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| Number | Title | Issue Date |
| 8178103 | Porcine reproductive and respiratory syndrome virus strains and compositions This invention relates to two attenuated strains of porcine reproductive and respiratory syndrome virus (PRRSV) and immunogenic compositions comprising one or more strains of attenuated porcine reproductive and respiratory syndrome virus (PRRSV). ... | 05/15/2012 |
| 8168193 | Molecules, compositions, methods and kits for applications associated with flaviviruses A method for controlling a flavivirus entry into a cell, kits for assaying the flavivirus entry into the cell, and methods of treating and preventing flaviviruses infections are disclosed, together with vaccine and pharmaceutical compositions. ... | 05/01/2012 |
| 8168192 | Enterovirus type 71 protein and method for production The invention provides a new type of a capsid protein VP1 of human enterovirus 71, named as MEL701-VP1 and functional/structural variants thereof, which is used for protection against enterovirus. The transgenic animal producing the protein, the composition comprisi... | 05/01/2012 |
| 8147839 | Fusion proteins of HIV regulatory/accessory proteins The invention relates to fusion proteins comprising the amino acid sequence of at least three HIV proteins selected from Vif, Vpr, Vpu, Rev, and Tat or derivatives of the amino acid sequence of one or more of said proteins, wherein the fusion protein is not processe... | 04/03/2012 |
| 8142788 | PRRSV GP5 based compositions and methods The disclosure includes compositions and methods for the production of an immune response against porcine reproductive and respiratory syndrome (PRRS) virus, or PRRSV. The disclosure is based in part on the use of two or more peptide domains, each with a different s... | 03/27/2012 |
| 8114408 | Peptide fragments reacting specifically with antibodies against highly pathogenic newcastle disease virus and uses thereof We disclose synthetic peptide fragments comprising amino acid sequences of specific antigen sites of pathogenic Newcastle disease virus in birds, and more particularly synthetic peptide fragments that comprise polybasic amino acid sequences at the cleavage site of t... | 02/14/2012 |
| 8114409 | Structural proteins of fish pancreatic disease virus and uses thereof The present invention relates to the structural proteins of the causative agent of Pancreatic Disease in fish, nucleotide sequences encoding said proteins, vaccines comprising said proteins or nucleotide sequences and diagnostic kits comprising said proteins or nucl... | 02/14/2012 |
| 8114410 | Composition and methods for the inhibition of membrane fusion by paramyxoviruses Fusion of the membrane of enveloped viruses with the plasma membrane of a receptive host cell is a prerequisite for viral entry and infection and an essential step in the life cycle of all enveloped viruses, such as paramyxoviruses. The instant invention is directed... | 02/14/2012 |
| 8105606 | Chimeric proteins that induce effects directed against viruses The present invention is related to the obtaining of chimeric chains coding for proteins capable of inducing, in the recipient, a serotype-specific and protective humoral immune response against the infection by the Dengue virus, thus eliminating the effects of the ... | 01/31/2012 |
| 8067010 | Immunological herpes simplex virus antigens and methods for use thereof The invention provides HSV antigens that are useful for the prevention and treatment of HSV infection. Disclosed herein are antigens and/or their constituent epitopes confirmed to be recognized by T-cells derived from herpetic lesions or from uterine cervix. T-cells... | 11/29/2011 |
| 7998484 | Nucleic acid and amino acid sequences of infectious salmon anaemia virus and their use as vaccines The present invention provides the use of nucleic acid sequences and/or amino acid sequences in the preparation of a vaccine for the protection of fish against infectious salmon anemia virus. Specifically, such vaccines contain at least one nucleic acid sequence whi... | 08/16/2011 |
| 7981428 | Flu vaccines and methods of use thereof This disclosure is directed, inter alia, to polynucleotides, polypeptides, vectors, cells and compositions comprising the same, and their use in affecting viral pathogenesis, in particular for influenza viral infection. ... | 07/19/2011 |
| 7981427 | Canine respiratory coronavirus (CRCV) spike protein A canine respiratory coronavirus (CRCV) that is present in the respiratory tract of dogs with canine infectious respiratory disease and which has a low level of homology to the enteric canine coronavirus, but which has a high level of homology to all bovine coronavi... | 07/19/2011 |
| 7947281 | Chimeric proteins that induce effects directed against viruses The present invention is related to the obtaining of chimeric chains coding for proteins capable of inducing, in the recipient, a serotype-specific and protective humoral immune response against the infection by the Dengue virus, thus eliminating the effects of the ... | 05/24/2011 |
| 7842295 | Canine influenza virus and related compositions and methods of use The present invention provides an isolated canine influenza virus of subtype H3N8 comprising an HA having SEQ ID NO: 4 or an amino acid sequence that is greater than 99% identical to SEQ ID NO: 4, with the proviso that the amino acids at positions 94 and 233 are ide... | 11/30/2010 |
| 7807173 | Influenza vaccine formulation Peptide-based anti-influenza formulations against influenza are disclosed. The peptides are derived from influenza-based epitopes. The formulations are based on peptide mixtures which may be formulated so that variability is present at particular residues. The formu... | 10/05/2010 |
| 7794724 | Fish vaccine The present invention relates to veterinary immunology, namely to the immunological response of fish to a virus. More specifically, the invention provides an epitope of salmonid alphaviruses which epitope is capable of inducing a virus neutralising immune response. ... | 09/14/2010 |
| 7749506 | Proteins derived from white spot syndrome virus and uses thereof Embodiments of the present invention generally relate to proteins derived from white spot syndrome virus, nucleic acid sequences encoding them, and their use in the manufacture of a vaccine for prophylaxis and/or treatment of white spot syndrome in crustaceans. ... | 07/06/2010 |
| 7740858 | SARS-CoV-specific B-cell epitope and applications thereof Disclosed is SARS-CoV-specific B-cell epitope and applications thereof. The epitopes are peptides and can either be expressed in phages or synthesized to diagnose SARS patients accurately. High sensitivity and specificity of the serologic detection are achievable by... | 06/22/2010 |
| 7736656 | Immunogenic compositions and vaccines for Ebola Using CTL epitopes to the Ebola GP, NP, VP24, VP30, VP35 and VP40 virion proteins, a method and composition for use in inducing an immune response which is protective against infection with Ebola virus is described. ... | 06/15/2010 |
| 7722878 | PRRSV subunit vaccines Vaccines effective against PRRSV include at least one portion of PRRSV ORF1. Such vaccines, upon administration, provoke an immune response in PRRSV-susceptible animals. Moreover, compositions in accordance with the present invention provide immune response up to an... | 05/25/2010 |
| 7666431 | Compositions and methods for the inhibition of membrane fusion by paramyxoviruses Fusion of the membrane of enveloped viruses with the plasma membrane of a receptive host cell is a prerequisite for viral entry and infection and an essential step in the life cycle of all enveloped viruses, such as paramyxoviruses. The instant invention is directed... | 02/23/2010 |
| 7622120 | Peptide originating from vaccinia virus A vaccine for preventing or treating Orthopoxvirus infection that induces a protective or therapeutic immune response, wherein the vaccine comprises (1) an amino acid sequence of 20 amino acid or less (preferably 12 amino acid or less and most preferably 11 amino ac... | 11/24/2009 |
| 7595053 | Chimeric T helper-B cell peptide vaccine for Japanese encephalitis virus A vaccine composition for humans and animals against Japanese encephalitis virus infection is a composition which comprises a chimeric synthetic peptide consisting of a B cell epitope linked to a T-helper cell epitope from Japanese encephalitis proteins, wherein the... | 09/29/2009 |
| 7585507 | Nucleic acid molecules and polypeptides for immune modulation The invention provides gp38 polypeptides, which play a role in immunomodulation, nucleic acid molecules encoding these polypeptides, and therapeutic and diagnostic methods employing these polypeptides and nucleic acid molecules. The invention also provides methods f... | 09/08/2009 |
| 7566457 | Chimeric proteins that induce effects directed against viruses The present invention is related to the obtaining of chimeric chains coding for proteins capable of inducing, in the recipient, a serotype-specific and protective humoral immune response against the infection by the Dengue virus, thus eliminating the effects of the ... | 07/28/2009 |
| 7556812 | Dengue and West Nile viruses proteins and genes coding the foregoing, and their use in vaccinal, therapeutic and diagnostic applications The present invention relates to the development of viral vectors expressing different immunogens from the West Nile Encephalitis Virus (WNV) or the Dengue virus which are able to induce protective humoral and cellular immune responses against WNV or Dengue virus in... | 07/07/2009 |
| 7537768 | Influenza virus vaccine composition and methods of use The present invention is directed to enhancing the immune response of a human in need of protection against IV infection by administering in vivo, into a tissue of the human, at least one polynucleotide comprising one or more regions of nucleic acid encoding an IV p... | 05/26/2009 |
| 7524503 | Human cytomegalovirus (HCMV) cytotoxic T cell epitopes, polyepitopes compositions comprising same and diagnostic and prophylactic and therapeutic uses therefor The present invention provides CTL epitope peptides and polyepitope peptides from 14 distinct antigens of human cytomegalovirus (HCMV) that are restricted through HLA the most commonly prevalent class I alleles in different ethnic populations of the world. These epi... | 04/28/2009 |
| 7507411 | Attenuated influenza NS1 variants Attenuated influenza virus variants comprising substitutions in NS1 that interfere with viral replication and phosphatidylinositol 3-kinase activation are described. NS1 variant polypeptides, polynucleotides encoding NS1 variant polypeptides, a reverse genetics syst... | 03/24/2009 |
| 7491397 | Receptor binding polypeptides Isolated polypeptides containing fragments of SARS CoV S protein and functional equivalents thereof. Also disclosed are isolated nucleic acids encoding the polypeptides, related expression vectors, related host cells, related antibodies, and related compositions. Me... | 02/17/2009 |
| 7442378 | Attenuated circovirus An isolated attenuated circovirus having a mutation in viral nucleic acid encoding viral protein 2 (VP2). The attenuated circovirus is particularly suitable for use in conferring immunity in an animal, particularly birds. ... | 10/28/2008 |
| 7431928 | Identification of new CD8 epitopes from HIV-1 proteins The invention relates to the identification and the selection of CTL epitopes able to induce a protection against an HIV infection. More particularly, the invention is concerned with peptides and nucleic acid sequence coding for these peptides derived from HIV-1 pro... | 10/07/2008 |
| 7427658 | Chicken anemia virus mutants and vaccines and uses based on the viral proteins VP1, VP2 and VP3 or sequences of that virus coding therefor The coding information for three putative chicken anemia virus proteins (VP1, VP2, VP3) was inserted into a baculovirus vector and expressed in insect cells. Only lysates of insect cells which have synthesized equivalent amounts of all three recombinant CAV proteins... | 09/23/2008 |
| 7425335 | Chimeric T helper-B cell peptide vaccine for Japanese encephalitis virus A vaccine composition for humans and animals against Japanese encephalitis virus infection is a composition which comprises a chimeric synthetic peptide selected from envelope glycoprotein consisting of amino acids Egp 149-SENHGNYSAQVGASQ-163 (SEQ ID NO:1) AND Egp 4... | 09/16/2008 |
| 7422751 | Epstein-barr-virus-specific immunization The invention provides materials and methods for using EBV EBNA2 peptide epitopes to treat and/or prevent post-transplant lymphoproliferative disorders (PTLD). The invention also provides compositions and articles of manufacture containing EBNA2 peptide epitopes tha... | 09/09/2008 |
| 7420028 | Replikins and methods of identifying replikin-containing sequences The present invention provides methods for identifying a class of peptides referred to as replikins and methods of using replikins to stimulate the immune system of a subject. The method of identifying replikin peptides is based on identifying amino acid sequences c... | 09/02/2008 |
| 7416733 | Flavivirus fusion inhibitors The present invention relates to peptides and methods of inhibiting fusion between the virion envelope of Flaviviruses and membranes of the target cell, the process that delivers the viral genome into the cell cytoplasm. The invention provides for methods which empl... | 08/26/2008 |
| 7411058 | Cold-adapted equine influenza viruses The present invention provides experimentally-generated cold-adapted equine influenza viruses, and reassortant influenza A viruses comprising at least one genome segment of such an equine influenza virus, wherein the equine influenza virus genome segment confers at ... | 08/12/2008 |
| 7410801 | Lambda phage display system and the process The present invention relates to a process of obtaining recombinant lambdoid bacteriophage with high density display of functional peptides and proteins on surface of said phage comprising of: constructing a donor plasmid having a nucleotide sequence that defines th... | 08/12/2008 |
