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| Number | Title | Issue Date |
| 7972603 | Stable immunogenic product comprising antigenic heterocomplexes The invention relates to a stable immunogenic product for the induction of antibodies against one or more antigenic proteins in a subject. The invention is characterised in that it comprises proteinaceous immunogenic heterocomplexes which are formed by associations ... | 07/05/2011 |
| 7534439 | Nucleic sequence and deduced protein sequence family with human endogenous retroviral motifs, and their uses The invention concerns a novel nucleic sequence and deduced protein sequence family with whole or partial human endogenous retroviral motifs. The invention also concerns the detection and/or the use of said nucleic sequences and said corresponding protein sequences ... | 05/19/2009 |
| 7482011 | Nucleic sequence and deduced protein sequence family with human endogenous retroviral motifs, and their uses The invention concerns a novel nucleic sequence and deduced protein sequence family with whole or partial human endogenous retroviral motifs. The invention also concerns the detection and/or the use of said nucleic sequences and said corresponding protein sequences ... | 01/27/2009 |
| 7431928 | Identification of new CD8 epitopes from HIV-1 proteins The invention relates to the identification and the selection of CTL epitopes able to induce a protection against an HIV infection. More particularly, the invention is concerned with peptides and nucleic acid sequence coding for these peptides derived from HIV-1 pro... | 10/07/2008 |
| 7410801 | Lambda phage display system and the process The present invention relates to a process of obtaining recombinant lambdoid bacteriophage with high density display of functional peptides and proteins on surface of said phage comprising of: constructing a donor plasmid having a nucleotide sequence that defines th... | 08/12/2008 |
| 7348136 | Method and device for detecting feline immunodeficiency virus A method and device for determining a feline immunodeficiency virus infection or vaccination in an animal. The method includes contacting a biological sample from a felid with various FIV polypeptides and determining the binding of antibodies in the sample to the po... | 03/25/2008 |
| 7335360 | Method and device for detecting feline immunodeficiency virus A method and device for determining a feline immunodeficiency virus infection or vaccination in an animal. The method includes contacting a biological sample from a felid with various FIV polypeptides and determining the binding of antibodies in the sample to the po... | 02/26/2008 |
| 7306804 | HIV-specific T-cell induction This invention discloses diagnostic, preventative, and treatment therapies of AIDS involving determining whether a subject exhibits an HLA-Cw7-restricted CTL response. Some methods are directed to the use of HLA-Cw7 as a genetic marker for long-term non-progression ... | 12/11/2007 |
| 7291338 | Method and device for detecting feline immunodeficiency virus FIV gag polypeptides and a method and device for determining a feline immunodeficiency virus infection in an animal. The method includes contacting a biological sample from a felid with the FIV polypeptides and determining the binding of antibodies in the sample to ... | 11/06/2007 |
| 7285278 | Method and device for detecting feline immunodeficiency virus A method and device for determining a feline immunodeficiency virus infection or vaccination in an animal. The method includes contacting a biological sample from a felid with various FIV polypeptides and determining the binding of antibodies in the sample to the po... | 10/23/2007 |
| 7285272 | Method and device for detecting feline immunodeficiency virus A method and device for determining a feline immunodeficiency virus infection or vaccination in an animal. The method includes contacting a biological sample from a felid with various FIV polypeptides and determining the binding of antibodies in the sample to the po... | 10/23/2007 |
| 7264802 | Proteins encoded by polynucleic acids of porcine reproductive and respiratory syndrome virus (PRRSV) The present invention provides a purified preparation containing, for example, at least one polypeptide selected from the group consisting of proteins encoded by one or more open reading frames (ORF's) of an Iowa strain of porcine reproductive and respiratory syndro... | 09/04/2007 |
| 7261891 | Antibodies to cytokines in the prevention and treatment of inflammatory bowel disease Methods are described for treating inflammatory bowel disease in animals, including humans. Specific avian polyclonal antibodies directed to proinflammatory cytokines (such as IL-6 and TNF) are shown to have a beneficial effect in animal models predictive of human t... | 08/28/2007 |
| 7201903 | Method and device for detecting feline immunodeficiency virus A method and device for determining a feline immunodeficiency virus infection or vaccination in an animal. The method includes contacting a biological sample from a felid with various FIV polypeptides and determining the binding of antibodies in the sample to the po... | 04/10/2007 |
| 7118874 | Immunogenic formulation and process for preparation thereof A process is disclosed for preparation of a immunogenic peptide mixture in a single synthesis. The peptide mixture collectively represents the in vivo variability seen in immunogenic epitopes from a pathogen. The mixture is termed a hypervariable epitope construct (... | 10/10/2006 |
| 7118888 | Gene expression vaccine An effective prophylactic mucosal gene expression vaccine (GXV), made up of a cocktail of at least 4 different plasmid DNAs encoding corresponding RSV antigens, coacervated with chitosan to formulate nanospheres. In a murine model of RSV infection, intranasal admini... | 10/10/2006 |
| 7094550 | Method to determine TGF-beta A method for treating or preventing cardiovascular pathologies by administering a compound of the formula (I): wherein Z is C═O or a covalent bond; Y is H or O(C1–C4)alkyl, R1 | 08/22/2006 |
| 7078483 | Retroviral vectors including modified envelope escort proteins A retroviral vector comprising a first retroviral envelope protein and at least one modified retroviral envelope protein, wherein the first retroviral envelope protein includes a surface protein comprising (i) a receptor binding region; (ii) a hypervariable polyprol... | 07/18/2006 |
| 7033751 | Antigenic fragment of human T-lymphotropic virus Antigenic fragments of human T-lymphotropic virus (HTLV), their fusion proteins with glutathione S-tranferase (GST) or thioredoxin (Thio), and a process for producing the fusion proteins thereof. The antigenic fragment of HTLV comprises the amino acid sequence of SE... | 04/25/2006 |
| 7030234 | Non-M, non-O HIV-1 strains, fragments and uses Retroviral strains of the non-M, non-O HIV-1 group, in particular a strain designated YBF30, its fragments and also its uses as a diagnostic reagent and as an immunogenic agent. The HIV-1 viruses which differ both from the M group and the O group exhibit the ... | 04/18/2006 |
| 7022482 | Use of immunogenic immunosuppressive and/or angiogenic proteins which have been rendered inactive, process for their preparation and pharmaceutical or vaccinal uses The invention concerns the use of a protein derived from cancer cells, virus-infected cells or immune-defence cells or a fragment of said protein, characterized in that said protein is initially an immunosuppressive and/or angiogenic protein with local activity and ... | 04/04/2006 |
| 7022325 | CD8 epitope from HIV-1 protein Vpu The invention relates to the identification and the selection of CTL epitopes able to induce a protection against an HIV infection. More particularly, the invention is concerned with peptides and nucleic acid sequence coding for these peptides derived from HIV-1 pro... | 04/04/2006 |
| 7022326 | Carboxymethylated retroviral regulatory proteins and interferon-α This invention relates to retroviral regulatory proteins or fragments thereof, or interferon alpha protein or fragments thereof, which are carboxymethylated. This chemical modification leads to new proteins or fragments which are biologically inactive but preserve t... | 04/04/2006 |
| 6936246 | Passive immunization of ASCR for prion disorders Disclosed are pharmaceutical compositions and methods for preventing or treating a number of amyloid diseases, including Alzheimer's disease, prion diseases, familial amyloid neuropathies and the like. The pharmaceutical compositions include immunologically reactive... | 08/30/2005 |
| 6806055 | HIV envelopolype peptides A method for the rational design and preparation of vaccines based on HIV envelope polypeptides is described. In one embodiment, the method for making an HIV gp120 subunit vaccine for a geographic region comprises determining neutralizing epitopes in the V2 and/or C... | 10/19/2004 |
| 6670466 | Human endogenous retrovirus in breast cancer The present invention is related to mammary tumor virus (MTV). MTV represents a group of retroviruses which possess very high homology to mouse mammary tumor virus (MMTV), a virus known to cause neoplastic mammary disease in mice. As described herein, MTV... | 12/30/2003 |
| 6656471 | HIV-specific T-cell induction This invention discloses diagnostic, preventative, and treatment therapies of AIDS involving determining whether a subject exhibits an HLA-Cw7-restricted CTL response. Some methods are directed to the use of HLA-Cw7 as a genetic marker for long-term non-p... | 12/02/2003 |
| 6602505 | Viral chimeras comprised of CAEV and HIV-1 genetic elements The invention provides a polynucleotide comprising portions of the genomes of caprine arthritis-encephalitis virus and HIV-1, resulting in a chimeric retrovirus referred to as a "CHIV. " The invention also provides a vaccine comprising a CHIV immunogen an... | 08/05/2003 |
| 6602705 | Expression of HIV polypeptides and production of virus-like particles The present invention relates to the efficient expression of HIV polypeptides in a variety of cell types, including, but not limited to, mammalian, insect, and plant cells. Synthetic expression cassettes encoding the HIV Gag-containing polypeptides are de... | 08/05/2003 |
| 6582703 | Isolated nucleotide sequences associated with multiple sclerosis or rheumatoid arthritis and a process of detecting The invention provides viral material and nucleotide fragments associated with multiple sclerosis and/or rheumatoid arthritis for use in methods of diagnosis, prophylaxis, and therapy.... | 06/24/2003 |
| 6579526 | Viral material and nucleotide fragments associated with multiple sclerosis, for diagnostic, prophylactic and therapeutic purposes Viral material, in the isolated or purified state, in which the genome comprises a nucleotide sequence chosen from the group including sequences SEQ ID NO:46, SEQ ID NO:51, SEQ ID NO:52, SEQ ID NO:53 and SEQ ID NO:56, their complementary sequences and the... | 06/17/2003 |
| 6573091 | Chimeric viral packaging signal without gag gene sequences A chimeric viral packaging signal is described for the transmission of genetic materials via retrovirus. The packaging signal contains an essential packaging nucleic acid sequence and a non-essential nucleic acid sequence. The packaging signal lacks gag g... | 06/03/2003 |
| 6528250 | Equine infectious anemia challenge model for testing vaccines, diagnostics and treatments The invention relates to a method for infecting equines with an equine infectious anemia virus (EIAV) in order to reproduce a natural infection challenge model. More specifically, the invention provides a multiple low dose equine EIA challenge model compr... | 03/04/2003 |
| 6514692 | Method for treatment of immunodeficiency virus infection The present invention relates to methods for treating immunodeficiency virus infection in an infected animal comprising administering an effective amount of a lytic peptide.... | 02/04/2003 |
| 6495315 | Channel forming toxins as antiviral agents The infectivity of a population of enveloped viruses which comprise a glycosylphosphatidylinositol-anchored protein in their membrane can be reduced by employing certain toxins such as aerolysin, alpha toxin of Clostridium septicum, or enterolobin. Toxins... | 12/17/2002 |
| 6455265 | Method for obtaining vaccines for preventing the pathogenic effects related to a retroviral infection A method of searching for and obtaining a vaccine against the pathogenic effects related to the infection of an animal or human host by a retrovirus that penetrates into a target cell of the host, and a vaccine obtained by the method are provided. The met... | 09/24/2002 |
| 6447993 | Multi-subtype FIV vaccines The subject invention pertains to novel methods and compositions for protecting cats from infection by a broad range of FIV strains using a multi-subtype FIV vaccine. Multi-subtype FIV vaccines comprising either cell free whole virus or cell lines infecte... | 09/10/2002 |
| 6444442 | Method of producing a recombinant non-glycosylated gp90 of equine infectious anemia virus (EIAV), and product thereof The present invention describes recombinant gp90 envelop protein derived from the equine infectious anemia virus, their corresponding encoding recombinant DNA molecule and the process of production of the recombinant protein produced through genetic engin... | 09/03/2002 |
| 6406841 | Methods for the detection of HTLV-II antibodies employing novel HTLV-II NRA envelope peptides The present invention relates generally to a novel human T-cell lymphotropic, or leukemia, virus type II (HTLV-II) isolate designated NRA. HTLV-IINRA was originally isolated from a patient with atypical hairy cell leukemia. Preliminary restrict... | 06/18/2002 |
| 6392029 | HIV chemokines Disclosed is a gene comprising an open reading frame encoded on the plus strand of the pro-viral DNA, and located in the region of HIV-1 long terminal repeat. The gene encodes a protein that is related to, and has a structural motif resembling that of che... | 05/21/2002 |
