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| Number | Title | Issue Date |
| 8084044 | outer membrane protein PA0427 An object of the present invention is to provide a protein or peptide antigen and an antibody against it, for use in the diagnosis, prevention, or treatment of diseases associated with Pseudomonas aeruginosa. According to the present invention, there is provi... | 12/27/2011 |
| 7976851 | Non-toxic biofilm inhibitor The present invention relates to a composition and method for preventing or inhibiting biofilm formation on biotic or abiotic surfaces. The composition comprises a peptide based on the C-terminal receptor binding domain of Pseudomonas aeruginosa type IV pilin... | 07/12/2011 |
| 7824695 | Delivery of proteins across polar epithelial cell layers This invention provides bioactive conjugates. The bioactive conjugates include: (1) a cell recognition moiety that binds to α2 macroglobulin receptor α2-MR and (2) a bioactive moiety which: (a) has a biological activity, (b) does not function solely as ... | 11/02/2010 |
| 7807185 | Methods of inhibiting growth of bacteria, yeast, fungus, and virus with and extracellular products The present invention discloses compositions derived from an isolated Bacillus species, spores, or an extracellular product of Bacillus coagulans comprising a supernatant or filtrate of a culture of said Bacillus coagulans strain, suitable for t... | 10/05/2010 |
| 7517533 | antigens Proteins derived from Pseudomonas aeruginosa are antigenic and are of use in the treatment, prophylaxis and diagnosis of P. aeruginosa infection. ... | 04/14/2009 |
| 7459165 | Polypeptides of The present invention relates to polypeptides of Pseudomonas aeruginosa which may be used to prevent, diagnose and/or treat Pseudomonas aeruginosa infection. ... | 12/02/2008 |
| 7384639 | Methods of treating or preventing an infectious disease using an immunogenic conjugate of a gram-negative bacterial autoinducer molecule The present invention relates to an immunogenic conjugate comprising a carrier molecule coupled to an autoinducer of a Gram negative bacteria The immunogenic conjugate, when combined with a pharmaceutically acceptable carrier, forms a suitable vaccine for mammals to... | 06/10/2008 |
| 7371393 | Methods for reducing fecal shedding The present invention provides methods for reducing shedding in an animal. Generally, the method includes administcriirn to an animal a composition including siderophore receptor polypeptides and porins from gram negative microbes, and preferably, lipopolysaccarhide... | 05/13/2008 |
| 7371394 | Antigenic composition of a protein A novel antigen from P. aeruginosa is provided. The use of the antigen in detecting/diagnosing P. aeruginosa as well as its use in eliciting an immune response are also provided. ... | 05/13/2008 |
| 7341732 | Methods for treating mastitis in a milk producing animal The present invention provides methods for treating mastitis in a milk producing animal. The methods include administering compositions including siderophore receptor polypeptides and porins from gram negative microbes, and preferably, lipopolysaccarhide at a concen... | 03/11/2008 |
| 7338794 | Amended recombinant cells for the production and delivery of gamma interferon as an antiviral agent, adjuvant and vaccine accelerant The present invention provides active cytokine and/or chemokine compositions, as well as inexpensive means for the production, amended-cell encasement of active cytokine and/or chemokine compositions, processing, and delivery of active cytokine and/or chemokine comp... | 03/04/2008 |
| 7335361 | Fusion antigen used as vaccine The present invention mainly provides a fusion antigen specific for a target cell comprising a ligand moiety which is capable of reacting, recognizing or binding to the receptors on the target cell, a Pseudomonas exotoxin A translocation domain II, an antigen... | 02/26/2008 |
| 7314632 | exotoxin A-like chimeric immunogens This invention provides Pseudomonas exotoxin A-like chimeric immunogens that include a non-native epitope in the Ib domain of Pseudomonas exotoxin. Methods of eliciting an immune response using these immunogens also are provided. ... | 01/01/2008 |
| 7273722 | Neurotoxins with enhanced target specificity Modified neurotoxins that contain protease cleavage sites susceptible uniquely to proteases present in certain tissues are described. The toxins can be selectively activated by proteases in muscle or selectively inactivated by proteases in blood. ... | 09/25/2007 |
| 7268209 | Peptides, derivates thereof, process for producing the same, novel strain producing the same, and antiviral agent comprising the same as active ingredient Peptides having, as constitutive amino acids, (1) 4 glutamine residues, 1 glutamic acid residue, 1 serine residue, 2 valine residues, 1 isoleucine residue and 5 leucine residues, and having a 3-hydroxydecanoyl group bonded, via an amide linkage, to the N-terminal le... | 09/11/2007 |
| 7252846 | Topical composition and method for the treatment and prophylaxis of dermal irritations A composition and method for the prevention and therapeutic treatment of skin conditions and disorders are disclosed. The composition and method of the invention are particularly directed to the treatment and prevention of dermal irritations. These irritations inclu... | 08/07/2007 |
| 7244703 | Pharmaceutical compositions and methods for peptide treatment Compositions and methods for treating a patient with a pharmaceutically active peptide that combines a pharmaceutically active peptide, a permeation enhancer, and a carrier, are disclosed. ... | 07/17/2007 |
| 7235246 | Dermatomycosis vaccine The present invention relates to the preparation of universal inactivated vaccines and their use in preparing compositions for the prophylaxis and therapy of dermatomycosis. Vaccines according to the present invention have the advantage of conferring immunity agains... | 06/26/2007 |
| 7192736 | Nucleic acid molecules encoding cytotoxic conjugates that contain a chemokine receptor targeting agent Nucleic acid moleucles that encode conjugates containing as a ligand a chemokine receptor targeting agent, such as a chemokine, and a targeted agent, such as a toxin are provided. These conjugates are used to treat inflammatory responses associated with activation, ... | 03/20/2007 |
| 7183100 | Aconitase A bacterial protein which converts 2-methyl citrate to 2-methyl isocitrate is a previously unknown target for antibacterial agents. The protein of this activity is associated with mucoid bacteria and inhibitors of production or activity of this protein in combinatio... | 02/27/2007 |
| 7166270 | Methods of screening compounds useful for prevention of infection or pathogenicity Screening procedures are disclosed for identifying compounds useful for inhibiting infection or pathogenicity. Methods are also disclosed for identifying pathogenic virulence factors. ... | 01/23/2007 |
| 7166702 | Cytotoxic conjugates comprising a chemokine receptor targeting agent Conjugates containing as a ligand chemokine receptor targeting agents, such as chemokines, and a targeted agent, such as a toxin are provided. These conjugates are used to treat inflammatory responses associated with activation, proliferation and migration of immune... | 01/23/2007 |
| 7160549 | Methods for making compositions including gram negative microbial polypeptides The present invention provides methods for making compositions including siderophore receptor polypeptides and porins from gram negative microbes. The methods include providing a gram negative microbe, disrupting the microbe, solubilizing the disrupted microbe, and ... | 01/09/2007 |
| 7157418 | Methods and compositions for treating secondary tissue damage and other inflammatory conditions and disorders Conjugates containing as a ligand a chemokine receptor targeting agents, such as chemokines, and a targeted agent, such as a toxin are provided. These conjugates are used to treat inflammatory responses associated with activation, proliferation and migration of immu... | 01/02/2007 |
| 7112561 | Pharmaceutical compositions and methods for insulin treatment Compositions and methods for treating a patient with insulin that combines insulin, a permeation enhancer, and a carrier that maintains an acidic pH, are disclosed. ... | 09/26/2006 |
| 7081529 | Recombinant vaccine against botulinum neurotoxin This invention is directed to preparation and expression of synthetic genes encoding polypeptides containing protective epitopes of botulinum neurotoxin (BoNT). The invention is also directed to production of immunogenic peptides encoded by the synthetic genes, as w... | 07/25/2006 |
| 7060462 | AopB gene, protein,homologs, fragments and variants thereof, and their use for cell surface display The present invention provides an Agrobacterium tumefaciens outer membrane protein designated aopB, its variants, homologs and fragments and corresponding DNA molecules. The invention also relates to a method whereby aopB.related proteins are used as carriers... | 06/13/2006 |
| 7029684 | Antigenic composition of a A novel antigen from P. aeruginosa is provided. The use of the antigen in detecting/diagnosing P. aeruginosa as well as its use in eliciting an immune response are also provided. ... | 04/18/2006 |
| 7018636 | Vaccine against Gram-negative bacterial infections A vaccine, effective in inducing the production of antibodies with which to immunize a second subject passively against infection by Gram-negative bacteria and LPS-mediated pathology, comprises a non-covalent polyvalent complex formed between purified, detoxified LP... | 03/28/2006 |
| 7005275 | Inducible alphaviral gene expression system The present invention provides novel expression vectors which permit tight regulation of gene expression in eucaryotic cells. More specifically, the invention provides DNA vectors comprising nucleotide sequences that are transcribed to form RNA molecules which are t... | 02/28/2006 |
| 6951652 | Vaccine for prevention of gram-negative bacterial infections and endotoxin related diseases A vaccine is disclosed which is useful for protecting a host from Gram negative infections and the effects of endotoxin, therefore preventing sepsis and septic shock. The vaccine is prepared by combining LPS free or in conjugate form with a stoichiometric excess of ... | 10/04/2005 |
| 6942858 | Compositions containing bacteriophages and methods of using bacteriophages to treat infections Purified, host-specific, non-toxic, wide host range and virulent bacteriophage preparations that are effective in killing bacterial organisms in vivo are disclosed. Also disclosed are compositions containing these bacteriophages, methods of making the bacteriophage ... | 09/13/2005 |
| 6936263 | Th1 inducing natural adjuvant for heterologous antigens The present invention relates to the use of the major OprI lipoprotein of Pseudomonas aeruginosa to elicit a Type-1 immune response towards a heterologous antigen. The invention relates specifically to the use of OprI—antigen fusion proteins to elicit the T... | 08/30/2005 |
| 6936447 | Autoinducer molecule Autoinducer molecules, e.g., N-(3-oxododecanoyl)homoserine lactone, for Pseudomonas aeruginosa are described. The molecules regulate gene expression in the bacterium. Therapeutic compositions and therapeutic methods involving analogs and/or inhibitors of the ... | 08/30/2005 |
| 6905692 | Topical compositions containing probiotic bacillus bacteria, spores, and extracellular products and uses thereof The present invention discloses compositions derived from an isolated Bacillus species, spores, or an extracellular product of Bacillus coagulans comprising a supernatant or filtrate of a culture of said Bacillus coagulans strain, suitable for t... | 06/14/2005 |
| 6872398 | Conjugate vaccine against gram-negative bacterial infections The present invention relates to a broadly reactive vaccine against Gram-negative bacteria which is composed of a biological glycan-pilus conjugate. The conjugate core is a common pilus type to which is attached the glycan of choice in vivo. Pooling of these bioconj... | 03/29/2005 |
| 6793925 | Pseudomycin natural products The invention relates to pseudomycin natural products including pseudomycins A′ and B′, methods for making such pseudomycins, and methods employing antifungal activity of these pseudomycins. NMR and mass spectrometry indicate formula (I) for pseudomycin A′. NM... | 09/21/2004 |
| 6767545 | Pseudomonas treatment composition and method A composition and method for treating or preventing infection by Pseudomonas aeruginosa is disclosed. The composition includes a P. aeruginosa pilin peptide modified to prevent oligomerization of the pilin. The method involves administered the composit... | 07/27/2004 |
| 6723326 | Topical compositions containing probiotic Bacillus bacteria, spores, and extracellular products and uses thereof The present invention discloses compositions derived from an isolated Bacillus species, spores, or an extracellular product of Bacillus coagulans comprising a supernatant or filtrate of a culture of said Bacillus coagulans strain, suitable for topical ... | 04/20/2004 |
| 6696064 | Methods of protecting vasculature from damage by diphtheria toxin-and pseudomonas toxin-based immunotoxins during therapy Vascular damage has proven to be dose limiting in administering immunotoxins into the brain to treat brain tumors. Vascular toxicity of immunotoxins which rely in part on exposure to lowered pH in cellular endosomes and lysosomes can be avoided by adminis... | 02/24/2004 |
