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"To place a man in a multi-stage rocket and project him into the controlling gravitational field of the moon where the passengers can make scientific observations, perhaps land alive, and then return to earth--all that constitutes a wild dream worthy of Jules Verne. I am bold enough to say that such a man-made voyage will never occur regardless of all future advances."
Lee deForest, American radio pioneer ; 1957
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| Number | Title | Issue Date |
| 8092811 | Interaction of with epithelial cells, extracellular matrix proteins and the complement system The present invention relates to surface proteins of Moraxella catarrhalis and their ability to interact with epithelial cells via cell-associated fibronectin and laminin, and also to their ability to inhibit the complement system. These surface proteins are ... | 01/10/2012 |
| 7811589 | Method for stimulating immune response against Provided is a method for stimulating in an individual an immune response against M. catarrhalis. The method is performed by administering to an individual a composition that contains at least one isolated M. catarrhalis protein in an amount effective t... | 10/12/2010 |
| 7691395 | BASB119 polypeptide and polynucleotide from The invention provides BASB119 polypeptides and polynucleotides encoding BASB119 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses. ... | 04/06/2010 |
| 7632516 | BASB115 polypeptides The invention provides BASB115 polypeptides and polynucleotides encoding BASB115 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses. ... | 12/15/2009 |
| 7470432 | Surface explosed immunoglobulin D-binding protein from Moraxella catarrhalis The present invention relates to a surface exposed protein, which can be detected in Moraxella catarrhalis, having an amino acid sequence as described in SEQ ID NO 1, an apparent molecular weight of 200 kDa and a capacity of selectively binding membrane bound... | 12/30/2008 |
| 7432366 | BASB034 polypeptides and used thereof Provided are Moraxella catarrhalis BASB034 polypeptides and immunogenic fragments of BASB034 polypeptides. Preferably, the immunogenic fragments have at least 15 amino acids that match an aligned contiguous segment of SEQ ID NOs:2, 4, 6 or 8. The immunogenic ... | 10/07/2008 |
| 7410648 | Polypeptides of () The present invention relates to polypeptides, more particularly polypeptides of Moraxella (Branhamella) catarrhalis which may be used to prevent, diagnose and/or treat Moraxella (Branhamella) catarrhalis infection. ... | 08/12/2008 |
| 7344724 | UspA1 and UspA2 antigens of The present invention discloses the existence of two novel proteins UspA1 and UspA2, and their respective genes uspA1 and uspA2. Each protein encompasses a region that is conserved between the two proteins and comprises an epitope that is recognized by the MAb 17C7.... | 03/18/2008 |
| 7341727 | outer membrane protein-106 polypeptide, methods of eliciting an immune response comprising same The invention discloses the Moraxella catarrhalis outer membrane protein-106 (OMP106) polypeptide, polypeptides derived therefrom (OMP106-derived polypeptides), nucleotide sequences encoding said polypeptides, and antibodies that specifically bind the OMP106 ... | 03/11/2008 |
| 7329500 | () polypeptides and corresponding DNA fragments The present invention relates to polypeptides of Moraxella (Branhamela) catarrhalis which may be used for prophy-laxis, diagnostic and/or therapy purposes. ... | 02/12/2008 |
| 7311917 | protein, gene sequence and uses thereof The invention discloses the Moraxella catarrhalis outer membrane protein polypeptide and polypeptides derived therefrom (collectively “OMP21”), nucleotide sequences encoding said OMP21, and antibodies that specifically bind OMP21. Also disclosed are pharm... | 12/25/2007 |
| 7267963 | Modified plant viruses and methods of use thereof The present invention relates to modulating the nature and/or level of an immune response to a molecule. In particular, the invention relates to effecting an increase in the TH1 immune response to molecules such as, but not limited to, antigens or immunogens. The in... | 09/11/2007 |
| 7241449 | Transferrin receptor genes of Purified and isolated nucleic acid molecules are provided which encode Tbp2 proteins of M. catarrhalis strains M35, 3 and LES1. The nucleic acid sequence may be used to produce recombinant Tbp2 proteins of the strain of Moraxella free of other proteins... | 07/10/2007 |
| 7128910 | outer membrane protein-106 polypeptide, gene sequences and uses thereof The invention discloses the Moraxella catarrhalis outer membrane protein-106 (OMP106) polypeptide, polypeptides derived therefrom (OMP106-derived polypeptides), nucleotide sequences encoding OMP106 polypeptides, and antibodies that specifically bind the OMP10... | 10/31/2006 |
| 7122197 | Compounds from The invention provides BASB020 polypeptides and polynucleotides encoding BASB020 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses. ... | 10/17/2006 |
| 7018639 | Vaccine antigens of The present invention relates to antigens of Moraxella, in particular, Moraxella bovis, nucleic acid sequences encoding these antigens and formulations for use in raising an immune response against Moraxella. ... | 03/28/2006 |
| 6951652 | Vaccine for prevention of gram-negative bacterial infections and endotoxin related diseases A vaccine is disclosed which is useful for protecting a host from Gram negative infections and the effects of endotoxin, therefore preventing sepsis and septic shock. The vaccine is prepared by combining LPS free or in conjugate form with a stoichiometric excess of ... | 10/04/2005 |
| 6921537 | Preparation and uses of los-depleted outer membrane proteins of gram-negative cocci Described herein is a method for removing toxic lipooligosaccharide (LOS) from outer membranes of Gram-negative cocci, such as Neisseria meningitidis. LOS-depleted outer membranes and LOS-depleted soluble outer membrane proteins can be prepared, which are abl... | 07/26/2005 |
| 6899885 | 74-kilodalton outer membrane protein from Moraxella catarrhalis A protein from M. catarrhalis, designated the 74 kD protein, is isolated and purified. The 74 kD protein has an amino-terminal amino acid sequence which is conserved among various strains of M. catarrhalis. The protein has a molecular weight of approxi... | 05/31/2005 |
| 6858211 | Vaccines against Escherichia coli O157 infection This invention relates to conjugates of the O-specific polysaccharide of E. coli O157 with a carrier, and compositions thereof, and to methods of using of these conjugates and/or compositions thereof for eliciting an immunogenic response in mammals, including... | 02/22/2005 |
| 6805868 | Moraxella catarrhalis antigen, corresponding gene and uses thereof The invention provides BASB109 polypeptides and polynucleotides encoding BASB109 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses. ... | 10/19/2004 |
| 6803043 | Basbo27 proteins and genes from moraxella catarrhalis, antigens, antibodies, and uses The invention provides BASB027 polypeptides and polynucleotides encoding BASB027 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses. ... | 10/12/2004 |
| 6770459 | Immunogenic compounds The invention provides BASB081 polypeptides and polynucleotides encoding BASB081 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses. ... | 08/03/2004 |
| 6764834 | BASB019 proteins and genes from Moraxella catarrhalis, antigens, antibodies, and uses The invention provides BASB019 polypeptides and polynucleotides encoding BASB019 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses. ... | 07/20/2004 |
| 6706269 | Moraxella catarrhalis PILQ proteins The invention provides BASB031 polypeptides and polynucleotides encoding BASB031 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses. ... | 03/16/2004 |
| 6706494 | BASB028 polypeptides and polynucleotides encoding therefor from moraxella catarrhalis The invention provides BASB028 polypeptides and polynucleotides encoding BASB028 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses. ... | 03/16/2004 |
| 6706271 | Cloning of BASB023 antigen from Moraxella catarrhalis The invention provides BASB023 polypeptides encoding BASB023 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses. ... | 03/16/2004 |
| 6685949 | Lipooligosaccharide based vaccine for prevention of moraxella (branhamella)catarrhalis infections in humans A conjugate vaccine for Moraxella (Branhamella) catarrhalis comprising isolated lipooligosaccharide from which esterified fatty acids have been removed, to produce a detoxified lipooligosaccharide (dLOS), or from which lipid A has been removed, to produce... | 02/03/2004 |
| 6649171 | Moraxella catarrahalis polynucleotides and polypeptides The invention provides BASB021 polypeptides and polynucleotides encoding BASB021 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses.... | 11/18/2003 |
| 6627728 | Compounds from moraxella catarrhalis The invention provides BASB010 polypeptides and polynucleotides encoding BASB010 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses.... | 09/30/2003 |
| 6613335 | Polypeptides from moraxella (branhamella) catarrhalis Provided are BASB011 polypeptides and polynucleotides encoding BASB011 polypeptide from Moraxella catarrhalis. Also provided are immunogenic uses.... | 09/02/2003 |
| 6461618 | 74 kilodalton outer membrane protein from moraxella catarrhalis A protein from the M. catarrhalis designated the 74 kD protein is isolated and purified. The 74 kD protein has an amino-terminal amino acid sequence which is conserved among various strains of M. catarrhalis. The protein has a molecular weight of approxim... | 10/08/2002 |
| 6440424 | High molecular weight major outer membrane protein of moraxella An isolated and purified outer membrane protein of a Moraxella strain, particularly M. catarrhalis, has a molecular mass of about 200 kDa. The about 200 kDa outer membrane protein as well as nucleic acid molecules encoding the same are useful in diagnosti... | 08/27/2002 |
| 6440425 | High molecular weight major outer membrane protein of moraxella An isolated and purified outer membrane protein of a Moraxella strain, particularly M. catarrhalis, having a molecular mass of about 200 kDa, is provided. The about 200 kDa outer membrane protein as well as nucleic acid molecules encoding the same are use... | 08/27/2002 |
| 6391313 | Multi-component vaccine to protect against disease caused by Haemophilus influenzae and Moraxella catarrhalis A multi-valent immunogenic composition confers protection on an immunized host against infection caused by both Haemophilus influenzae and Moraxella catarrhalis. Such composition comprises at least four antigens comprising at least one antigen from Haemop... | 05/21/2002 |
| 6355253 | Preparation and uses of LOS-depleted outer membrane proteins of gram-negative cocci Described herein is a method for removing toxic lipooligosaccharide (LOS) from outer membranes of Gram-negative cocci, such as Neisseria meningitidis. LOS-depleted outer membranes and LOS-depleted soluble outer membrane proteins can be prepared, which are... | 03/12/2002 |
| 6348198 | Lactoferrin receptor protein An isolated and purified lactoferrin receptor protein is isolated and purified from bacterial pathogens, including Moraxella and Neisseria, and has a molecular weight of between about 70,000 and about 90,000, as determined by SDS-PAGE. Such lactoferrin re... | 02/19/2002 |
| 6344200 | Lactoferrin receptor protein An isolated and purified lactoferrin receptor protein is isolated and purified from bacterial pathogens, including Moraxella and Neisseria, and has a molecular weight of between about 70,000 and about 90,000, as determined by SDS-PAGE. Such lactoferrin re... | 02/05/2002 |
| 6335018 | High molecular weight major outer membrane protein of moraxella An isolated and purified outer membrane protein of a Moraxella strain, particularly M. catarrhalis, has a molecular mass of about 200 kDa. The about 200 kDa outer membrane protein as well as nucleic acid molecules encoding the same are useful in diagnosti... | 01/01/2002 |
| 6290970 | Transferrin receptor protein of Moraxella An isolated and purified non-denatured transferrin receptor protein of a Moraxella strain, particularly M. catarrhalis, has an apparent molecular mass of about 80 to about 90 kDa, as determined by SDS-PAGE. The transferrin receptor protein or a fragment a... | 09/18/2001 |
