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| Number | Title | Issue Date |
| 5298416 | Attenuated polioviruses An attenuated enterovirus or rhinovirus, suitable for use as a vaccine, has a reversed base pairing in the part, or in a part corresponding to the part, of the 5' non-coding region of the genome of poliovirus type 3 Leon strain shown below: ##STR1## ... | 03/29/1994 |
| 5298413 | Attenuated polioviruses An attenuated enterovirus or rhinovirus, suitable for use as a vaccine, has an attenuating mutation at least at a position which is, or corresponds with, position 471 or 484 of the genome of poliovirus type 3 Leon strain.... | 03/29/1994 |
| 5286640 | Attenuated polioviruses An attenuated enterovirus or rhinovirus, suitable for use as a vaccine, has an attenuating mutation at least at a position which is, or corresponds with, position 479 and/or 482 of poliovirus type 3 Leon strain.... | 02/15/1994 |
| 5230888 | Production of neutralizing antibodies by polypeptide VP1 of enteroviruses and by oligopeptide fragments of polypeptide VP1 The production of neutralizing antibodies for poliovirus, or other enteroviruses, are disclosed herein employing the capsid polypeptide VP1. Vaccines can be produced employing this polypeptide in place of killed or live attenuated virus, and the VP1 polyp... | 07/27/1993 |
| 5198536 | Peptides comprising an immunogenic site of poliovirus and DNAs containing nucleotide sequences coding for these peptides The invention relates to a DNA fragment containing at the most 315 pairs of nucleotides coding for a peptide which can be recognized by antibodies acting both against the "C" and "D" particles of the same poliovirus and against the VP-1 structural polypep... | 03/30/1993 |
| 5019557 | Method for the effective treatment of disease conditions in humans associated with HTLV-III infection A method for the treatment of human disease conditions associated with HTLV infection is disclosed which is effective both as a treatment for HTLV infected individuals as well as a prophylactic treatment. The method comprises the step of hyperimmunizing a... | 05/28/1991 |
| 4968627 | DNA fragments coding an immunogen peptide liable of inducing in vivo synthesis of anti-poliovirus antibodies DNA fragment capable of coding for an immunogenic peptide capable of inducing in vivo antibody reacting with anti-poliovirus. It possesses up to the order of 1.2 kilobase pairs and contains a nucleotide sequence coding for the poliovirus VP1 protein.... | 11/06/1990 |
| 4946676 | Vaccine comprising an immunogenic protein and, as an adjuvant, a substantially non-immunogenic, sequentially homologous peptide The invention relates to a new vaccine comprising a native protein capable of inducing the production of protective antibodies in a host, together with an adjuvant amount of certain proteins or peptides which, as such, are not capable of inducing substant... | 08/07/1990 |
| 4857634 | Peptides useful in vaccination against enteroviruses A synthetic peptide, suitable for use in vaccination against or diagnosis of a disease caused by an enterovirus and especially by a poliovirus, is the peptide coded for by codons 286-290 in the RNA sequence coding for the structural capsid protein VP1 of ... | 08/15/1989 |
| 4810491 | Polypeptides useful in vaccination against enteroviruses A synthetic polypeptide, suitable for use in vaccination against or diagnosis of a disease caused by an enterovirus, is an octapeptide coded for by codons 93-100 in the RNA sequence coded for the structural capsid protein VP1 for poliovirus type 3 Sabin s... | 03/07/1989 |
| 4769237 | Synthetic picornavirus antigen A specific synthetic antigenic peptide that contains a sequence of about 20 amino acid residues corresponding to a certain region of the antigenic picornavirus capsid protein such as the VP1 capsids of foot-and-mouth disease and poliomyelitis viruses. Tha... | 09/06/1988 |
| 4751083 | Production of neutralizing antibodies by polypeptide VP1 of enteroviruses and by oligopeptide fragments of polypeptide VP1 The production of neutralizing antibodies for poliovirus, or other enteroviruses, are disclosed herein employing the capsid polypeptide VP1. Vaccines can be produced employing this polypeptide in place of killed or live attenuated virus, and the VP1 polyp... | 06/14/1988 |
| 4744983 | Immunogenic protein or peptide complex, method of producing said complex and the use thereof as an immune stimulant and as a vaccine The invention relates to an immunogenic complex containing antigenic membrane proteins or peptides from viruses mycoplasmas, bacteria, parasites or animal cells or prepared synthetically or with hybride DNA technique and glycoside. The invention also rela... | 05/17/1988 |
| 4694071 | Polypeptides useful in vaccination against enteroviruses A synthetic polypeptide, suitable for use in vaccination against or diagnosis of a disease caused by an enterovirus, is an octapeptide coded for by codons 93-100 in the RNA sequence coded for the structural capsid protein VP1 for poliovirus type 3 Sabin s... | 09/15/1987 |
| 4593002 | Viruses with recombinant surface proteins Foreign protein segments having specific medically or commercially useful biological functions are incorporated in surface proteins of viruses. The viruses with the incorporated protein segments are convenient agents for introducing the protein segments i... | 06/03/1986 |
| 4578269 | Immunogenic protein or peptide complex, method or producing said complex and the use thereof as an immune stimulant and as a vaccine The invention relates to an immunogenic complex containing antigenic membrane proteins or peptides from viruses mycoplasmas, bacteria, parasites or animal cells or prepared synthetically or with hybride DNA technique and glycoside. The invention also rela... | 03/25/1986 |
| 4525349 | Process for the large-scale production of a vaccine against poliomyelitis and the resulting vaccine A process for large-scale production of poliomyelitis vaccine separately entails, for each type of poliomyelitis virus used, the following steps. A cell strain, using a cell stock, is multiplied by culturing the same in a liquid nutritive medium on microc... | 06/25/1985 |
| 4508708 | Virus vaccines and process for preparing the same The invention relates to virus vaccines and to a process for the preparation thereof especially to polio virus vaccines and other picorna virus vaccines, such as foot-and-mouth disease vaccine. The invention provides vaccines which are stabilized and show an i... | 04/02/1985 |
| 4337242 | Vaccine stabilizer containing L-glutamic acid and L-arginine An improved stabilized liquid live viral vaccine contains a live virus, partially hydrolyzed gelatin, a monosaccharide or disaccharide, a cell culture medium, L-glutamic acid, L-arginine and sufficient physiologically acceptable acidic buffer to maintain ... | 06/29/1982 |
| 4258029 | Synthetic adjuvants for stimulation of antigenic responses Long chain alcohol esters of amino acids are used as adjuvants in vaccines to provide an improved antigenic capability when compared with conventional adjuvants.... | 03/24/1981 |
| 4147772 | Vaccine stabilizer A stabilized lyophlized or liquid live viral vaccine contains a live virus, partially hydrolyzed gelatin, a 6-carbon polyhydric alcohol, Medium 199 and acidic buffer.... | 04/03/1979 |
| 4072565 | Production of viruses in tissue culture without use of serum Growth of cells in tissue culture and virus vaccine production in tissue culture in the absence of serum are disclosed. The cells in tissue culture are grown initially in a chemically defined medium containing protamine zinc insulin, and the protamine zin... | 02/07/1978 |
| 4071619 | Method of producing vaccines A method for producing vaccines wherein a suspension of the viral culture is purified by gel chromatography in a column packed with a porous virion non-sorbing silicate material having pore diameter of 50 to 10000 A, followed by adsorption-elution concent... | 01/31/1978 |
| 4070454 | Vaccines, the process for preparing the same and the applications thereof This invention relates to a process for preparing vaccines, which consists in bringing into contact a toxic product with glutaraldehyde at a concentration and for a duration just sufficient to detoxify or inactivate said toxic product, and in stopping the... | 01/24/1978 |
