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| Number | Title | Issue Date |
| 8187610 | strain The invention provides Streptococcus vaccine strains (e.g. S. equi which is causative of ‘strangles’) comprising the following modifications in their genomes: (i) attenuation of one or more essential biosynthetic genes, (ii) attenuation of one or m... | 05/29/2012 |
| 8168205 | polypeptides The present invention provides polynucleotide sequences of the genome of Streptococcus pneumoniae, polypeptide sequences encoded by the polynucleotide sequences, corresponding polynucleotides and polypeptides, vectors and hosts comprising the polynucleotides,... | 05/01/2012 |
| 8147849 | Protective antigens for group B hypervirulent strains The invention provides protective antigens for Group B streptococcus hypervirulent strains. The fragments are useful in vaccine compositions to induce protection against S. agalactiae, particularly against hypervirulent strains. ... | 04/03/2012 |
| 8114417 | Recombinant protective protein from The present invention discloses amino acid sequences and nucleic acid sequences relating to a Streptococcus pneumoniae surface associated Pneumo Protective Protein (PPP) having a molecular weight of about 20 kilo Daltons (kDa). The PPP exhibits the ability to... | 02/14/2012 |
| 8110199 | proteins and nucleic acid molecules Protein antigens from Streptococcus pneumoniae are disclosed, together with nucleic acid sequences encoding them. Their use in vaccines and in screening methods is also described. ... | 02/07/2012 |
| 8105612 | Serum resistance factors of gram positive bacteria A newly identified serum resistance factor of gram positive bacteria can be used to treat or prevent bacterial infection. ... | 01/31/2012 |
| 8084040 | Use of bacterium for manufacture of a vaccine The present invention relates to the use of live attenuated bacteria for the manufacture of a vaccine for submucosal administration. ... | 12/27/2011 |
| 8071111 | Virulence of The invention relates to the field of diagnosis of and vaccination against Streptococcal infections and to the detection of virulence markers of Streptococci. The invention discloses a method for modulating virulence of a Streptococcus, the method comprising ... | 12/06/2011 |
| 8071112 | Compositions and methods of use of ORF-1358 from beta-hemolytic streptococcal strains The present invention relates to polynucleotides encoding Streptococcus group C and G polypeptides and their use in immunogenic compositions. The invention also relates to immunogenic compositions comprising polypeptides encoded by those polynucleotides. In a... | 12/06/2011 |
| 8039005 | Mutant forms of streptolysin O Forms of GAS25 (streptolysin O) which are not toxic but which still maintain the ability to induce protection against S. pyogenes are useful in vaccine compositions to induce protection against S. pyogenes. ... | 10/18/2011 |
| 8025890 | Nucleic acids and proteins from groups A and B The invention provides proteins from group B streptococcus (Streptococcus agalactiae) and group A streptococcus (Streptococcus pyogenes), including amino acid sequences and the corresponding nucleotide sequences. Data are given to show th... | 09/27/2011 |
| 7955604 | Nucleic acids and proteins from groups A and B The invention provides proteins from group B streptococcus (Streptococcus agalactiae) and group A streptococcus (Streptococcus pyogenes), including amino acid sequences and the corresponding nucleotide sequences. Data are given to show th... | 06/07/2011 |
| 7955605 | Multivalent pneumococcal polysaccharide-protein conjugate composition An immunogenic composition having 13 distinct polysaccharide-protein conjugates and optionally, an aluminum-based adjuvant, is described. Each conjugate contains a capsular polysaccharide prepared from a different serotype of Streptococcus pneumoniae (1, 3, 4... | 06/07/2011 |
| 7939087 | Nucleic acids and proteins from groups A & B The invention provides proteins from group B streptococcus (Streptococcus agalactiae) and group A streptococcus (Streptococcus pyogenes), including amino acid sequences and the corresponding nucleotide sequences. Data are given to show th... | 05/10/2011 |
| 7939088 | vaccine The present invention relates to the use of bacteria of the species Streptococcus phocae for the manufacture of a vaccine, to methods for the production of such vaccines, to bacteria of the species Streptococcus phocae for use in a vaccine and to metho... | 05/10/2011 |
| 7927608 | polypeptides and polynucleotides encoding same and their use in vaccinal and diagnostic applications The present invention relates to the field of Streptococcus. More specifically, the present invention relates to the identification of polypeptides and polynucleotide sequences encoding the same which are involved in the pathogenic mechanism of S. suis... | 04/19/2011 |
| 7919104 | Functional epitopes of PsaA antigen and uses thereof Provided is a P4 peptide, which contains functional epitopes of the PsaA protein of Streptococcus pneumoniae, and related methods and compositions. P4 peptide mimetics having a conformational structure identical or similar to the conformation of P4 (e.g., SEQ... | 04/05/2011 |
| 7914798 | Compositions and methods of use of ORF1358 from beta-hemolytic streptococcal strains The present invention relates to polynucleotides encoding Streptococcus group C and G polypeptides and their use in immunogenic compositions. The invention also relates to immunogenic compositions comprising polypeptides encoded by those polynucleotides. In a... | 03/29/2011 |
| 7883710 | Peptide vaccines against Group A streptococci This invention, in one aspect, relates to synthetic immunoreactive peptides. These peptides are approximately 20-25 amino acids in length which are portions of the N termini of the M proteins of the most prevalent United States (U.S.) Group A Streptococcus (G... | 02/08/2011 |
| 7867501 | Nucleic acid and amino acid sequences relating to for diagnostics and therapeutics The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polype... | 01/11/2011 |
| 7858101 | Modified streptococcal polysaccharides and uses thereof Modified streptococcal polysaccharides and methods of using the modified polysaccharides are provided herein. ... | 12/28/2010 |
| 7754226 | Compositions and methods of use of ORF 554 from beta hemolytic streptococcal strains The present invention relates to compositions and methods of use comprising peptidyl-prolyl isomerase (PPI) polypeptides of group C and G streptococci and polynucleotides encoding same. The invention also relates to immunogenic compositions comprising the PPI polype... | 07/13/2010 |
| 7749516 | Immunization of dairy cattle with GapC protein against infection The GapC plasmin binding protein genes of Streptococcus dysgalactiae (S. dysgalactiae), Streptococcus agalactiae (S. agalactiae), Streptococcus uberis (S. uberis), Streptococcus parauberis (S. parauberis), and ... | 07/06/2010 |
| 7740870 | Group B antigens and corresponding DNA fragments The present invention relates to antigens, more particularly antigens of Group B Streptococcus (GBS) (S. agalactiae) which may be useful to prevent, diagnose and/or treat streptococcal infections. ... | 06/22/2010 |
| 7731978 | Mutant forms of streptolysin O Forms of GAS25 (streptolysin O) which are not toxic but which still maintain the ability to induce protection against S. pyogenes are useful in vaccine compositions to induce protection against S. pyogenes. ... | 06/08/2010 |
| 7722888 | proteins and nucleic Protein antigens from Streptococcus pneumoniae are disclosed, together with nucleic acid sequences encoding them. Their use in vaccines and in screening methods is also described. ... | 05/25/2010 |
| 7713534 | proteins and nucleic acid molecules Protein antigens from Streptococcus pneumoniae are disclosed, together with nucleic acid sequences encoding them. Their use in vaccines and in screening methods is also described. ... | 05/11/2010 |
| 7709009 | Immunogenic compositions for streptococcus pyogenes The invention includes a GAS antigen, GAS 40, which is particularly suitable for use either alone or in combinations with additional GAS antigens, such as GAS 117, GAS 130, GAS 277, GAS 236, GAS 40, GAS 389, GAS 504, GAS 509, GAS 366, GAS 159, GAS 217, GAS 309, GAS ... | 05/04/2010 |
| 7700117 | Camp factor of The CAMP factor gene of Streptococcus uberis (S. uberis) is described, as well as the recombinant production of CAMP factor therefrom. Also disclosed are chimeric CAMP factor constructs, including CAMP factor epitopes from more than one bacterial speci... | 04/20/2010 |
| 7648708 | proteins and nucleic acid molecules Protein antigens from Streptococcus pneumoniae are disclosed, together with nucleic acid sequences encoding them. Their use in vaccines and in screening methods is also described. ... | 01/19/2010 |
| 7638136 | Streptococcus pyogene antigens The present invention discloses isolated nucleic acid molecules encoding a hyperimmune serum reactive antigen or a fragment thereof as well as hyperimmune serum reactive antigens or fragments thereof from S. pyogenes, methods for isolating such antigens and s... | 12/29/2009 |
| 7635487 | antigens The present invention discloses isolated nucleic acid molecules encoding a hyperimmune serum reactive antigen or a fragment thereof as well as hyperimmune serum reactive antigens or fragments thereof from S. pneumoniae, methods for isolating such antigens and... | 12/22/2009 |
| 7632515 | proteins and nucleic acid molecules Protein antigens from Streptococcus pneumoniae are disclosed, together with nucleic acid sequences encoding them. Their use in vaccines and in screening methods is also described. ... | 12/15/2009 |
| 7597895 | Signal peptides, nucleic acid molecules and methods for treatment of caries Compounds that competitively inhibit binding of CSP to S. mutans histidine kinase are provided. The compounds are preferably a peptide or an antibody, and are preferably a derivative of [SEQ ID NO:2], a fragment of [SEQ ID NO:2] or a derivative of a fragment ... | 10/06/2009 |
| 7595057 | antigens and corresponding DNA fragments The present invention relates to antigens, more particularly antigens of Streptococcus pyogenes (also called group A Streptococcus (GAS)) bacterial pathogen which are useful as vaccine component for therapy and/or prophylaxis. ... | 09/29/2009 |
| 7588773 | Methods and compositions for diagnosing and preventing a group B streptococcal infection The present invention provides a group B streptococcal (GBS) surface antigen, designated epsilon antigen, that is co-expressed with the delta antigen on a subset of serotype III GBS. Epsilon is expressed on more pathogenic Restriction Digest Pattern (RDP) III... | 09/15/2009 |
| 7572457 | Use of 38 kDa polypeptide as an immunogen Disclosed are methods, compositions, and kits for inducing polyclonal antibodies against one or more pathogens that include Streptococcus suis. The methods may include administering to an animal a composition that includes an isolated 38 kDa polypeptide of | 08/11/2009 |
| 7504110 | Protein-based vaccines The present invention is primarily directed to a method for preventing infection of a mammalian subject with S. pneumoniae, wherein said method comprises administering to said subject an effective amount of one or more S. pneumoniae cell wall and/or ce... | 03/17/2009 |
| 7501132 | Multiple antigenic peptides immunogenic against The invention provides a nucleic acid encoding the 37-kDa pneumococcal surface adhesion A protein (PsaA) from Streptococcus pneumoniae. Also provided are isolated nucleic acids comprising a unique fragment of at least 10 nucleotides of the 37-kDa protein. The... | 03/10/2009 |
| 7479282 | Polypeptide comprising the amino acid of an N-terminal choline binding protein a truncate, vaccine derived therefrom and uses thereof This invention provides an isolated polypeptide comprising an amino acid sequence of a N-terminal choline binding protein A truncate in which the amino acid sequence is set forth in any of SEQ ID NOS: 1, 3-7, or 9-11, including fragments, mutants, variants, analogs,... | 01/20/2009 |
