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| Number | Title | Issue Date |
| 8124106 | Virus purification methods Provided is a method for purifying a virus from a host cell, the method comprising: a) culturing host cells, b) infecting the host cells with a virus, c) treating the cell culture with nuclease, and d) lysing the host cells to provide a lysate comprising the virus. ... | 02/28/2012 |
| 8105610 | Method of making novel erythrovirus V9 VP2 capsid polypeptides The invention relates to nucleic sequences derived from a human erythrovirus type V9, fragments of the sequences and their methods of use including applications as a diagnostic reagent and as immunogenic agent. ... | 01/31/2012 |
| 8067014 | Chimeric AAV capsid proteins Recombinant adeno-associated viral (AAV) capsid proteins are provided. Methods for generating the recombinant adeno-associated viral capsid proteins and a library from which the capsids are selected are also provided. ... | 11/29/2011 |
| 7947288 | Viral particles encoding multifunctional cytokines The present invention relates to a novel fusion protein with the formula X-Y, or Y-X, wherein X represents a first immunoregulating polypeptide and Y represents a second immunoregulating polypeptide different from X. The present invention also relates to a nucleic a... | 05/24/2011 |
| 7923436 | Methods and compounds for controlled release of recombinant parvovirus vectors The invention uses recombinant parvoviruses, and particularly recombinant adeno-associated virus (rAAV) to deliver genes and DNA sequences for gene therapy following manipulation of the therapeutic virus for packaging and transport. The invention delivers therapeuti... | 04/12/2011 |
| 7625570 | Methods for purifying adeno-associated virus The present invention provides methods of purifying adeno-associated virus (AAV) from compositions comprising AAV and at least a second, non-AAV; and methods for selectively inactivating a non-adeno-associated virus (non-AAV) in a liquid composition comprising AAV a... | 12/01/2009 |
| 7588772 | AAV capsid library and AAV capsid proteins Recombinant adeno-associated viral (AAV) capsid proteins are provided. Methods for generating the recombinant adeno-associated viral capsid proteins and a library from which the capsids are selected are also provided. ... | 09/15/2009 |
| RE40832 | Viral obesity methods and compositions A source of viral induced obesity has been discovered. A virus known as AD-36P adenovirus type 36 has been found to be associated with obesity in both animals and humans. Diagnostic DNA sequences are presented so that DNA based tests for the presence of the obesity... | 07/07/2009 |
| 7507418 | Adenovirus status as a predictor of body composition change, disease status, and treatment outcomes Infection with obesifying adenoviruses in animals and humans may be used to predict changes in body weight and disease status. More particularly, infection with certain adenoviruses, such as adenovirus type 36 (Ad-36) and adenovirus type 37 (Ad-37) may cause removal... | 03/24/2009 |
| 7419808 | Methods and compositions for the production of adenoviral vectors The present invention addresses the need to improve the yield of adenovirus when grown in cell culture systems. In particular, it has been demonstrated that for adenovirus, the use of infection temperatures lower than 37° C. in a cell culture system results in impr... | 09/02/2008 |
| 7414035 | hKIS composition and methods of use Disclosed herein are novel composition and methods for altering the proliferation of a cell. Included are wild-type and mutant hKIS polypeptides along with cyclin kinase inhibitors containing mutations that prevent their inhibition with serine/threonine kinases.... | 08/19/2008 |
| 7410954 | Adenovirus serotype 30 (Ad30) The present invention provides an adenovirus serotype 30 (Ad30) fiber amino acid sequence. The present invention also provides polynucleotides and expression vectors encoding an Ad30 fiber and viral particles and cells containing such expression vectors. The present... | 08/12/2008 |
| 7351415 | Adenovirus formulations The invention relates to viral formulations and related pharmaceutical products for use in gene therapy and/or vaccine applications. Especially preferred viral formulations disclosed herein are liquid adenovirus formulations, which show improved stability when store... | 04/01/2008 |
| 7344873 | Methods of adenovirus production A simple yet effective method of increasing production of a thermo-stable virus, such as adenovirus and picornavirus, is presented. The method entails a temperature shift strategy whereby the culture of host cells are shifted to a sub-optimal temperature for a perio... | 03/18/2008 |
| 7335353 | Porcine cells comprising an adenovirus E3 gene region The complete nucleotide sequence of the genome of porcine adenovirus type 3 (PAV-3) is provided. Methods for construction of infectious PAV genomes by homologous recombination in procaryotic cells are provided. Recombinant PAV viruses are obtained by transfection of... | 02/26/2008 |
| 7326555 | Methods of adenovirus purification A process for purifying virus particles, especially recombinant adenovirus vector particles, is presented. The process relies on various combinations of cell lysis, detergent-based precipitation of host cell contaminants away from the virus, depth filtration or cent... | 02/05/2008 |
| 7323177 | Recombinant porcine adenovirus vector This invention relates to a recombinant vector including a recombinant porcine adenovirus, stably incorporating and capable of expression of at least one heterologous nucleotide sequence. The nucleotide sequence is preferably one which encodes an antigenic determina... | 01/29/2008 |
| 7291452 | Erythrovirus and its applications The invention concerns nucleic acids derived from human V9 erythrovirus, fragments thereof, encoded polypeptides, and applications as diagnostic reagents and as immunogenic agents. ... | 11/06/2007 |
| 7270825 | Production of a parvovirus vaccine in plants as viral coat protein fusions The present invention relates to foreign peptide sequences fused to recombinant plant viral structural proteins and a method of their production. Fusion proteins are economically synthesized in plants at high levels by biologically contained tobamoviruses. The fusio... | 09/18/2007 |
| 7267825 | Parvovirus vectors and their use This invention relates to a parvovirus vector having a parvovirus DNA excisable from the vector DNA in a parvovirus-permissive cell, the parvovirus DNA having a left terminus which comprises a parvovirus minimal origin of replication, and a system comprising the par... | 09/11/2007 |
| 7267815 | Methods and reagents for the enhancement of virus transduction in the bladder epithelium Agents and methods for enhancing recombinant virus transduction in the bladder epithelium are described. A first method involves contacting the luminal surface of the bladder with a composition comprising a transduction enhancing agent and an oncolytic virus. Altern... | 09/11/2007 |
| 7264818 | BAV packaging regions and E1 transcriptional control regions The present invention relates to the identification of bovine adenovirus sequence(s) essential for encapsidation and E1 transcriptional control regions. The present invention provides adenovirus expression systems, host cells and compositions comprising adenovirus v... | 09/04/2007 |
| 7264958 | Method for obtaining a purified viral preparation The invention concerns a method for purifying a crude viral preparation containing viral, in particular adenoviral, particles of interest. The invention is characterised in that it comprises a step of adsorption on a fluidised bed. The invention also concerns a prot... | 09/04/2007 |
| 7259151 | AAV virions with decreased immunoreactivity and uses therefor Methods of making and using recombinant AAV virions with decreased immunoreactivity are described. The recombinant AAV virions include mutated capsid proteins or are derived from non-primate mammalian AAV serotypes and isolates that display decreased immunoreactivit... | 08/21/2007 |
| 7252997 | Structural protein of adeno-associated virus with modified antigenicity, its production and its use The invention relates to a structural protein of adeno-associated virus (AAV) that contains at least one modification that reduces the antigenicity of the virus. The invention further relates to the production of the structural protein and to its use. ... | 08/07/2007 |
| 7241447 | Adeno-associated virus vectors and uses thereof The invention provides an isolated and purified DNA molecule comprising at least one DNA segment, a biologically active subunit or variant thereof, of a circular intermediate of adeno-associated virus, which DNA segment confers increased episomal stability, persiste... | 07/10/2007 |
| 7238493 | Acetylation of pRb by p300 assay method for compounds which modulate this process The present invention is based upon the finding that the protein p300 has acetylation activity which is directed to the retinoblastoma tumour suppressor protein pRb by the presence in the cell of the adenovirus E1A protein. This represents a target for modulators of... | 07/03/2007 |
| 7208315 | Compositions and methods for efficient AAV vector production The present invention provides packaging cell lines for the efficient production of an Adeno-associated virus (AAV) vector which does not require “helper” virus function for the replication and encapsidation of the AAV vector particles. Packaging cells, methods ... | 04/24/2007 |
| 7202078 | Composition intended for the preservation of infectious recombinant adenoviruses Liquid or frozen compositions containing adenoviral-particles, comprising a buffer solution capable of maintaining the pH of the medium at slightly alkaline values, supplemented with glycerol and without addition of divalent metal cations or of alkali metal cations.... | 04/10/2007 |
| 7195896 | Complementary adenoviral vector systems and cell lines The present invention provides multiply deficient adenoviral vectors and complementing cell lines. Also provided are recombinants of the multiply deficient adenoviral vectors and a therapeutic method, particularly relating to gene therapy, vaccination, and the like,... | 03/27/2007 |
| 7172893 | Virus vectors and methods of making and administering the same The present invention provides genetically-engineered parvovirus capsids and viruses designed to introduce a heterologous gene into a target cell. The parvoviruses of the invention provide a repertoire of vectors with altered antigenic properties, packaging capabili... | 02/06/2007 |
| 7172899 | Methods to culture circovirus The present invention relates to methods for culturing circovirus and in particular, porcine circovirus. The present invention provides compositions and methods for culturing porcine circovirus in mammalian cells expressing mammalian adenovirus E1 function. ... | 02/06/2007 |
| 7157439 | HoxD3, HoxA3, and HoxB3 compositions and methods for improved wound healing The present invention provides methods and compositions useful in localized transfer of genetic material or proteins. Moreover, the present invention provides methods and compositions for improving and/or controlling wound healing by applying a wound care device com... | 01/02/2007 |
| 7148341 | AAV DNA comprising helper virus sequences The present invention relates to an AAV DNA having helper virus sequences which are necessary for developing AAV viral particles, a system containing such a DNA and the use of both. ... | 12/12/2006 |
| 7135187 | System for production of helper dependent adenovirus vectors based on use of endonucleases The present invention relates to methods for efficient and reliable construction of adenovirus vectors which contain and express foreign DNA and are useful for gene transfer into mammalian cells, for vaccines and for gene therapy. The invention provides for the grow... | 11/14/2006 |
| 7135180 | Preservation of bioactive materials by freeze dried foam This invention provides methods and compositions to preserve bioactive materials in a dried foam matrix. Methods provide non-boiling foam generation and penetration of preservative agents at temperatures near the phase transition temperature of the membranes. ... | 11/14/2006 |
| 7132280 | Recombinant protein production in a human cell Methods and compositions for the production of recombinant proteins in a human cell line. The methods and compositions are particularly useful for generating stable expression of human recombinant proteins of interest that are modified post-translationally, for exam... | 11/07/2006 |
| 7125706 | Method for the production and purification of adenoviral vectors The present invention addresses the need to improve the yields of viral vectors when grown in cell culture systems. In particular, it has been demonstrated that for adenovirus, the use of low-medium perfusion rates in an attached cell culture system provides for imp... | 10/24/2006 |
| 7115582 | HoxD3 and HoxA3 compositions and methods for improved wound healing The present invention provides methods and compositions useful in localized transfer of genetic material or proteins. Moreover, the present invention provides methods and compositions for improving and/or controlling wound healing by applying a wound care device com... | 10/03/2006 |
| 7109025 | Viral vectors and viral vaccines based on recombinant porcine adenoviruses An in vivo replicative and recombined porcine adenovirus characterized in that it comprises a heterologous nucleotide sequence inserted into the porcine adenovirus in conditions enabling the latter to be replicated in vivo and to express the inserted heterologous nu... | 09/19/2006 |
