Did You Know...
...that Robert Adler has the dubious distinction of being the Father of the Couch Potato? Back in 1955 Adler was employed by what was then Zenith Radio Corp., where he was charged to invent something that would allow viewers to turn down the TV volume without leaving their chairs. After a series of flops (such as a wired contraption that people tripped over), Adler hit on the idea of using sound waves. Thus the Remote Control was born...
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| Number | Title | Issue Date |
| 7892563 | Methods for treatment of severe acute respiratory syndrome (SARS) Compositions and methods for treating Severe Acute Respiratory Syndrome (SARS) are disclosed herein. Inhibitors of SARS-associated inflammatory cytokines are provided herein for use in treating SARS, including SARS-associated coronavirus (SARS-CoV) infection. Inhibi... | 02/22/2011 |
| 7776340 | Canine respiratory coronavirus (CRCV) spike protein, polymerase and hemagglutinin/esterase A canine respiratory coronavirus (CRCV) that is present in the respiratory tract of dogs with canine infectious respiratory disease and which has a low level of homology to the enteric canine coronavirus, but which has a high level of homology to all bovine coronavi... | 08/17/2010 |
| 7722886 | Compositions and methods for treatment of severe acute respiratory syndrome (SARS) Compositions and methods for treating Severe Acute Respiratory Syndrome (SARS) are disclosed herein. Inhibitors of SARS-associated inflammatory cytokines are provided herein for use in treating SARS, including SARS-associated coronavirus (SARS-CoV) infection. Inhibi... | 05/25/2010 |
| 7691390 | Viral protein The present invention is directed to an isolated polypeptide containing SEQ ID NO: 1 or an immunogenic fragment thereof. Also disclosed is an isolated nucleic acid encoding the polypeptide or containing a sequence at least 70% identical to SEQ ID NO: 3. Within the s... | 04/06/2010 |
| 7452542 | Live attenuated coronavirus vaccines The present invention is directed live, attenuated coronavirus vaccines. The vaccine comprises a viral genome encoding a p59 protein having at mutation at a specific tyrosine residue, and may include other attenuating mutations. Such viruses show reduced growth and ... | 11/18/2008 |
| 7407662 | Modified viral particles with immunogenic properties and reduced lipid content The present invention relates to a method for reducing the occurrence and severity of infectious diseases, especially infectious diseases in which lipid-containing infectious viral organisms are found in biological fluids, such as blood. The present invention employ... | 08/05/2008 |
| 7368557 | Polynucleotides encoding porcine transmissible gastroenteritis virus The present invention relates to methods of preparing a DNA comprising steps, wherein (a) a DNA comprising a full length copy of the genomic RNA (gRNA) or an RNA virus; or (b) a DNA comprising one or several fragments of a gRNA of an RNA virus, which fragments code ... | 05/06/2008 |
| 7329408 | Eliciting HCV-specific antibodies Described herein is a method of eliciting antibodies and neutralizing of binding antibodies against a hepatitis C virus (HCV) E1E2 or E2 antigen using HCV E2 or HCV E1E2 polypeptides and/or HCV E2 or E1E2 polynucleotides. Elicitation of anti-E2 antibodies and anti-E... | 02/12/2008 |
| 7309493 | Inactivated bovine scours vaccines, process and method of preventing bovine scours Inactivated scours vaccines for immunization and protection of bovine animals from disease caused by infection with bovine rotavirus and bovine coronavirus, which comprise and effective amount of at least one inactivated viral strain are described. Polyvalent inacti... | 12/18/2007 |
| 7279327 | Methods for producing recombinant coronavirus A helper cell for producing an infectious, replication defective, coronavirus (or more generally nidovirus) particle cell comprises (a) a nidovirus permissive cell; (b) a nidovirus replicon RNA comprising the nidovirus packaging signal and a heterologous RNA ... | 10/09/2007 |
| 7264802 | Proteins encoded by polynucleic acids of porcine reproductive and respiratory syndrome virus (PRRSV) The present invention provides a purified preparation containing, for example, at least one polypeptide selected from the group consisting of proteins encoded by one or more open reading frames (ORF's) of an Iowa strain of porcine reproductive and respiratory syndro... | 09/04/2007 |
| 7244585 | 3′ Sequence of the GB virus B (GBV-B) genome The present invention relates generally to the fields of biochemistry, molecular biology, and virology. More particularly, it relates to the identification of 259 nucleotides located at the 3′ end of the GB virus B (GBV-B) genome. The invention involves nucleic ac... | 07/17/2007 |
| 7172893 | Virus vectors and methods of making and administering the same The present invention provides genetically-engineered parvovirus capsids and viruses designed to introduce a heterologous gene into a target cell. The parvoviruses of the invention provide a repertoire of vectors with altered antigenic properties, packaging capabili... | 02/06/2007 |
| 7169394 | bacterin vaccine The invention provides an improved Mycoplasma hyopneumoniae bacterin vaccine composition, which advantageously provides immunity from infection after a single administration. The composition comprises an inactivated Mycoplasma hyopneumoniae bacterin an... | 01/30/2007 |
| 7151163 | Antiviral agents for the treatment, control and prevention of infections by coronaviruses The invention provides compositions and methods that are useful for preventing and treating a coronavirus infection in a subject. More specifically, the invention provides peptides and conjugates and pharmaceutical compositions containing those peptides and conjugat... | 12/19/2006 |
| 7135180 | Preservation of bioactive materials by freeze dried foam This invention provides methods and compositions to preserve bioactive materials in a dried foam matrix. Methods provide non-boiling foam generation and penetration of preservative agents at temperatures near the phase transition temperature of the membranes. ... | 11/14/2006 |
| 7097841 | Ferritin fusion proteins for use in vaccines and other applications An isolated ferritin fusion protein is provided in which ferritin is fused with a protein or peptide capable of being fused to ferritin without interfering with the polymeric self-assembly of the resulting fusion protein, and the protein may be of the endocapsid for... | 08/29/2006 |
| 7087234 | Recombinant multivalent viral vaccine The present invention relates to multivalent recombinant raccoon poxviruses, containing more than one exogenous gene inserted into either the thymidine kinase gene, the hemagglutinin gene, or a combination thereof. Disclosed is the use of the multivalent recombinant... | 08/08/2006 |
| 7041300 | Vectors based on recombinant defective viral genomes, and their use in the formulation of vaccines The vectors comprise a recombinant defective viral genome expressing at least one antigen suitable for the induction of systemic and secretory immune responses or an antibody conferring protection against an infectious agent. The defective viral genome comprises the... | 05/09/2006 |
| 7018638 | Mycoplasma hyopneumoniae bacterin vaccine The invention provides an improved Mycoplasma hyopneumoniae bacterin vaccine composition, which advantageously provides immunity from infection after a single administration. The composition comprises an inactivated Mycoplasma hyopneumoniae bacterin an... | 03/28/2006 |
| 6974577 | Inactivated bovine scours vaccines, processes and method of preventing bovine scours Inactivated scours vaccines for immunization and protection of bovine animals from disease caused by infection with bovine rotavirus and bovine coronavirus, which comprise and effective amount of at least one inactivated viral strain are described. Polyvalent inacti... | 12/13/2005 |
| 6602504 | Canine coronavirus S gene and uses therefor The present invention provides the amino acid and nucleotide sequences of a CCV spike gene, and compositions containing one or more fragments of the spike gene and encoded polypeptide for prophylaxis, diagnostic purposes and treatment of CCV infections.... | 08/05/2003 |
| 6514502 | Propagation of bovine cononavirus in chinese hamster ovary cells The present invention provides methods for using Chinese hamster ovary (CHO) cells for the anchorage-dependent and suspension-culture propagation of coronaviruses, including bovine coronavirus. In one embodiment, bovine coronavirus VR874 is cultured in CH... | 02/04/2003 |
| 6368603 | Lyme combination compositions and uses Disclosed and claimed are compositions containing a Borrelia burgdorferi antigen, and methods for making and using them. The antigen can be OspA. The compositions can contain at least one additional antigen from a pathogen other than Borrelia burgdorferi.... | 04/09/2002 |
| 6358512 | Feline infectious peritonitis vaccine The invention comprises the nucleotide sequences comprising the FIPV S gene, or a fragment of this gene, which are modified in at least one of the antigenic regions A1 and A2 which are involved in enhancement, as well as the use of these sequences for the... | 03/19/2002 |
| 6348196 | Feline polynucleotide vaccine formula Disclosed are plasmids that contain and express in vivo in a feline host cell nucleic acid molecules. The plasmid can include nucleic molecule(s) having sequence(s) encoding infectious peritonitis virus M; feline immunodeficiency virus env, or gag, or pro... | 02/19/2002 |
| 6294176 | Recombinant raccoonpox virus and uses thereof as a vaccine in mammalian and avian species The present invention provides a recombinant raccoonpox virus comprising a raccoonpox virus viral genome which contains a foreign DNA sequence inserted into a non-essential region within the HindIII "U" genomic region, the HindIII "M" genomic region, or H... | 09/25/2001 |
| 6280974 | Recombinant feline coronavirus S proteins The present invention provides polynucleotide molecules encoding portions of the S protein from feline infectious peritonitis virus (FIPV). The present invention further provides polynucleotide molecules encoding the entire S protein or portions thereof f... | 08/28/2001 |
| 6268199 | Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof An infectious clone based on the genome of a wild-type RNA virus is produced by the process of providing a host cell not susceptible to infection by the wild-type RNA virus, providing a recombinant nucleic acid based on the genome of the wild-type RNA vir... | 07/31/2001 |
| 6241989 | Recombinant multivalent viral vaccine The present invention relates to multivalent recombinant raccoon poxviruses, containing more than one exogenous gene inserted into either the thymidine kinase gene, the hemagglutinin gene, or a combination thereof. Disclosed is the use of the multivalent ... | 06/05/2001 |
| 6168787 | Pluripotent vaccine against enveloped viruses The present invention is directed to compositions and methods for the induction of immune responses in mammals against enveloped animal viruses. More particularly, the invention provides vaccine compositions containing multiple MHC allotypes. By generatin... | 01/02/2001 |
| 6057436 | Canine coronavirus S gene and uses therefor The present invention provides the amino acid and nucleotide sequences of a CCV spike gene, and compositions containing one or more fragments of the spike gene for prophylaxis, diagnostic, and treatment of CCV infections.... | 05/02/2000 |
| 6042830 | Viral agent associated with mystery swine disease A substantially avirulent vaccine against Porcine Reproductive and Respiratory Syndrome (PRRS) is provided, which effectively immunizes swine against the U.S. and European forms of the disease, together with a method of growing the viral agent in vitro, a... | 03/28/2000 |
| 5882652 | Empty canine parvovirus capsids having CPV recombinant VP2 and vaccines having such capsids The present invention is a method for the production of a subunit vaccine against canine parvovirus (CPV). The method includes the step wherein a recombinant protein VP2 of CPV is obtained by using the replication of a recombinant baculovirus wherein the ... | 03/16/1999 |
| 5858373 | Recombinant poxvirus-feline infectious peritionitis virus, compositions thereof and methods for making and using them Attenuated recombinant viruses containing DNA encoding FIPV antigen(s) compositions thereof, as well as methods for making and using the compositions, expression products therefrom, and antibodies generated, are disclosed and claimed. The recombinant viru... | 01/12/1999 |
| 5820869 | Recombinant raccoon pox viruses and their use as an effective vaccine against feline immunodeficiency virus infection This invention provides a recombinant raccoon poxvirus that express the envelope protein of Feline Immunodeficiency Virus. The recombinant viruses are useful as vaccines, either alone or in combination with carries and adjuvants.... | 10/13/1998 |
| 5811104 | Recombinant structural and non-structural proteins of FIPV and method of immunizing The present invention relates to the development of an efficacious vaccine against Feline Infectious Peritonitis Virus (FIPV). The invention provides the tools for the synthesis and manipulation of the structural and non-structural proteins of FIPV. These... | 09/22/1998 |
| 5770211 | Recombinant raccoon pox viruses and their use as an effective vaccine against feline infectious peritonitis virus disease This invention provides a recombinant raccoon poxvirus that expresses the nucleocapsid and transmembrane proteins of Feline Infectious Peritonitis Virus. The recombinant viruses are useful as vaccines, either alone or in combination with carriers and adju... | 06/23/1998 |
| 5750112 | Canine coronavirus vaccine from feline enteric coronavirus This invention provides a vaccine which contains, per dose, an effective immunizing amount of an inactivated feline enteric coronavirus and a suitable carrier. The vaccine of this invention may also contain an adjuvant, an effective immunizing amount of a... | 05/12/1998 |
| 5672350 | Recombinant bovine coronavirus E2 and E3 polypeptides and vaccines Nucleic acid sequences encoding the Bovine Coronavirus E2 (or BCV S) and E3 (or BCV HE) structural glycoproteins and methods of producing these proteins, including recombinant expression, e.g., in mammalian or insect cells, are provided. The E2 and E3 pro... | 09/30/1997 |
