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| Number | Title | Issue Date |
| 8034359 | Tissue targeted antigenic activation of the immune response to cancers The invention provides in part methods of treating cancers of a specific organ or tissue by administering a composition that is antigenically specific for one or more microbes that are pathogenic in the specific organ or tissue in which the cancer is situated. The f... | 10/11/2011 |
| 7408044 | Carrier protein having an adjuvant effect The invention relates to an adjuvant product which is intended to improve the activity of a molecule when administered to a host, characterized in that it comprises at least one part of the P40 protein of Klebsiella pneumoniae or a protein having at least 80% homolo... | 08/05/2008 |
| 7371393 | Methods for reducing fecal shedding The present invention provides methods for reducing shedding in an animal. Generally, the method includes administcriirn to an animal a composition including siderophore receptor polypeptides and porins from gram negative microbes, and preferably, lipopolysaccarhide... | 05/13/2008 |
| 7341732 | Methods for treating mastitis in a milk producing animal The present invention provides methods for treating mastitis in a milk producing animal. The methods include administering compositions including siderophore receptor polypeptides and porins from gram negative microbes, and preferably, lipopolysaccarhide at a concen... | 03/11/2008 |
| 7160549 | Methods for making compositions including gram negative microbial polypeptides The present invention provides methods for making compositions including siderophore receptor polypeptides and porins from gram negative microbes. The methods include providing a gram negative microbe, disrupting the microbe, solubilizing the disrupted microbe, and ... | 01/09/2007 |
| 7125696 | Method for preparing a polypeptide soluble in an aqueous solvent in the absence of detergent A invention concerns a novel method for preparing a polypeptide soluble in an aqueous solvent in the absence of detergent, and polypeptides obtainable by said method. The invention also concerns the use of said polypeptides, in particular for preparing medicines or ... | 10/24/2006 |
| 7090853 | Noscapine derivatives as adjuvant compositions and methods of use thereof An adjuvant composition comprising noscapine and its derivatives, for use in the treatment of tumors, cancer, as an adjuvant for vaccines. ... | 08/15/2006 |
| 7033591 | Immunostimulant bacterial membrane fractions in cancer treatment The invention concerns the use of a membrane fraction of gram-negative bacteria, in particular Klebsiella pnemoniae for preparing a pharmaceutical composition that is immunostimulant and/or capable of inducing an antitumoral immune response, designed in parti... | 04/25/2006 |
| 7018636 | Vaccine against Gram-negative bacterial infections A vaccine, effective in inducing the production of antibodies with which to immunize a second subject passively against infection by Gram-negative bacteria and LPS-mediated pathology, comprises a non-covalent polyvalent complex formed between purified, detoxified LP... | 03/28/2006 |
| 6913753 | Incapacitated whole-cell immunogenic bacterial compositions The invention features incapacitated whole cell bacterial immunogenic compositions produced by infecting a bacterium with Lys minus bacteriophage, which are deficient in the lysin protein. Lys minus bacteriophage retain activity in infection of its appropriate bacte... | 07/05/2005 |
| 6905691 | Vaccines containing attenuated bacteria The invention relates to a vaccine comprising a bacterium attenuated by a non-reverting mutation in a gene encoding a protein which promotes folding of extracytoplasmic proteins. Such mutations were initially identified as being useful in vaccines from a bank of ran... | 06/14/2005 |
| 6780420 | Carrier protein having an adjuvant effect, immunogenic complex containing it, process for their preparation, nucleotide sequence and vaccine The invention relates to an adjuvant product which is intended to improve the activity of a molecule when administered to a host, characterized in that it comprises at least one part of the P40 protein of Klebsiella pneumoniae or a protein having at least 80%... | 08/24/2004 |
| 6632431 | Anti-idiotypic antibody against FimH adhesion of uropathogenic type I-fimbriated Escherichia coli, compositions containing same and method for using same The present invention relates to an anti-idiotypic antibody or antigen-binding fragment against FimH adhesin of uropathogenic Type I-fimbriated Escherichia coli and an immunizing composition containing such an anti-idiotypic antibody or antigen-binding fr... | 10/14/2003 |
| 6423320 | Inhibitor of immunoglobulin E antibody production A polysaccharide and fragments thereof derived from Klebsiella oxytoca or Klebsiella pneumonia inhibit the IgE antibody production and response and, therefore, are useful in the prophylaxis and/or treatment of type I allergy-related diseases.... | 07/23/2002 |
| 6197929 | Carrier protein having an adjuvant effect, immunogenic complex containing it, process for their preparation, nucleotide sequence and vaccine The invention relates to an adjuvant product which is intended to improve the activity of a molecule when administered to a host, characterized in that it comprises at least one part of the P40 protein of Klebsiella pneumoniae or a protein having at least... | 03/06/2001 |
| 6083928 | Skin healing method A method for facilitating the healing of skin comprising applying topically to skin a composition containing an amount of a lipopolysaccharide extracted from gram negative bacteria effective to facilitate skin healing.... | 07/04/2000 |
| 6045805 | Oligosaccharide derived from an antigenic polysaccharide obtained from a pathogenic agent An oligosaccharide derived from an antigen polysaccharide obtained from a pathogenic agent, a method for its preparation, and its use particularly as a vaccinal agent. The oligosaccharide is prepared by oxidation-reduction depolymerization reaction.... | 04/04/2000 |
| 6027736 | Active immunization using a siderophore receptor protein The invention provides a vaccine for immunizing poultry and other animals against infection by a gram-negative bacteria, and a method of immunizing an animal using the vaccine. The vaccine may contain purified siderophore receptor proteins derived from a ... | 02/22/2000 |
| 6007818 | Oligosaccharide derived from an antigenic polysaccharide obtained from a pathogenic agent An oligoside derived from an antigen polyoside obtained from a pathogenic agent, a method for its preparation, and its use particularly as a vaccinal agent. The oligoside is prepared by oxidation-reduction depolymerisation reaction.... | 12/28/1999 |
| 5997881 | Method of making non-pyrogenic lipopolysaccharide or A The present invention provides gram-negative bacterial strains that produce substantially pure non-pyrogenic lipopolysaccharide or lipid A. The present invention also relates to a use of said strains for the preparation of non-pyrogenic DNA and use of the... | 12/07/1999 |
| 5906826 | Method of inducing an immune response in a young animal The invention provides a method of priming an immune response in the presence of maternal antibody in a young animal by administering to a 1-90 day old animal, a biocompatible and non-toxic solid phase implant containing an immunogenic agent. A preferred ... | 05/25/1999 |
| 5538727 | Anti-cholesterolemic vaccine Anti-cholesterolemic eggs are disclosed, said eggs being obtained from animals hyperimmunized against at least one anti-cholesterolemic antigen. A vaccine producing said anti-cholesterolemic egg is disclosed, said vaccine comprising at least one anti-chol... | 07/23/1996 |
| 5538733 | Method of priming an immune response in a one-day old animal The invention provides a method of priming an immune response in the presence of maternal antibody in a young animal by administering to a 1-90 day old animal, a biocompatible and non-toxic solid phase implant containing an immunogenic agent. A preferred ... | 07/23/1996 |
| 4764370 | Vaccine utilizing an avirulent strain of Salmonella typhimurium A vaccine against a microbial pathogen comprised of a live, immunogenic but prototrophic and avirulent mutant strain of the selected microbial pathogen in an amount effective to confer immunity. A method of obtaining a vaccine that induces a heightened ce... | 08/16/1988 |
| 4755381 | Klebsiella capsular polysaccharide vaccine The present invention relates to immunogenic preparations of Klebsiella species serotype-specific capsular polysaccharides. The invention involves the treatment of Klebsiella capsular polysaccharides in dilute sodium hydroxide to detoxify co-purified toxi... | 07/05/1988 |
| 4663160 | Vaccines for gram-negative bacteria An immunizing composition is disclosed and comprises a detoxified polysaccharide from a gram-negative bacterium covalently coupled to a detoxified protein from said gram-negative bacterium by means of a 4-12 carbon moiety. To prepare the above immunizing ... | 05/05/1987 |
| 4606919 | Vaccine for the treatment of urinary tract infections containing aluminum phosphate A vaccine for curative and prophylactic treatment of urinary tract infections in humans. The vaccine contains inactivated bacteria which originate from the cultures of 8 to 14 uropathogenic bacteria strains isolated from the urine of a person suffering fr... | 08/19/1986 |
| 4460575 | Vaccinal complex containing a specific antigen and vaccine containing it The present invention relates to a vaccinal complex containing a specific antigen. This is a vaccinal complex characterized in that it is composed of bacterial ribosomal RNA or fragments of bacterial ribosomal RNA on which are coupled from 1 to 5% by weig... | 07/17/1984 |
| 4402939 | Vaccinating glycopeptidic antigenic fraction with a very high level of immunogenicity, isolated from cultures of pathogenic germs, processes for isolating said fraction and vaccines containing said fraction A glycopeptic vaccinating antigenic fraction with a very high level of immunogenicity, which is isolated from a culture of pathogenic germs comprises an osidic part present in a proportion of about 50%, with a proteinic part, which are linked together by ... | 09/06/1983 |
| 4396607 | Muramyl peptide derivatives and pharmaceutical compositions The invention relates to new compounds useful notably as regulator of immune responses and which are derivatives of muramyl peptides substituted at the end of the peptide chain by a group containing at least four carbon atoms.... | 08/02/1983 |
| 4356171 | Novel glycoproteins Novel water-soluble, immunostimulating glycoproteins extracted from Klebsiella Pneumoniae containing 20 to 35% by weight of proteins, 50 to 70% by weight of neutral monosaccharides, 3 to 8% by weight of glucuronic acid, 1.5 to 3% by weight of osamines and... | 10/26/1982 |
| 4349540 | Process for preparing vaccines based on antigenic ribosomal fractions Vaccines which comprise in association the ribosomal fraction extracted from the bacterias against which a protection is wanted, and the peptidoglycanes extracted from the membranes of at least one of the bacteria previously used.... | 09/14/1982 |