Famous Patents
The first match was accidentally discovered in 1826 when John Walker scraped a stick with chemicals on the end against a stone floor.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 6099847 | Chimeric Gag pseudovirions The present invention provides, inter alia, recombinant chimeric nucleic acids encoding a Gag-fs-fusion partner fusion protein; a pseudovirion comprising a retroviral Gag protein and a fusion partner, wherein the fusion partner is present in a Gag-fs-fusi... | 08/08/2000 |
| 6096869 | Treatment of papillomavirus-associated lesions Interleukin-12 (IL-12) or a functional analogue thereof, or a polynucleotide encoding IL-12 or encoding a functional analogue thereof, is used as a therapeutic material or adjuvant in treating papillomavirus-associated lesions e.g. warts due to HPV 6 and/... | 08/01/2000 |
| 6086890 | Bovine adenovirus expression vector system The present invention relates novel live bovine adenovirus (BAV) expression vector systems in which part or all of one or both of the early region 1 (E1) and early region 3 (E3) genes are deleted and replaced by a foreign gene or fragment thereof and nove... | 07/11/2000 |
| 6074649 | Recombinant composition containing feline herpes virus type 1, particularly for treating feline infectious peritonitis The recombinant live vaccine comprises, as vector, a feline herpesvirus comprising and expressing at least one nucleotide sequence encoding a polypeptide, this sequence being inserted into the ORF5 and/or ORF2 sites. Polyvalent vaccine formula and feline ... | 06/13/2000 |
| 6066503 | Recombinant DNA molecules encoding aminopeptidase enzymes and their use in the preparation of vaccines against helminth infections The present invention provides nucleic acid molecules containing nucleotide sequences encoding helminth aminopeptidase enzymes, and antigenic fragments and functionally-equivalent variants thereof, their use in the preparation of vaccines for use against ... | 05/23/2000 |
| 6066324 | Carboxyl terminal of papilloma virus L1 region is not required for formation of virus-like particles Recombinant papilloma virus-like particles result from the expression of viral structural protein L1 and/or L2 in which one or several sections of the L1 and/or L2 protein are deleted. The ability to form virus-like particles is at least the same as, pref... | 05/23/2000 |
| 6063385 | DNA vaccine for parvovirus Disclosed herein are methods for vaccinating mammals against parvovirus. In one form, a recombinant, replication incompetent vector containing DNA coding for canine parvoviral capsid protein is administered to a dog while the pup's maternal antibodies are... | 05/16/2000 |
| 6063384 | Encapsidated recombinant viral nucleic acid and methods of making and using same The present invention pertains to a method of encapsidating a recombinant poliovirus nucleic acid to obtain a yield of encapsidated viruses which substantially comprises encapsidated recombinant poliovirus nucleic acid. The method of encapsidating a recom... | 05/16/2000 |
| 6060064 | Chimeric virus-like particle antigen presentation and delivery system Chimeric virus-like particles produced by a non-natural particle-forming protein. The non-natural particle forming protein comprises a self-assembling particle-forming first amino acid sequence substantially homologous with a yeast retrotransposon Ty p1 p... | 05/09/2000 |
| 6060308 | RNA respiratory syncytial virus vaccines A vector comprising a first DNA sequence which is complementary to at least part of an alphavirus RNA genome and having the complement of complete alphavirus DNA genome replication regions, a second DNA sequence encoding a paramyxovirus protein, particula... | 05/09/2000 |
| 6051238 | Stabilizers for lyophilized mumps vaccines Vaccine stabilizers, vaccine formulations and lyophilized vaccines with enhanced thermostability are disclosed. The vaccine formulations comprise an increased amount of a 6-carbon polyhydric alcohol (such as sorbitol), an increase amount of a disaccharide... | 04/18/2000 |
| 6051428 | Rapid production of autologous tumor vaccines An autologous vaccine to tumor cells is produced by transducing the tumor cells with a herpes simplex virus amplicon containing the gene for an immunomodulatory protein to provide transient expression of the immunomodulatory protein by the cells. The tumo... | 04/18/2000 |
| 6048536 | Vaccine compositions The invention relates to a vaccine composition adapted for mucosal administration, and in particular for intranasal administration, the composition comprising an influenza virus antigen or antigens, such as haemagglutinin and neuraminidase influenza virus... | 04/11/2000 |
| 6048535 | Multivalent in ovo avian vaccine A multivalent poultry vaccine is provided having two or more live biological agents or microbial components. Each live biological agent or microbial component is effective in preventing or treating an avian disease, and the multivalent vaccine is safe and... | 04/11/2000 |
| 6045803 | Live recombinant avian vaccine using an avian herpesvirus as vector The live recombinant avian vaccine comprises, as vector, an avian herpesvirus comprising at least one nucleotide sequence coding for and expressing an antigenic polypeptide of an avian pathogenic agent, inserted into the region lying between the ATG of OR... | 04/04/2000 |
| 6045802 | Enhanced immune response to an antigen by a composition of a recombinant virus expressing the antigen with a recombinant virus expressing an immunostimulatory molecule The present invention is a composition of recombinant virus which has incorporated into its genome or portion thereof a gene encoding an antigen to a disease causing agent and a recombinant virus which has incorporated into its genome or portion thereof a... | 04/04/2000 |
| 6045798 | Membrane-associated immunogens of mycobacteria Nucleic acid encoding four novel immunodeterminant protein antigens of M. bovis BCG, which is a vaccine strain for tuberculosis, have been isolated. These genes were isolated as immunoreactive recombinant clones from a genomic library of M. bovis BCG DNA,... | 04/04/2000 |
| 6042832 | Polypeptides fused with alfalfa mosaic virus or ilarvirus capsid proteins A fusion capsid protein comprising a plant virus capsid protein fused to an antigenic polypeptide is used as a molecule for presentation of that polypeptide to the immune system of an animal such as a human. The plant virus capsid protein is that of an al... | 03/28/2000 |
| 6039959 | Treatment and diagnosis of infections due to helicobacter pylori The present invention provides agents for the detection of urease from H. pylori, and agents and epitopes for use in the treatment or diagnosis of infection due to H. pylori, as well as diagnostic tests and kits therefor and the use of the agents and epit... | 03/21/2000 |
| 6033668 | Chimeric protein which confers protection against parainfluenza virus and respiratory syncytial virus Multimeric hybrid genes encoding the corresponding chimeric protein comprise a gene sequence coding for an antigenic region of a protein from a first pathogen linked to a gene sequence coding for an antigenic region of a protein from a second pathogen. Th... | 03/07/2000 |
| 6033670 | Recombinant live avian vaccine, using as vector the avian infectious laryngotracheitis virus The recombinant live avian vaccine comprises as vector an ILTV virus comprising and expressing at least one heterologous nucleotide sequence, this nucleotide sequence being inserted into the insertion locus formed by the intergenic region located between ... | 03/07/2000 |
| 6025163 | DNA coding for a peptide of a papilloma virus main capside protein and use thereof This invention relates to a DNA encoding a peptide of a papilloma virus major capsid protein. Furthermore, this invention deals with a papilloma virus genome containing such a DNA. In addition, this invention concerns proteins encoded by the papilloma vir... | 02/15/2000 |
| 6025181 | Equine herpesvirus-4TK mutant An Equine herpesvirus-4 (EHV-4) mutant which does not produce a functional thymidine kinase due to a deletion and/or insertion in the gene encoding thymidine kinase, the deletion and/or insertion made at a position within the thymidine kinase gene such as... | 02/15/2000 |
| 6025125 | Methods for the detection of HIV-specific immune responses employing non-infectious, non-replicating, IIV retrovirus-like particles containing heterologous antigenic markers The present invention is concerned with the ability to differentiate between infection by HIV and immunization with an immunogenic preparation. Accordingly, the present invention provides a non-infectious, non-replicating, HIV retrovirus-like particle con... | 02/15/2000 |
| 6019978 | Replication-defective adenovirus human type 5 recombinant as a vaccine carrier A replication defective recombinant adenovirus is provided which contains a complete deletion of its E1 gene and at least a partial deletion of its E3 gene, said virus containing in the site of the E1 deletion a sequence comprising a non-adenovirus promot... | 02/01/2000 |
| 6017539 | Chimeric protein which confers protection against parainfluenza virus and respiratory syncytial virus Multimeric hybrid genes encoding the corresponding chimeric protein comprise a gene sequence coding for an antigenic region of a protein from a first pathogen linked to a gene sequence coding for an antigenic region of a protein from a second pathogen. Th... | 01/25/2000 |
| 6017542 | Nucleotide and amino acid sequences of canine herpesvirus GD and uses therefor Disclosed and claimed are nucleotides for genes encoding the canine herpesvirus (CHV) gB, gC and gD homologues. These genes encode polypeptides of 879, 459 and 345 amino acids, respectively, which are also disclosed and claimed. The genes are useful as DN... | 01/25/2000 |
| 6017759 | Chimeric infectious bursal disease virus cDNA clones, expression products and vaccines based thereon Chimeric cDNA for the expression of immunogenic polypeptides include the genetic epitopic determinants for a base infectious bursal disease virus strain and at least one other infectious bursal disease virus strain. The genetic epitopic determinants encod... | 01/25/2000 |
| 6015694 | Method for stimulating an immune response utilizing recombinant alphavirus particles The present invention provides compositions and methods for utilizing recombinant alphavirus vectors. Also disclosed are compositions and methods for making and utilizing eukaryotic layered vector initiation systems.... | 01/18/2000 |
| 6015565 | Glycoprotein B of the RFHV/KSHV subfamily of herpes viruses This invention relates to polynucleotides encoding Glycoprotein B from the RFHV/KSHV subfamily of gamma herpes viruses, three members of which are characterized in detail. DNA extracts were obtained from Macaque nemestrina and Macaque mulatta monkeys affe... | 01/18/2000 |
| 6013265 | Vaccine composition for herpes simplex virus and methods of using The present invention discloses a new vaccine composition for HSV-1 and HSV-2 comprising a whole live HSV-2 virus having the oncogene deleted. Methods of using the vaccine composition are also included.... | 01/11/2000 |
| 6013261 | Recombinant Marek's disease virus (MDV) and vaccine A recombinant herpes virus is provided which efficiently expresses an exogenous protein of interest in an inoculated animal host to thereby endow the host with excellent immunization. A recombinant herpes virus which incorporates an exogenous gene express... | 01/11/2000 |
| 6013258 | Immunogenic peptides from the HPV E7 protein The invention provides immunogenic peptides from the HPV type 16 E7 protein that comprise overlapping class I restricted T cell epitopes. Also disclosed are methods of administering DNA molecules encoding these peptides to a host mammal.... | 01/11/2000 |
| 6013266 | Live attenuated bacteria of the species Actinobacillus pleuropneumoniae The present invention relates to live attenuated bacteria of the genus Actinobacillus pleuropneumoniae that have a mutation in an apxIV gene such that no functional ApxIV toxin can be produced. The invention also relates to methods for the production of s... | 01/11/2000 |
| 6013506 | Feline leukemia virus vaccines Disclosed are recombinant baculovirus expressing the gag, gp70, and gp85 genes of feline leukemia virus. Also disclosed are vaccines based on protein expressed from these recombinants. Also disclosed is a combined mucosal/parenteral inoculation method.... | 01/11/2000 |
| 6010703 | Recombinant poxvirus vaccine against feline rhinotracheitis A recombinant poxvirus vaccine against feline herpesvirus (FHV-1) is described. The recombinant poxviruses include synthetic genes encoding either a gB or gD precursor polypeptide or mixtures of the two recombinant poxviruses. The vaccine is used to provi... | 01/04/2000 |
| 6004557 | Variants of human papillomavirus antigens Variants of human papilloma virus (HPV) E6 and E7 able to elicit a humoral or cellular immune response against HPV in a host animal but not being cell-transforming in the host animal are disclosed, and are useful in treatment or prevention of diseases or ... | 12/21/1999 |
| 6001987 | Isolated nucleotide sequences associated with Multiple sclerosis Viral material, in the isolated or purified state, in which the genome comprises a nucleotide sequence chosen from the group including sequences SEQ ID NO:46, SEQ ID NO:51, SEQ ID NO:52, SEQ ID NO:53 and SEQ ID NO:56, their complementary sequences and the... | 12/14/1999 |
| 6001591 | Recombinant bovine adenoviruses The present invention provides recombinant bovine adenovirus (BAV) vectors and expression systems for introduction and expression of non-BAV sequences in mammalian cells. Methods for the preparation and use of these vectors and expression systems are also... | 12/14/1999 |
| 6001369 | Recombinant fowlpox viruses and uses thereof This invention provides a recombinant fowlpox virus comprising a foreign DNA sequence inserted into the fowlpox virus genomic DNA, wherein the foreign DNA sequence is inserted within a 4.2 kB EcoRI fragment of the fowlpox virus genomic DNA and is capable ... | 12/14/1999 |
