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| Number | Title | Issue Date |
| 8133495 | Live attenuated antigenically marked classical swine fever virus Classical swine fever virus is a world-wide distributed highly-contagious disease affecting swine. The two main strategies for diseases control are prophylactic vaccination and non-vaccination stamping out policies. Marker vaccines are a promising strategy. Here we ... | 03/13/2012 |
| 8088748 | Antisense respiratory syncytial virus vaccine and therapy A method is provided for immunizing against pulmonary inflammation and airway hyperresponsiveness associated with infantile RSV infection. This method includes administering an antisense oligonucletide to a subject in need thereof. ... | 01/03/2012 |
| 7951383 | Attenuated parainfluenza virus (PIV) vaccines The invention provides isolated nucleic acids encoding recombinant genomes or antigenomes of Human Parainfluenza Viruses that are useful as vaccines. The recombinant genomes or antigenomes can be incorporated into expression vectors for production of recombinant vir... | 05/31/2011 |
| 7846455 | Attenuated chimeric respiratory syncytial virus Chimeric respiratory syncytial virus (RSV) and vaccine compositions thereof are produced by introducing one or more heterologous gene(s) or gene segment(s) from one RSV subgroup or strain into a recipient RSV backround of a different subgroup or strain. The resultin... | 12/07/2010 |
| 7829102 | Production of attenuated, human-bovine chimeric respiratory syncytial virus vaccines Chimeric human-bovine respiratory syncytial virus (RSV) are infectious and attenuated in humans and other mammals and useful in vaccine formulations for eliciting an anti-RSV immune response. Also provided are isolated polynucleotide molecules and vectors incorporat... | 11/09/2010 |
| 7820182 | Production of attenuated, human-bovine chimeric respiratory syncytial viruses for use in immunogenic compositions Chimeric human-bovine respiratory syncytial virus (RSV) are infectious and attenuated in humans and other mammals and useful in immunogenic compositions for eliciting an anti-RSV immune response. Also provided are isolated polynucleotide molecules and vectors incorp... | 10/26/2010 |
| 7820181 | Recovery of recombinant human parainfluenza virus type 2 (HPIV2) from cDNA and use of recombinant HPIV2 in immunogenic compositions and as vectors to elicit immune responses against PIV and other human pathogens Recombinant human parainfluenza virus type 2 (HPIV2) viruses and related immunogenic compositions and methods are provided. The recombinant HPIV2 viruses, including HPIV2 chimeric and chimeric vector viruses, provided according to the invention are infectious and at... | 10/26/2010 |
| 7744902 | Respiratory syncytial virus vaccines expressing protective antigens from promotor-proximal genes Recombinant respiratory syncytial virus (RSV) having the position of genes shifted within the genome or antigenome of the recombinant virus are infectious and attenuated in humans and other mammals. Gene shifted RSV are constructed by insertion, deletion or rearrang... | 06/29/2010 |
| 7709007 | Production of attenuated respiratory syncytial virus vaccines from cloned nucleotide sequences Attenuated respiratory syncytial virus (RSV) and vaccine compositions thereof are produced by introducing specific mutations associated with attenuating phenotypes into wild-type or RSV which is incompletely attenuated by cold-passage or introduction of mutations wh... | 05/04/2010 |
| 7704509 | Recovery of recombinant human parainfluenza virus type 1 (HPIV1) from cDNA and use of recombinant HPIV1 in immunogenic compositions and as vectors to elicit immune responses against PIV and other human pathogens Recombinant human parainfluenza virus type 1 (HPIV1) compostions, formulations and methods are provided. The recombinant HPIV1 viruses and HPIV1 chimeric and chimeric vector viruses provided according to the invention are infectious and attenuated in permissive mamm... | 04/27/2010 |
| 7662397 | Respiratory syncytial virus vaccines expressing protective antigens from promoter-proximal genes Recombinant respiratory syncytial virus (RSV) having the position of genes shifted within the genome or antigenome of the recombinant virus are infectious and attenuated in humans and other mammals. Gene shifted RSV are constructed by insertion, deletion or rearrang... | 02/16/2010 |
| 7588770 | Recombinant viruses of the paramyxoviridae family with heterologous envelope glycoproteins The invention provides recombinant viruses comprising heterologous envelope proteins capable of mediating entry of the recombinant viruses into host cells. In one embodiment, a recombinant virus of the invention is a member of the Paramyx-ovirzdae fami... | 09/15/2009 |
| 7442544 | Recombinant sendai virus A method for regenerating Sendai virus particles by transfecting the Sendai virus genome to a host expressing all genes for the initial viral replication has been developed, enabling the genetic manipulation of Sendai virus and effective utilization of said virus as... | 10/28/2008 |
| 7442379 | Recombinant Newcastle disease virus RNA expression systems and vaccines This invention relates to genetically engineered Newcastle disease viruses and viral vectors which express heterologous genes or mutated Newcastle disease viral genes or a combination of viral genes derived from different strains of Newcastle disease virus. The inve... | 10/28/2008 |
| 7402427 | Vectors with modified protease-dependent tropism The present invention provides cell fusogenic vectors having replicative ability, whose protease-dependent tropism has been modified. M gene-deficient viral vectors encoding modified F proteins, in which the cleavage site of the F protein of paramyxovirus is ... | 07/22/2008 |
| 7374751 | QS-21 and IL-12 as an adjuvant combination Adjuvant compositions comprising an effective amount IL-12 and QS-21 are disclosed. Immunogenic, vaccine and pharmaceutical compositions comprising a mixture of antigen and an adjuvant composition comprising an effective amount of IL-12 and QS-21 are also disclosed.... | 05/20/2008 |
| 7371392 | Cd40 ligand adjuvant for respiratory syncytial virus The present invention provides methods and adjuvants for enhancing an immune response to RSV in a host, wherein the methods and adjuvants comprise a source of a CD40 binding protein. Preferably, the CD40 binding protein is CD40L and the source is a vector comprising... | 05/13/2008 |
| 7368537 | Subunit vaccine against respiratory syncytial virus infection The present invention relates generally to methods of treating or preventing RSV infections, and more specifically, to compositions, and the use thereof, comprising one or more RSV G protein immunogen or fragment thereof capable of eliciting protective immunity with... | 05/06/2008 |
| 7364742 | RSV proteins, antibodies, compositions, methods and uses The present invention relates to at least one novel RSV proteins, antibodies, including isolated nucleic acids that encode at least one RSV protein or antibody, RSV vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including... | 04/29/2008 |
| 7348012 | Methods and vaccines for providing in ovo protection against turkey rhinotracheitis Methods and compositions for protecting avian hosts (e.g., turkeys and/or chickens) from turkey rhinotracheitis virus and/or TRT or SHS respiratory distress utilize in ovo administration of live, avirulent strains of TRTV at appropriate dosage levels on a per egg ba... | 03/25/2008 |
| 7341729 | Recombinant parainfluenza virus expression systems and vaccines The present invention relates to recombinant bovine para influenza virus (bPIV) cDNA or RNA which may be used to express heterologous gene products in appropriate host cell systems and/or to rescue negative strand RNA recombinant viruses that express, package, and/o... | 03/11/2008 |
| 7335366 | Attenuated bovine respiratory syncytial virus The present invention relates i.a. to Bovine Respiratory Syncytial Viruses that are not capable of expressing a functional SH-protein and/or G-protein due to a mutation in the genes encoding the said proteins. Also the invention relates to diagnostic test kits for d... | 02/26/2008 |
| 7335361 | Fusion antigen used as vaccine The present invention mainly provides a fusion antigen specific for a target cell comprising a ligand moiety which is capable of reacting, recognizing or binding to the receptors on the target cell, a Pseudomonas exotoxin A translocation domain II, an antigen... | 02/26/2008 |
| 7332169 | Newcastle disease virus infectious clones, vaccines and new diagnostic assays The invention relates to a process for generating infectious Newcastle disease virus (NDV) entirely from cloned full-length cDNA and to the use of vaccines and diagnostic assays generated with and derived from the process. The process offers the possibility to modif... | 02/19/2008 |
| 7323172 | Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment The present invention encompasses novel antibodies and fragments thereof which immunospecifically bind to one or more RSV antigens and compositions comprising said antibodies and antibody fragments. The present invention encompasses methods preventing respiratory sy... | 01/29/2008 |
| 7314631 | Use of recombinant live-attenuated parainfluenza virus (PIV) as a vector to protect against disease caused by PIV and respiratory syncytial virus (RSV) Chimeric parainfluenza viruses (PIVs) are provided that incorporate a PIV vector genome or antigenome and one or more antigenic determinant(s) of a heterologous PIV or non-PIV pathogen. These chimeric viruses are infectious and attenuated in humans and other mammals... | 01/01/2008 |
| 7309494 | Peptides of the respiratory syncytial virus (RSV) G protein and their use in a vaccine The invention concerns novel immunogenic peptides derived from the RSV G protein of the sub-group A or B comprising at least: a first peptide derived from the BRSV G protein of sub-group A or B including at least in position 173, 176, 182 and 186 a cysteine and wher... | 12/18/2007 |
| 7276590 | Ion exchange chromatography of proteins and peptides The present invention relates to an ion exchange chromatography process for purifying a peptide from a mixture containing the peptide and related impurities, and to an industrial method including such ion exchange chromatography process. ... | 10/02/2007 |
| 7264802 | Proteins encoded by polynucleic acids of porcine reproductive and respiratory syndrome virus (PRRSV) The present invention provides a purified preparation containing, for example, at least one polypeptide selected from the group consisting of proteins encoded by one or more open reading frames (ORF's) of an Iowa strain of porcine reproductive and respiratory syndro... | 09/04/2007 |
| 7250171 | Construction and use of recombinant parainfluenza viruses expressing a chimeric glycoprotein Chimeric parainfluenza viruses (PIVs) are provided that incorporate a PIV vector genome or antigenome modified to encode a chimeric glycoprotein incorporating one or more heterologous antigenic domains, fragments, or epitopes of a second, antigenically distinct HPIV... | 07/31/2007 |
| 7229619 | Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment The present invention encompasses novel antibodies and fragments thereof which immunospecifically bind to one or more RSV antigens and compositions comprising said antibodies and antibody fragments. The present invention encompasses methods preventing respiratory sy... | 06/12/2007 |
| 7229623 | Her-2/neu fusion proteins The present invention is generally directed to Her-2/neu fusion proteins, nucleic acid molecules encoding Her-2/neu fusion proteins, viral vectors expressing Her-2/neu fusion proteins, and pharmaceutical compositions (e.g., vaccines) comprising the Her-2/neu fusion ... | 06/12/2007 |
| 7223410 | Inactivated respiratory syncytial viral vaccines An immunogenic composition capable of producing a respiratory syncytial (RS) virus specific immune response in a host immunized therewith comprises purified, inactivated RS virus which is substantially free from cellular and serum components and which is non-infecti... | 05/29/2007 |
| 7223584 | Recombinant rabies vaccine and methods of preparation and use Live rabies virus vaccines comprising a recombinant rabies virus genome which overexpresses the rabies virus G protein increase apoptotic activity in infected cells, and enhance the generation of anti-rabies immunity in a subject. ... | 05/29/2007 |
| 7220545 | Peptide fragment of respiratory syncytial virus protein G, immunogenic agent, pharmaceutical composition containing it and preparation method A polypeptide useful as an immunogen element and characterised in that it is carried on the peptide sequence between amino acid residues 130–230 of the G protein sequence of the human respiratory syncytial virus of sub-groups A and B, or of the bovine respiratory ... | 05/22/2007 |
| 7217418 | Multivalent dengue virus vaccine The present invention provides vaccine compositions of attenuated dengue virus. More specifically, the attenuated virus is produced by serial passage in PDK cells. The invention also provides methods for stimulating the immune system of an individual to induce prote... | 05/15/2007 |
| 7208161 | Production of attenuated parainfluenza virus vaccines from cloned nucleotide sequences Isolated polynucleotide molecules provide recombinant PIV genomes and antigenomes for production of recombinant PIV vaccines. The recombinant genome or antigenome can be expressed with a nucleoprotein (N), phosphoprotein (P), and a large (L) polymerase protein to pr... | 04/24/2007 |
| 7208162 | Combination therapy of respiratory diseases using antibodies and anti-inflammatory agents Therapeutically effective anti-viral compositions, useful especially against respiratory diseases caused or mediated by respiratory syncytial virus (RSV) are disclosed, wherein said compositions comprise at least one anti-RSV antibody, including high affinity antibo... | 04/24/2007 |
| 7208163 | Method for producing temperature-sensitive morbillivirus It was found that a mutation of an amino acid at a specific position in the P protein of a morbillivirus gives a temperature-sensitivity character to a virus. By introducing this mutation, a virus to which a temperature-sensitivity character has been introduced can ... | 04/24/2007 |
| 7205013 | Recombinant RSV virus expression systems and vaccines The present invention relates to genetically engineered recombinant respiratory syncytial viruses and viral vectors which contain deletions of various viral accessory gene(s) either singly or in combination. In accordance with the present invention, the recombinant ... | 04/17/2007 |
