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| Number | Title | Issue Date |
| 7279169 | Mucosal DTPa vaccines Mucosal DTPa vaccines, especially intranasal vaccines, comprising (a) a diphtheria antigen, a tetanus antigen and an acellular pertussis antigen, and (b) a detoxified mutant of cholera toxin (CT) or E. coli heat labile toxin (LT). Component (b) acts as a muco... | 10/09/2007 |
| 7101555 | Mycobacterial proteins, microorganisms producing them and their use for vaccines and the detection of tuberculosis Mycobacterium tuberculosis protein having a molecular weight of 28 779 Da, and hybrid proteins containing at least portions of its sequence. These proteins may in particular be used in vaccines or for the detection of specific tuberculosis antibodies. | 09/05/2006 |
| 7070781 | Nontoxic mucosal adjuvant A non-toxic mucosal adjuvant is provided which may be admixed with further antigens to provide a vaccine administrable to mucosal surfaces in organisms including man. Preferably, the non-toxic mucosal adjuvant is a detoxified mutant of a bacterial ADP-ribosylating t... | 07/04/2006 |
| 6927235 | Vaccine composition comprising iron phosphate as vaccine adjuvant The present invention relates to vaccine compositions comprising iron phosphate as adjuvant. This iron phosphate is in the form of particles, the size of which is between 0.01 μm and 300 μm; it can be obtained by mixing a solution of iron salt and of phosphate sal... | 08/09/2005 |
| 6887484 | Vaccine composition containing a promoter peptide A vaccine having a good vaccination effect, which comprises an antigen; a peptide selected from the group consisting of a peptide having the amino acid sequence of SEQ ID NO: 1, a peptide having the amino acid sequence of SEQ ID NO: 2, and a peptide derived from a p... | 05/03/2005 |
| 6746677 | Stable vaccine compositions for parenteral administration, a method for their use, and a process for their preparation The invention relates to certain stable vaccine compositions comprising a macrocyclic lactone compound, a milbemycin compound, an avermectin compound or mixtures thereof; at least one antigen; a dispersing agent; an adjuvant; a water soluble organic solvent; and sal... | 06/08/2004 |
| 6733759 | Nutrient formulation and process for enhancing the health, livability, cumulative weight gain or feed efficiency in poultry and other animals A nutrient formulation including moisture, a coloring agent, a palatability modifier, and/or an adjuvant which is designed for use in poultry and other animals, and a method of feeding it which improves subsequent livability, cumulative feed efficiency, weight gain,... | 05/11/2004 |
| 6696064 | Methods of protecting vasculature from damage by diphtheria toxin-and pseudomonas toxin-based immunotoxins during therapy Vascular damage has proven to be dose limiting in administering immunotoxins into the brain to treat brain tumors. Vascular toxicity of immunotoxins which rely in part on exposure to lowered pH in cellular endosomes and lysosomes can be avoided by adminis... | 02/24/2004 |
| 6676945 | Mycobacterial proteins, microorganisms producing them and their use for vaccines and for the detection of tuberculosis Mycobacterium tuberculosis protein having a molecular weight of 28.779 Da, and hybrid proteins containing at least portions of its sequence. These proteins may in particular be used in vaccines or for the detection of specific tuberculosis antibodies.... | 01/13/2004 |
| 6605696 | Lawsonia intracellularis proteins, and related methods and materials Isolated polynucleotide molecules contain a nucleotide sequence that encodes a L. intracellularis HtrA, PonA, HypC, LysS, YcfW, ABC1, or Omp100 protein, a substantial portion of the sequences, or a homologous sequence. Related polypeptides, immunogenic co... | 08/12/2003 |
| 6548287 | Non-pyrogenic bacterial strains and use of the same The present invention provides gram-negative bacterial strains that produce substantially pure non-pyrogenic lipopolysaccharide or lipid A. The present invention also relates to a use of said strains for the preparation of non-pyrogenic DNA and use of the... | 04/15/2003 |
| 6506388 | Immunomodulator, immunomodulator food An immunomodulator having suppressive activity on IgE antibody production is provided and contains bacterial cells, or their decomposition materials. It can be taken as a food. Bacterial cells such as Corynebacterium, Brevibacterium, Microbacterium, or ba... | 01/14/2003 |
| 6486132 | Immunomodulator, immunomodulator food and immunomodulator feed To provide an immunomodulator in which DNA can be administered orally or percutaneously, not through injection, or can be taken daily like a food, or an immunomodulator food or feed. DNA derived from cells of procaryotes such as Bacillus subtilis, lactic ... | 11/26/2002 |
| 6455673 | Multi-mutant diphtheria toxin vaccines Disclosed are diphtheria toxin polypeptides having multiple mutations, which render the polypeptides useful as vaccines.... | 09/24/2002 |
| 6156302 | Adoptive immunotherapy using macrophages sensitized with heat shock protein-epitope complexes The present invention relates to methods and compositions for enhancing immunological responses and for the prevention and treatment of infectious diseases or primary and metastatic neoplastic diseases based on the administration of macrophages and/or oth... | 12/05/2000 |
| 6139844 | Method for treating or eliminating a parasitic disease A method for treating or eliminating a protozoal or parasitic disease in an animal in which a sufficient amount of a bacterial cell wall extract is administered to the animal having the protozoal or the parasitic disease. The cell wall extract is preferab... | 10/31/2000 |
| 6040148 | Corynebacterial stress proteins The present invention relates to a purified stress protein of 86 Kd and fragments thereof isolated from the genus Corynebacterium. Particular fragments include those with apparent molecular weights of 50 Kd and 52 Kd. The stress protein has been found to ... | 03/21/2000 |
| 6019985 | Immunostimulation methods for providing disease protection in poultry Methods are provided for improved immunization against coccidiosis and other bacterial, viral, or parasitic diseases in poultry. One method includes administering a solution of Propionibacterium acnes suspended in normal saline to a chick at age day one, ... | 02/01/2000 |
| 5997881 | Method of making non-pyrogenic lipopolysaccharide or A The present invention provides gram-negative bacterial strains that produce substantially pure non-pyrogenic lipopolysaccharide or lipid A. The present invention also relates to a use of said strains for the preparation of non-pyrogenic DNA and use of the... | 12/07/1999 |
| 5989566 | Stable vaccine compositions for parenteral administration, a method for their use, and a process for their preparation The invention relates to certain stable vaccine compositions comprising a macrocyclic lactone compound, a milbemycin compound, an avermectin compound or mixtures thereof; at least one antigen; a dispersing agent; an adjuvant; a water soluble organic solve... | 11/23/1999 |
| 5917017 | Diphtheria toxin vaccines bearing a mutated R domain Diphtheria toxin polypeptides comprising a mutant R binding domain exhibit reduced target cell binding and may be used as vaccines to immunize a mammal against infection by Corynebacterium diphtheria.... | 06/29/1999 |
| 5843462 | Diphtheria toxin epitopes A method for identifying an immunodominant sequence region in a diphtheria toxin-specific peptide is provided. Also provided are diphtheria toxin specific peptides with an immunodominant sequence region.... | 12/01/1998 |
| 5837269 | Vaccine compositions and method for enhancing an immune response The invention relates to a vaccine which comprises an antigen and an immune response augmenting agent. The immune response augmenting agent is capable of enhancing T cell lymphokine production. Suitable immune response augmenting agents include, but are n... | 11/17/1998 |
| 5824313 | Vaccine compositions and method for induction of mucosal immune response via systemic vaccination The invention relates to a vaccine which comprises an antigen and a lymphoid organ modifying agent. Suitable lymphoid organ modifying agents include, but are not limited to, 1,25-dihydroxy Vitamin D3, biologically active Vitamin D3 d... | 10/20/1998 |
| 5807757 | Preparation of ionically cross-linked polyphosphazene microspheresy by coacervation A method is provided for preparing polyphosphazene microspheres wherein the polyphosphazene microspheres are produced by coacervation. A solution containing a polyphosphazene is admixed with a solution containing a salt of a monovalent ion such as a salt ... | 09/15/1998 |
| 5728385 | Method and composition for an early vaccine to protect against both common infectious diseases and chronic immune mediated disorders or their sequelae A method of immunization, and compositions therefor, are provided for substantially preventing or reducing the symptoms of at least one infectious disease and at least one chronic immune mediated disorder. An immunogenic challenge which supplements the no... | 03/17/1998 |
| 5650154 | Protective antigens against disease pathogens Methods and kits for identifying antigens from a pathogen. The antigens identified are preferably those that provide protection for an animal against the pathogen. The steps of the method include providing a sample of the pathogen, isolating the protectiv... | 07/22/1997 |
| 5637303 | Use of a phospholipase D mutant of Corynebacterium pseudotuberculosis for vaccination The present invention relates to a vaccine vector comprising a virulent corynebacterium or related organism which is incapable of expressing an active virulent factor or a non-virulent corynebacterium or related organism which synthesises an immuno protec... | 06/10/1997 |
| 5604108 | Test for determining the dose response of a conjugated vaccine The dosage response of humans to conjugate vaccines comprising a bacterial polysaccharide and a strongly-immunogenic carrier protein is determined in animals by coadministering to the animal unconjugated strongly-immunogenic carrier protein in an amount c... | 02/18/1997 |
| 5562910 | Vaccine compositions and method for enhancing an immune response The invention relates to a vaccine which comprises an antigen and an immune response augmenting agent. The immune response augmenting agent is capable of enhancing T cell lymphokine production. Suitable immune response augmenting agents include, but are n... | 10/08/1996 |
| 5554730 | Method and kit for making a polysaccharide-protein conjugate A method and kit for making a polysaccharide-protein Schiff base conjugate. A polysaccharide is oxidized with an oxidizing agent and combined with a protein in the presence of a macromolecular crowding agent to form a Schiff base. Preferably, the macromol... | 09/10/1996 |
| 5552145 | Feed composition and a method for decreasing piglet mortality in piglets Administering a feed composition, containing at least one member selected from the group consisting of sterilized bacterial cells; disrupted cell fragments obtained by mechanical disruption or enzymatic decomposition of the cells and cell wall component-c... | 09/03/1996 |
| 5540924 | Composition for the prevention and treatment of white diarrhea and diarrhea in livestock, etc. A composition for the prevention and treatment of diarrhea in animals, containing sterilized cells of bacteria belonging to the genus Bacillus, Brevibacterium, Corynebacterium, Escherichia, Lactobacillus, Streptococcus, or Streptomyces, a cell homogenate ... | 07/30/1996 |
| 5518725 | Vaccine compositions and method for induction of mucosal immune response via systemic vaccination The invention relates to a vaccine which comprises an antigen and a lymphoid organ modifying agent. Suitable lymphoid organ modifying agents include 1,25-dihydroxy Vitamin D3, biologically active Vitamin D3 derivatives which are capa... | 05/21/1996 |
| 5198215 | Composition for controlling mastitis in ruminants, method for its preparation and method of treatment of ruminants The invention presents a composition for controlling mastitis in ruminants, a method for preparing the composition and a method of treatment of ruminants. The composition contains one or more soluble exoantigens of gram-positive bacteria involved in masti... | 03/30/1993 |
| 5039522 | Immunogens containing peptides with an attached hydrophobic tail for adsorption to hepatitis B virus surface antigen An immunogenic complex comprising a peptide containing a hydrophobic tail, the peptide being adsorbed to hepatitis B virus surface antigen via the hydrophobic tail. Such complex in a immunogenically effective amount when administered with a physiologicall... | 08/13/1991 |
| 4957736 | Composition for vaccines The invention is concerned with the use of a compound analogous to tuftsin, having the formula (I) ##STR1## or of a pharmaceutically acceptable base-addition or acid-additon salt thereof, as an adjuvant in order to potentiate, in a living organism, t... | 09/18/1990 |
| 4698221 | Vaccines containing fat soluble vitamins, zinc compounds and selenium compounds The invention relates to vaccines which, in addition to antigens, contain fat-soluble vitamins (such as vitamins A, D or E), physiologically acceptable zinc and selenium compounds and, optionally, absorption-promoting agents and/or spreading oils.... | 10/06/1987 |
| 4578270 | Process for the preparation of lyophilized, adsorbed polyvalent vaccines The invention relates to the preparation of lyophilized, absorbed polyvalent vaccines. According to the invention tetanus, diphtheria, pertussis and optionally typhus antigens concentrated to 5 to 15 doses/3 ml are adsorbed at a pH value of 3 to 6 to an i... | 03/25/1986 |
| 4554101 | Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity An immunoglobulin is provided which consists essentially of a mono-specific, hetero-molecular antibody which is mono-specific to a single antigenic or allergenic determinant. The antibody is specific to the H-epitope of a protein antigen or allergen. The ... | 11/19/1985 |
