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| Number | Title | Issue Date |
| 8425919 | Recombinant polyprotein vaccines for the treatment and diagnosis of leishmaniasis Compositions and methods for preventing, treating and detecting leishmaniasis are disclosed. The compositions generally comprise fusion polypeptides comprising multiple Leishmania antigens, in particular, KMP11, SMT, A2 and/or CBP, or immunogenic portions or ... | 04/23/2013 |
| 8318184 | MGLU2 agonists The present invention provides novel mGlu2 agonists useful in the treatment of bipolar disorder, schizophrenia, depression, and generalized anxiety disorder. ... | 11/27/2012 |
| 8246966 | Trypanosome microsome system and uses thereof The present invention provides cell free preparations of protozoan microsomes, wherein the cell free preparation of protozoan microsomes demonstrate the ability to translocate a protozoan polypeptide into the microsome, methods of preparing cell free preparations of... | 08/21/2012 |
| 8231881 | Fusion proteins and their use in the diagnosis and treatment of leishmaniasis The present invention relates generally to a fusion protein made from a synthetic gene construct comprising of elements derived from the Leishmania antigens K26, K39, and K9. The fusion protein is particularly useful in the diagnosis of leishmaniasis, particu... | 07/31/2012 |
| 8216594 | Proteins with repetitive Bacterial-Ig-like (Big) domains present in species The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in the Leptospira sp bacterium which have repetitive Bacterial-Ig-like (Big) domains and their use in diagnostic, therapeutic and vaccine applications. Acc... | 07/10/2012 |
| 8216593 | Parasite vaccine The present invention includes compositions and methods for the development and use of a vaccine that includes one or more FusM antigens in a carrier adapted to trigger a FusM-specific immune response in the human blood stream. ... | 07/10/2012 |
| 8168207 | Immunogenic proteins of The invention provides novel immunogenic proteins LigA and LigB from Leptospira for use in the development of effective vaccines and antibodies, as well as improved diagnostic methods and kits. ... | 05/01/2012 |
| 8124110 | Proteins with repetitive bacterial-Ig-like (Big) domains present in species The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in the Leptospira sp bacterium which have repetitive Bacterial-Ig-like (Big) domains and their use in diagnostic, therapeutic and vaccine applications. Acc... | 02/28/2012 |
| 8021673 | Proteins with repetitive Bacterial-Ig-like (Big) domains present in species The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in the Leptospira sp bacterium which have repetitive Bacterial-Ig-like (Big) domains and their use in diagnostic, therapeutic and vaccine applications. Acc... | 09/20/2011 |
| 7972610 | Antimicrobial compounds The present invention relates to compounds that modulate the shikimate pathway and/or a pathway branching from the shikimate pathway in members of the Amoebida Order. In particular these compounds may be useful in the treatment or prevention of diseases caused or co... | 07/05/2011 |
| 7935357 | Proteins with repetitive Bacterial-Ig-like (Big) domains present in species The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in the Leptospira sp bacterium which have repetitive Bacterial-Ig-like (Big) domains and their use in diagnostic, therapeutic and vaccine applications. Acc... | 05/03/2011 |
| 7892568 | Methods and compositions for detection of (p120) The invention provides methods and compositions for the detection of Ehrlichia chaffeensis. ... | 02/22/2011 |
| 7858103 | Method for defining, identifying and isolating fatty acid and retinal binding protein complexes having immuno-suppressive activity A method for defining, identifying and isolating recombinantly produced protein complex is provided. The protein complex comprises a group of fatty acid and retinol-binding proteins wherein the complex protein structure is entirely alpha-helical. The molecular weigh... | 12/28/2010 |
| 7794736 | Canine vaccine The present invention provides vectors that contain and express in vivo Leishmania KMP11 or an epitope thereof that elicits an immune response in a dog against Leishmania, compositions comprising said vectors, methods of vaccination against Leishman... | 09/14/2010 |
| 7780969 | proteome compositions and methods Molecular targets are identified in T. cruzi suitable for use in diagnosis of Chagas disease, drug development, and vaccines, including live vaccines. ... | 08/24/2010 |
| 7718183 | Proteins with repetitive bacterial-Ig-like (big) domains present in species The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in the Leptospira sp bacterium which have repetitive Bacterial-Ig-like (Big) domains and their use in diagnostic, therapeutic and vaccine applications. Acc... | 05/18/2010 |
| 7700121 | Gene associated with leishmania parasite virulence The invention relates to the field of combating leishmaniases. Said invention results from the isolation, from wild isolates of Leishmania major, of a protein-coding gene known as LmPDI which has two regions that are identical to the sequence (Cys-Gly-His-Cys... | 04/20/2010 |
| 7585511 | Apolipoprotein L-I and/or derivated polypeptide for the treatment of and/or the prevention of diseases induced by The present invention is related to a composition comprising apolipoprotein L-l, the use of apolipoprotein L-l or a derivated polypeptide for the diagnostic, the treatment and/or the prevention of diseases induced in mammals by Trypanosoma. Another aspect is ... | 09/08/2009 |
| 7569229 | Monocyte locomotion inhibitory factor The invention relates to an anti-inflammatory oligopeptide which can be obtained from the microorganism Entamoeba histolytica or synthesized by known methods. The oligopeptides are useful in treating inflammatory diseases when formulated in pharmaceutical com... | 08/04/2009 |
| 7514090 | Monocyte locomotion inhibitory factor The invention relates to an anti-inflammatory oligopeptides which contain the terminal pharmacophore Cys-Asn-Ser which is capable of inhibiting the NF-κβ signaling pathway. The oligopeptides are useful in stimulating the in vivo production of IL-10, and for treati... | 04/07/2009 |
| 7462359 | vaccines A Neospora caninum vaccine comprising tissue culture grown Neospora and methods of making and using said vaccines. Neospora caninum vaccines described include those containing whole Neospora tachyzoites, extracts of Neospora tachyz... | 12/09/2008 |
| 7419668 | Vaccine to control equine protozoal myeloencephalitis in horses The present invention provides vaccines and methods for making the vaccines that actively or passively protect an equid or other animal against Sarcocystis neurona. In particular, the present invention provides vaccines that provide active immunity which comp... | 09/02/2008 |
| 7361359 | isolate The present invention relates to a novel Neospora caninum isolate from Nowra and extracts thereof. The strain is useful in the development of diagnostic assays for the detection of parasites in animals. The present invention also relates to pharmaceutical com... | 04/22/2008 |
| 7282210 | Process for the in vitro culture of different stages of tissular parasites The present invention provides a method for carrying out in vitro the complete developmental sequence culture of tissular parasites, which includes culturing the parasites in a totally defined culture medium which is an axenic . . . monophasic liquid culture medium,... | 10/16/2007 |
| 7273709 | Detection of sarcocystis neurona A gene encoding a 29 kilodalton protein found on the surface of merozoite stage S. neurona has been cloned and sequenced. The protein encoded by this gene, termed SnSAG-1, is an immunodominant antigen recognized on protein blots. Methods for using nucleic aci... | 09/25/2007 |
| 7256282 | Nucleic acids encoding antigen and uses thereof The present invention provides novel isolated nucleic acids encoding antigenic proteins derived from Sarcocystis neurona, or unique fragments thereof. In particular, the invention provides novel isolated nucleic acids encoding membrane-associated polypeptides... | 08/14/2007 |
| 7250173 | Use of parasitic biological agents for prevention and control of autoimmune diseases The invention relates to a method of treating an excessive immune response including an aberrant/enhanced Th1 response by administering a helminthic parasite preparation in an amount sufficient to reduce the excessive immune response in an individual. This invention... | 07/31/2007 |
| 7247297 | Use of DF3/MUC1 regulated expression in gene therapy The present invention provides for improved vectors for use in gene therapy. Utilizing the cancer specific DF3/MUC1 promoter to drive a replication essential gene, vectors are made conditionally replication-competent, permitting wider infection and expression of tum... | 07/24/2007 |
| 7238347 | Suicidal mutant vaccine The present invention discloses the use of a mutant Leishmania as a suicidal vaccine wherein the mutant Leishmania is responsive to external signals to become porphyric and commit suicidal cytolysis. The mutant can be selected from natural Leishmani... | 07/03/2007 |
| 7205143 | Feline IL-12 single chain nucleic acid molecules The present invention relates to canine and feline proteins. In particular, the present invention discloses feline interleukin-18, feline caspase-1, feline interleukin-12 single chain and canine interleukin-12 single chain proteins. The present invention also includ... | 04/17/2007 |
| 7189399 | Chimeric gene formed of the DNA sequences that encode the antigenic determinants of four proteins of L. infantum, useful for serologic diagnosis of canine leishmaniosis and protein obtained Chimeric gene formed by the DNA sequences that encode the antigenic determinants of four proteins of L. infantum, useful for the serological diagnosis of canine Leishmaniosis and protein obtained, that consists of the prior employment of a cloning strategy. T... | 03/13/2007 |
| 7179615 | Method of prophylaxis and treatment The present invention relates generally to a method for the prophylaxis and treatment of parasitic infections in animals and birds. More particularly, the present invention contemplates a method for the prophylaxis and treatment of Plasmodium infection in mam... | 02/20/2007 |
| 7169398 | Equine protozoal myeloencephalitis vaccine The present invention provides an immunogenically active component comprising inactivated Sarcocystis neurona cells and/or inactivated Neospora hughesi cells; antigens derived therefrom; DNA derived therefrom; or a mixture; or in combination with other... | 01/30/2007 |
| 7150873 | Coccidiosis vaccines The present invention relates to hydrophilic Eimeria polypeptides, DNA-fragments encoding those peptides, recombinant DNA molecules comprising such DNA-fragments, live recombinant carriers comprising such DNA-fragments or recombinant DNA molecules and host ce... | 12/19/2006 |
| 7141245 | Process for preparation of a microbial agent A method of killing mosquito larvae and particularly the species comprising Culex tritaeniorhynchus, Cx. pseudovishnui, Cx. (Cx) sp., Cx. (Lutzia) sp. and Anopheles hyrcanus group which comprises in allowing Chilodonella uncinat... | 11/28/2006 |
| 7094576 | Methods and compositions for detecting larval with a cloned diagnostic antigen Compositions and methods for the detection of Taenia solium and the diagnosis of T. solium infection are described. The nucleotide and amino acid sequences of the antigenic T. solium polypeptides gp50a, gp50b and gp50c are provided. The composit... | 08/22/2006 |
| 7078044 | Anti-amoebic vaccine The invention relates to an anti-amoebic vaccine containing an oligopeptide which can be obtained from the microorganism Entamoeba histolytica or synthesized by known methods. The anti-amoebic vaccines are particularly effective against inflammation and liver absces... | 07/18/2006 |
| 7071296 | antigens inducing protective antibodies The present invention relates to immunogenic compositions comprising as an immunogen a long synthetic or recombinant peptide of a merozoite surface protein 3b (MSP-3b) peptide, an MSP-3c peptide and a MSP-3d peptide. Vaccines against malaria are also disclosed using... | 07/04/2006 |
| 7067315 | Identification of anti-protozoal agents The present invention provides novel assay systems and methods for monitoring cell invasion by protozoal parasites. The present invention further provides methods of using these assays systems to identify compounds that treat or prevent protozoal infection. The pres... | 06/27/2006 |
| 7063848 | Lipoglycan compositions and methods of treating parasitic infections A composition for and a method of eliciting in a vertebrate a protective immune response against an eukaryotic parasite are disclosed. The method includes administering to the vertebrate a composition having a carrier group coupled to an oligosaccharide obtained fro... | 06/20/2006 |
