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| Number | Title | Issue Date |
| 8137681 | Polyanionic polymer adjuvants for B saccharide vaccines The present invention relates to the field of vaccines, and in particular vaccines comprising antigens of low isoelectric point at pH 7.0, in particular the capsular polysaccharide or oligosaccharide of H. influenzae B (PRP). Immunogenic compositions and meth... | 03/20/2012 |
| 8007818 | Polyanionic polymer adjuvants for haemophilus influenzae B saccharide vaccines The present invention relates to the field of vaccines, and in particular vaccines comprising antigens of low isoelectric point at pH 7.0, in particular the capsular polysaccharide or oligosaccharide of H. influenzae B (PRP). Immunogenic compositions and meth... | 08/30/2011 |
| 7998490 | Genes of an otitis media isolate of nontypeable The invention relates to the polynucleotide sequence of a nontypeable stain of Haemophilus influenzae (NTHi) and polypeptides encoded by the polynucleotides and uses thereof. The invention also relates to NTHi genes which are upregulated during or in response... | 08/16/2011 |
| 7901692 | Nontypeable virulence factors The invention relates to a mutation within the sap operon of an avirulent clone of a nontypeable strain of Haemophilus influenzae (NTHi). The invention also relates to the NTHi sap operon genes and the polypeptides encoded by these polynucleotide sequences. T... | 03/08/2011 |
| 7811590 | outer membrane protein and use thereof in vaccination This invention relates to recombinant bacterial outer membrane proteins comprising one or more LB1(f) peptides from surface-exposed loop 3 of MOMP P5 of non-typeable H. influenzae. Polynucleotides encoding these recombinant proteins are also covered. The inve... | 10/12/2010 |
| 7811591 | Chimeric vaccine for -induced disease The invention described herein relates to a chimeric protein comprising the NTHi twitching pilus major subunit protein (PilA) presenting a portion of the NTHi OMP P5 protein. The invention provides for vaccine compositions comprising the recombinant chimeric protein... | 10/12/2010 |
| 7785609 | Recombinant adhesin proteins Recombinant production of Hia protein, in full-length and N-terminally truncated forms, of non-typeable strains of Haemophilus influenzae, is described. The nucleic acid and deduced amino acid sequences of Hia genes of various strains of non-typeable and type... | 08/31/2010 |
| 7749518 | Polypeptides from non-typeable Polypeptides comprising non-typeable Haemophilus influenzae (NTHi) amino acid sequences. Over 2500 specific NTHi proteins are disclosed. The invention also provides related polypeptides, nucleic acids, antibodies and methods. These can all be used in medicine... | 07/06/2010 |
| RE41277 | Protein D—an IGD binding protein of Haemophilus influenzae A novel surface exposed protein of Haemophilus influenzae or related Haemophilus species is described. The protein named protein D is an Ig receptor for human IgD and has an apparent molecular weight of 42,000. Protein D can be detected in all of 116 encapsulated an... | 04/27/2010 |
| 7615229 | Mutants of the P4 protein of nontypable with reduced enzymatic activity A P4 variant protein that has reduced enzymatic activity and that induces antibody to wild-type P4 protein and/or has good bactericidal activity against non-typable H. influenzae (NTHi) is useful as an active component in an immunogenic composition for humans... | 11/10/2009 |
| 7429388 | Vaccine for nontypeable infection This invention provides a method for identifying strains of nontypeable Haemophilus influenzae that can be used as immunogenic compositions having specificity against a plurality of Haemophilus influenzae strains. The invention also provides compositio... | 09/30/2008 |
| 7413743 | Active immunization using a siderophore receptor protein The invention provides a vaccine for immunizing poultry and other animals against infection by a gram-negative bacteria, and a method of immunizing an animal using the vaccine. The vaccine may contain purified siderophore receptor proteins derived from a single stra... | 08/19/2008 |
| 7364206 | Compression fitting for pipes A compression fitting for rigid or semi-rigid pipes comprising an internal element 11 onto which the pipe 12 is fitted and into which at least one circumferential groove 13 is machined and an external sleeve 20 usually cylindrical is posi... | 04/29/2008 |
| 7306805 | Nontypeable virulence factors The invention relates to a mutation within the sap operon of an avirulent clone of a nontypeable strain of Haemophilus influenzae (NTHi). The invention also relates to the NTHi sap operon genes and the polypeptides encoded by these polynucleotide sequences. T... | 12/11/2007 |
| 7297340 | Vaccine and method for preventing biofilm formation The present invention is directed to compounds and methods for immunizing a patient against a biofilm-producing bacterial infection and a vaccine related thereto. ... | 11/20/2007 |
| 7291722 | Polypeptide from haemophilus influenza The invention provides BASB203 polypeptides and polynucleotides encoding BASB203 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses. ... | 11/06/2007 |
| 7235242 | IgA1 protease fragment as carrier peptides The present invention is concerned with a fragment of IgA1-protease having 40 to 200 amino acid residues and comprising at least 40 amino acids of an amino acid sequence as shown in SEQ ID NO:1, beginning with the amino acid in any one of positions 1 to 5 and ending... | 06/26/2007 |
| 7229622 | Synthetic chimeric fimbrin peptides The present invention provides synthetic chimeric fimbrin peptides which induce an immunogenic response in animals to non-typable Haemophilus influenzae and that do not require tedious purification techniques. The synthetic chimeric fimbrin peptides reduce th... | 06/12/2007 |
| 7226588 | Non-toxic mutants of pathogenic gram-negative bacteria A method is provided for identifying, isolating, and producing htrB mutants of gram-negative bacterial pathogens. The method comprises mutating the htrB gene of a gram-negative bacterial pathogen so that there is a lack of a functional HtrB protein, resulting in a m... | 06/05/2007 |
| 7166298 | Genetic immunization with cationic lipids A method for immunization using genetic material is disclosed. Compositions for genetic immunization comprising cationic lipids and polynucleotides are also disclosed. Methods for using genetic immunization to produce polyclonal and monoclonal antibodies are also di... | 01/23/2007 |
| 7160549 | Methods for making compositions including gram negative microbial polypeptides The present invention provides methods for making compositions including siderophore receptor polypeptides and porins from gram negative microbes. The methods include providing a gram negative microbe, disrupting the microbe, solubilizing the disrupted microbe, and ... | 01/09/2007 |
| 7122191 | Microfluidized oil-in-water emulsions and vaccine compositions This invention provides submicron oil-in-water emulsions useful as a vaccine adjuvant for enhancing the immunogenicity of antigens. The present invention also provides vaccine compositions containing an antigen combined with such emulsions intrinsically or extrinsic... | 10/17/2006 |
| 7118749 | Transferrin receptor genes Purified and isolated nucleic acid is provided which encodes a transferrin receptor protein of a strain of Haemophilus or a fragment or an analog of the transferrin receptor protein. The nucleic acid sequence may be used to produce peptides free of contaminan... | 10/10/2006 |
| 7115271 | Protein D—an IgD-binding protein of A novel surface exposed protein of Haemophilus influenzae or related Haemophilus species is described. The protein named protein D is an Ig receptor for human IgD and has an apparent molecular weight of 42,000. Protein D can be detected in all of 116 e... | 10/03/2006 |
| 7101989 | DsrA protein and polynucleotides encoding the same DsrA is an outer membrane protein of H. ducreyi that confers serum resistance to the bacteria. Isolated polynucleotides encoding the protein, end expression vectors and host cells encoding the same, are described. Also described is a mutant H. ducreyi ... | 09/05/2006 |
| 7090853 | Noscapine derivatives as adjuvant compositions and methods of use thereof An adjuvant composition comprising noscapine and its derivatives, for use in the treatment of tumors, cancer, as an adjuvant for vaccines. ... | 08/15/2006 |
| 7057016 | Process for the production of biologically active protein The present invention relates to a folding process for the preparation of biologically active, dimeric, TGF-β (Transforming Growth Factor type β)-like protein in a detergent-free folding buffer. ... | 06/06/2006 |
| 7052860 | Identification of antigens for use in the diagnosis, treatment, and monitoring of periodontal diseases Antibodies, polypeptides, and polynucleotides are provided for the detection, prevention, amelioration and treatment of diseases caused by Actinobacillus actinomycetemcomitans. ... | 05/30/2006 |
| 7015033 | Co-expression of recombination proteins Expression vectors are described which permit the recombinant expression of proteins which essentially contain, in addition to nucleic acid encoding the recombinant protein, nucleic acid encoding a non-proteolytic analog of Haemophilus Hin47 protein, with or ... | 03/21/2006 |
| 7005129 | Non-toxic mutants of pathogenic gram-negative bacteria A method is provided for identifying, isolating, and producing htrB mutants of gram-negative bacterial pathogens. The method comprises mutating the htrB gene of a gram-negative bacterial pathogen so that there is a lack of a functional htrB protein, resulting in a m... | 02/28/2006 |
| 6974581 | Multi-component vaccine comprising at least two antigens from to protect against disease A multi-component immunogenic composition confers protection on an immunized host against infection caused by Haemophilus influenzae. Such composition comprises at least two different antigens of Haemophilus influenzae, one of which is an adhesin. High... | 12/13/2005 |
| 6921537 | Preparation and uses of los-depleted outer membrane proteins of gram-negative cocci Described herein is a method for removing toxic lipooligosaccharide (LOS) from outer membranes of Gram-negative cocci, such as Neisseria meningitidis. LOS-depleted outer membranes and LOS-depleted soluble outer membrane proteins can be prepared, which are abl... | 07/26/2005 |
| 6919080 | Polypeptide for Haemophilus paragallinarum and process for preparing the same A novel peptide obtained from Haemophilus paragallinarum has been found useful for preventing avian infectious coryza. This polypeptide induces production of hemagglutination-inhibition antibody and prevents infection and onset of avian infectious coryza. The... | 07/19/2005 |
| 6913753 | Incapacitated whole-cell immunogenic bacterial compositions The invention features incapacitated whole cell bacterial immunogenic compositions produced by infecting a bacterium with Lys minus bacteriophage, which are deficient in the lysin protein. Lys minus bacteriophage retain activity in infection of its appropriate bacte... | 07/05/2005 |
| 6905691 | Vaccines containing attenuated bacteria The invention relates to a vaccine comprising a bacterium attenuated by a non-reverting mutation in a gene encoding a protein which promotes folding of extracytoplasmic proteins. Such mutations were initially identified as being useful in vaccines from a bank of ran... | 06/14/2005 |
| 6887483 | Non-toxic mutants of pathogenic gram-negative bacteria A method is provided for identifying, isolating, and producing htrB mutants of gram-negative bacterial pathogens. The method comprises mutating the htrB gene of a gram-negative bacterial pathogen so that there is a lack of a functional HtrB protein, resulting in a m... | 05/03/2005 |
| 6887484 | Vaccine composition containing a promoter peptide A vaccine having a good vaccination effect, which comprises an antigen; a peptide selected from the group consisting of a peptide having the amino acid sequence of SEQ ID NO: 1, a peptide having the amino acid sequence of SEQ ID NO: 2, and a peptide derived from a p... | 05/03/2005 |
| 6872398 | Conjugate vaccine against gram-negative bacterial infections The present invention relates to a broadly reactive vaccine against Gram-negative bacteria which is composed of a biological glycan-pilus conjugate. The conjugate core is a common pilus type to which is attached the glycan of choice in vivo. Pooling of these bioconj... | 03/29/2005 |
| 6858209 | Means for detecting bacteria of the taylorella equigenitalis species and their biological applications Means for detection of bacteria of the genus Taylorella and biological applications thereof are described. In particular, the detection of T. equigenitalis and the treatment or prevention of infections caused by bacteria of this species are disclosed. ... | 02/22/2005 |
| 6814971 | Adjuvants for use in vaccines The invention relates to adjuvants that contain a lecithin, an oil and an amphiphilic surfactant and that are capable of forming a stable oil-in-water emulsion vaccine so as to minimize local reactions to the vaccine in the injected animal. ... | 11/09/2004 |
