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| Number | Title | Issue Date |
| 8173139 | High energy electron beam irradiation for the production of immunomodulators in poultry Populations of Salmonella in animals may be substantially reduced by treatment with a vaccine composition which has been produced by exposing whole, intact cells of a Salmonella species to irradiation with an electron beam under conditions effective to... | 05/08/2012 |
| 8163297 | Live attenuated aldolase-negative bacterial vaccine The present invention relates to live attenuated bacteria for use in a medicament. The invention also relates to vaccines based upon such bacteria useful for the prevention of microbial pathogenesis and to the use of such bacteria for the manufacture of a vaccine. F... | 04/24/2012 |
| 8119147 | Compositions produced using enteric pathogens and methods of use The present invention provides compositions including polypeptides having the characteristics of polypeptides expressed by a reference microbe such E. coli or Salmonella. Examples of Salmonella strains that can be used include, for instance, ... | 02/21/2012 |
| 8071113 | Live, oral vaccine for protection against serotype 1 The invention relates to Salmonella typhi Ty21a comprising core-linked Shigella dysenteriae serotype 1 O-specific polysaccharide (O-Ps) and DNA encoding O antigen biosynthesis, said DNA selected from the group consisting of: a) the DNA sequence set out... | 12/06/2011 |
| 8062645 | vaccine The present invention relates to the field of vaccination against Salmonella in animals, particularly avian animals. The present invention also encompasses kits and uses of Salmonella immunogenic compositions or vaccines. The present invention further ... | 11/22/2011 |
| 7935355 | Composition and method for controlling intestinal pathogenic organisms An antigen composition for stimulating an immune response in an inoculated avian species to at least one intestinal pathogenic organism includes naturally-occurring wild Salmonella enterica subspecies in O-serogroups B, C3 and D. Subspecies in O-se... | 05/03/2011 |
| 7887816 | Attenuated microorganisms for the treatment of infection The present invention pertains to a Salmonella microorganism having an attenuating mutation which disrupts the expression of a gene located within the Spi2 pathogenicity island, and an auxotrophic mutation. The microorganism therefore has a double mutation wh... | 02/15/2011 |
| 7754227 | Method of immunizing humans against using a Vi-EPA conjugate vaccine This invention relates to conjugates of the Vi polysaccharide of S. typhi with the carrier Pseudomonas aeruginosa recombinant exoprotein A (rEPA), and compositions thereof, and to methods of using of these conjugates and/or compositions thereof for eli... | 07/13/2010 |
| 7541043 | Vaccine for protection against disease Compositions and methods for protecting a susceptable host against an infection of Shigella sonnei are disclosed. Such compositions and methods are useful for protecting the host against bacillary dysentery and shigellosis. ... | 06/02/2009 |
| 7514089 | Genetically modified tumor-targeted bacteria with reduced virulence The present invention is directed to mutant Salmonella sp. having a genetically modified msbB gene in which the mutant Salmonella is capable of targeting solid tumors. The present invention further relates to the therapeutic use of the mutant Salmon... | 04/07/2009 |
| 7404960 | Multivalent vaccine composition having increased stability of capsular polysaccharide A vaccine composition comprising two valences is provided: (i) a first valence which is adjuvant-enhanced with aluminum hydroxide and (ii) a second valence which contains a polysaccharide of bacterial capsule comprising one or more o-acetyl groups and which is not a... | 07/29/2008 |
| 7371393 | Methods for reducing fecal shedding The present invention provides methods for reducing shedding in an animal. Generally, the method includes administcriirn to an animal a composition including siderophore receptor polypeptides and porins from gram negative microbes, and preferably, lipopolysaccarhide... | 05/13/2008 |
| 7354592 | Genetically modified tumor-targeted bacteria with reduced virulence The present invention is directed to mutant Salmonella sp. having a genetically modified msbB gene in which the mutant Salmonella is capable of targeting solid tumors. The invention is also directed to Salmonella sp. containing a genetically mod... | 04/08/2008 |
| 7341732 | Methods for treating mastitis in a milk producing animal The present invention provides methods for treating mastitis in a milk producing animal. The methods include administering compositions including siderophore receptor polypeptides and porins from gram negative microbes, and preferably, lipopolysaccarhide at a concen... | 03/11/2008 |
| 7297338 | Avian vaccine composition for the protection of poultry against disease and infection caused by and Salmonella There is provided a vaccine composition comprising a combination of a genetic deletion mutant S. typhimurium microorganism and a genetic deletion mutant E. coli microorganism, suitable for mass application to poultry. Also provided is a safe and effect... | 11/20/2007 |
| 7255851 | Non-invasive localization of a light-emitting conjugate in a mammal Methods and compositions for detecting and localizing light originating from a mammal are disclosed. Also disclosed are methods for targeting light emission to selected regions, as well as for tracking entities within the mammal. In addition, animal models for disea... | 08/14/2007 |
| 7247307 | Vaccines against O157 infection This invention relates to conjugates of the O-specific polysaccharide of E. coli O157 with a carrier, and compositions thereof, and to methods of using of these conjugates and/or compositions thereof for eliciting an immunogenic response in mammals, including... | 07/24/2007 |
| 7211264 | Attenuated microorganisms for the treatment of infection The present invention pertains to a Salmonella microorganism having an attenuating mutation which disrupts the expression of a gene located within the Spi2 pathogenicity island, and an auxotrophic mutation. The microorganism therefore has a double mutation wh... | 05/01/2007 |
| 7198774 | Non-invasive localization of a light-emitting conjugate in a mammal Methods and compositions for detecting and localizing light originating from a mammal are disclosed. Also disclosed are methods for targeting light emission to selected regions, as well as for tracking entities within the mammal. In addition, animal models for disea... | 04/03/2007 |
| 7166290 | Methods for producing oocysts The present invention provides improved methods and compositions for producing oocysts. The oocysts produced according to the invention find use in the manufacture of vaccines. In preferred embodiments, the present invention provides methods and compositions for the... | 01/23/2007 |
| 7160549 | Methods for making compositions including gram negative microbial polypeptides The present invention provides methods for making compositions including siderophore receptor polypeptides and porins from gram negative microbes. The methods include providing a gram negative microbe, disrupting the microbe, solubilizing the disrupted microbe, and ... | 01/09/2007 |
| 7147857 | Methods for treating high somatic cell counts The present invention provides methods for treating an animal having a high somatic cell count. The methods include administering compositions including siderophore receptor polypeptides and porins from gram negative microbes, and preferably, lipopolysaccarhide at a... | 12/12/2006 |
| 7138125 | Methods for treating an animal for low milk production The present invention provides methods for treating an animal for low milk production. The methods include administering compositions including siderophore receptor polypeptides and porins from gram negative microbes, and preferably, lipopolysaccarhide at a concentr... | 11/21/2006 |
| 7138124 | Polypeptides obtained from gram negative microbes The present invention provides compositions including at least two siderophore receptor polypeptides and at least two porins from a gram negative microbe, and preferably, lipopolysaccharide at a concentration of no greater than about 10.0 endotoxin units per millili... | 11/21/2006 |
| 7132108 | Biodegradable and biocompatible polymeric microspheres encapsulating bacteria Biodegradable and biocompatible polymeric microspheres encapsulating Salmonella enteritidis are administered to chickens to provide the chickens with sustained protection against S. enteritidis infections. ... | 11/07/2006 |
| 7115269 | Attenuated strain used as a vehicle for oral immunization The present invention is directed to an attenuated Salmonella comprising a eukaryotic expression vector for delivery of the eukaryotic expression vector to a eukaryotic cell. Delivery may be to eukaryotic cells cultured in vitro or to cells in vivo, such as b... | 10/03/2006 |
| 7101555 | Mycobacterial proteins, microorganisms producing them and their use for vaccines and the detection of tuberculosis Mycobacterium tuberculosis protein having a molecular weight of 28 779 Da, and hybrid proteins containing at least portions of its sequence. These proteins may in particular be used in vaccines or for the detection of specific tuberculosis antibodies. | 09/05/2006 |
| 7083794 | Recombinant vaccines comprising immunogenic attenuated bacteria having RpoS positive phenotype Attenuated immunogenic bacteria having an RpoS+ phenotype, in particular, Salmonella enterica serotype Typhi having an RpoS+ phenotype and methods therefor are disclosed. The Salmonella have in addition to an RpoS+ | 08/01/2006 |
| 7045122 | vaccine The present invention relates to live attenuated Salmonella strains comprising a first attenuating mutation, that are not capable of making functional RecA. The invention also relates to these bacteria for use in vaccines. Furthermore, the invention relates t... | 05/16/2006 |
| 7029678 | Vaccines The present invention provides vaccine compositions comprising an oil-in-water emulsion optionally with 3 De-O-acylated monophosphoryl lipid A and QS21. The vaccine compositions are potent induces of a range of immune responses. ... | 04/18/2006 |
| 7026155 | Method of reducing bacterial proliferation Bacteria and in particular pathogenic bacteria are treated in a manner which alters the bacteria's native level or activity of DNA methyltransferase (Dam). The alteration results in a change in the bacteria's native level of methylation of adenine in a GATC tetranuc... | 04/11/2006 |
| 7011836 | Mutants of gram negative mucosal bacteria and application thereof in vaccines It is possible to inactivate the early stage of lipid A synthesis of mucosal gram negative bacteria without compromising cell viability. In particular the lpxA gene in N. meningitidis was mutated and resulting lpxA knockout mutants were found to be completely... | 03/14/2006 |
| 7005129 | Non-toxic mutants of pathogenic gram-negative bacteria A method is provided for identifying, isolating, and producing htrB mutants of gram-negative bacterial pathogens. The method comprises mutating the htrB gene of a gram-negative bacterial pathogen so that there is a lack of a functional htrB protein, resulting in a m... | 02/28/2006 |
| 6969513 | Plasmid maintenance system for antigen delivery The present invention relates generally to a Plasmid Maintenance System for the stabilization of expression plasmids encoding foreign antigens, and methods for making and using the Plasmid Maintenance System. The invention optimizes the maintenance of expression pla... | 11/29/2005 |
| 6960344 | Use of imine-forming polysaccharides as adjuvants and immunostimulants The present invention relates to polysaccharide conjugates that comprise: a polysaccharide that binds to surface-receptors present on Antigen Presenting Cells, conjugated to one or more compounds having stable carbonyl groups covalently attached, either directly or ... | 11/01/2005 |
| 6951652 | Vaccine for prevention of gram-negative bacterial infections and endotoxin related diseases A vaccine is disclosed which is useful for protecting a host from Gram negative infections and the effects of endotoxin, therefore preventing sepsis and septic shock. The vaccine is prepared by combining LPS free or in conjugate form with a stoichiometric excess of ... | 10/04/2005 |
| 6939749 | Method of manufacturing a semiconductor device that includes heating the gate insulating film A process for fabricating a thin film transistor, which comprises crystallizing an amorphous silicon film, forming thereon a gate insulating film and a gate electrode, implanting impurities in a self-aligned manner, adhering a coating containing a catalyst element w... | 09/06/2005 |
| 6923972 | Methods for use of genetically modified tumor-targeted bacteria with reduced virulence The present invention is directed to mutant Salmonella sp. having a genetically modified msbB gene in which the mutant Salmonella is capable of targeting solid tumors. The present invention further relates to the therapeutic use of the mutant Salmon... | 08/02/2005 |
| 6905691 | Vaccines containing attenuated bacteria The invention relates to a vaccine comprising a bacterium attenuated by a non-reverting mutation in a gene encoding a protein which promotes folding of extracytoplasmic proteins. Such mutations were initially identified as being useful in vaccines from a bank of ran... | 06/14/2005 |
| 6872547 | Functional balanced-lethal host-vector systems The invention encompasses methods of maintaining desired recombinant genes in a genetic population of cells expressing the desired gene. The methods utilize microbial cells that have an inactivating mutation in a native essential gene encoding an enzyme which cataly... | 03/29/2005 |
