Celebrity Inventors
Glam girl Heddy Lamar may have used her good looks to good effect on the silver screen, but she put her smarts to better use as an inventor. During World War II, she co-patented a frequency-switching system for torpedo guidance that was considered years ahead of its time.
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| Number | Title | Issue Date |
| 8168195 | Vaccines against O157 infection This invention relates to conjugates of the O-specific polysaccharide of E. coli O157 with a carrier, and compositions thereof, and to methods of using of using of these conjugates and/or compositions thereof for eliciting an immunogenic response in mammals, ... | 05/01/2012 |
| 8012488 | Polyoxyalkylene derivative A novel polyoxyalkylene derivative represented by the following formula (1), wherein each symbol is as defined in the specification, which has a functional group capable of reacting with various physiologically active substances according to the object is provided. | 09/06/2011 |
| 7951379 | Hollow nanoparticle of NBsAg large protein for drug delivery The invention provides a therapeutic drug that uses hollow protein nanoparticles displaying an antibody against a specific cell or specific tissue. The effectiveness of the drug has been proved by animal testing. The invention also provides a therapeutic method usin... | 05/31/2011 |
| 7943141 | Activated polyoxazolines and compositions comprising the same The present disclosure provides terminally activated monofunctional POZ derivatives having a range of functional active groups allowing conjugation of the monofunctional POZ derivatives to a variety of target molecules under a wide range of reaction conditions to pr... | 05/17/2011 |
| 7887811 | Method for preparing a stable immunogenic product comprising antigenic heterocomplexes of TNFα and a carrier protein The present invention concerns a novel method for preparing a stable immunogenic product comprising antigenic heterocomplexes of TNFα and a carrier protein, the method steps of which are disclosed in the specification. ... | 02/15/2011 |
| 7807175 | Therapeutic vaccine The present invention is related to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis. In particular, the pr... | 10/05/2010 |
| 7550146 | Glycopeptide conjugates and uses thereof The present invention provides novel glycoconjugates such as glycopeptides, as well as convergent methods for the synthesis thereof. An exemplary preparative approach is exemplified by the synthesis of the mucin motif commonly found on epithelial tumor cell surfaces... | 06/23/2009 |
| 7547441 | PAI-2 conjugates for the treatment and imaging of cancer A method is described for detecting, visualizing, or treating cells, particularly cancerous cells, that express a uPA/uPAR complex. The method employs a PAI-2 conjugate molecule that comprises PAI-2 or a functional derivative, homologue, analogue, chemical equivalen... | 06/16/2009 |
| 7442376 | Glycoprotein hormone compositions containing two β subunits Forms of differentially acting glycoprotein hormones are disclosed. These compositions are of the formula β1-(linker1)m-α-(linker2)n-β2; (1) β1-(linker1 | 10/28/2008 |
| 7413738 | Releasable polymeric conjugates based on biodegradable linkers Activated polymeric bicine derivatives such as, as well as conjugates made therewith are disclosed. Methods of making and using the bicine derivatives are also disclosed. ... | 08/19/2008 |
| 7408044 | Carrier protein having an adjuvant effect The invention relates to an adjuvant product which is intended to improve the activity of a molecule when administered to a host, characterized in that it comprises at least one part of the P40 protein of Klebsiella pneumoniae or a protein having at least 80% homolo... | 08/05/2008 |
| 7405266 | Sterically hindered poly(ethylene glycol) alkanoic acids and derivatives thereof The invention provides a sterically hindered polymer that comprises a water-soluble and non-peptidic polymer backbone having at least one terminus covalently bonded to an alkanoic acid or alkanoic acid derivative, wherein the carbon adjacent to the carbonyl group of... | 07/29/2008 |
| 7402314 | In vivo activation of tumor-specific cytotoxic T cells The present invention relates to methods and compositions of activating cytotoxic T lymphocytes (CTLs) in vivo with specificity for particular antigenic peptides, and to methods and compositions of using activated CTLs in vivo for the treatment of a variety of disea... | 07/22/2008 |
| 7396531 | Preventive and therapeutic use of polypeptides from African Swine virus as vaccines The present invention relates to the use of selected polypeptides from African Swine virus for the prevention and therapy of African Swine infections as well as other infections, including immune deficiencies in mammals and humans. ... | 07/08/2008 |
| 7348453 | Labile linkage for compound delivery to a cell Described are ortho carboxy phenol derived acetals and compositions containing ortho carboxy phenol derived acetals which are useful for delivering biologically active compounds to cells. The acetals can be used to reversibly link up to three different molecules and... | 03/25/2008 |
| 7335733 | Tissue cement proteins from The present invention relates to tissue cement proteins produced by certain species of blood-feeding ectoparasites. These proteins and compositions comprising these proteins are particularly useful for the temporary or permanent bonding of animal tissues to each oth... | 02/26/2008 |
| 7329500 | () polypeptides and corresponding DNA fragments The present invention relates to polypeptides of Moraxella (Branhamela) catarrhalis which may be used for prophy-laxis, diagnostic and/or therapy purposes. ... | 02/12/2008 |
| 7320793 | Molecular antigen array The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array. The invention also provides a process for produc... | 01/22/2008 |
| 7311892 | Multidrug multiligand conjugates for targeted drug delivery Described is a multi drug multiligand conjugate for targeted drug delivery. The MDML conjugate contains a plurality of tripartite molecules linked to a central scaffold moiety, with each tripartite molecule comprising a targeting molecule, a therapeutic agent and a ... | 12/25/2007 |
| 7309491 | Heat shock protein-based vaccines and immunotherapies Hybrid antigens comprising at least one antigenic domain, at least one heat shock protein binding domain, and at least one improved peptide linker there between are described which are useful for the induction of an immune response to the antigenic domain when admin... | 12/18/2007 |
| 7306782 | Method for the production of conjugates and uses thereof for the prevention and treatment of allergic reactions and autoimmune diseases The present invention relates to a method for the preparation of a conjugate comprising a first and a second polypeptide, said method comprising the steps of (a) incubating said first polypeptide in the presence of a heterobifunctional crosslinker comprising an N-hy... | 12/11/2007 |
| 7291713 | Branched polyalkylene glycols The present invention provides a branched polyalkylene glycol wherein three or more single-chain polyalkylene glycols and a group having reactivity with an amino acid side chain, the N-terminal amino group or the C-terminal carboxyl group in a polypeptide or a group... | 11/06/2007 |
| 7291343 | antigens and vaccines A majority of E. faecalis and E. faecium clinical isolates fall into two groups and three groups, respectively. Distinct antigens are associate with each of the five groups. The Enterococcus antigens are readily obtained from strains of E. fa... | 11/06/2007 |
| 7279165 | Amyloid β1-6 antigen arrays The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular an Aβ1-6 peptide-VLP-composit... | 10/09/2007 |
| 7273722 | Neurotoxins with enhanced target specificity Modified neurotoxins that contain protease cleavage sites susceptible uniquely to proteases present in certain tissues are described. The toxins can be selectively activated by proteases in muscle or selectively inactivated by proteases in blood. ... | 09/25/2007 |
| 7264810 | Molecular antigen array The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array. The invention also provides a process for produc... | 09/04/2007 |
| 7259146 | Neuroprotective peptides Methods of treating diseases of the nervous system by administration of compositions having the neurological therapeutic activity of human erythropoietin are disclosed. These compositions include therapeutic agents such as peptides, peptide dimers, polypeptides, and... | 08/21/2007 |
| 7252827 | Conserved motif of hepatitis C virus E2/NS1 region Fusion proteins comprising an immunogenic polypeptide are disclosed. The immunogenic polypeptide consists of the amino acid sequence motif Xaa-Thr-Xaa-Val-Thr-Gly-Gly-Xaa-Ala-Ala-Arg-Thr-Thr-Xaa-Gly-Xaa-Xaa-Ser-Leu-Phe-Xaa-Xaa-Gly-Xaa-Ser-Gln-Xaa-Ile-Gln-Leu-Ile (SE... | 08/07/2007 |
| 7232797 | Erythropoietin dosing regimen for treating anemia The present invention provides a new subcutaneous injection dosing regimen for erythropoietin to treat anemia. The new erythropoietin treatment regimen of the present invention results in improved hemoglobin levels with less frequent dosing. ... | 06/19/2007 |
| 7230068 | Polymer derivatives The invention provides water-soluble compounds that include a polymer and at least one terminal azide or acetylene moiety. Also provided are highly efficient methods for the selective modification of proteins with PEG derivatives, which involves the selective incorp... | 06/12/2007 |
| 7227010 | Recombinant light chains of botulinum neurotoxins and light chain fusion proteins for use in research and clinical therapy Botulinum neurotoxins, the most potent of all toxins, induce lethal neuromuscular paralysis by inhibiting exocytosis at the neuromuscular junction. The light chains (LC) of these dichain neurotoxins are a new class of zinc-endopeptidases that specifically cleave the... | 06/05/2007 |
| 7226603 | HBV core antigen particles with multiple immunogenic components attached via peptide ligands This invention relates to hepatitis B virus (“HBV”) core antigen particles that are characterized by multiple immunogen specificities. More particularly, the invention relates to HBV core antigen particles comprising immunogens, epitopes, or other related struct... | 06/05/2007 |
| 7220842 | Immunoassays for buprenorphine and norbuprenorphine Methods, compositions and kits are disclosed directed at haptens, immunogens and immunoassays for buprenorphine (BUP) and nor buprenorphine (norBUP). The method comprises providing in combination in a medium (i) a sample suspected of containing buprenorphine (BUP) o... | 05/22/2007 |
| 7211445 | Conjugation of biomolecules using diels-alder cycloaddition A method is provided for covalently linking carbohydrates, proteins, nucleic acids, and other biomolecules under neutral conditions, using a Diels-Alder cycloaddition reaction. In an example, activated carbon-carbon double bonds were attached to free amino sites of ... | 05/01/2007 |
| 7208157 | Proteolysis targeting chimeric pharmaceutical The present invention is based on the discovery of a composition that provides targeted ubiquitination. Specifically the composition contains a ubiquitin pathway protein binding moiety which recognizes a ubiquitin pathway protein and a targeting moiety which recogni... | 04/24/2007 |
| 7205380 | Sterically hindered poly (ethylene glycol) alkanoic acids and derivatives thereof The invention provides a sterically hindered polymer that comprises a water-soluble and non-peptidic polymer backbone having at least one terminus covalently bonded to an alkanoic acid or alkanoic acid derivative, wherein the carbon adjacent to the carbonyl group of... | 04/17/2007 |
| 7201897 | Interferon conjugates Physiologically active PEG-IFNα conjugate having a formula as follows: ... | 04/10/2007 |
| 7198791 | Compositions and methods for the generation of protective immune responses against malaria The invention presents vaccine formulations comprising highly antigenic epitopes identified within the semi-conserved loop-I of domain III that are capable of eliciting parasite growth inhibitory antibodies. The cyclized or linear peptides can be applied by known ad... | 04/03/2007 |
| 7196059 | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith Pharmaceutical compositions that include insulin, an insulin drug-oligomer conjugate, a fatty acid component, and a bile salt component or a bile salt component without a fatty acid component are described. The insulin drug is covalently coupled to an oligomeric moi... | 03/27/2007 |
| 7193031 | Polyalkylene glycol acid additives A new class of activated polyalkylene glycol acids and their active ester reagents for conjugation to biopharmaceuticals such as polypeptides, sugars, proteins and therapeutically active small molecules to produce biologically active conjugates of these pharmaceutic... | 03/20/2007 |
