this parasite was prepared. Recombinant clones which are of diagnostic interest were ident... | 02/08/2000 |
| 5976553 | Transfection and genetic manipulations in obligate intracellular parasites A method of transient transfection of obligate intracellular parasites is described. This method is exploited to develop a system for stable transformation utilizing selectable genes. For example, introduction of the chloramphenicol acetyl transferase (CA... | 11/02/1999 |
| 5935583 | Intestinal protozoal vaccines The invention provides vaccines and methods for preventing or treating intestinal protozoal infections in an animal. In particular, vaccines and methods for prevention or treatment of giardiasis are provided. The invention also encompasses methods of prep... | 08/10/1999 |
| 5851535 | Mimotopic polypeptides of Toxoplasma gondii and applications The invention relates to a polypeptide capable of reacting specifically with an anti-Toxoplasma gondii P30 protein antibody, and comprising a peptide sequence, in which any succession of 6 contiguous amino acids exhibits at most 67% homology with the pept... | 12/22/1998 |
| 5824788 | Cloning of gene encoding the GP28.5 protein of toxoplasma gondii; peptide fragments of said protein and their applications The invention relates to cloning of the gene for the toxoplasma GP28.5 anen. It also encompasses purified GP28.5 antigen preparations and antigenic polypeptides derived from said antigen, and their applications.... | 10/20/1998 |
| 5554506 | Isolated, MAGE-3 derived peptides which complex with HLA-A2 molecules and uses thereof Tumor rejection antigens derived from tumor rejection precursor MAGE-3 have been identified. These "TRAS" bind to the MHC-class I molecule HLA-A2, and the resulting complexes stimulate the production of cytolytic T cell clones which lyse the presenting ce... | 09/10/1996 |
| 5045313 | Vaccine for immunizing cats against toxoplasma oocyst shedding A new mutant strain vaccine, and a corresponding method of immunization, against Toxoplasma in cats is provided which makes use of a reproductively deficient strain of T.gondii, designated T-263. Bradyzoites in tissue cysts from laboratory animals infecte... | 09/03/1991 |
| 5015476 | Immunization implant and method Antigenic parasites are encapsulated in semipermeable polymeric envelope membranes to prepare implant capsules for immunizing an animal against parasitic infection. An animal may be immunized against parasitic infection by implanting into the animal the i... | 05/14/1991 |
| 4824666 | Method of large scale growth of toxoplasmic microorganisms A method of producing large scale growth of parasites of the genus Toxoplasma is disclosed which comprises inoculating the microorganisms into a non-adherent human cell line, such as a monocytoid lymphoma cell line, and maintaining the cell line in tissue... | 04/25/1989 |
| 4744983 | Immunogenic protein or peptide complex, method of producing said complex and the use thereof as an immune stimulant and as a vaccine The invention relates to an immunogenic complex containing antigenic membrane proteins or peptides from viruses mycoplasmas, bacteria, parasites or animal cells or prepared synthetically or with hybride DNA technique and glycoside. The invention also rela... | 05/17/1988 |
| 4621054 | Biologically active substance, process for preparing the substance and immunoactive composition This invention relates to a biologically active substance which is a glycoprotein having a molecular weight of 3,000 to 5,000 and has activity to inhibit toxoplasma multiplication in homologous cells and heterologous cells. This invention also relates to ... | 11/04/1986 |
| 4578269 | Immunogenic protein or peptide complex, method or producing said complex and the use thereof as an immune stimulant and as a vaccine The invention relates to an immunogenic complex containing antigenic membrane proteins or peptides from viruses mycoplasmas, bacteria, parasites or animal cells or prepared synthetically or with hybride DNA technique and glycoside. The invention also rela... | 03/25/1986 |
| 4564592 | Toxoplasmosis factor and production of same A vaccine for the prevention of congenital Toxoplasmosis and methods for its production.... | 01/14/1986 |
| 4473549 | Method for the immunization of animals and men against Toxoplasma gondii _ A method for the immunization of mammals (including man) and birds, against Toxoplasma gondii is described which involves subcutaneous administration of a live, low-virulent vaccine comprising a temperature-sensitive mutant of the persistent, virulent RH ... | 09/25/1984 |
| 4473548 | Method of immunizing cats against shedding of Toxoplasma oocysts A method of immunizing cats against shedding of Toxoplasma oocysts is described wherein cats are given a primary Toxoplasma infection, preferably by feeding of tissue cysts, and are chemoprophylactically treated to suppress oocyst shedding as a result of ... | 09/25/1984 |
