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| Number | Title | Issue Date |
| 7399472 | Vaccines The present invention relates to adjuvant compositions which are suitable to be used in vaccines. In particular, the adjuvant compositions of the present invention comprises a saponin and an immunostimulatory oligonucleotide, optionally with a carrier. Also provided... | 07/15/2008 |
| 7384652 | Complexed-acidic-phospholipid-collagen composites for bone induction The present invention provides a composition for osteoinduction, which comprises a complexed-acidic-phospholipid complex containing calcium, phospholipid, and inorganic phosphate combined with collagen in a composite form. The composition is effective to promote new... | 06/10/2008 |
| 7279169 | Mucosal DTPa vaccines Mucosal DTPa vaccines, especially intranasal vaccines, comprising (a) a diphtheria antigen, a tetanus antigen and an acellular pertussis antigen, and (b) a detoxified mutant of cholera toxin (CT) or E. coli heat labile toxin (LT). Component (b) acts as a muco... | 10/09/2007 |
| 7169392 | serogroup B glycoconjugates and methods of producing the same The present invention pertains generally to novel Neisseria meningitidis serogroup B glycoconjugates. More particularly, the invention pertains to glycoconjugates formed from a Neisseria meningitidis serogroup B capsular oligosaccharide derivative (Men... | 01/30/2007 |
| 7098303 | Conserved motif of hepatitis C virus E2/NS1 region Immunogenic polypeptides comprising hepatitis C virus (HCV) immunogens are described. The HCV immunogen comprises the amino acid sequence Xaa-Thr-Xaa-Val-Thr-Gly-Gly-Xaa-Ala-Ala-Arg-Thr-Thr-Xaa-Gly-Xaa-Xaa-Ser-Leu-P he-Xaa-Xaa-Gly-Xaa-Ser-Gln-Xaa-Ile-Gln-Leu-Ile (SE... | 08/29/2006 |
| 6866847 | Method of delivering a protein to poultry A method of delivering a protein to domestic poultry by administering to the poultry by whole body spray an effective amount of a live avirulent derivative of an enteropathogenic bacterium that contains a recombinant gene encoding the protein. ... | 03/15/2005 |
| 6846484 | DTAT fusion toxin The invention provides fusion toxins that contain one or more regions of diphtheria toxin and a portion of urokinase-type plasminogen activator, as well as the nucleic acids that encode the fusion toxins and methods of using the fusion toxins. ... | 01/25/2005 |
| 6841160 | Meningococcal vaccines formulated with interleukin-12 This invention pertains to vaccine compositions comprising a mixture of antigen, such as pneumococcal or meningococcal antigen, and interleukin IL-12, which may be adsorbed onto a mineral in suspension. The pneumococcal or meningococcal antigen may be conjugated to ... | 01/11/2005 |
| 6746677 | Stable vaccine compositions for parenteral administration, a method for their use, and a process for their preparation The invention relates to certain stable vaccine compositions comprising a macrocyclic lactone compound, a milbemycin compound, an avermectin compound or mixtures thereof; at least one antigen; a dispersing agent; an adjuvant; a water soluble organic solvent; and sal... | 06/08/2004 |
| 6737511 | Receptor-mediated uptake of an extracellular BCL-xL fusion protein inhibits apoptosis Apoptosis-modifying fusion polypeptides, and the corresponding nucleic acid molecules, are disclosed. Pharmaceutical compositions comprising these polypeptides, and the use of these polypeptides to modify apoptosis are also provided. ... | 05/18/2004 |
| 6506388 | Immunomodulator, immunomodulator food An immunomodulator having suppressive activity on IgE antibody production is provided and contains bacterial cells, or their decomposition materials. It can be taken as a food. Bacterial cells such as Corynebacterium, Brevibacterium, Microbacterium, or ba... | 01/14/2003 |
| 6455673 | Multi-mutant diphtheria toxin vaccines Disclosed are diphtheria toxin polypeptides having multiple mutations, which render the polypeptides useful as vaccines.... | 09/24/2002 |
| 6444446 | Calcium binding proteolipid compositions and methods The invention relates to the cloning and sequencing of the DNA encoding a membrane associated proteolipid from C. matruchotii that is capable of inducing in vitro calcium binding. A proteolipid was extracted from cultures of C. matruchotii and separated i... | 09/03/2002 |
| 5897867 | Efficacious vaccines against Bordetella pertussis comprising a combination of individually purified pertussis antigens This invention is directed to a vaccine for the prevention of disease caused by Bordetella pertussis which comprises the pertussis antigens filamentous hemagglutinin, detoxified lymphocytosis promoting factor and a 69 kilodalton outer membrane protein, wh... | 04/27/1999 |
| 5895655 | Efficacious vaccines against Bordetella pertussis comprising a combination of individually purified pertussis antigens This invention is directed to a vaccine for the prevention of disease caused by Bordetella pertussis which comprises the pertussis antigens filamentous hemagglutinin, detoxified lymphocytosis promoting factor and a 69 kilodalton outer membrane protein, wh... | 04/20/1999 |
| 5885586 | Efficacious vaccines against bordetella pertussis comprising a combination of individually purified pertussis antigens This invention is directed to a vaccine for the prevention of disease caused by Bordetella pertussis which comprises the pertussis antigens filamentous hemagglutinin, detoxified lymphocytosis promoting factor and a 69 kilodalton outer membrane protein, wh... | 03/23/1999 |
| 5885587 | Efficacious vaccines against Bordetella pertussis comprising a combination of individually purified pertussis antigens This invention is directed to a vaccine for the prevention of disease caused by Bordetella pertussis which comprises the pertussis antigens filamentous hemagglutinin, detoxified lymphocytosis promoting factor and a 69 kilodalton outer membrane protein, wh... | 03/23/1999 |
| 5866128 | Method for the treatment and prevention of gastric and duodenal ulcer Immunogenic compositions useful for the treatment or prevention of gastric or duodenal ulcer disease are disclosed. The immunogenic compositions effectively operate by inducing antibodies in a subject which selectively neutralize specific peptide gastric ... | 02/02/1999 |
| 5861162 | Multivalent inocula for lessening incidence of liver abscesses in cattle Novel inocula for administration to ruminant animals such as cattle or sheep are provided in order to immunize the animals and lessen the incidence of liver abscesses and/or foot rot therein. In one aspect, the invention pertains to an A. pyogenes-derived... | 01/19/1999 |
| 5843462 | Diphtheria toxin epitopes A method for identifying an immunodominant sequence region in a diphtheria toxin-specific peptide is provided. Also provided are diphtheria toxin specific peptides with an immunodominant sequence region.... | 12/01/1998 |
| 5830478 | Method for delivering functional domains of diphtheria toxin to a cellular target The method of the present invention employs a hybrid reagent comprising a first portion (i.e., a cell-targeting portion) which binds to cell surfaces coupled to a second portion (i.e., a toxin-binding portion) which binds to, or has bound to it, an endoso... | 11/03/1998 |
| 5785970 | Method of the treatment of gastrointestinal disorders with immunogenic compositions against gastrin Immunogenic compositions useful for the treatment of ulcers or tumors whose growth is dependent on or stimulated by gastrin hormones are disclosed. The immunogenic compositions induce antibodies in a subject which selectively neutralize the specific hormo... | 07/28/1998 |
| 5725857 | Immunotoxin with in vivo T cell suppressant activity and methods of use In one embodiment, the invention provides a method of treating an autoimmune disease in an animal comprising administering to the animal an antibody-CRM9 conjugate which routes by the anti-CD3 pathway, or derivatives thereof, under conditions such that th... | 03/10/1998 |
| 5601827 | Diphtheria toxin vaccines A DNA encoding an immunologically cross-reactive form of diphtheria toxin Fragment A, wherein the codons corresponding to Val-147 and Glu-148 of naturally-occurring diphtheria toxin are deleted from the DNA.... | 02/11/1997 |
| 5529777 | Hydrogel microencapsulated vaccines Water soluble polymers or polymeric hydrogels are used to encapsulate antigen to form vaccines. The antigen is mixed with a polymer solution, microparticles are formed of the polymer and antigen, and, optionally, the polymer is crosslinked to form a stabl... | 06/25/1996 |
| 5139776 | Method for culturing Bordetella pertussis, a pertussis toxoid and a pertussis vaccine There is disclosed a method for culturing Bordetella pertussis in the presence of a cellulose and/or cellulose derivatives. The present method is useful for obtaining a mixed antigen comprising pertussis toxin and filamentous hemagglutinin in a large amou... | 08/18/1992 |
| 5110794 | Method of immunization with partially cationized substances and said partially cationized substances A partially cationized protein-containing substance that exhibits enhanced immunogenicity as compared to the native protein-containing substance and is useful in mammalian immunization by oral or parenteral administration.... | 05/05/1992 |
| 5097020 | Immunogenic conjugates An immunogenic conjugate which is the reductive amination product of an immunogenic capsular polymer fragment having at least one reducing group and derived from a bacterial capsular polymer of a bacterial pathogen, and a bacterial toxin or toxoid. The in... | 03/17/1992 |
| 5019383 | Fatty acid carriers for synthetic peptides A synthetic vaccine is contemplated comprising a peptide residue coupled to one or more alkyl or alkenyl groups of at least 12 carbon atoms or other lipophilic substance wherein said peptide residue contains a sequence of 6 amino acids corresponding to th... | 05/28/1991 |
| 4902506 | Immunogenic conjugates An immunogenic conjugate which is the reductive amination product of an immunogenic capsular polymer fragment having at least one reducing group and derived from a bacterial capsular polymer of a bacterial pathogen, and a bacterial toxin or toxoid. The in... | 02/20/1990 |
| 4762713 | Boosting of immunogenic conjugate vaccinations by unconjugated bacterial capsular polymers This invention relates to immunogenic conjugates of capsular polymers or polymer fragments from bacterial pathogens and bacterial toxins, toxoids or subunits. The invention also relates to methods for the preparation of the conjugates and a vaccine contai... | 08/09/1988 |
| 4711779 | Glycoproteinic conjugates having trivalent immunogenic activity Glycoproteinic conjugates having trivalent immunogenic activity obtained by binding, by a covalent bond, to a protein selected among CRM 197, tetanus toxoid, and pertussis toxin, at least an oligosaccharidic hapten derived from the capsular polysaccharide... | 12/08/1987 |
| 4705686 | Process for the preparation of acellular Bordetalla pertussis vaccine This invention discloses a process for preparing an acellular Bordetella pertussis vaccine by passing culture supernatants or cellular extracts of B. pertussis through a column containing an ion exchange resin. The eluate from the column is detoxified and... | 11/10/1987 |
| 4673574 | Immunogenic conjugates An immunogenic conjugate which is the reductive amination product of an immunogenic capsular polymer fragment having a reducing end and derived from a bacterial capsular polymer of a bacterial pathogen, and a bacterial toxin or toxoid. The invention also ... | 06/16/1987 |
| 4619828 | Polysaccharide exotoxoid conjugate vaccines A water-soluble covalent polysaccharide-antigen conjugate having a molecular size between 140,000 and 4,500,000 dalton and a nominal polysaccharide/protein ratio between 0.25 and 2, capable of producing T-cell dependent antibody response to polysaccharide... | 10/28/1986 |
| 4578270 | Process for the preparation of lyophilized, adsorbed polyvalent vaccines The invention relates to the preparation of lyophilized, absorbed polyvalent vaccines. According to the invention tetanus, diphtheria, pertussis and optionally typhus antigens concentrated to 5 to 15 doses/3 ml are adsorbed at a pH value of 3 to 6 to an i... | 03/25/1986 |
| 4478823 | Immunological preparations containing purified MHC antigens bonded to other antigens An immunologically active preparation for human or veterinary use comprises an antigenic material in combination with an MHC antigen.... | 10/23/1984 |
| 4455142 | Method of coadministering an antigen and an immunopotentiator A method is disclosed for potentiating the immune response of an animal. The method consists in administering an antigen and an immunopotentiator in effective low dose, at a controlled rate, and continuously to produce the desired immune response.... | 06/19/1984 |
| 4428931 | Bacterial toxoids and gram-negative immune globulin therefrom ADP-ribosylating toxins are rendered exzymatically inactive by reactions with photolabile affinity reagents. The toxoids retain the antigenic and immunogenic properties of the original toxins. These bacterial toxoids can be used as immunogens to protect a... | 01/31/1984 |
| 4400376 | Immunological preparations An immunological preparation of an antigenic material in combination with a major histocompatibility complex antigen, which is itself in the form of complex with a protein with which it is normally associated in nature or with a modified form of such prot... | 08/23/1983 |
