Bizarre Patents
Mouthguard made at least partially from an edible candy
A mouthguard includes a U-shaped upper bite plate which removably fits over upper teeth of a person, with the entire upper bite plate being made from a soft, deformable and edible gummi candy.
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| Number | Title | Issue Date |
| 7887819 | Antigenic polypeptide SE36 of malaria plasmodium, process for purification thereof, and vaccine and diagnostic agent using the antigen The present invention provides a polypeptide SE36 derived from the N-terminal domain (47 kd) of SERA (serine-repeat antigen) produced by malaria parasite, Plasmodium falciparum, at the erythrocyte stage, a process for purifying said polypeptide, and a malaria... | 02/15/2011 |
| 7790186 | hybrid circumsporozoite protein and vaccine Described in this application is a synthetic P. vivax circumsporozoite protein useful as a diagnostic reagent, for antibody production, and as a vaccine protective against infection with any strain of P. vivax. ... | 09/07/2010 |
| 7722889 | Plasmodium liver stage antigens The invention provides isolated liver stage Plasmodium polypeptides comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 1-48 and immunogenic derivatives thereof. The invention also provides isolated nucleic acid molecules encoding the... | 05/25/2010 |
| 7575755 | Immunogenic compositions and uses thereof The present invention relates generally to a method of eliciting or otherwise inducing an effective immune response to a micro-organism and compositions for use therein. More particularly, the present invention relates to a method of inducing an immune response to a... | 08/18/2009 |
| 7488489 | Identification of a conserved region of MSP3 targeted by biologically active antibodies Antigenic and immunogenic determinants of Merozoite surface protein 3 (MSP3). Antigenicity and functional assays identified a 68-amino acid conserved domain of MSP3 as a target of biologically active antibodies. A peptide comprising amino acid residues 184-251 of SE... | 02/10/2009 |
| 7462358 | Antigenic polypeptide SE36 of malaria plasmodium, process for purification thereof, and vaccine and diagnostic agent using the antigen The present invention provides a polypeptide SE36 derived from the N-terminal domain (47 kd) of SERA (serine-repeat antigen) produced by malaria parasite, Plasonodium falciparum, at the erythrocyte stage, a process for purifying said polypeptide, and a malari... | 12/09/2008 |
| 7438916 | Therapeutic target for protozoal diseases A novel Fasciclin Related Adhesive Protein (FRAP) from Plasmodium and related parasites is provided as a target for therapeutic intervention in diseases caused by the parasites. FRAP has been shown to play a critical role in adhesion to, or invasion into, hos... | 10/21/2008 |
| 7438917 | Peptide sequences specific for the hepatic stages of bearing epitopes capable of stimulating the T lymphocytes The present invention relates to an in vitro diagnostic method for malaria in an individual comprising placing a tissue or a biological fluid taken from an individual in contact with a molecule or polypeptide composition, wherein said molecule or polypeptide composi... | 10/21/2008 |
| 7431936 | Proteins involved in cytoadhesion of plasmodium falciparum ring-stage-infected erythrocytes, antibodies which bind to the proteins, and methods for detecting infection, stage of infection and vaccines for protecting against infection The present invention provides the RSP-1 and RSP-2 proteins which are involved in the cytoadhesion of P. falciparum during ring-stage infection of erythrocytes, antibodies which bind to the proteins, methods of screening for a P. falciparum infection, ... | 10/07/2008 |
| 7404962 | Combination kit used in the treatment of malaria A combination kit for the treatment of malaria caused by Plasmodium vivax (P. vivax) having individual doses of an anti-malarial agent, 3-[1-[[4-[(6-methoxy-8-quinolinyl)amino]pentyl]amino]ethylidene]-dihydro-2(3H)-furanone (I) in the form of capsules;... | 07/29/2008 |
| 7354594 | Merozoite surface protein 1 lacking glycosylation sites The invention provides modified recombinant nucleic acid sequences (preferably DNA) and methods for increasing the mRNA levels and protein expression of malarial surface protein MSP-1 which is known to be difficult to express in cell culture systems, mammalian cell ... | 04/08/2008 |
| 7351413 | Stabilized HBc chimer particles as immunogens for chronic hepatitis A method of treating chronic hepatitis B is disclosed that comprises administering a T cell-stimulating amount of a vaccine to a patient. The vaccine comprises an immunogenic amount of chimeric, carboxy-terminal truncated hepatitis B virus nucleocapsid (core) protei... | 04/01/2008 |
| 7332595 | DNA sequences encoding peptide sequences specific for the hepatic stages of P. falciparum bearing epitopes capable of stimulating the T lymphocytes The invention discloses isolated DNA sequences encoded by polypeptides characterized by the presence in their structure of one or more sequences bearing all or part of one or more T epitopes, and possibly other epitopes, particularly B epitopes, characteristic of pr... | 02/19/2008 |
| 7309814 | Nucleic acid molecules encoding bacterial autoinducer inactivation protein as targets for engineering disease resistance The present invention relates to isolated nucleic acid molecules encoding a bacterial autoinactivation protein and methods for increasing disease resistance and preventing or reducing bacterial damage in plants and animals. The nucleic acid that encodes the bacteria... | 12/18/2007 |
| 7306806 | Recombinant merozoite protein-142 vaccine In this application is the expression and purification of a recombinant Plasmodium falciparum (3D7) MSP-142. The method of the present invention produces a highly purified protein which retains folding and disulfide bridging of the native molecule.... | 12/11/2007 |
| 7256281 | Recombinant merozoite protein-1vaccine In this application is described the expression and purification of a recombinant Plasmodium falciparum (FVO) MSP-142. The method of the present invention produces a highly purified protein that retains folding and disulfide bridging of the native ... | 08/14/2007 |
| 7211256 | antigens inducing protective antibodies The present invention relates, in part, to a purified polyclonal or monoclonal antibody which recognizes an epitope of a protein of 48,000 dalton, where the protein recognizes is a surface protein of a merozoite of Plasmodium falciparum which has a peptide of... | 05/01/2007 |
| 7198791 | Compositions and methods for the generation of protective immune responses against malaria The invention presents vaccine formulations comprising highly antigenic epitopes identified within the semi-conserved loop-I of domain III that are capable of eliciting parasite growth inhibitory antibodies. The cyclized or linear peptides can be applied by known ad... | 04/03/2007 |
| 7179615 | Method of prophylaxis and treatment The present invention relates generally to a method for the prophylaxis and treatment of parasitic infections in animals and birds. More particularly, the present invention contemplates a method for the prophylaxis and treatment of Plasmodium infection in mam... | 02/20/2007 |
| 7125958 | Malaria polypeptides The present invention relates to carbohydrates capable of acting as receptors for malaria antigens present on the surfaces of malaria infected erythrocytes. The receptors according to the invention comprises negatively charged glycosaminoglycan-like moities, prefera... | 10/24/2006 |
| 7101556 | Preparation and usage of plasmodium fusion antigen The invention provides a fusion protein comprising the Plasmodium merozoite surface protein-1 (MSP1) and the Plasmodium apical membrane antigen 1 (AMA-1), the encoding DNA sequence, the vector containing the sequence, the host cell containing the vecto... | 09/05/2006 |
| 7087231 | Peptide sequences specific for the hepatic stages of bearing epitopes capable of stimulating the T lymphocytes The present invention relates to an in vitro diagnostic method for malaria in an individual comprising placing a tissue or a biological fluid taken from an individual in contact with a molecule or polypeptide composition, wherein said molecule or polypeptide composi... | 08/08/2006 |
| 7078043 | Malaria vaccine A non-naturally occurring variant of a C-terminal fragment of a Plasmodium merozoite surface protein-1 (MSP-1) wherein said variant has (i) a reduced affinity, compared with a naturally occurring Plasmodium MSP-119, for at least one first an... | 07/18/2006 |
| 7078507 | Synthetic genes for malarial proteins and methods of use Synthetic gene sequences encoding erythrocyte binding protein of a malaria pathogen for the expression of the erythrocyte binding protein. The codon composition of the synthetic gene sequences approximates the mammalian codon composition. The synthetic gene sequence... | 07/18/2006 |
| 7071296 | antigens inducing protective antibodies The present invention relates to immunogenic compositions comprising as an immunogen a long synthetic or recombinant peptide of a merozoite surface protein 3b (MSP-3b) peptide, an MSP-3c peptide and a MSP-3d peptide. Vaccines against malaria are also disclosed using... | 07/04/2006 |
| 7067315 | Identification of anti-protozoal agents The present invention provides novel assay systems and methods for monitoring cell invasion by protozoal parasites. The present invention further provides methods of using these assays systems to identify compounds that treat or prevent protozoal infection. The pres... | 06/27/2006 |
| 7060276 | AMA-1 protein and uses thereof In this application is described the expression and purification of a recombinant Plasmodium falciparum (3D7) AMA-1 ectodomain. The method of the present invention produces a highly purified protein which retains folding and disulfide bridging of the native m... | 06/13/2006 |
| 7056518 | Malarial pre-erythrocytic stage polypeptide molecules Polypeptide molecules containing at least 10 consecutive amino acids of the amino acid sequence shown in FIG. 2, representing the LSA3 antigen, the following peptides being excluded: | 06/06/2006 |
| 7029678 | Vaccines The present invention provides vaccine compositions comprising an oil-in-water emulsion optionally with 3 De-O-acylated monophosphoryl lipid A and QS21. The vaccine compositions are potent induces of a range of immune responses. ... | 04/18/2006 |
| 7029685 | AMA-1 protein and uses thereof In this application is described the expression and purification of a recombinant Plasmodium falciparum (3D7) AMA-1 ectodomain. The method of the present invention produces a highly purified protein which retains folding and disulfide bridging of the native m... | 04/18/2006 |
| 6949627 | Plasmodium falciparum antigens inducing protective antibodies The present invention relates, in part, to a purified polyclonal or monoclonal antibody which recognizes an epitope of a protein of 48,000 dalton, where the protein recognizes is a surface protein of a merozoite of Plasmodium falciparum which has a peptide of... | 09/27/2005 |
| 6942866 | Malaria immunogen and vaccine A chimeric, carboxy-terminal truncated hepatitis B virus nucleocapsid protein (HBc) is disclosed that contains an immunogen for inducing the production of antibodies to malarial proteins. An immunogenic malarial epitope is expressed between residues 78 and 79 of the... | 09/13/2005 |
| 6855322 | Isolation and purification of P. falciparum merozoite protein-142 vaccine This application is the expression and purification of a recombinant Plasmodium falciparum (3D7) MSP-142. The method of the present invention produces a highly purified protein which retains folding and disulfide bridging of the native molecule. Th... | 02/15/2005 |
| 6815183 | Plasmodium sp. chitinase The present invention is directed to isolated nucleic acid molecules encoding Plasmodium sp. chitinases. Expression vectors and host cells comprising the nucleic acid molecules are also provided, as well as methods for increasing or decreasing the expr... | 11/09/2004 |
| 6783765 | Process for the preparation of a vaccine for the treatment of tuberculosis and other intracellular infections diseases and the vaccine produced by the process The present invention relates to a process for the preparation of a vaccine against tuberculosis and other intracellular pathogens, this vaccine is targeted against intracellular pathogens, more particularly the pathogen Mycobacterium tuberculosis and Salmone... | 08/31/2004 |
| 6780417 | Transmission blocking immunogen from malaria The present invention relates to transmission blocking vaccines against malaria. Vaccines of the present invention contain a recombinant virus encoding all, or a unique portion, of the 25 kDa sexual stage surface protein of Plasmodium falciparum, Pfs25, or th... | 08/24/2004 |
| 6623739 | Vaccines The present invention provides vaccine compositions comprising an oil-in-water emulsion optionally with 3 De-O-acylated monophosphoryl lipid A and QS21. The vaccine compositions are potent inducers of a range of immune responses.... | 09/23/2003 |
| 6593463 | Modified MSP-1 nucleic acid sequences and methods for increasing MRNA levels and protein expression in cell systems The invention provides modified recombinant nucleic acid sequences (preferably DNA) and methods for increasing the mRNA levels and protein expression of malarial surface protein MSP-1 which is known to be difficult to express in cell culture systems, mamm... | 07/15/2003 |
| 6491920 | Polypeptides and DNA encoding same Proteins from the merozoite stage of the malaria parasite, fragments and derivatives thereof, DNA coding for the said proteins, and processes for the preparation of the proteins and plasmid and viral vectors useful in said processes. The invention also pr... | 12/10/2002 |
| 6420523 | Baculovirus produced plasmodium falciparum vaccine The present invention provides compositions of matter comprising a polypeptide expressed from insect cells harboring a baculovirus vector the encodes the polypeptide, wherein the polypeptide comprises amino acid sequences derived from the p42 fragment of ... | 07/16/2002 |
