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"What, sir, would you make a ship sail against the wind and currents by lighting a bonfire under her deck? I pray you, excuse me, I have not the time to listen to such nonsense."
Napoleon Bonaparte ; When told of the Robert Fulton steamboat
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| Number | Title | Issue Date |
| 8133493 | Regulated attenuation of live vaccines to enhance cross-protective immunogenicity A live attenuated derivative of a pathogenic bacterium intended for use as a vaccine. ... | 03/13/2012 |
| 8114414 | Compositions and methods for treatment of cervical cancer The present invention provides methods of treating, protecting against, and inducing an immune response against cervical cancer, comprising the step of administering to a subject a recombinant Listeria strain, comprising a fusion peptide that comprises an LLO... | 02/14/2012 |
| 8048428 | DNA composition encoding an immunogenic VEGF receptor peptide and methods of use thereof A DNA composition effective for inhibiting endothelial cell proliferation comprises a DNA construct operably encoding a vascular endothelial growth factor (VEGF) receptor polypeptide, which can be a full length VEGF receptor protein or an immunogenic fragment thereo... | 11/01/2011 |
| 7988977 | Modified live vaccine for aquatic animals Safe and effective live vaccines against Aeromonas hydrophila of fish were created through the induction of rifampicin resistance in native Aeromonas hydrophila isolates; these including rifampicin-resistant mutants NRRL-B-50040 and NRRL-B-50041. Singl... | 08/02/2011 |
| 7972606 | T24 antigen for immunodiagnosis of cysticercosis The present disclosure relates to T24 nucleic acid sequences, amino acid sequences, and antibodies. Methods for detecting and diagnosing Taenia solium infection in a subject using the T24 sequences and specific binding agents are also disclosed. The T24 seque... | 07/05/2011 |
| 7959926 | Methods for expression and purification of recombinant human growth hormone mutants The present invention relates generally to the production, purification, and isolation of human growth hormone (hGH). More particularly, the invention relates to the production, purification, and isolation of substantially purified hGH comprising non-naturally encod... | 06/14/2011 |
| 7887812 | Live attenuated vaccines Targeted disruption of the centrin gene leads to attenuation of growth in Leishmania. Preferred embodiments of the invention provide attenuated strains of Leishmania useful for the preparation of immunogenic preparations including vaccines against a di... | 02/15/2011 |
| 7858097 | Antibiotic resistance free strains and methods for constructing and using same The present invention provides Listeria strains that express a heterologous antigen and a metabolic enzyme, and methods of generating same. ... | 12/28/2010 |
| 7820180 | -based and LLO-based vaccines This invention provides methods of treating and vaccinating against an antigen-expressing tumor and inducing an immune response against a sub-dominant epitope of antigen, comprising a fusion of an LLO fragment to the antigen or a recombinant Listeria strain e... | 10/26/2010 |
| 7794728 | Attenuated and methods for using the same Attenuated Listeria bacteria are provided. The subject bacteria are characterized by having a mutation in a gene chosen from the IpIA gene and the hly gene. The subject bacteria find use in a variety of applications, where representative applications of inter... | 09/14/2010 |
| 7794730 | Polyvalent attenuated live vaccine for preventing and curing vibriosis of cultivated fish A novel polyvalent attenuated live bacterial vaccine for preventing and curing vibriosis of cultivated fish is provided. The vaccine mainly comprises attenuated deletion strain of Vibrio anguillarum without marker gene, which has significant low toxicity, but... | 09/14/2010 |
| 7794729 | Methods and compositions for immunotherapy of cancer The present invention includes compositions, methods and kits for inducing an immune response to a tumor and for treating cancer with a Listeria vaccine strain expressing an antigen fused to a truncated LLO protein. ... | 09/14/2010 |
| 7740864 | Vaccines for diseases of fish Fish are immunized by a mass vaccination method, such as by immersion in water containing an attenuated strain of a pathogenic bacterium that does not effectively cause disease in fish when the non-attenuated pathogenic bacterium is exposed to the fish by immersion.... | 06/22/2010 |
| 7722882 | Live attenuated vaccine against porcine pleuropneumonia The present invention provides a method for obtaining an immunogenic, non-haemolytic strain of Actinobacillus pleuropneumoniae which is modified, at least in a segment of the apxIA gene and optionally in a segment of the apxIIA gene that encodes a transmembra... | 05/25/2010 |
| 7662396 | Compositions and methods for enhancing the immunogenicity of antigens The present invention provides recombinant polypeptides comprising an N-terminal fragment of an ActA protein or LLO protein fused to an antigen or a fragment thereof, nucleotides encoding same, recombinant vectors comprising same, and immunogenic and therapeutic met... | 02/16/2010 |
| 7655241 | Methods and compositions for vaccination against or involving enterobacteriaceae bacteria The present invention concerns the use of methods and compositions to prophylactically or therapeutically vaccinate a subject against a pathogen or disease. Embodiments of the invention include the production of an attenuated bacterium from the family Enterobacteria... | 02/02/2010 |
| 7638133 | Recombinant BCG vaccine A recombinant BCG vaccine being transformed with an expression vector that has a polynucleotide encoding a foreign antigenic protein, wherein the polynucleotide is a modified one in which the third position of each codon is substituted with G or C without a change o... | 12/29/2009 |
| 7635486 | Recombinant lipidated PsaA protein, methods of preparation and use The present invention relates to recombinant lipidated PsaA proteins and recombinant constructs from which such lipidated PsaA proteins may be expressed. The invention relates further to lipidated PsaA proteins in which lipidation is effected by the use of a heterol... | 12/22/2009 |
| 7618640 | Method and composition for reducing disease and enhancing performance Bacillus strains that inhibit pathogenic swine E. coli and/or improve performance are provided. Inhibition of pathogenic swine E. coli decreases E. coli disease. At least one strain enhanced swine performance by improving average daily ga... | 11/17/2009 |
| 7592013 | Delivery of trefoil peptides The present invention relates to a microorganism, preferably a bacterial strain, preferably a non-pathogenic strain, preferably a non-invasive strain, preferably a food grade strain, preferably a gram-positive bacterial strain, delivering a trefoil peptide in vivo. ... | 09/22/2009 |
| 7524507 | Recombinant microorganisms A method of enhancing expression of a desired protein at mucosal effector sites, the method including placing the protein to be expressed under the control of a promoter having SEQ ID NO: 2, SEQ ID NO: 3 or SEQ ID NO: 4, or a fragment or variant of any of these that... | 04/28/2009 |
| 7459161 | Methods for eliciting an immune response using cytolysin and hemolysin fusion proteins The disclosure below provides a protein export system for efficiently producing recombinant protein from a host cell. In a preferred embodiment, the protein export system utilizes protein export machinery endogenous to the host bacterium into which the protein expor... | 12/02/2008 |
| 7438918 | Lipid A deficient mutants of The invention provides lipid A deficient mutant Neisseria meningitidis cells, pharmaceutical compositions incorporating such cells, and methods of using such cells. ... | 10/21/2008 |
| 7399476 | Nucleic acid free ghost preparations The invention relates to preparations of bacterial ghosts which are substantially free of living bacterial cells and/or nucleic acids and their use in pharmaceutical preparations. ... | 07/15/2008 |
| 7364729 | Method of inducing a CTL response Disclosed herein are methods for inducing an immunological CTL response to an antigen by sustained, regular delivery of the antigen to a mammal so that the antigen reaches the lymphatic system. Antigen is delivered at a level sufficient to induce an immunologic CTL ... | 04/29/2008 |
| 7364745 | Development of a live, attenuated, recombinant vaccine for Brucellosis A recombinant, attenuated strain of Brucella suis or Brucella melitensis with a deficiency in carboxyl-terminal protease activity or tail-specific protease activity can be used as a vaccine for the prevention or treatment of Brucellosis. Prior exposure... | 04/29/2008 |
| 7357935 | Avian vaccine for protection against colibacillosis A genetic deletion mutant live E. coli vaccine suitable for mass application to poultry, including chickens, is provided. Also provided is a safe and effective method to protect poultry against the ravages of Escherichia coli bacillosis infection and d... | 04/15/2008 |
| 7344703 | Mycobacterial sulfation pathway proteins and methods of use thereof Novel mycobacterial sulfation pathway proteins and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptide and nucleic acid compositions find use in a variety of applications, including research, di... | 03/18/2008 |
| 7334538 | Topical medicants for aquatic animals A topical medicant for fishes, amphibians, reptiles, and aquatic macroinvertebrates applied in a site-specific manner for the localized treatment of skin wounds, lesions and diseases. The medicant comprises a hydrophilic carrier with an antimicrobial therapeutant fo... | 02/26/2008 |
| 7332172 | Transformed bacteria producing CS6 antigens as vaccines Disclosed herein are antigens that stimulate protective antibodies against enterotoxigenic Escherichia coli. Also disclosed herein are proteins encoded by cssA and cssB genes as well as constructs containing the genes and methods of using thereof. ... | 02/19/2008 |
| 7332174 | Mutant forms of cholera holotoxin as an adjuvant Mutant cholera holotoxins having single or double amino acid substitutions or insertions have reduced toxicity compared to the wild-type cholera holotoxin. The mutant cholera holotoxins are useful as adjuvants in antigenic compositions to enhance the immune response... | 02/19/2008 |
| 7329513 | High level constitutive production of anthrax protective antigen The present invention relates to a process for preparing anthrax protective antigen protein from E. coli using fed batch culture. This process creates a constitutively expressing system for rapid, efficient, cost-effective and high-level production of anthrax... | 02/12/2008 |
| 7326542 | Compositions and methods for regulating bacterial pathogenesis The production of a purified extracellular bacterial signal called autoinducer-2 is regulated by changes in environmental conditions associated with a shift from a free-living existence to a colonizing or pathogenic existence in a host organism. Autoinducer-2 stimul... | 02/05/2008 |
| 7320794 | Transporter protein A novel protein which has an activity to transport hydantoin compounds is described, as well as a recombinant expressing this transporter protein. From Microbacterium liquefaciens strain AJ3912, a novel gene was discovered to encode a protein which is able to... | 01/22/2008 |
| 7304015 | Compositions for separating molecules The present invention provides compositions for the separation of metals or biomolecules such as polypeptides, nucleic acids, or endotoxins using modified solid supports. ... | 12/04/2007 |
| 7302913 | Vaccine against salmonid rickettsial septicaemia based on arthrobacter cells A vaccine based on live Arthrobacter cells is useful in preventing piscirickettsiosis in fish. ... | 12/04/2007 |
| 7304016 | Compositions for separating molecules The present invention provides compositions for the separation of metals or biomolecules such as polypeptides, nucleic acids, or endotoxins using modified solid supports. ... | 12/04/2007 |
| 7300660 | Abundant extracellular products and methods for their production and use Vaccines based on one or more combinations of majorly abundant extracellular products of pathogens and methods for their use and production are presented. The most prevalent or majorly abundant extracellular products of a target pathogen are selected irrespective of... | 11/27/2007 |
| 7264815 | Process for producing a recombinant protein in a mycobacterium host plasmid pJAM2 This invention relates to a novel mycobacterial protein named DES, which appears to share significant amino acid sequence homology with soluble stearoyl-ACP desaturases. The results of allelic exchange experiments, indicate that the des gene may be essential to the ... | 09/04/2007 |
| 7261899 | Method of producing thy A-strains of , such strains and their use A method of producing a thy A−strain of vibrio cholerae comprising the step of site-directed mutagenesis in the V. cholerae chromosome at the locus of the thy A gene SEQ ID NO: 1 of FIG. 1, is described. Particularly, a Δ thy A str... | 08/28/2007 |
