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| Number | Title | Issue Date |
| 8147841 | toxin, and process for the preparation of immunogenic composition The present invention relates to the field of bacterial toxic proteins, in particular toxins from Clostridium or other pathogenic organisms using, for example, promoter nucleic acids to control expression of polypeptides such as bacterial toxins. ... | 04/03/2012 |
| 8142789 | Method for selecting and producing vaccine components and vaccines based thereon The invention relates to the field of biology, more specifically to the field of immunology and microbiology. The invention further relates to the field of vaccines against microbial infections and especially bacterial vaccines, in particular to pneumococcal vaccine... | 03/27/2012 |
| 8137673 | Nucleic acids and proteins from groups A & B The invention provides proteins from group B streptococcus (Streptococcus agalactiae) and group A streptococcus (Streptococcus pyogenes), including amino acid sequences and the corresponding nucleotide sequences. Data are given to show th... | 03/20/2012 |
| 8128936 | Immunogenic compositions for The invention includes a GAS antigen, GAS 40, which is particularly suitable for use either alone or in combinations with additional GAS antigens, such as GAS 117, GAS 130, GAS 277, GAS 236, GAS 40, GAS 389, GAS 504, GAS 509, GAS 366, GAS 159, GAS 217, GAS 309, GAS ... | 03/06/2012 |
| 8124098 | Polypeptides from non-typeable Polypeptides comprising non-typeable Haemophilus influenzae (NTHi) amino acid sequences. Over 2500 specific NTHi proteins are disclosed. The invention also provides related polypeptides, nucleic acids, antibodies and methods. These can all be used in medicine... | 02/28/2012 |
| 8114411 | E-ict-VL33 strain, vaccines thereof, and a method for protecting fishes using said vaccines A novel Edwardsiella ictaluri E-ict-VL33 strain, a vaccine derived from the novel Edwardsiella ictaluri E-ict-VL33 strain, especially in immersion form and oral form, and a method for protecting fishes from the infection of Edwardsiella ictaluri... | 02/14/2012 |
| 8105607 | Porin B (PorB) as a therapeutic target for prevention and treatment of infection by The present invention features the use of PorB polypeptide as a therapeutic agent. In specific embodiment the invention features a chlamydial vaccine based on a PorB polypeptide, as well as methods for induction of a protective immune response against infecti... | 01/31/2012 |
| 8101187 | Secreted proteins Novel proteins from Streptococcus pneumoniae are described, together with nucleic acid sequences encoding them. Their use in vaccines and in screening methods is also described. ... | 01/24/2012 |
| 8052975 | Compounds and methods for treatment and diagnosis of chlamydial infection Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia antigen and DNA sequences encoding such polypeptides. Pharmaceu... | 11/08/2011 |
| 8025885 | Polypeptides and immunizing compositions containing gram positive polypeptides and methods of use The present invention provides isolated polypeptides isolatable from a Staphylococcus spp. Also provided by the present invention are compositions that include one or more of the polypeptides, and methods for making and methods for using the polypeptides.... | 09/27/2011 |
| 8007812 | Flagellin related polypeptides and uses thereof The use of flagellin and flagellin related polypeptides for the protection of mammals from the effects of apoptosis is described. ... | 08/30/2011 |
| 8007811 | Polypeptides and immunizing compositions containing gram positive polypeptides and methods of use The present invention provides isolated polypeptides isolatable from a Staphylococcus spp. Also provided by the present invention are compositions that include one or more of the polypeptides, and methods for making and methods for using the polypeptides.... | 08/30/2011 |
| 7972604 | Recombinant attenuated clostridium organisms and vaccine The present invention discloses attenuated Clostridium perfringens organisms that express a substantially nontoxic alpha-toxin. The expressed alpha-toxin is a deletion mutein that relative to the alpha-toxin of the mature alpha-toxin of Clostridium perfrin... | 07/05/2011 |
| 7968100 | Surface proteins from coagulase-negative staphylococci and that generate cross-reactive monoclonal and polyclonal antibodies Surface proteins are provided which generate polyclonal and monoclonal antibodies which are cross-reactive to both coagulase-positive staphylococcus bacteria, such as S. aureus and to coagulase-negative bacteria, such as S. epidermidis and S.... | 06/28/2011 |
| 7914794 | Group B streptococcus antigens Group B streptococcus (GBS) proteins and polynucleotides encoding them are disclosed. Said proteins are antigenic and therefore useful vaccine components for the prophylaxis or therapy of streptococcus infection in animals. Also disclosed are recombinant meth... | 03/29/2011 |
| 7914795 | outer membrane protein-106 polypeptide, gene sequence and uses thereof The invention discloses the Moraxella catarrhalis outer membrane protein-106 (OMP106) polypeptide, polypeptides derived therefrom (OMP106-derived polypeptides), nucleotide sequences encoding OMP106 polypeptides, and antibodies that specifically bind the OMP10... | 03/29/2011 |
| 7883706 | Methods for using polypeptides The present invention relates to antigens, more particularly antigens of Streptococcus pyogenes (also called group A streptococcus (GAS)) bacterial pathogen which are useful as vaccine component for prophylaxis, therapy and/or diagnostic. ... | 02/08/2011 |
| 7858096 | Mutant forms of meningococcal ADP-ribosylating toxin NMB1343 is an ADP-ribosylating toxin from Neisseria meningitidis. The invention provides a mutant toxin having a substitution at one or more of amino Glu-109, Glu-111 or Glu-120. The mutations(s) is/are preferably Glu to Asp. The protein of the invention pref... | 12/28/2010 |
| 7850974 | Bioinformatic method for identifying surface-anchored proteins from gram-positive bacteria and proteins obtained thereby A bioinformatic method for identifying and isolating proteins and peptides with MSCRAMM®-like characteristics from Gram positive bacteria, such as Enterococcus, Staphylococcus, Streptococcus and Bacillus bacteria, and proteins and peptides obtained th... | 12/14/2010 |
| 7846451 | protein, nucleic acid sequence and uses thereof The invention discloses the Moraxella catarrhalis outer membrane protein polypeptide and polypeptides derived therefrom (collectively “OMP21”), nucleotide sequences encoding said OMP21, and antibodies that specifically bind OMP21. Also disclosed are pharm... | 12/07/2010 |
| 7842297 | Immunisation against chlamydia trachomatis The present invention provides antigenic proteins of Chlamydia trachomatis. The proteins of the present invention are useful for eliciting an immune response to Chlamydia in a patient. For example, an effective amount of protein of the present inventio... | 11/30/2010 |
| 7842296 | Sequences from The present invention relates to a fish vaccine. More specifically the invention relates to a vaccine to protect salmon against infection by Piscirickettsia salmonis. The invention is based on or derived from the nucleic acid or amino acid sequence of antigen... | 11/30/2010 |
| 7838003 | BASB205 polypeptides and polynucleotides from The invention provides BASB205 polypeptides and polynucleotides encoding BASB205 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses. ... | 11/23/2010 |
| 7794726 | Mutants of lysine decarboxylase, vaccines for periodontitis, and methods of use The present invention is directed to mutants of lysine decarboxylase, nucleic acids encoding the mutants, and vaccines comprising the mutants for inhibiting and reducing the development of periodontal diseases, including gingivitis and chronic periodontitis. The vac... | 09/14/2010 |
| 7790172 | Methods for reducing nasopharyngeal colonization of non-typable with synthetic chimeric fimbrin peptides The present invention provides synthetic chimeric fimbrin peptides which induce an immunogenic response in animals to non-typable Haemophilus influenzae and that do not require tedious purification techniques. The synthetic chimeric fimbrin peptides reduce th... | 09/07/2010 |
| 7776338 | Adjuvant activities of mutants of LT-IIa and LT-IIb enterotoxin lacking binding to ganglioside The present invention describes the adjuvant activity of mutants of LT-IIa and LT-IIb enterotoxin which lack ganglioside binding activity. The adjuvant activity of the LT-IIb(T13I) mutant is comparable to that of the wild type LT-IIb. The adjuvant activity of LT-IIa... | 08/17/2010 |
| 7776336 | Compositions comprising antigens Disclosed are several Y. pestis antigens that are particularly suitable for immunisation purposes, particularly when used in combinations. ... | 08/17/2010 |
| 7776337 | Bacteriocins and novel bacterial strains Novel bacteriocins and/or the novel lactic acid-producing strains are used for at least reducing the levels of colonization by at least one target bacteria in animals, especially poultry. ... | 08/17/2010 |
| 7771728 | Method for identification, isolation and production of antigens to a specific pathogen Described is a method for identification, isolation and production of hyperimmune serum-reactive antigens from a specific pathogen, a tumor, an allergen or a tissue or host prone to autoimmunity, said antigens being suited for use in a vaccine for a given type of an... | 08/10/2010 |
| 7722880 | Immunoreactive 38-KDA ferric binding protein of and uses thereof The present invention is directed to the cloning, sequencing, expression, and characterization of an immunoreactive ferric binding protein (Fbp) (38-kDa) protein of Ehrlichia canis encoded by a polynucleotide therefor. In particular embodiments, the protein i... | 05/25/2010 |
| 7722879 | Babesia vaccines The invention relates to Babesia proteins of a 28kDa protein family and to immunogenic fragments of such proteins, to nucleic acids encoding such proteins or fragments, to cDNA fragments, recombinant DNA molecules, live recombinant carriers, or host cells com... | 05/25/2010 |
| 7691385 | Polypeptides encoded by polynucleotides that are useful for detecting resistance to streptogramin A or to streptogramin B and related compounds Polypeptides are provided, which are useful to produce specific monoclonal or polyclonal antibodies that serve as detection means in order to characterize any staphylococcal strain carrying genes encoding resistance to streptogramin A or to streptogramin B. | 04/06/2010 |
| 7662391 | outer membrane protein (OMP) and vaccine uses of the protein The present invention provides vaccines and methods for immunizing a host, including humans, against disease caused by infection by a strain of Chlamydia, specifically C. pneumoniae. The vaccine and method employ an OMP (outer membrane protein) of a st... | 02/16/2010 |
| 7662390 | subunit vaccine The present invention relates to nucleic acid sequences encoding novel Lawsonia intracelluaris proteins. It furthermore relates to DNA fragments, recombinant DNA molecules and live recombinant carriers comprising these sequences. Also it relates to host cells... | 02/16/2010 |
| 7658931 | Mutant forms of cholera holotoxin as an adjuvant Mutant cholera holotoxins having single or double amino acid substitutions or insertions have reduced toxicity compared to the wild-type cholera holotoxin. The mutant cholera holotoxins are useful as adjuvants in antigenic compositions to enhance the immune response... | 02/09/2010 |
| 7655240 | Vaccine composition comprising an immunoadjuvant compound consisting of a Rho GTPase family activator This invention is based on the experimental finding that activators of Rho GTPases, namely the cytotoxic necrotizing factor 1 (CNF1), and DNT bear immunostimulatory properties towards the systemic response to orally administered ovalbumine. This invention concerns a... | 02/02/2010 |
| 7638130 | Truncated recombinant major outer membrane protein antigen (R56) of strains Karp, Kato and Gilliam and its use in antibody based detection assays and vaccines A recombinant, refolded non-fusion polypeptide expressed from a truncated r56 gene of the causative agent of scrub typhus, Orientia tsutsugamushi for the Karp, Kato and Gilliam strains has been produced. The invention is useful for detecting prior exposure to... | 12/29/2009 |
| 7635480 | Peptides for preventing, diagnosing and treating animal and/or human leptospirosis The present invention provides a compound chosen from: a peptide represented by the sequence SEQ ID No: 1 below: SEQ ID No: 1 Lys-Ala-Lys-Pro-Val-Gln-Lys-Leu-Asp-Asp-Asp-Asp-Asp-Gly-Asp-Asp-Thr-Tyr-Lys-Glu-Glu-Arg-His-Asn-Lys ... | 12/22/2009 |
| 7635482 | antigens Streptococcus proteins and polynucleotides encoding them are disclosed. Said proteins are antigenic and therefore useful vaccine components for the prophylaxis or therapy of streptococcus infection in animals. Also disclosed are recombinant methods of ... | 12/22/2009 |
| 7635481 | Canine vaccine for protection against ehrlichiosis The present invention provides a safe and effective vaccine composition which comprises: an effective immunizing amount of an inactivated Ehrlichia canis bacterin; a pharmacologically acceptable carrier; and an immunogenically stimulating amount of an adjuvan... | 12/22/2009 |
