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| Number | Title | Issue Date |
| 8173138 | Stable liquid formulations of botulinum toxin The invention includes liquid formulations of botulinum toxin that are stable to storage in liquid form at standard refrigerator temperatures for at least 1-2 years and to storage at higher temperatures for at least 6 months. The invention also includes methods of t... | 05/08/2012 |
| 8128939 | Mutants of cholesterol-dependent cytolysins and uses thereof Mutants of cholesterol-dependent cytolysins comprising at least one amino acid substitution in at least one of Loop 1, Loop 2, or Loop 3 of Domain 4, nucleic acids encoding such polypeptide mutants, and compositions and vaccines comprising such polypeptide mutants. | 03/06/2012 |
| 8105611 | Treatment of autoimmune disorder with a neurotoxin Methods of treating one or more autoimmune disorders include a step of administering a Clostridial neurotoxin, such as a botulinum toxin, to a patient that has an autoimmune disorder. In one aspect, a method includes a step of administering the neurotoxin to the thy... | 01/31/2012 |
| 8092809 | exotoxin A-like chimeric immunogens This invention provides Pseudomonas exotoxin A-like chimeric immunogens that include a non-native epitope in the Ib domain of Pseudomonas exotoxin. Methods of eliciting an immune response using these immunogens also are provided. ... | 01/10/2012 |
| 7968103 | Compositions comprising fetal hemoglobin and bacterial endotoxin and optionally additional fetal liver components The present invention relates to a pharmaceutical composition representing a novel immunomodulating principle comprising bacterial endotoxin, fetal hemoglobin or more particularly a heme-free derivative or the γ-chain thereof, and optionally, components which are p... | 06/28/2011 |
| 7883709 | Stabilised compositions This invention relates to the stabilization of a bacterial ADP-ribosylating exotoxin class protein (bARE), a method for analysing a bARE class protein, a method for the stabilization of the bARE class bacterial protein, compositions comprising a stabilized bARE prot... | 02/08/2011 |
| 7846456 | Methods for breast treatment A method for treating a mammary gland disorder, including hyperplastic, hypertonic, cystic and/or neoplastic mammary gland tissue by local administration of a botulinum toxin to or to the vicinity of the afflicted breast tissue. ... | 12/07/2010 |
| 7838007 | Methods for treating mammary gland disorders A method for treating a mammary gland disorder, including hyperplastic, hypertonic, cystic and/or neoplastic mammary gland tissue by local administration of a botulinum toxin to or to the vicinity of the afflicted breast tissue. ... | 11/23/2010 |
| 7838009 | Use of botulinum toxin for the preparation of a medicament for the treatment of lithiasis of salivary gland, gall bladder, kidney, or pancreas The invention relates to the use of a pre-synaptic neuromuscular blocking substance for preparing a medicament intended to treat a gland, organ or duct obstructed by a naturally formed stone. This method can be applied notably for salivary gland, gall bladder, kidne... | 11/23/2010 |
| 7838008 | Methods for treating diverse cancers Methods for treating diverse cancers by local administration of a botulinum toxin to or to the vicinity of the cancer. ... | 11/23/2010 |
| 7780967 | Reduced toxicity Clostridial toxin pharmaceutical compositions A Clostridial toxin pharmaceutical composition comprising a Clostridial toxin, such as a botulinum toxin and a polysaccharide, such as a hydroxyethyl starch, wherein the pharmaceutical composition has a reduced toxicity. The Clostridial toxin pharmaceutical composit... | 08/24/2010 |
| 7758871 | Transdermal botulinum toxin administration Pharmaceutical compositions for transdermal administration of neurotoxins to a patient include a neurotoxin, such as a botulinum toxin, and an enhancing agent that facilitates absorption of the neurotoxin through the skin of the patient and does not eliminate the bi... | 07/20/2010 |
| 7744904 | Stabilization of neurotoxin complex A stable composition including botulinum neurotoxin and a cyclodextrin and a method of preserving botulinum neurotoxin and for producing a botulinum neurotoxin composition with improved stability properties in an efficient and economically advan... | 06/29/2010 |
| 7704511 | Methods for treating headache The present invention features methods for selecting a patient with an enhanced therapeutic response to a botulinum toxin treatment of a headache. In some embodiments, the methods comprise the step of identifying a patient who is not using a prophylactic head... | 04/27/2010 |
| 7655243 | Methods and systems for toxin delivery to the nasal cavity Methods and systems for delivering toxin and toxin fragments to a patient's nasal cavity provide for both release of the toxin and delivery of energy which selectively porates target cells to enhance uptake of the toxin. The use of energy-mediated delivery is partic... | 02/02/2010 |
| 7632514 | Universal carrier for targeting molecules to Gb3 receptor expressing cells The present invention concerns an universal polypeptidic carrier for targeting directly or indirectly a molecule to Gb3 receptor expressing cells and having the following formula STxB-Z(n)-Cys, wherein: STxB is the Shiga Toxin B subunit or a functional equivalent th... | 12/15/2009 |
| 7632513 | Immunogenic detoxified mutants of cholera toxin An immunogenic detoxified protein comprising the amino acid sequence of subunit A of a cholera toxin (CT-A) or a fragment thereof or the amino acid sequence of subunit A of an Escherichia coli heat labile toxin (LT-A) or a fragment thereof wherein the amino a... | 12/15/2009 |
| 7608275 | Systems and methods for delivery of a therapeutic agent Methods and apparatus are provided for applying an fragment of a neurotoxin such as the active light chain (LC) of the botulinum toxin (BoNT), such as one of the serotype A, B, C, D, E, F or G botulinum toxins, via permeabilization of targeted cell membranes to enab... | 10/27/2009 |
| 7579011 | Exoenzyme toxin of , and uses therefor A novel protein toxin named Aeromonas salmonicida exoenzyme T (AexT), which belongs to the family of ADP-ribosylating toxins, is disclosed as is a novel Calcium (or other cation concentration) dependent promoter of A. salmonicida. Also disclosed are di... | 08/25/2009 |
| 7579010 | Botulinum toxin pharmaceutical compositions with a recombinant human serum albumin A botulinum toxin pharmaceutical formulation free of animal derived proteins, comprising a botulinum toxin and a recombinant albumin, suitable for therapeutic administration to a human patient, and methods for treating patients with various diseases and afflictions ... | 08/25/2009 |
| 7541040 | Chimeric molecule for the treatment of th2-like cytokine mediated disorders The invention provides uses and methods for alleviating respiratory tract symptoms of allergy, asthma, and of viral, bacterial, fungal and parasitic infections by shifting inappropriate TH2 responses to TH1 responses by administering IL-13 receptor-targeted immunoto... | 06/02/2009 |
| 7501130 | Methods for treating myofascial pain A method and composition for treating a patient suffering from a disease, disorder or condition and associated pain include the administration to the patient of a therapeutically effective amount of a neurotoxin selected from a group consisting of Botulinum toxin ty... | 03/10/2009 |
| 7479281 | Botulinum toxin for treating postherpetic neuralgia Methods for treating conditions in an animal or human subject. The conditions may be pain, skeletal muscle conditions, smooth muscle conditions, glandular conditions and cosmetic conditions. The methods comprise the step of administering a Clostridium neuroto... | 01/20/2009 |
| 7455843 | Adjuvant activities of mutants of LT-IIa and LT-IIb enterotoxin lacking binding to ganglioside The present invention describes the adjuvant activity of mutants of LT-IIa and LT-IIb enterotoxin which lack ganglioside binding activity. The adjuvant activity of the LT-IIb(T13I) mutant is comparable to that of the wild type LT-IIb. The adjuvant activity of LT-IIa... | 11/25/2008 |
| 7438914 | Composition and method for enhancing immune response A composition and method for enhancing immune response in a living organism is disclosed. In particular, the present disclosure provides an adjuvant peptide for use in raising an immune response to an antigen. The adjuvant peptide is selected from a group of peptide... | 10/21/2008 |
| 7438921 | Buttock deformity treatment Methods for treating a buttock deformity or for preventing development of a buttock deformity by local administration of a Clostridial toxin, such as a botulinum neurotoxin, to a buttock deformity or to the vicinity of a buttock deformity. ... | 10/21/2008 |
| 7431935 | Proteins within the type E botulinum neurotoxin complex The invention features a polypeptide complex synthesized by bacteria of the genus Clostridia that contains the serotype E botulinum neurotoxin and five neurotoxin associated polypeptides having molecular weights of about 118, 80, 65, 40, and 18 kDa. re... | 10/07/2008 |
| 7429386 | Stretch mark treatment Methods for treating stretch marks by local administration of a Clostridial toxin, such as a botulinum toxin, to a patient with a stretch mark. ... | 09/30/2008 |
| 7429387 | Use of botulinum toxin therapy for treatment of recalcitrant voiding dysfunction The present invention related to methods for treating neurological-urological conditions. This is accomplished by administration of at least one neurotoxin. ... | 09/30/2008 |
| 7425338 | Clostridial toxin derivatives and methods for treating pain Agents for treating pain, methods for producing the agents and methods for treating pain by administration to a patient of a therapeutically effective amount of the agent. The agent can include a clostridial neurotoxin, or a component or fragment or derivative there... | 09/16/2008 |
| 7422753 | Methods for treating trichotillomania Methods for treating trichotillomania by local administration of a Clostridial toxin. The local administration can be by intramuscular, transdermal, intradermal or subdermal administration of a low dose of botulinum toxin. ... | 09/09/2008 |
| 7419675 | Method for treating peritoneal adhesions Methods for treating peritoneal adhesions by local administration of a Clostridial toxin, such as a botulinum toxin, to a patient with a peritoneal adhesion. ... | 09/02/2008 |
| 7413742 | Clostridial toxin derivatives and methods for treating pain Agents for treating pain, methods for producing the agents and methods for treating pain by administration to a patient of a therapeutically effective amount of the agent. The agent can include a clostridial neurotoxin, or a component or fragment or derivativ... | 08/19/2008 |
| 7399470 | Sandwich immunoassay kits for detecting ciguatoxin CTX3C A sandwich immunoassay kit for detecting ciguatoxins based on a combination of two anti-ciguatoxin CTX3C monoclonal antibodies produced by hybridomas, 3D11 (deposited at IPOD, AIST under accession number FMRM PB-8293) and 10C9 (FMRM PB-8292). In particular, one of t... | 07/15/2008 |
| 7396535 | Therapy for obsessive compulsive head banging Methods for treating a head banging disorder by local administration of a Clostridial toxin. The local administration can be by intramuscular, transdermal, intradermal or subdermal administration of a low dose of botulinum toxin. ... | 07/08/2008 |
| 7393538 | Clostridial toxin treatment for dermatillomania Methods for treating a dermatillomania by local administration of a Clostridial toxin. The local administration can be by intramuscular, transdermal, intradermal or subdermal administration of a low dose of botulinum toxin. ... | 07/01/2008 |
| 7393537 | Botulinum toxin for treatment of obsessive compulsive finger biting disorder Methods for treating obsessions and compulsions by local administration of a Clostridial toxin. The obsessions or compulsions can be eye poking, body rocking, finger biting, counting, checking and related disorders treated by low dose, intramuscular administration o... | 07/01/2008 |
| 7390496 | Therapeutic treatments for repetitive hand washing Methods for treating a hand washing disorder by local administration of a Clostridial toxin. The local administration can be by intramuscular, transdermal, intradermal or subdermal administration of a low dose of botulinum toxin. ... | 06/24/2008 |
| 7384918 | Botulinum toxin for treating muscle contracture The invention provides for the use of a botulinum toxin to treat contracture, such as muscle contracture, in patients by transdermal administration of the botulinum toxin. ... | 06/10/2008 |
| 7378389 | Botulinum toxin neurotoxic component for treating juvenile cerebral palsy The invention provides for the use of a presynaptic neurotoxin (for example a bacterial neurotoxin such as botulinum toxin A) for the manufacture of a medicament for the treatment of cerebral palsy in juvenile patients. The juvenile patients are preferably juveniles... | 05/27/2008 |
