Celebrity Inventors
Mark Twain (Samuel L. Clemens) received Patent No. 121,992 for "An Improvement in Adjustable and Detachable Straps for Garments." He later received two more patents: one for a self-pasting scrapbook and one for a game to help players remember important historical dates.
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| Number | Title | Issue Date |
| 8178110 | Reovirus compositions and methods of use The present invention relates to novel strains of avian reovirus that were isolated from severe cases of Runting Stunting Syndrome in young broiler chickens in southeast United States. The invention is directed to avian reoviruses that impair digestion in poultry, d... | 05/15/2012 |
| 8168202 | Hexavalent bovine rotavirus reassortant composition designed for use in developing countries The present invention provides vaccine compositions for protection against human rotaviral disease designed for use in particular areas of the world. Human× bovine reassortant rotavirus comprising each of the four clinically most important VP7 serotypes of human ro... | 05/01/2012 |
| 8147845 | Reovirus clearance of ras-mediated neoplastic cells from mixed cellular compositions Reovirus can be used to selectively remove ras-mediated neoplastic cells from a cellular composition. It is of particular interest to purge autographs which may contain neoplastic cells with reovirus before transplanting the autographs back into the recipient, there... | 04/03/2012 |
| 7959932 | Human rotavirus and vaccine composition comprising same Provided are G12 human rotaviruses having VP7 gene of SEQ ID NO: 1 or 2 and VP4 gene of SEQ ID NO: 3 or 4; antibodies specific for said rotaviruses; and a vaccine composition containing the same. The antibodies and the vaccine composition are effective for diagnosin... | 06/14/2011 |
| 7910113 | Tolerizing agents Described herein is the development of fusion proteins useful for inducing tolerance in a subject. In particular embodiments, the tolerizing agents are useful for influence autoimmune, inflammatory, and/or allergic reactions. Example tolerizing fusion proteins conta... | 03/22/2011 |
| 7807179 | Modified reoviral therapy The present invention relates to hyperproliferative diseases. Specifically, the present invention encompasses pharmaceutical compositions comprising a modified Reoviridae virus, wherein the Reoviridae virus is conjugated to a hydroxylated hydrocarbon or a polycation... | 10/05/2010 |
| 7803385 | Reoviruses having modified sequences The invention provides for modified reovirus nucleic acid sequences and modified reovirus polypeptide sequences as well as reoviruses containing such modified nucleic acid or polypeptide sequences. The invention also provides for pharmaceutical compositions that inc... | 09/28/2010 |
| 7790179 | Homogeneous attenuated human rotavirus population The invention provides an attenuated rotavirus population comprising a single variant or substantially a single variant which is defined by a nucleotide sequence encoding at least one of the major viral proteins designated as VP4 and VP7. The invention particularly ... | 09/07/2010 |
| 7790180 | Immunogenic composition of a homogeneous live attenuated human rotavirus population The invention provides an attenuated rotavirus population comprising a single variant or substantially a single variant which is defined by a nucleotide sequence encoding at least one of the major viral proteins designated as VP4 and VP7. The invention particularly ... | 09/07/2010 |
| 7579008 | Immunization with an attenuated human rotavirus The invention provides a method of inducing an immune response against rotavirus infection from one rotavirus serotype, the method comprising administering to a subject a composition comprising an attenuated rotavirus vaccine from a different serotype. There is in p... | 08/25/2009 |
| 7431931 | Compositions and method for preventing reactogenicity associated with administration of immunogenic live rotavirus compositions The present invention provides compositions for making a medicament and methods for the administration of a vaccine compositions for protection against human rotaviral disease without significant reactogenicity. Human x rhesus reassortant rotavirus compositions were... | 10/07/2008 |
| 7431932 | Reovirus clearance of ras-mediated neoplastic cells from mixed cellular compositions Reovirus can be used to selectively remove ras-mediated neoplastic cells from a cellular composition. It is of particular interest to purge autographs which may contain neoplastic cells with reovirus before transplanting the autographs back into the recipient, there... | 10/07/2008 |
| 7311918 | Rotavirus subunit vaccine The present invention is directed to the generation and use of recombinant rotavirus fusion proteins as immunogens to produce a protective immune response from immunized individuals. In one embodiment, the present invention contemplates a recombinant rotavirus fusio... | 12/25/2007 |
| 7309493 | Inactivated bovine scours vaccines, process and method of preventing bovine scours Inactivated scours vaccines for immunization and protection of bovine animals from disease caused by infection with bovine rotavirus and bovine coronavirus, which comprise and effective amount of at least one inactivated viral strain are described. Polyvalent inacti... | 12/18/2007 |
| 7300650 | Reovirus for the treatment of neoplasia Methods for treating neoplasia, by administering reovirus to a Ras-mediated neoplasm, and use of reovirus for manufacture of a medicament for the treatment of neoplasia, are disclosed. The reovirus is administered so that it ultimately directly contacts cells of the... | 11/27/2007 |
| 7285280 | Vaccine The invention provides an attenuated rotavirus population comprising a single variant or substantially a single variant which is defined by a nucleotide sequence encoding at least one of the major viral proteins designated as VP4 and VP7. The invention particularly ... | 10/23/2007 |
| 7264798 | Sensitization of chemotherapeutic agent resistant neoplastic cells with a virus The present invention relates to a method of increasing the sensitivity of neoplastic cells to chemotherapeutic agents by using a virus, a method of treating proliferative disorders with a virus and chemotherapeutic agents, and a method for preventing a neoplasm fro... | 09/04/2007 |
| 7223388 | Modified reoviral therapy The present invention relates to hyperproliferative diseases. Specifically, the present invention encompasses pharmaceutical compositions comprising a modified Reoviridae virus, wherein the Reoviridae virus is conjugated to a hydroxylated hydrocarbon or a polycation... | 05/29/2007 |
| 7198783 | Sensitization of neoplastic cells to radiation therapy with reovirus The present invention relates to methods of sensitizing neoplastic cells to irradiation by using oncolytic viruses, particularly reoviruses. Also provided are methods of treating or ameliorating a tumor with a combination of oncolytic viruses and radiotherapy. ... | 04/03/2007 |
| 7186542 | Method of extracting virus from cell culture The present invention is directed to a method of extracting virus, particularly reovirus, from a culture of cells. Infectious virus can be extracted from the culture with a detergent at a convenient temperature such as 25° C. or 37° C. to produce high virus titers... | 03/06/2007 |
| 7163678 | Reovirus for the treatment of ral-mediated cellular proliferative disorders Methods for treating proliferative disorders, by administering reovirus to a ral-mediated proliferative disorder, are disclosed. The reovirus is administered so that it ultimately directly contacts target cancer cells. Proliferative disorders include but are not lim... | 01/16/2007 |
| 7150984 | Attenuated human rotavirus vaccine The present invention provides vaccine compositions of attenuated human rotavirus. More particularly, the attenuated human rotavirus is produced by cold passage and thus contains attenuating mutations which produce virus having a cold-adapted (ca) and temperature se... | 12/19/2006 |
| 7128909 | Immunstimulating lipid formulation A pharmaceutical formulation for parenteral or mucosal administration of antigens and/or vaccines to humans and animals, comprising monoglyceride preparations having at least 80% monoglyceride content and where the acyl group contains from 6 to 24 carbon atoms, toge... | 10/31/2006 |
| 7014847 | Methods for preventing reovirus recognition for the treatment of cellular proliferative disorders The present invention pertains to methods for preventing reovirus recognition in the treatment of cellular proliferative disorders, and particularly ras-mediated cellular proliferative disorders, in mammals. The method comprises suppressing or otherwise inhibiting t... | 03/21/2006 |
| 6994858 | Reovirus clearance of ras-mediated neoplastic cells from mixed cellular compositions Reovirus can be used to selectively remove ras-mediated neoplastic cells from a cellular composition. It is of particular interest to purge autographs which may contain neoplastic cells with reovirus before transplanting the autographs back into the recipient, there... | 02/07/2006 |
| 6974577 | Inactivated bovine scours vaccines, processes and method of preventing bovine scours Inactivated scours vaccines for immunization and protection of bovine animals from disease caused by infection with bovine rotavirus and bovine coronavirus, which comprise and effective amount of at least one inactivated viral strain are described. Polyvalent inacti... | 12/13/2005 |
| 6951650 | Antigenic class of avian reoviruses The present invention provides a new antigenic class of avian reoviruses which are involved in enteric disease conditions in poultry. Moreover, the invention provides a vaccine for use in the protection of poultry against such disease conditions derived from the new... | 10/04/2005 |
| 6942865 | Methods and reagents to detect and characterize norwalk and related viruses Double-stranded cDNA was synthesized from nucleic acid extracted from Norwalk virus purified from stool specimens of volunteers. One clone was isolated from a cDNA library constructed in a pUC-13 vector after amplification of the cDNA. The specificity of this cDNA (... | 09/13/2005 |
| 6867353 | Production method of recombinant rotavirus structural proteins and vaccine composition The present invention relates to a method for producing recombinant rotavirus structural proteins by culturing a transformed plant cell, and to a vaccine composition comprising the same as an effective component. More specifically, the method comprises the steps of ... | 03/15/2005 |
| 6811775 | Reovirus for the treatment of cellular proliferative disorders Methods for treating proliferative disorders, by administering reovirus to a Ras-mediated proliferative disorder, are disclosed. The reovirus is administered so that it ultimately directly contacts ras-mediated proliferating cells. Proliferative disorders include bu... | 11/02/2004 |
| 6808916 | Method of extracting virus from cell culture The present invention is directed to a method of extracting virus, particularly reovirus, from a culture of cells. Infectious virus can be extracted from the culture with a detergent at a convenient temperature such as 25° C. or 37° C. to produce high virus titers... | 10/26/2004 |
| 6805867 | Bovine rotavirus genes The present invention provides the genes encoding the following BRV proteins: for group A, the VP4 and VP7 proteins of the Indiana (IND) strain, and the VP7 protein of the 2292B strain; for group B, the VP7 protein of the WD653 strain; for group C, the VP4 and VP7 p... | 10/19/2004 |
| 6716431 | Differential cytotoxicity of alternative forms of rotavirus nonstructural protein 4 The nonstructural protein 4 (NSP4) in the SA11 ATCC rotavirus strain has a histidine at amino acid position 47. This substituted form is more cytotoxic than the NSP4 of the Australia rotavirus strain, which has an asparagine at amino acid position 47. The histidine ... | 04/06/2004 |
| 6673355 | Rotavirus enterotoxin NSP4 and methods of using same The rotavirus nonstructural glycoprotein, NSP4, performs multiple functions in the virus replication cycle, especially during viral morphogenesis. Specifically, NSP4 is an intracellular receptor that mediates the acquisition of a transient membrane envelo... | 01/06/2004 |
| 6616931 | Rotavirus vaccine formulations The present invention provides liquid and lyophilized formulations of vaccines against rotavirus infection and methods of their preparation. The formulations include buffering agents appropriate for oral administration of rotavirus vaccines. The formulati... | 09/09/2003 |
| 6589529 | Rotavirus subunit vaccine The present invention is directed to the generation and use of recombinant rotavirus fusion proteins as immunogens to produce a protective immune response from immunized individuals. In one embodiment, the present invention contemplates a recombinant rota... | 07/08/2003 |
| 6576234 | Reovirus for the treatment of neoplasia Methods for treating neoplasia, by administering reovirus to a Ras-mediated neoplasm, and use of reovirus for manufacture of a medicament for the treatment of neoplasia, are disclosed. The reovirus is administered so that it ultimately directly contacts c... | 06/10/2003 |
| 6565831 | Methods for preventing reovirus recognition for the treatment of cellular proliferative disorders The present invention pertains to methods for preventing reovirus recognition in the treatment of cellular proliferative disorders, and particularly ras-mediated cellular proliferative disorders, in mammals. The method comprises suppressing or otherwise i... | 05/20/2003 |
| 6534067 | Rotavirus enterotoxin adjuvant This invention relates to a method of potentiating an immune response by administering a viral enterotoxin or derivative as an adjuvant. More particularly it relates to administering a viral enterotoxin or derivative as an adjuvant and an antigen to a muc... | 03/18/2003 |
| 6455038 | Reovirus for the treatment of cellular proliferative disorders Methods for treating proliferative disorders, by administering reovirus to a Ras-mediated proliferative disorder, are disclosed. The reovirus is administered so that it ultimately directly contacts ras-mediated proliferating cells. Proliferative disorders... | 09/24/2002 |
