Quotables
"There is no reason anyone would want a computer in their home."
Ken Olsen, chairman and founder of Digital Equipment Corporation ; 1977
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 8101190 | Method for diagnosing staphylococcal infections The present invention relates to a method for determining if an individual is infected by a staphylococcus bacterium, comprising: determining if antibodies directed against at least 2 proteins comprising a sequence selected ... | 01/24/2012 |
| 7927607 | antigens I and II The present invention discloses isolated nucleic acid molecules encoding a hyperimmune serum reactive antigen or a fragment thereof as well as hyperimmune serum reactive antigens or fragments thereof from S. agalactiae, and methods for isolating such antigens... | 04/19/2011 |
| 7838010 | Immunogenic and therapeutic compositions for Group A streptococcal (GAS) antigens useful for providing immunity against pyogenes infection. ... | 11/23/2010 |
| 7541041 | Vaccine against dental caries based on virulence-associated immunomodulatory extracellular proteins produced by the cariogenic bacteria and This invention is concerned with a vaccine against dental caries obtained from the supernatant over cultures of the cariogenic bacteria Streptococcus sobrinus and S. mutans that consists of extracellular proteins. These proteins provide the suppression... | 06/02/2009 |
| 7491402 | Superantigens SMEZ-2, SPE-G, SPE-H and SPE-J and uses thereof The invention provides superantigens SMEZ-2, SPE-G, SPE-H and SPE-J, as well as polynucleotides which encode them. Such superantigens have, inter alia, diagnostic and therapeutic application. ... | 02/17/2009 |
| 7435421 | Derivatives of choline binding proteins for vaccines The present invention provides bacterial immunogenic agents for administration to humans and non-human animals to stimulate an immune response. It particularly relates to the vaccination of mammalian species with pneumococcal derived polypeptides that include an alp... | 10/14/2008 |
| 7339043 | Compositions and methods for affecting virulence determinants in bacteria A novel sarR gene and sarR gene product which down regulates the expression of sarA and the resulting virulence determinants in Staphylococcus aureus is provided. Methods for modulating the expression of sarA and virulence determinants are also provided. A pr... | 03/04/2008 |
| 7323179 | Methods and compositions for the treatment and prevention of and other bacterial infections The invention features methods and compositions for treatment or prevention of infection by, or disease caused by infection with, certain species of bacteria, including in particular bacteria in which a RAP-type and/or TRAP-type molecule plays a role in pathogenesis... | 01/29/2008 |
| 7316910 | Rapid test for hemolytic streptococcus A reagent for the detection of an extracellular enzymatically active protein produced by a beta-hemolytic streptococcus bacteria found in a host biological fluid includes a proteinaceous substrate or a cholesterol-containing membrane substrate for the extracellular ... | 01/08/2008 |
| 7255867 | Vaccine Effective stimulation of immune responses is achieved through the use of a group A streptococcal antigen combined with proteosome adjuvant. The compositions are provided in particular for intranasal administration. The vaccine compositions are provided for use in in... | 08/14/2007 |
| 7256265 | Streptococcal C5a peptidase vaccine Novel vaccines for use against β-hemolytic Streptococcus colonization or infection are disclosed. The vaccines contain an immunogenic amount of a variant of streptococcal C5a peptidase (SCP). Also disclosed is a method of protecting a susceptible mamm... | 08/14/2007 |
| 7252828 | Polysaccharide vaccine for infections The invention relates to compositions of the capsular polysaccharide/adhesin (PS/A) of staphylococci. The PS/A may be isolated or synthesized and includes various modifications to the structure of native PS/A based on the chemical characterization of PS/A. Th... | 08/07/2007 |
| 7241592 | Cross-reactive displacing antibodies from collagen-binding proteins and method of identification and use Antibodies to the CNA protein and to other regions from the collagen binding domain, including domain CNA19, are provided, and antibodies produced in this manner have been shown to be cross reactive to both Staphylococcus aureus and Staphylococcus epidermi... | 07/10/2007 |
| 7235243 | Immunological combination compositions and methods Immununological compositions and methods for making and using them. The compositions contain at least one antigen and at least one lipoprotein and optionally an adjuvant. The lipoprotein can itself be antigenic or immunogenic. The antigen can be influenza HA and the... | 06/26/2007 |
| 7220415 | Vaccine composition A polypeptide is described herein which comprises (a) the sequence of SEQ ID No. 2, (b) a variant of (a) which is capable of generating a protective immune response to S. pyogenes, or (c) a fragment of (a) or (b) of at least 6 amino acids in length which is c... | 05/22/2007 |
| 7211263 | Use of adenylate cyclase or bacteria producing it as vaccines against The invention relates to a method of immunizing a mammal against infection by a first Bordetella species. The method comprises administering to the mammal a preparation comprising a portion of the amino acid sequence of mature adenylate cyclase of a second | 05/01/2007 |
| 7204993 | vaccine A composition prepared from intact killed cells of isolated β-hemolytic Streptococcus agalactiae and a concentrated extract of a culture of β-hemolytic Streptococcus agalactiae, is effective for the protection of fish against infection by the same an... | 04/17/2007 |
| 7189404 | Strain selection of pneumococcal surface proteins The present invention relates to vaccine composition(s) comprising at least two PspAs from strains selected from at least one family, the family being defined by PspAs from strains belonging to the family having greater than or equal to 50% homology in aligned seque... | 03/13/2007 |
| 7189398 | Broad spectrum pyrogenic exotoxins antagonists and vaccines The invention relates to peptides having an amino acid sequence substantially homologous to an amino sequence of a domain of a pyrogenic exotoxin, which domain forms a central turn in the exotoxin starting within β-strand 7 and connecting the β-strand 7, via short... | 03/13/2007 |
| 7163686 | Protein A based binding domains with desirable activities Provided are Staphylococcal protein A (SpA) variants for binding immunoglobulin (Ig), comprising a polypeptide which varies by one or more amino acids from the amino acid sequence of a natural variable heavy chain III (“VH3”) Ig-Fab binding region (“binding re... | 01/16/2007 |
| 7153515 | Method of preventing T cell-mediated responses by the use of the major histocompatibility complex class II analog protein (map protein) from A method of immunomodulating the T cell response in Staphylococcal bacteria is provided wherein an effective amount of the Map protein from Staphylococcus aureus is administered to a host to prevent or suppress the T cell response. The present method may be u... | 12/26/2006 |
| 7135188 | Methods and compositions for immunotherapy of cancer Methods and vaccines for suppressing formation of or inhibiting growth of tumors in a host are provided, via administration of a vaccine containing either a fusion protein of the tumor associated antigen fused to a truncated form of listeriolysin or a recombinant fo... | 11/14/2006 |
| 7122194 | Vaccine compositions comprising polypeptides having selected structural motifs A vaccine composition is disclosed that comprises polypeptides and fragments of polypeptides containing histidine triad residues or coiled-coil regions, some of which polypeptides or fragments lie between 80 and 680 residues in length. Also disclosed are processes f... | 10/17/2006 |
| 7115268 | Peptides useful for reducing symptoms of toxic shock syndrome and septic shock This invention relates to compositions and methods which provide protection against, or reduce the severity of toxic shock and septic shock from bacterial infections. More particularly it relates to peptides derived from homologous sequences of the family of staphyl... | 10/03/2006 |
| 7087235 | Fusion protein of streptococcal pyrogenic exotoxins The present invention relates to genetically attenuated superantigen toxin vaccines altered such that superantigen attributes are absent, however the superantigen is effectively recognized and an appropriate immune response is produced. The attenuated superantigen t... | 08/08/2006 |
| 7078042 | Pneumococcal surface protein C (PspC), epitopic regions and strain selection thereof, and uses therefor Disclosed and claimed are: epitopic regions of Pneumococcal Surface Protein C or “PspC”, different clades of PspC, isolated and/or purified nucleic acid molecules such as DNA encoding a fragment or portion of PspC such as an epitopic region of PspC or at least o... | 07/18/2006 |
| 7074416 | Antigen of hybrid M protein and carrier for group A streptococcal vaccine Recombinant hybrid streptococcal M protein antigens are provided which elicit protective antibodies against Group A streptococci and prevent rheumatic fever. Recombinant hybrid genes which encode the antigen are provided. Vaccine compositions and methods of administ... | 07/11/2006 |
| 7067127 | GIcNAc phosphotransferase of the lysosomal targeting pathway The present invention provides nucleotide and amino sequences of the lysosomal targeting pathway enzyme GlcNAc-phosphotransferase, methods of producing and methods of purifying this enzyme. ... | 06/27/2006 |
| 7060277 | Broad spectrum antagonists and vaccines directed against pyrogenic exotoxins The invention relates to peptides comprising an amino acid sequence homologous to the amino sequence of a fragment of a pyrogenic exotoxin, and functional derivatives of said peptides, capable of eliciting protective immunity against toxic shock induced by a pyrogen... | 06/13/2006 |
| 6984381 | Vaccine for the prevention of bacterial infection of the bovine mammary gland A novel vaccine for immunizing animals against Staphylococcus aureus-induced mastitis is disclosed. The vaccine is comprised of whole killed cells of S. aureus in a dosage effective to immunize an animal against the organism, in combination with a phar... | 01/10/2006 |
| 6984385 | Immunological combination compositions and methods Immunological compositions and methods for making and using them. The compositions contain at least one antigen and at least one lipoprotein and optionally an adjuvant. The lipoprotein can itself be antigenic or immunogenic. The antigen can be influenza HA and the l... | 01/10/2006 |
| 6979446 | Monoclonal antibodies to the ClfA protein and method of use in treating or preventing infections Monoclonal antibodies which can bind to the ClfA protein and which are generated from binding subdomains or active fragments of the ClfA protein from Staphylococcus aureus, including the active fragments proteins from its fibrinogen binding domain such as Clf... | 12/27/2005 |
| 6969616 | Enterotoxin adsorbent, method of adsorptive removal, and adsorption apparatus The present invention is directed to an enterotoxin adsorbent comprising a compound having a log P (P denotes a partition coefficient in an octanol-water system) value of not less than 2.50 as immobilized on a water-insoluble carrier. ... | 11/29/2005 |
| 6951652 | Vaccine for prevention of gram-negative bacterial infections and endotoxin related diseases A vaccine is disclosed which is useful for protecting a host from Gram negative infections and the effects of endotoxin, therefore preventing sepsis and septic shock. The vaccine is prepared by combining LPS free or in conjugate form with a stoichiometric excess of ... | 10/04/2005 |
| 6951653 | Streptococcal C5a peptidase vaccine Novel vaccines for use against β-hemolytic Streptococcus colonization or infection are disclosed. The vaccines contain an immunogenic amount of a variant of streptococcal C5a peptidase (SCP). Also disclosed is a method of protecting a susceptible mammal agai... | 10/04/2005 |
| 6936258 | Staphylococcus antigen and vaccine A negatively-charged Staphylococcus antigen contains amino acids and a N-acetylated hexosamine as a major carbohydrate component. The antigen is common to many coagulase-negative strains of Staphylococcus, including S. epidermidis, S. haemolyticus | 08/30/2005 |
| 6908619 | Camp factor of streptococcus uberis The CAMP factor gene of Streptococcus uberis (S. uberis) is described, as well as the recombinant production of CAMP factor therefrom. CAMP factors can be used in vaccine compositions for the prevention and treatment of bacterial infections. ... | 06/21/2005 |
| 6875853 | Immunization of dairy cattle with chimeric GapC protein against streptococcus infection The recombinant production of Gap4, a chimeric GapC plasmin binding protein comprising the entire amino acid sequence of the Streptococcus dysgalactiae GapC protein in addition to unique amino acid sequences from the Streptococcus parauberis and Str... | 04/05/2005 |
| 6872394 | Non-toxic immune stimulating enterotoxin compositions Pyrogenic toxins, such as staphylococcal enterotoxins, modified in the disulfide loop region are provided. The modified toxins retain useful biological properties but have substantially reduced toxicity compared to the corresponding unmodified native toxin. T... | 03/29/2005 |
| 6863893 | Derivatives of choline binding proteins for vaccines The present invention provides bacterial immunogenic agents for administration to humans and non-human animals to stimulate an immune response. It particularly relates to the vaccination of mammalian species with pneumococcal derived polypeptides that include an alp... | 03/08/2005 |
