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| Number | Title | Issue Date |
| 8137676 | Genetically engineered equine influenza virus and uses thereof The present invention relates, in general, to attenuated equine influenza viruses having an impaired ability to antagonize the cellular interferon (IFN) response, and the use of such attenuated viruses in vaccine and pharmaceutical formulations. In particular, the i... | 03/20/2012 |
| 8124101 | Genetically engineered swine influenza virus and uses thereof The present invention relates, in general, to attenuated swine influenza viruses having an impaired ability to antagonize the cellular interferon (IFN) response, and the use of such attenuated viruses in vaccine and pharmaceutical formulations. In particular, the in... | 02/28/2012 |
| 8114415 | Method for producing temperature sensitive influenza A viruses Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invent... | 02/14/2012 |
| 8088393 | Swine influenza hemagglutinin variants Polypeptides, polynucleotides, methods, compositions, and vaccines comprising influenza hemagglutinin and neuraminidase variants are provided. ... | 01/03/2012 |
| 8057803 | Attenuated negative strand viruses with altered interferon antagonist activity for use as vaccines and pharmaceuticals The present invention relates, in general, to attenuated negative-strand RNA viruses having an impaired ability to antagonize the cellular interferon (IFN) response, and the use of such attenuated viruses in vaccine and pharmaceutical formulations. The invention als... | 11/15/2011 |
| 8048430 | Influenza hemagglutinin and neuraminidase variants Polypeptides, polynucleotides, methods, compositions, and vaccines comprising influenza hemagglutinin and neuraminidase variants are provided. ... | 11/01/2011 |
| 8039002 | Influenza hemagglutinin and neuraminidase variants Polypeptides, polynucleotides, methods, compositions, and vaccines comprising (avian pandemic) influenza hemagglutinin and neuraminidase variants are provided. ... | 10/18/2011 |
| 7981429 | Influenza hemagglutinin and neuraminidase variants Polypeptides, polynucleotides, methods, compositions, and vaccines comprising (avian pandemic) influenza hemagglutinin and neuraminidase variants are provided. ... | 07/19/2011 |
| 7968101 | Recombinant influenza vectors with tandem transcription units The invention provides a composition useful to prepare influenza viruses, e.g., in the absence of helper virus, using vectors which include tandem transcription cassettes containing PolI and/or PolII promoters. ... | 06/28/2011 |
| 7959929 | Materials and methods for respiratory disease control in canines The subject invention pertains to isolated influenza virus that is capable of infecting canids and causing respiratory disease in the canid. The subject invention also pertains to compositions and methods for inducing an immune response against an influenza virus of... | 06/14/2011 |
| 7914797 | Influenza vaccine The present invention relates to influenza vaccines for human and veterinary use. In particular, the present invention provides a vaccine able to effect long term and cross-strain protection by including at least two influenza virus epitopes expressed as a chimeric ... | 03/29/2011 |
| 7871626 | Modified influenza virus for monitoring and improving vaccine efficiency The immunogenicity of the influenza virus hemagglutinin (HA) molecule may be increased by substitutions of amino acids in the HA sequence. The substitution of specific HA residues, such as asparagine at position 223 of H5 HA, increase the sensitivity of the hemagglu... | 01/18/2011 |
| 7758867 | Attenuated influenza virus and a live vaccine comprising the same The present invention relates to an isolated attenuated influenza virus strain and a live vaccine comprising the same. The isolated attenuated influenza virus strain is prepared by cold-adaptation of a mother strain which carries 6 internal genomes of A/PR/8/34(H1N1... | 07/20/2010 |
| 7744901 | Influenza hemagglutinin and neuraminidase variants Polypeptides, polynucleotides, methods, compositions, and vaccines comprising (avian pandemic) influenza hemagglutinin and neuraminidase variants are provided. ... | 06/29/2010 |
| 7604809 | Reinforcing systemic immune responses with The invention concerns the use of Lactobacillus casei in a composition for oral administration to enhance immunity specific to pathogenic micro-organisms. Said composition can in particular be a food or a food supplement. ... | 10/20/2009 |
| 7588768 | Attenuated negative strand viruses with altered interferon antagonist activity for use as vaccines and pharmaceuticals The present invention relates, in general, to attenuated negative-strand RNA viruses having an impaired ability to antagonize the cellular interferon (IFN) response, and the use of such attenuated viruses in vaccine and pharmaceutical formulations. The invention als... | 09/15/2009 |
| 7566458 | Influenza hemagglutinin and neuraminidase variants Polypeptides, polynucleotides, methods, compositions, and vaccines comprising influenza hemagglutinin and neuraminidase variants are provided. ... | 07/28/2009 |
| 7527800 | Influenza hemagglutinin and neuraminidase variants Polypeptides, polynucleotides, methods, compositions, and vaccines comprising (avian pandemic) influenza hemagglutinin and neuraminidase variants are provided. ... | 05/05/2009 |
| 7514086 | Peptide-based vaccine for influenza A human synthetic peptide-based influenza vaccine for intranasal administration comprises a mixture of flagella containing at least four epitopes of influenza virus reactive with human cells, each expressed individually in Salmonella flagellin, said influenza... | 04/07/2009 |
| 7510719 | Methods of producing influenza vaccine compositions Methods and compositions for the optimization and production of influenza viruses, e.g., ca influenza B strains, in eggs and host cells suitable as influenza vaccines are provided. ... | 03/31/2009 |
| 7504109 | Influenza hemagglutinin and neuraminidase variants Polypeptides, polynucleotides, methods, compositions, and vaccines comprising (avian pandemic) influenza hemagglutinin and neuraminidase variants are provided. ... | 03/17/2009 |
| 7494659 | Live attenuated influenza vaccine The invention relates to a simple and efficient process for isolating viruses from various sources and for producing live attenuated influenza vaccines in a serum-free Vero cell culture under conditions where alterations in the surface antigens of the virus due to a... | 02/24/2009 |
| 7459162 | Influenza hemagglutinin and neuraminidase variants Polypeptides, polynucleotides, methods, compositions, and vaccines comprising influenza hemagglutinin and neuraminidase variants are provided. ... | 12/02/2008 |
| 7420028 | Replikins and methods of identifying replikin-containing sequences The present invention provides methods for identifying a class of peptides referred to as replikins and methods of using replikins to stimulate the immune system of a subject. The method of identifying replikin peptides is based on identifying amino acid sequences c... | 09/02/2008 |
| 7399840 | Proteosome influenza vaccine Improved forms of vaccines which comprise proteosomes and protein antigens are described. Vaccines which contain influenza HA as the antigen are used for illustration as to demonstrate efficacy. Improvements in the preparation of the vaccines themselves and the prot... | 07/15/2008 |
| 7384642 | Canine influenza vaccines The present invention encompasses influenza vaccines, in particular canine influenza vaccines. The vaccine may be a recombinant poxvirus vaccine or an inactivated vaccine. The invention also encompasses recombinant poxvirus vectors encoding and expressing influenza ... | 06/10/2008 |
| 7384774 | Helper-free rescue of recombinant negative strand RNA virus The present invention relates methods of generating infectious negative-strand virus in host cells by an entirely vector-based system without the aid of a helper virus. In particular, the present invention relates methods of generating infectious recombinant negativ... | 06/10/2008 |
| 7374751 | QS-21 and IL-12 as an adjuvant combination Adjuvant compositions comprising an effective amount IL-12 and QS-21 are disclosed. Immunogenic, vaccine and pharmaceutical compositions comprising a mixture of antigen and an adjuvant composition comprising an effective amount of IL-12 and QS-21 are also disclosed.... | 05/20/2008 |
| 7368537 | Subunit vaccine against respiratory syncytial virus infection The present invention relates generally to methods of treating or preventing RSV infections, and more specifically, to compositions, and the use thereof, comprising one or more RSV G protein immunogen or fragment thereof capable of eliciting protective immunity with... | 05/06/2008 |
| 7354706 | Use of photopolymerization for amplification and detection of a molecular recognition event The invention provides methods to detect molecular recognition events. The invention also provides methods to detect the presence of or identify a target species based on its interaction with one or more probe species. The methods of the invention are based on ampli... | 04/08/2008 |
| 7344722 | Cold-adapted influenza virus The cold-adapted master strain A/Ann Arbor/6/60 7PI (H2N2) and progenitor wild type E2(3) viral strains have been deposited and their genomic sequences identified. Seven nucleotide differences were found between the sequences identified herein and the previously pub... | 03/18/2008 |
| 7341988 | Method of treating influenza with geranyl-geranyl acetone To provide a novel preventive and/or therapeutic agent against a virus, disclosed is a preventive and/or therapeutic agent against a viral infection containing geranyl-geranyl acetone as an active ingredient. Also, disclosed are inducers for increasing the activity ... | 03/11/2008 |
| 7339037 | Glycosylation-resistant cyanovirins and related conjugates, compositions, nucleic acids, vectors, host cells, methods of production and methods of using nonglycosylated cyanovirins The invention provides a method of inhibiting prophylactically or therapeutically an influenza viral infection in a host. The method comprises instilling into or onto a host a cell producing an antiviral protein, antiviral peptide, or antiviral conjugate comprising ... | 03/04/2008 |
| 7323183 | Vaccine compositions including chitosan for intranasal administration and use thereof There is provided vaccine compositions for intranasal administration, which compositions comprise one or more antigens and an effective adjuvant amount of a chitosan. ... | 01/29/2008 |
| 7316813 | Influenza vaccine composition An inactivated influenza virus preparation is described which comprises a haemagglutinin antigen stabilized in the absence of thiomersal, or at low levels of thiomersal, wherein the haemagglutinin is detectable by a SRD assay. The influenza virus preparation may com... | 01/08/2008 |
| 7314626 | Use of peptide vectors to improve the immune response to antigens The invention relates to conjugates of an antigen coupled to a linear derivative of a β-stranded antibiotic peptide, which are useful for immunogenic agents to enhance a CTL response. Two groups of preferred peptides are derived from the antibiotics protegrin and t... | 01/01/2008 |
| 7285289 | Nanoparticle vaccines The present invention relates to nanoparticle vaccines comprised of a carrier, particularly polymerized lipids, having multiple copies of an antigen or combinations of different antigens displayed on the carrier. Such antigen-displaying nanoparticles may also displa... | 10/23/2007 |
| 7262045 | Methods of producing influenza vaccine compositions Methods and compositions for the optimization of production of influenza viruses suitable as influenza vaccines are provided. ... | 08/28/2007 |
| 7255859 | Monoclonal antibodies against the epitope YPYDVPDYA, a process for their production and their use The invention concerns monoclonal antibodies against the epitope YPYDVPDYA (SEQ ID NO: 1) which is derived from the haemagglutinin of the human influenza virus and are suitable for the detection and isolation of native haemagglutinin of the human influenza virus, of... | 08/14/2007 |
| 7192595 | Peptide-based vaccine for influenza A human synthetic peptide-based influenza vaccine for intranasal administration comprises a mixture of flagella containing at least four epitopes of influenza virus reactive with human cells, each expressed individually in Salmonella flagellin, said influenza... | 03/20/2007 |
