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| Number | Title | Issue Date |
| 8168203 | protein antigens and methods The present invention relates to protein antigens IcsP2 and SigA2 from Shigella that are common among numerous Shigella types and species and which can protect against shigellosis or other enteric infections when administered as vaccines. In addition, ... | 05/01/2012 |
| 8147846 | Method for the treatment of airway diseases A method for the treatment of allergic airway diseases in mammals related to Pythiosis insidiosum is described. The method relies upon an immunotherapeutic product of pythium proteins as antigens. The method is particularly useful in equine cicatrix. | 04/03/2012 |
| 8147847 | protein antigens and methods The present invention relates to protein antigens IcsP2 and SigA2 from Shigella that are common among numerous Shigella types and species and which can protect against shigellosis or other enteric infections when administered as vaccines. In addition, ... | 04/03/2012 |
| 8137678 | Canine lyme disease vaccine The present invention provides a vaccine for canine Lyme disease and methods of making and using the vaccine alone, or in combinations with other protective agents. ... | 03/20/2012 |
| 8137679 | Immunogen adherence inhibitor directed to organisms and method of making and using it A microbial adherence inhibitor specific to lactic acid producing microorganisms, in the form of fowl egg antibodies is disclosed, along with the method of making it and methods of using it. The inhibitor functions by substantially preventing the attachment or adher... | 03/20/2012 |
| 8137677 | Non-protein stabilized clostridial toxin pharmaceutical compositions A Clostridial toxin pharmaceutical composition comprising a Clostridial toxin, such as a botulinum toxin, wherein the Clostridial toxin present in the pharmaceutical composition is stabilized by a non-protein excipient such as a polyvinylpyrrolidone, a disaccharides... | 03/20/2012 |
| 8133496 | Compositions and methods for diagnosing and treating urinary tract infections The present invention relates to methods and compositions for treating urinary tract infections. In particular, the present invention relates to vaccines and immune modulators for treating urinary tract infections. ... | 03/13/2012 |
| 8092808 | Ovo vaccination of in avian species The present invention provides a method of inducing an immune response against Campylobacter in an avian species, especially a domesticated avian species such as chicken, turkey, duck, goose and quail, by administering, in ovo, live cells of Campylobacter.... | 01/10/2012 |
| 8071109 | VMP-like sequences of pathogenic The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borreliae, the use of the DNA sequences in recombinant vectors to express polypeptides, the encoded amino acid sequences, application of the DNA and amino acid sequenc... | 12/06/2011 |
| 8057805 | E-ict-VL33 strain, vaccines thereof, and a method for protecting fishes using said vaccines A novel Edwardsiella ictaluri E-ict-VL33 strain, a vaccine derived from the novel Edwardsiella ictaluri E-ict-VL33 strain, especially in immersion form and oral form, and a method for protecting fishes from the infection of Edwardsiella ictaluri... | 11/15/2011 |
| 8052978 | Vaccine composition against A method for preparing a soluble antigenic extract from Rhodococcus equi is disclosed. The method includes a step of solubilizing membranes of said bacteria by contacting said bacteria with an extraction solution containing a nonionic detergent of sorbitan po... | 11/08/2011 |
| 8048433 | Deacylation of LPS in gram negative bacteria The current invention provides new Gram negative polypeptides exhibiting lipid A 3-O-deacylase activity and are capable of modifying and/or detoxifying gram negative LPS. The present invention also provides Gram negative bacteria, Gram negative bacterial lipopolysac... | 11/01/2011 |
| 8048432 | Polysaccharide-protein conjugate vaccines Abstract of the Disclosure Methods for synthesis and manufacture of polysaccharide-protein conjugate vaccines at high yield are provided. The methods involve reaction of a hydrazide group on one reactant with an aldehyde or cyanate ester group on the other reactant.... | 11/01/2011 |
| 8029804 | Recombinant chimeric antigens for diagnosis and prevention of scrub typhus Recombinant chimeric antigens comprising unmodified and modified reactive polypeptide fragments of expressed product of the recombinant 56 kDa proteins of multiple strain of scrub typhus, such as Karp, Kato (Ktr56), Gilliam (Gmr56), and TA763 (TAr56). The invention ... | 10/04/2011 |
| 8029805 | Recombinant adhesin protein and methods and uses thereof Isolated and/or recombinant adhesin polypeptides from B. pseudomallei are provided, which are used as vaccines. Genetic constructs comprising nucleic acid sequences encoding such polypeptides are also provided. Vectors comprising such constructs have been pre... | 10/04/2011 |
| 7988979 | antigens and compositions The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics. ... | 08/02/2011 |
| 7951385 | Probiotic strain and antimicrobial peptide derived therefrom The invention relates to a strain of Enterococcus mundtii having probiotic qualities. The strain of E. mundtii (ST4SA) produces an antimicrobial peptide which exhibits antimicrobial activity against a broad range of bacteria. The invention also provide... | 05/31/2011 |
| 7947289 | Multimeric protein toxins to target cells having multiple identifying characteristics The present invention provides compositions comprising modified bacterial toxins and methods for using the modified bacterial toxins for targeting particular cell populations and for treating diseases. ... | 05/24/2011 |
| 7943150 | Immunizing compositions and methods of use The present invention provides compositions including siderophore receptor polypeptides and porins from gram negative microbes, and preferably, lipopolysaccarhide at a concentration of no greater than about 10.0 endotoxin units per milliliter. The present invention ... | 05/17/2011 |
| 7943151 | Immunizing compositions and methods of use The present invention provides compositions including siderophore receptor polypeptides from gram negative microbes, and preferably, lipopolysaccharide at a concentration of no greater than about 10.0 endotoxin units per milliliter. The present invention also provid... | 05/17/2011 |
| 7927605 | Environmentally regulated genes of The invention relates to the field of the diagnosis of and vaccination against Streptococcal infections, and to the detection of virulence markers of Streptococci. The invention discloses a method for modulating virulence of a Streptococcus comprising modifyi... | 04/19/2011 |
| 7927606 | Modified free-living microbes, vaccine compositions and methods of use thereof Free-living microbes are provided in which the nucleic acid has been modified so that the microbe is attenuated for proliferation and/or which comprise genetic mutations that attenuate the ability of the microbe to repair its nucleic acid. Methods of using the modif... | 04/19/2011 |
| 7910114 | Methods of treating infectious diseases The present invention provides methods of treating a human or other mammal infected with a parasitic microorganism by administering an effective amount in unit dosage form of a C8-C16-alpha, beta-unsaturated aliphatic aldehyde, such as trans-2-... | 03/22/2011 |
| 7906123 | Modified adenylate cyclase comprising or lacking CD11b/CD18 interaction domain and uses thereof The invention relates to modified Bordetella adenylate cyclase toxins which are deficient for CD11b/CD18 binding and to their use in the preparation of pharmaceutical composition for the treatment of whooping cough and/or for the protection against Bordete... | 03/15/2011 |
| 7887815 | Peptide diagnostic agent for lyme disease The present invention relates, e.g., to an isolated peptide consisting of the sequence MKKDDQIAAAIALRGMA (SEQ ID NO:1) or an active variant thereof, wherein the peptide or active variant can bind specifically to an antibody induced by a causative agent of Lyme disea... | 02/15/2011 |
| 7875280 | Methods and compositions involving LcrV proteins The present invention concerns methods and compositions involving modified LcrV proteins from Yersinia bacteria. These methods and compositions can be employed to invoke an immune response in a subject against the bacteria, while not suppressing the immune sy... | 01/25/2011 |
| 7858100 | Bacterium and vaccine The present invention relates to a novel rod-shaped pleiomorphic non-motile Gram-negative bacterium causing a new, deadly, disease in fish, to a microbiological culture comprising said bacterium, to a vaccine comprising said bacterium and methods for the preparation... | 12/28/2010 |
| 7833534 | Compounds and methods for diagnosis and treatment of leishmaniasis Compounds and methods are provided for diagnosing, preventing, treating and detecting leishmaniasis infection and stimulating immune responses in patients are disclosed. The compounds disclosed are include polypeptides and fusion proteins that contain at least one i... | 11/16/2010 |
| 7824691 | Use of RIP in treating infections The present composition combines an RNAIII-inhibiting peptide (RIP) with an antimicrobial peptide, such as a cathelicidin, that is capable of binding and neutralizing lipidic and polyanionic components of bacterial cell envelope. In another embodiment, the RIP is co... | 11/02/2010 |
| 7824692 | disulfide bond formation proteins and uses thereof Novel genes encoding homologous immunoreactive thio-disulfide oxidoreductases, or disulfide bond formation (Dsb) proteins from Ehrlichia chaffeensis and Ehrlichia canis are disclosed. While the E. chaffeensis and E. canis Dsb proteins are... | 11/02/2010 |
| 7811583 | Antigens and vaccines against The present invention discloses novel proteins, e.g., antigens, from Piscirickettsia salmonis. The present invention further discloses nucleic acids that encode these proteins. The present invention also discloses the use of the proteins, e.g., antigens, and ... | 10/12/2010 |
| 7807181 | Neisseria mutants, lipooligosaccharides and immunogenic compositions Provided herein are mutant strains of Neisseria meningitidis which produce Kdo-free lipid A as well as the Kdo-free lipid A molecules and immunogenic compositions containing such Kdo-free lipid A molecules from a Neisseria strain containing a genetical... | 10/05/2010 |
| 7803386 | Poly-gamma-glutamic conjugates for eliciting immune responses directed against bacilli Immunogenic compositions and methods for eliciting an immune response against B. anthracis and other bacilli are provided that include immunogenic conjugates of a poly-γ-glutamic acid (γPGA) polypeptide of B. anthracis, or of another Bacillus ... | 09/28/2010 |
| 7794731 | Use of flagellin in the immunotherapy of The invention provides a fusion protein comprising a flagellin adjuvant and a Yersinia pestis antigen. Also provided are compositions comprising a flagellin adjuvant and a Yersinia pestis antigen. The invention also discloses methods of making a fusion... | 09/14/2010 |
| 7790183 | Combination of antimicrobial agents and bacterial interference to coat medical devices This invention relates to a method for coating a medical device comprising the steps of applying to at least a portion of the surface of said medical device, an antimicrobial coating layer and a non-pathogenic bacterial coating layer, wherein the antimicrobial and n... | 09/07/2010 |
| 7790184 | Cytochrome c synthesis inhibitors The invention provides methods for identifying a compound that inhibits cytochrome c synthesis. This invention further provides a method for the high throughput screening of compounds that inhibit cytochrome c synthesis. ... | 09/07/2010 |
| 7785606 | Genetically engineered clostridial genes, proteins encoded by the engineered genes, and uses thereof The present invention relates to an isolated Clostridial neurotoxin propeptide having a light chain region, a heavy chain region, where the light and heavy chain regions are linked by a disulfide bond, and an intermediate region connecting the light and heavy chain ... | 08/31/2010 |
| 7758870 | of european origin and vaccines, diagnostic agents and methods of use thereof The present invention relates to Lawsonia intracellularis vaccines and methods for protecting against and diagnosing L. intracellularis infection. The products and processes of the invention are attainable, in part, as the result of an improved method ... | 07/20/2010 |
| 7758869 | Immunogenic compositions The invention relates to immunogenic compositions and to methods for immunizing animals using the same. The immunogenic composition comprises a lipid formulation most usually in solid form, and at least one immunogenic component. A preferred immunogenic component is... | 07/20/2010 |
| 7754223 | antigens and use thereof The present invention discloses novel proteins, e.g., antigens, from Piscirickettsia salmonis. The present invention further discloses nucleic acids that encode these proteins. The present invention also discloses the use of the proteins, e.g., antigens, and ... | 07/13/2010 |
