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| Number | Title | Issue Date |
| 8158132 | Clostridial toxin derivatives able to modify peripheral sensory afferent functions This invention describes a novel agent for the targeted control of a mammalian cell activity, in particular the agent is used to control the interaction of particular cell types with their external environment. The agent has applications as a pharmaceutical for the ... | 04/17/2012 |
| 8153139 | Treatment of rosacea with clostridia neurotoxins Methods of using clostridial toxins and other biological agents to treat rosacea in humans is provided. The disclosed methods provide beneficial effects in humans. ... | 04/10/2012 |
| 8147848 | Method for treating premature ejaculation with a neurotoxin Methods for prolongation of climax time in a patient in need thereof are presented, as are methods for treating premature ejaculation by local administration of a Clostridial neurotoxin, such a botulinum neurotoxin, to the patient, are provided. ... | 04/03/2012 |
| 8133497 | Systems and methods for delivery of a therapeutic agent Methods and apparatus are provided for applying an fragment of a neurotoxin such as the active light chain (LC) of the botulinum toxin (BoNT), such as one of the serotype A, B, C, D, E, F or G botulinum toxins, via permeabilization of targeted cell membranes to enab... | 03/13/2012 |
| 8128940 | Modified clostridial toxins with enhanced targeting capabilities for endogenous clostridial toxin receptor systems The specification discloses modified Clostridial toxins comprising a Clostridial toxin enzymatic domain, a Clostridial toxin translocation domain and an enhanced Clostridial toxin binding domain; polynucleotide molecules encoding such modified Clostridial toxins; an... | 03/06/2012 |
| 8071110 | Activatable clostridial toxins Compositions comprising activatable recombinant neurotoxins and polypeptides derived therefrom. The invention also comprises nucleic acids encoding such polypeptides, and methods of making such polypeptides and nucleic acids. ... | 12/06/2011 |
| 8062643 | Use of neurotoxin therapy for treatment of urologic and related disorders The present invention related to methods for treating neurological-urological conditions. This is accomplished by administration of at least one neurotoxin. ... | 11/22/2011 |
| 8057807 | Use of botulinum toxin therapy for treatment of recalcitrant voiding dysfunction The present invention related to methods for treating neurological-urological conditions. This is accomplished by administration of at least one neurotoxin. ... | 11/15/2011 |
| 8057806 | Viruses comprising mutant ion channel protein A method to prepare viruses lacking ion channel activity is provided. ... | 11/15/2011 |
| 8052979 | Modified clostridial toxins with altered targeting capabilities for clostridial toxin target cells The specification discloses modified Clostridial toxins comprising a Clostridial toxin enzymatic domain, a Clostridial toxin translocation domain and an enhanced Clostridial toxin binding domain; polynucleotide molecules encoding such modified Clostridial toxins; an... | 11/08/2011 |
| 8034357 | Treatment of fine wrinkles with clostridia neurotoxins Methods of using clostridial toxins and other biological agents to thin skin and control fine wrinkles in humans are provided. In preferred embodiments the methods provide beneficial effects in humans. ... | 10/11/2011 |
| 8025889 | Botulinum toxin administration to treat various conditions Methods for treating conditions in an animal or human subject. The conditions may be pain, skeletal muscle conditions, smooth muscle conditions, glandular conditions and cosmetic conditions. The methods comprise the step of administering a Clostridium neuroto... | 09/27/2011 |
| 8017131 | Clostridial toxin derivatives and methods for treating pain Agents for treating pain, methods for producing the agents and methods for treating pain by administration to a patient of a therapeutically effective amount of the agent. The agent can include a clostridial neurotoxin, or a component or fragment or derivative there... | 09/13/2011 |
| 7998489 | Degradable clostridial toxins The specification discloses modified Clostridial toxins comprising a PAR ligand domain, a Clostridial toxin enzymatic domain, a Clostridial toxin translocation domain and a Clostridial toxin binding domain; polynucleotide molecules encoding modified Clostridial toxi... | 08/16/2011 |
| 7993656 | Modified clostridial toxins with enhanced translocation capabilities and altered targeting activity for clostridial toxin target cells The invention provides modified Clostridial toxins comprising a Clostridial toxin enzymatic domain, a Clostridial toxin translocation domain, a translocation facilitating domain and an altered target domain; polynucleotide molecules encoding such modified Clostridia... | 08/09/2011 |
| 7985411 | Activatable recombinant neurotoxins Compositions comprising activatable recombinant neurotoxins and polypeptides derived therefrom. The invention also comprises nucleic acids encoding such polypeptides, and methods of making such polypeptides and nucleic acids. ... | 07/26/2011 |
| 7981432 | Proteins within the type E botulinum neurotoxin complex The invention features a polypeptide complex synthesized by bacteria of the genus Clostridia that contains the serotype E botulinum neurotoxin and five neurotoxin associated polypeptides having molecular weights of about 118, 80, 65, 40, and 18 kDa, respectiv... | 07/19/2011 |
| 7981433 | Targeted delivery of botulinum toxin to the sphenopalatine ganglion Botulinum toxin, among other presynaptic neurotoxins is used for the treatment and prevention of migraine and other headaches associated with vascular disorders. Presynaptic neurotoxins are delivered focally, targeting the sphenopalatine ganglion. Exemplary delivery... | 07/19/2011 |
| 7972608 | Carrier proteins for vaccines The present invention provides, among other things, improved carrier proteins for antigen-based vaccines, including polysaccharide-based vaccines. An aspect of the invention advantageously employs tetanus toxin Fragment C. ... | 07/05/2011 |
| 7968104 | Use of neurotoxin therapy for treatment of urologic and related disorders The present invention related to methods for treating neurological-urological conditions. This is accomplished by administration of at least one neurotoxin. ... | 06/28/2011 |
| 7959933 | Activatable recombinant neurotoxins Compositions comprising activatable recombinant neurotoxins and polypeptides derived therefrom. The invention also comprises nucleic acids encoding such polypeptides, and methods of making such polypeptides and nucleic acids. ... | 06/14/2011 |
| 7943152 | Treatment of chronic chalazion and hordeolum with botulinum toxin Chalazia and hordeola are the most common lesions occurring in the human eyelid, and often recurrences are managed by surgical intervention to remove fatty inclusions within the lid with associated inflammatory reaction. The present invention provides non-surgical m... | 05/17/2011 |
| 7906124 | Inactivation of smooth muscle tissue Treatment and procedures for treating bodily conduits involves deactivating, killing, or otherwise treating smooth muscle tissue of the conduit. ... | 03/15/2011 |
| 7897157 | Activatable clostridial toxins Compositions comprising activatable recombinant neurotoxins and polypeptides derived therefrom. The invention also comprises nucleic acids encoding such polypeptides, and methods of making such polypeptides and nucleic acids. ... | 03/01/2011 |
| 7892565 | Degradable clostridial toxins The specification discloses modified Clostridial toxins comprising a PAR ligand domain, a Clostridial toxin enzymatic domain, a Clostridial toxin translocation domain and a Clostridial toxin binding domain; polynucleotide molecules encoding modified Clostridial toxi... | 02/22/2011 |
| 7879340 | Treatment of mammalian reaction of IgE interactions A method is disclosed for blocking or reducing physiological reaction in a mammal to the interaction of IgE antibodies present in said mammal upon contact with the corresponding antigen, by the administration to said mammal of a therapeutically effective amount of a... | 02/01/2011 |
| 7838011 | Stabilized protein compositions for topical administration and methods of making same A stabilizing composition that also enhances permeation is provided for the topical or transdermal administration of an active ingredient. The composition comprises collagen, elastin, sphingosine and cerebroside. Also provided are pharmaceutical or cosmetic formulat... | 11/23/2010 |
| 7833535 | Clostridial toxin derivatives and methods for treating pain Agents for treating pain, methods for producing the agents and methods for treating pain by administration to a patient of a therapeutically effective amount of the agent. The agent can include a clostridial neurotoxin, or a component or fragment or derivative there... | 11/16/2010 |
| 7824693 | Treatment of fine wrinkles with clostridia neurotoxins Methods of using clostridial toxins and other biological agents to thin skin and control fine wrinkles in humans are provided. In preferred embodiments the methods provide beneficial effects in humans. ... | 11/02/2010 |
| 7820183 | Botulinum toxin in treatment of clubfoot relapse Botulinum toxin, or other neuromuscular inhibitors, injected into the lower leg muscle of infants, less than a year old, with idiopathic clubfoot is shown to be an effective therapy in correcting this physical deformity. Following a protocol of manipulations, castin... | 10/26/2010 |
| 7815917 | Botulinum neurotoxin serotype B activatable Botulinum neurotoxin serotype Bs The specification discloses modified Clostridial toxins comprising a Clostridial toxin substrate cleavage site located within the di-chain loop region; polynucleotide molecules encoding such modified Clostridial toxins comprising a Clostridial toxin substrate cleava... | 10/19/2010 |
| 7811584 | Multivalent clostridial toxins The present invention is directed to multivalent Clostridial toxin comprising more than one binding domain directed to a cell surface molecule of a target cell. Such modified toxins are useful as therapeutic compositions to prevent exocytosis and secretion by the ta... | 10/12/2010 |
| 7780968 | Clostridial toxin derivatives and methods for treating pain Agents for treating pain, methods for producing the agents and methods for treating pain by administration to a patient of a therapeutically effective amount of the agent. The agent can include a clostridial neurotoxin, or a component or fragment or derivative there... | 08/24/2010 |
| 7749515 | Targeted delivery of botulinum toxin to the sphenopalatine ganglion Botulinum toxin, among other presynaptic neurotoxins is used for the treatment and prevention of migraine and other headaches associated with vascular disorders. Presynaptic neurotoxins are delivered focally, targeting the sphenopalatine ganglion. Exemplary delivery... | 07/06/2010 |
| 7749514 | Activatable clostridial toxins Compositions comprising activatable recombinant neurotoxins and polypeptides derived therefrom. The invention also comprises nucleic acids encoding such polypeptides, and methods of making such polypeptides and nucleic acids. ... | 07/06/2010 |
| 7740868 | Activatable clostridial toxins Compositions comprising activatable recombinant neurotoxins and polypeptides derived therefrom. The invention also comprises nucleic acids encoding such polypeptides, and methods of making such polypeptides and nucleic acids. ... | 06/22/2010 |
| 7736659 | Clostridial toxin derivatives and methods for treating pain Agents for treating pain, methods for producing the agents and methods for treating pain by administration to a patient of a therapeutically effective amount of the agent. The agent can include a clostridial neurotoxin, or a component or fragment or derivative there... | 06/15/2010 |
| 7731977 | Use of a botulinum neurotoxin to alleviate various disorders Methods for treating obsessions and compulsions by local administration of a Clostridial toxin. The obsessions or compulsions can be eye poking, body rocking, finger biting, counting, checking and related disorders treated by low dose, intramuscular administration o... | 06/08/2010 |
| 7727538 | Methods and compounds for the treatment of mucus hypersecretion A method of treating mucus hypersecretion, the causative factor in chronic obstructive pulmonary disease (COPD), asthma and other clinical conditions involving COPD, comprises administering a compound that inhibits exocytosis in mucus secreting cells or neurones tha... | 06/01/2010 |
| 7727537 | Stabilized compositions for topical administration and methods of making same A stabilizing composition that also enhances permeation is provided for the topical or transdermal administration of an active ingredient. The composition preferably comprises collagen, elastin, sphingoside and cerebroside. Also provided are pharmaceutical or cosmet... | 06/01/2010 |
